MA32909B1 - Composes thiazolopyridines de modulation des sirtuines - Google Patents

Composes thiazolopyridines de modulation des sirtuines

Info

Publication number
MA32909B1
MA32909B1 MA33955A MA33955A MA32909B1 MA 32909 B1 MA32909 B1 MA 32909B1 MA 33955 A MA33955 A MA 33955A MA 33955 A MA33955 A MA 33955A MA 32909 B1 MA32909 B1 MA 32909B1
Authority
MA
Morocco
Prior art keywords
diseases
disorders
compounds
sertoin
modification
Prior art date
Application number
MA33955A
Other languages
Arabic (ar)
English (en)
Inventor
Christopher Oalmann
Jeremy S Disch
Pui Yee Ng
Robert B Perni
Original Assignee
Sirtris Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42269132&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32909(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sirtris Pharmaceuticals Inc filed Critical Sirtris Pharmaceuticals Inc
Publication of MA32909B1 publication Critical patent/MA32909B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur de nouveaux composés de modulation des sirtuines de formule structurale (Ia) et sur leurs procédés d'utilisation. Les composés de modulation des sirtuines peuvent être utilisés pour augmenter la durée de vie d'une cellule, et pour traiter et/ou prévenir une large diversité de maladies et de troubles comprenant, par exemple les maladies ou les troubles liés au vieillissement ou au stress, le diabète, l'obésité, les maladies neurodégénératives, les maladies cardiovasculaires, les troubles de la coagulation du sang, l'inflammation, le cancer et/ou les bouffées vasomotrices ainsi que les maladies ou troubles qui pourraient bénéficier d'une activité mitochondriale accrue. L'invention porte également sur des compositions comportant un composé de modulation des sirtuines en combinaison avec un autre agent thérapeutique.
MA33955A 2008-12-19 2011-06-17 Composes thiazolopyridines de modulation des sirtuines MA32909B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20315608P 2008-12-19 2008-12-19
PCT/US2009/068865 WO2010071853A1 (fr) 2008-12-19 2009-12-18 Composés thiazolopyridines de modulation des sirtuines

Publications (1)

Publication Number Publication Date
MA32909B1 true MA32909B1 (fr) 2011-12-01

Family

ID=42269132

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33955A MA32909B1 (fr) 2008-12-19 2011-06-17 Composes thiazolopyridines de modulation des sirtuines

Country Status (22)

Country Link
US (2) US8343997B2 (fr)
EP (1) EP2376502B1 (fr)
JP (1) JP5628828B2 (fr)
KR (1) KR20110110194A (fr)
CN (1) CN102388054B (fr)
BR (1) BRPI0922435A2 (fr)
CA (1) CA2747715A1 (fr)
CO (1) CO6400181A2 (fr)
CR (1) CR20110353A (fr)
DO (1) DOP2011000188A (fr)
EA (1) EA021424B1 (fr)
ES (1) ES2544258T3 (fr)
IL (1) IL213217A0 (fr)
MA (1) MA32909B1 (fr)
MX (1) MX2011006555A (fr)
MY (1) MY160006A (fr)
NZ (1) NZ594122A (fr)
PE (1) PE20120057A1 (fr)
SG (1) SG171835A1 (fr)
UA (1) UA104447C2 (fr)
WO (1) WO2010071853A1 (fr)
ZA (1) ZA201104060B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070014833A1 (en) * 2005-03-30 2007-01-18 Sirtris Pharmaceuticals, Inc. Treatment of eye disorders with sirtuin modulators
JP5425891B2 (ja) 2008-05-01 2014-02-26 サートリス ファーマシューティカルズ， インコーポレイテッド サーチュイン調節薬としてのキノリンおよび関連する類似体
AU2009266889B2 (en) 2008-07-03 2013-05-02 Glaxosmithkline Llc Benzimidazoles and related analogs as sirtuin modulators
CN102227420B (zh) 2008-09-29 2015-06-24 西特里斯药业公司 作为沉默调节蛋白调节剂的喹唑啉酮、喹诺酮和相关的类似物
US9556201B2 (en) 2009-10-29 2017-01-31 Glaxosmithkline Llc Bicyclic pyridines and analogs as sirtuin modulators
WO2013142817A2 (fr) 2012-03-23 2013-09-26 Dennis Brown Compositions et procédés d'amélioration du bénéfice thérapeutique de l'indirubine et de ses analogues y compris du mésoindigo
RU2014149136A (ru) 2012-05-08 2016-07-10 Мерк Шарп И Доум Корп. ТЕТРАГИДРОНАФТИРИДИНОВЫЕ И РОДСТВЕННЫЕ БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ RORγ АКТИВНОСТИ И ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ
WO2013169864A2 (fr) 2012-05-08 2013-11-14 Lycera Corporation Tétrahydro[1,8]naphtyridine-sulfonamide et composés apparentés pour utilisation en tant qu'agonistes de rorγ et dans le traitement d'une maladie
JP2015525223A (ja) 2012-06-14 2015-09-03 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 動物有害生物を駆除するための置換３−ピリジルチアゾール化合物および誘導体を使用する有害生物防除方法
BR112015028613A2 (pt) 2013-05-13 2017-07-25 Glaxosmithkline Llc análogos de uréia com ligações por pontes substituída como moduladores de sirtuína
WO2016081692A2 (fr) * 2014-11-19 2016-05-26 Glaxosmithkline Llc Analogues d'urée pontés substitués utilisés comme modulateurs de la sirtuine
US10172915B2 (en) 2013-10-20 2019-01-08 Duke University Methods and compositions for activation of sirtuins with Annexin A1 peptides
US9663502B2 (en) 2013-12-20 2017-05-30 Lycera Corporation 2-Acylamidomethyl and sulfonylamidomethyl benzoxazine carbamates for inhibition of RORgamma activity and the treatment of disease
US9809561B2 (en) 2013-12-20 2017-11-07 Merck Sharp & Dohme Corp. Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
US9783511B2 (en) 2013-12-20 2017-10-10 Lycera Corporation Carbamate benzoxazine propionic acids and acid derivatives for modulation of RORgamma activity and the treatment of disease
MX2016010998A (es) 2014-02-27 2017-03-31 Lycera Corp Terapia celular adoptiva que usa un agonista de receptor huérfano gamma relacionado con receptor de ácido retinoico y métodos terapéuticos relacionados.
US9896441B2 (en) 2014-05-05 2018-02-20 Lycera Corporation Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
JP6523337B2 (ja) 2014-05-05 2019-05-29 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ＲＯＲγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物
WO2015186068A1 (fr) 2014-06-02 2015-12-10 Glaxosmithkline Intellectual Property (No.2) Limited Préparation et utilisation de bêta-d-nicotinamide riboside cristallin
RU2016149767A (ru) 2014-06-06 2018-07-16 Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед Аналоги никотинамидрибозида и фармацевтические композиции и их применение
CA2975997A1 (fr) 2015-02-11 2016-08-18 Merck Sharp & Dohme Corp. Composes pyrazole substitues utilises en tant qu'inhibiteurs de rorgammat et utilisations desdits composes
CA2982847A1 (fr) 2015-05-05 2016-11-10 Lycera Corporation Sulfonamides de dihydro-2h-benzo[b][1,4]oxazine et composes apparentes destines a etre utilises comme agonistes de ror.gamma. et pour le traitement de maladies
HK1253734A1 (zh) 2015-06-11 2019-06-28 The Regents Of The University Of Michigan 用作RORγ激动剂和用於治疗疾病的芳基二氢-2H-苯并[B][1，4]恶嗪磺酰胺和相关化合物
US9782859B2 (en) * 2015-07-16 2017-10-10 Siemens Energy, Inc. Slag free flux for additive manufacturing
CA3002850A1 (fr) 2015-10-27 2017-05-04 Merck Sharp & Dohme Corp. Composes indazole substitues utilises en tant qu'inhibiteurs de rorgammat et utilisations associees
AU2016344111A1 (en) 2015-10-27 2018-05-10 Merck Sharp & Dohme Corp. Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof
JP2018531958A (ja) 2015-10-27 2018-11-01 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ＲＯＲγＴ阻害薬としてのヘテロアリール置換安息香酸及びその使用
BR112018017077A2 (pt) 2016-02-23 2018-12-26 Univ Indiana Res & Tech Corp terapias de combinação para tratamento de atrofia muscular espinhal
WO2020247608A1 (fr) * 2019-06-04 2020-12-10 The Regents Of The University Of California Inhibiteurs à petites molécules d'un complexe protéique

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3164603A (en) 1965-01-05 xnhcox
DE1108698B (de) 1959-09-03 1961-06-15 Hoechst Ag Verfahren zur Herstellung von 2-(2'-Aminoaryl)-4, 5-arylen-1, 2, 3-triazolen
FR1439129A (fr) 1965-04-02 1966-05-20 Chimetron Nouveaux sulfonylbenzimidazoles
FR1476529A (fr) 1965-04-24 1967-04-14 Chimetron Sarl Nouveaux dérivés benzimidazole-sulfoniques et sulfamides correspondants
US3503929A (en) 1965-10-21 1970-03-31 Minnesota Mining & Mfg Polyimidazoquinazolines and polyamidobenzimidazoles
US3517007A (en) 1968-04-05 1970-06-23 American Home Prod 5 - acetamido - 4 - pyrimidinecarboxamides,5 - acetamido - 4 - pyrimidinecarboxylic acid hydrazides and related compounds
US3928228A (en) 1969-04-28 1975-12-23 Sterling Drug Inc 4,4{40 -Stilbenebis-pyridooxazoles and related optical brighteners and polymeric compositions brightened thereby
US3712888A (en) 1970-12-14 1973-01-23 American Cyanamid Co Bis-pyridoxazole-stilbene derivatives for optical brightening
CA1006165A (en) 1971-04-06 1977-03-01 Eastman Kodak Company Ballasted color photographic couplers
AR208500A1 (es) 1972-06-14 1977-02-15 Merck & Co Inc Procedimiento para la preparacion de derivados de oxazolo(4,5-b)-piridinas
US4038396A (en) 1975-02-24 1977-07-26 Merck & Co., Inc. Anti-inflammatory oxazole[4,5-b]pyridines
PL96241B1 (pl) 1975-06-30 1977-12-31 Sposob wytwarzania 2-/2-podstawionych-4-tiazolilo/-benzimidazoli
JPS6040016B2 (ja) 1977-08-31 1985-09-09 コニカ株式会社 マゼンタ色素画像の形成方法
US4471040A (en) 1980-09-10 1984-09-11 Canon Kabushiki Kaisha Electrophotographic disazo photosensitive member
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4939133A (en) 1985-10-01 1990-07-03 Warner-Lambert Company N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade
DE3807084A1 (de) 1988-03-04 1989-09-14 Knoll Ag Neue benzimidazo(1,2-c)chinazoline, ihre herstellung und verwendung
JPH04190232A (ja) 1990-11-26 1992-07-08 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
US5814651A (en) 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
JPH06247969A (ja) 1992-12-28 1994-09-06 Takeda Chem Ind Ltd 縮合複素環化合物及びそれを含む農園芸用殺虫剤
ES2172585T3 (es) 1994-05-31 2002-10-01 Mitsui Chemicals Inc Derivado de benzoimidazol.
AUPN449295A0 (en) 1995-07-28 1995-08-24 Inner And Eastern Health Care Network, The Radioprotectors
AU6966696A (en) 1995-10-05 1997-04-28 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
US5808087A (en) 1995-11-29 1998-09-15 Mitsui Chemicals, Inc. Sulfonium salts of pyrrolylbenzimidazoles
IL136911A0 (en) 1997-12-31 2001-06-14 Univ Rutgers Heterocyclic topoisomerase poisons
US6653309B1 (en) 1999-04-26 2003-11-25 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme technical field of the invention
AU778393B2 (en) 1999-05-12 2004-12-02 Ortho-Mcneil Pharmaceutical, Inc. Pyrazole carboxamides useful for the treatment of obesity and other disorders
PT1194425E (pt) 1999-06-23 2005-10-31 Aventis Pharma Gmbh Benzimidazoles substituidos
WO2001021615A1 (fr) 1999-09-17 2001-03-29 Yamanouchi Pharmaceutical Co., Ltd. Dérivés de benzimidazole
DE19948434A1 (de) 1999-10-08 2001-06-07 Gruenenthal Gmbh Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine
AU2001259707A1 (en) 2000-06-14 2001-12-24 Warner Lambert Company 6,5-fused bicyclic heterocycles
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
JP2002161084A (ja) 2000-11-28 2002-06-04 Sumitomo Pharmaceut Co Ltd 複素環誘導体
US20040010033A1 (en) 2001-02-20 2004-01-15 Pfizer Inc. Non-peptide GnRH agents, methods and intermediates for their preparation
WO2002066454A1 (fr) 2001-02-21 2002-08-29 Sankyo Company, Limited Derives de chromene
CN1514833A (zh) 2001-03-28 2004-07-21 ����˹�ж�-����˹˹������˾ 新型酪氨酸激酶抑制剂
US7081454B2 (en) 2001-03-28 2006-07-25 Bristol-Myers Squibb Co. Tyrosine kinase inhibitors
WO2003007959A1 (fr) 2001-07-16 2003-01-30 Fujisawa Pharmaceutical Co., Ltd. Derives de quinoxaline ayant une action inhibitrice sur parp
WO2003011219A2 (fr) 2001-07-27 2003-02-13 Curis, Inc. Mediateurs des voies de signalisation hedgehog, compositions associees et utilisations de ces dernieres
WO2004043335A2 (fr) 2001-09-13 2004-05-27 Genesoft, Inc. Procede de traitement d'infections par des bacteries pharmacoresistantes
US6897208B2 (en) 2001-10-26 2005-05-24 Aventis Pharmaceuticals Inc. Benzimidazoles
EP1460067A4 (fr) 2001-11-26 2005-12-07 Takeda Pharmaceutical Derive bicyclique, procede de production de ce derive et utilisation correspondante
AU2002349705A1 (en) 2001-12-03 2003-06-17 Japan Tobacco Inc. Azole compound and medicinal use thereof
KR20040084896A (ko) 2002-02-06 2004-10-06 버텍스 파마슈티칼스 인코포레이티드 Ｇｓｋ-3의 억제제로서 유용한 헤테로아릴 화합물
GB0205256D0 (en) 2002-03-06 2002-04-17 Oxford Glycosciences Uk Ltd Novel compounds
ATE432261T1 (de) 2002-03-18 2009-06-15 Merck Frosst Canada Ltd Pde4-inhibitoren mit heterobrückensubstituiertem 8-arylchinolin
NZ535603A (en) 2002-03-20 2007-10-26 Metabolex Inc Substituted phenylacetic acids
TW200304820A (en) 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
JP4239463B2 (ja) 2002-04-09 2009-03-18 大正製薬株式会社 ３−トリフルオロメチルアニリド誘導体
JP4224979B2 (ja) 2002-04-09 2009-02-18 大正製薬株式会社 インターロイキン１２抑制剤
KR20040099449A (ko) 2002-04-18 2004-11-26 쉐링 코포레이션 히스타민 ｈ3 길항제로서의1-(4-피페리디닐)벤즈이미다졸론
JP2003313176A (ja) 2002-04-24 2003-11-06 Sankyo Co Ltd アミノアゾール誘導体
DE50312261D1 (de) 2002-07-12 2010-02-04 Sanofi Aventis Deutschland Heterozyklisch substituierte benzoylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
SE0202429D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel Compounds
DE10237722A1 (de) 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
JP2004075614A (ja) 2002-08-20 2004-03-11 Sankyo Co Ltd クロメン誘導体を含有する医薬
TW200501960A (en) 2002-10-02 2005-01-16 Bristol Myers Squibb Co Synergistic kits and compositions for treating cancer
US20040171073A1 (en) 2002-10-08 2004-09-02 Massachusetts Institute Of Technology Compounds for modulation of cholesterol transport
EP1551809A1 (fr) 2002-10-09 2005-07-13 Pfizer Products Inc. Composes pyrazole pour le traitement de maladies neurodegeneratives
WO2004033666A2 (fr) 2002-10-11 2004-04-22 Board Of Regents, The University Of Texas System Procedes et composes pour inhiber l'activite de hec1 dans le traitement des maladies proliferatives
US7265129B2 (en) 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
AU2003286757B2 (en) 2002-11-01 2009-06-04 Merck Sharp & Dohme Corp. Carbonylamino-benzimidazole derivatives as androgen receptor modulators
AU2003302497A1 (en) 2002-11-27 2004-06-23 Ph. D. Edward M. Eddy Glyceraldehyde 3-phosphate dehydrogenase-s(gapds), a glycolytic enzyme expressed only in male germ cells,is a target for male contraception
DE10300398A1 (de) 2003-01-09 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten 2-Phenylbenzimidazolen als Arzneimittel
JP2006516626A (ja) 2003-01-28 2006-07-06 スミスクライン ビーチャム コーポレーション 化学的化合物
CA2515215A1 (fr) 2003-02-10 2004-08-26 Amgen Inc. Ligands du recepteur vanilloide et leur utilisation dans des traitements
US7157460B2 (en) 2003-02-20 2007-01-02 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
GEP20084341B (en) 2003-02-26 2008-03-25 Sugen Inc Aminoheteroaryl compounds as protein kinase inhibitors
JP2006519833A (ja) 2003-03-11 2006-08-31 ファイザー・プロダクツ・インク トランスフォーミング成長因子（ｔｇｆ）阻害剤としてのピラジン化合物
JP2006520794A (ja) 2003-03-21 2006-09-14 スミスクライン ビーチャム コーポレーション 化合物
TWI372050B (en) 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
GB2405793A (en) 2003-09-12 2005-03-16 4 Aza Bioscience Nv Pteridine derivatives for treating TNF-alpha related disorders
AU2004271721A1 (en) 2003-09-12 2005-03-24 4 Aza Bioscience Nv Pteridine derivatives for the treatment of septic shock and TNF-alpha-related diseases.
MXPA06002943A (es) 2003-09-19 2006-05-31 Hoffmann La Roche Derivados de tiazolopiridina como ligandos del receptor de adenosina.
JP4795634B2 (ja) 2003-10-31 2011-10-19 出光興産株式会社 有機薄膜トランジスタ
JP2005162855A (ja) 2003-12-02 2005-06-23 Konica Minolta Holdings Inc 着色組成物、インクジェット記録用インク、カラートナー、光記録媒体、感熱転写記録材料用インクシート、カラーフィルター、及び該インクジェット記録用インクを用いたインクジェット記録方法
CA2553704C (fr) 2004-02-11 2011-04-19 Basilea Pharmaceutica Ag Benzimidazoles substitues et leur utilisation pour induire l'apoptose
WO2005100342A1 (fr) 2004-03-26 2005-10-27 Vertex Pharmaceuticals, Incorporated Inhibiteurs de erk2 a base de pyridine et utilisation de ceux-ci
DE102004021716A1 (de) 2004-04-30 2005-12-01 Grünenthal GmbH Substituierte Imidazo[1,2-a]pyridin-Verbindungen und Arzneimittel enthaltend substituierte Imidazo[1,2-a]pyridin-Verbindungen
TW200600492A (en) 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
MX341797B (es) 2004-06-24 2016-09-02 Vertex Pharmaceuticals Incorporated * Moduladores de transportadores con casete de union con atp.
ES2401138T3 (es) 2004-08-13 2013-04-17 Genentech, Inc. Inhibidores basados en tiazol de enzimas que usan ATP
DE102004039789A1 (de) 2004-08-16 2006-03-02 Sanofi-Aventis Deutschland Gmbh Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
GB0421525D0 (en) 2004-09-28 2004-10-27 Novartis Ag Inhibitors of protein kineses
CA2587489C (fr) 2004-11-03 2013-12-31 Curis, Inc. Mediateurs de chemins de signalisation hedgehog, compositions et utilisations liees a ceux-ci
TW200628159A (en) 2004-11-10 2006-08-16 Synta Pharmaceuticals Corp IL-12 modulatory compounds
EP1853610A1 (fr) 2005-03-03 2007-11-14 Sirtris Pharmaceuticals, Inc. Dérivés de n-phénylbenzamide en tant qu'agents régulant la sirtuine
WO2006094237A2 (fr) 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. Modulateurs de la sirtuine a base d'acridine et de quineoline
WO2006113458A1 (fr) 2005-04-15 2006-10-26 Bristol-Myers Squibb Company Inhibiteurs heterocycliques des proteines arginine methyle transferases
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
CA2618370A1 (fr) 2005-08-04 2007-02-15 Sirtris Pharmaceuticals, Inc. Derives d'oxazolopyridine comme modulateurs du sirtuin
CN101282974A (zh) * 2005-08-04 2008-10-08 西特里斯药业公司 作为sirtuin调节剂的咪唑并吡啶衍生物
JP4396777B2 (ja) 2006-07-14 2010-01-13 東洋インキ製造株式会社 ポリエステル分散剤とその製造方法、及びそれを用いた顔料組成物
WO2008073451A2 (fr) 2006-12-11 2008-06-19 Sirtris Pharmaceuticals, Inc. Composés modulateurs de la sirtuine
ES2431163T3 (es) 2007-03-01 2013-11-25 Novartis Ag Inhibidores de PIM quinasa y métodos para su uso
CL2008001822A1 (es) * 2007-06-20 2009-03-13 Sirtris Pharmaceuticals Inc Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
CL2008001821A1 (es) 2007-06-20 2009-03-13 Sirtris Pharmaceuticals Inc Compuestos derivados de imidazo[2,1-b]-tiazol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de diabetes, sindrome metabolico, resistencia a la insulina, entre otras.
WO2009058348A1 (fr) 2007-11-01 2009-05-07 Sirtris Pharmaceuticals, Inc. Dérivés d'amide comme modulateurs de sirtuines
CN101910184A (zh) 2007-11-08 2010-12-08 西特里斯药业公司 可溶性噻唑并吡啶
US20100168084A1 (en) 2008-05-08 2010-07-01 Huber L Julie Therapeutic compounds and related methods of use
MX2011001702A (es) 2008-08-12 2011-04-28 Sirtris Pharmaceuticals Inc Benzoxazoles, benzotiazoles y analogos relacionados como moduladores de sirtuina.

Also Published As

Publication number Publication date
EP2376502A1 (fr) 2011-10-19
BRPI0922435A2 (pt) 2018-09-11
CN102388054A (zh) 2012-03-21
KR20110110194A (ko) 2011-10-06
AU2009327373A1 (en) 2011-06-30
US8492401B2 (en) 2013-07-23
MX2011006555A (es) 2011-08-03
PE20120057A1 (es) 2012-02-24
EA021424B1 (ru) 2015-06-30
US20110306609A1 (en) 2011-12-15
CR20110353A (es) 2011-10-27
SG171835A1 (en) 2011-07-28
EA201170847A1 (ru) 2011-12-30
CO6400181A2 (es) 2012-03-15
EP2376502A4 (fr) 2012-07-18
JP5628828B2 (ja) 2014-11-19
US8343997B2 (en) 2013-01-01
CA2747715A1 (fr) 2010-06-24
ES2544258T3 (es) 2015-08-28
JP2012512907A (ja) 2012-06-07
EP2376502B1 (fr) 2015-06-17
DOP2011000188A (es) 2011-07-31
CN102388054B (zh) 2015-03-04
UA104447C2 (uk) 2014-02-10
IL213217A0 (en) 2011-07-31
ZA201104060B (en) 2012-02-29
NZ594122A (en) 2013-03-28
US20130085155A1 (en) 2013-04-04
MY160006A (en) 2017-02-15
WO2010071853A1 (fr) 2010-06-24

Similar Documents

Publication Publication Date Title
MA32909B1 (fr) Composes thiazolopyridines de modulation des sirtuines
MA31506B1 (fr) Composes modulant les sirtuines
MA31568B1 (fr) Composes d'imidazothiazole modulant les sirtuines
WO2006094209A3 (fr) Modulateurs de sirtuine a amide n-benzimidazolylalkyle substitue
EP2342188A4 (fr) Analogues de chroménone en tant que modulateurs de sirtuine
MX2011006084A (es) Isoindolinona y analogos relacionados como moduladores de sirtuina.
MX2010012961A (es) Imidazopiridina y analogos relacionados como moduladores de sirtuina.
MX2010005186A (es) Tiazolopiridinas solubilizadas.
WO2007019344A8 (fr) Dérivés d'imidazo [2,1-b] thiayole en tant que modulateurs de sirtuine
MA37450B1 (fr) Inhibiteurs d'indazole du trajet de signal de wnt et leurs utilisations thérapeutiques
MX2011009213A (es) Quinolinas 8-sustituidas y analogos relacionados como moduladores de sirtuina.
EA200701036A1 (ru) Лактамные соединения и их применение в качестве фармацевтических препаратов
WO2008100376A3 (fr) Variants de troncature de sirt1 et procédés d'utilisation de ceux-ci
MA32422B1 (fr) Compositions fongicides
EA200901166A1 (ru) Соединения и композиции в качестве модуляторов активности gpr 119
WO2014186313A8 (fr) Urées pontées substituées et analogues associés, utilisés comme modulateurs de la sirtuine
EA201070551A1 (ru) Сиртуинмодулирующие соединения
MA28660B1 (fr) Composes et compositions en tant que modulateurs de ppar
MA49055B1 (fr) Dérivés d'imidazoles pentacycliques fusionnés en tant que modulateurs de l'activité de tnf
ATE555081T1 (de) Adamantyl-derivate als inhibitoren des 11-beta- hydroxysteroid-dehydrogenase-1-enzyms
MA34074B1 (fr) Compositions inhibitrices virales pour une utilisation thérapeutique in vivo comprenant une combinaison de (-)-carvone, de géraniol et d'un autre composant d'huile essentielle
BRPI0517015A (pt) compostos e composições como inibidores de atividade de receptor 1 de canabinóide
EA200970791A1 (ru) N-АДАМАНТИЛБЕНЗАМИДЫ В КАЧЕСТВЕ ИНГИБИТОРОВ 11-β-ГИДРОКСИСТЕРОИДДЕГИДРОГЕНАЗЫ
BRPI0606228A2 (pt) inibidores de enzima 11-beta-hidroxiesteróide desidrogenase tipo 1
MX2007009356A (es) Compuestos y composiciones como moduladores de ppar.