MA33072B1 - Composes pyridazinone - Google Patents

Composes pyridazinone

Info

Publication number
MA33072B1
MA33072B1 MA34133A MA34133A MA33072B1 MA 33072 B1 MA33072 B1 MA 33072B1 MA 34133 A MA34133 A MA 34133A MA 34133 A MA34133 A MA 34133A MA 33072 B1 MA33072 B1 MA 33072B1
Authority
MA
Morocco
Prior art keywords
cycle
substituent
substituted
compound
hydrogen atom
Prior art date
Application number
MA34133A
Other languages
Arabic (ar)
English (en)
Inventor
Takahiko Taniguchi
Akira Kawada
Mitsuyo Kondo
John F Quinn
Jun Kunitomo
Masato Yoshikawa
Makoto Fushimi
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MA33072B1 publication Critical patent/MA33072B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE UN COMPOSÉ QUI EXERCE UN EFFET D'INHIBITION DE PDE, ET QUI EST UTILE COMME MÉDICAMENT POUR PRÉVENIR OU TRAITER LA SCHIZOPHRÉNIE OU DES MALADIES SIMILAIRES. ELLE CONCERNE UN COMPOSÉ DE FORMULE (I0), DANS LAQUELLE R1 REPRÉSENTE UN SUBSTITUANT; R2 REPRÉSENTE UN ATOME D'HYDROGÈNE, OU UN SUBSTITUANT; R3 REPRÉSENTE UN ATOME D'HYDROGÈNE, OU UN SUBSTITUANT; LE CYCLE A REPRÉSENTE UN CYCLE AROMATIQUE QUI PEUT ÊTRE SUBSTITUÉ, ET LE CYCLE B REPRÉSENTE UN CYCLE HÉTÉROAROMATIQUE À 5 CHAÎNONS QUI PEUT ÊTRE SUBSTITUÉ, OU L'UN DE SES SELS.
MA34133A 2009-02-05 2010-02-04 Composes pyridazinone MA33072B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20220709P 2009-02-05 2009-02-05
US21392709P 2009-07-30 2009-07-30
PCT/US2010/000307 WO2010090737A1 (fr) 2009-02-05 2010-02-04 Composés pyridazinone

Publications (1)

Publication Number Publication Date
MA33072B1 true MA33072B1 (fr) 2012-02-01

Family

ID=42398214

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34133A MA33072B1 (fr) 2009-02-05 2010-02-04 Composes pyridazinone

Country Status (37)

Country Link
US (7) US8916566B2 (fr)
EP (2) EP3006031A1 (fr)
JP (1) JP5659166B2 (fr)
KR (1) KR101730665B1 (fr)
CN (1) CN102365020B (fr)
AR (1) AR075238A1 (fr)
AU (1) AU2010211050B2 (fr)
BR (1) BRPI1008498B8 (fr)
CA (1) CA2751565C (fr)
CO (1) CO6410258A2 (fr)
CR (1) CR20110440A (fr)
DK (1) DK2393360T3 (fr)
DO (1) DOP2011000254A (fr)
EA (1) EA020690B1 (fr)
EC (1) ECSP11011305A (fr)
ES (1) ES2561181T3 (fr)
GE (1) GEP20146004B (fr)
HR (1) HRP20160065T1 (fr)
HU (1) HUE027478T2 (fr)
IL (1) IL214137A (fr)
JO (1) JO3114B1 (fr)
MA (1) MA33072B1 (fr)
ME (1) ME02337B (fr)
MX (1) MX2011008305A (fr)
MY (1) MY170610A (fr)
NZ (1) NZ594851A (fr)
PE (1) PE20110991A1 (fr)
PL (1) PL2393360T3 (fr)
RS (1) RS54504B1 (fr)
SG (1) SG173175A1 (fr)
SI (1) SI2393360T1 (fr)
SM (1) SMT201600008B (fr)
TN (1) TN2011000362A1 (fr)
TW (1) TWI457333B (fr)
UY (1) UY32417A (fr)
WO (1) WO2010090737A1 (fr)
ZA (1) ZA201106074B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009054791A1 (fr) * 2007-10-26 2009-04-30 Astrazeneca Ab Dérivés de 1,2,4-triazole pyrrolidine fusionnés utilisés en tant que modulateurs de mglur5
JP5627574B2 (ja) * 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
MY170610A (en) 2009-02-05 2019-08-20 Takeda Pharmaceuticals Co Pyridazinone compounds
MA34385B1 (fr) 2010-06-24 2013-07-03 Takeda Pharmaceutical Composés hétérocycliques condensés comme inhibiteurs de phosphodiestérases (pdes)
US20130116231A1 (en) * 2010-07-12 2013-05-09 Merck Sharp & Dohme Corp. Tyrosine kinase inhibitors
EP2602254B1 (fr) 2010-08-04 2017-06-14 Takeda Pharmaceutical Company Limited Composé hétérocyclique
EP2601192B1 (fr) 2010-08-04 2017-03-01 Takeda Pharmaceutical Company Limited Composés hétérocycliques condensés
US8883788B2 (en) 2010-08-04 2014-11-11 Takeda Pharmaceutical Company Limited Fused heterocyclic ring compound
US9150588B2 (en) 2010-08-10 2015-10-06 Takeda Pharmaceutical Company Limited Substituted pyridazin-4(1H)-ones as phosphodiesterase 10A inhibitors
JP2013234123A (ja) * 2010-09-03 2013-11-21 Taisho Pharmaceutical Co Ltd ３−ピラゾリル−２−ピリドン誘導体
MX2013009575A (es) 2011-02-18 2014-10-14 Exonhit Therapeutics Sa Derivados de 6, 7-dialcoxi-3-isoquinolinol sustituidos como inhibidores de fosfodiesterasa 10 (pdei0a).
WO2012124782A1 (fr) 2011-03-16 2012-09-20 武田薬品工業株式会社 Composé hétérocyclique condensé
US10813630B2 (en) 2011-08-09 2020-10-27 Corquest Medical, Inc. Closure system for atrial wall
US10307167B2 (en) 2012-12-14 2019-06-04 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
US10314594B2 (en) 2012-12-14 2019-06-11 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
CA2846122C (fr) * 2011-08-22 2019-06-11 Takeda Pharmaceutical Company Limited Composes radiomarques et leur utilisation en tant que radiotraceurs pour l'imagerie quantitative de la phosphodiesterase (pde10a) chez les mammiferes
JO3115B1 (ar) 2011-08-22 2017-09-20 Takeda Pharmaceuticals Co مركبات بيريدازينون واستخدامها كمثبطات daao
AP2014007637A0 (en) 2011-11-15 2014-05-31 Takeda Pharmaceutical Dihydroxy aromatic heterocyclic compound
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
WO2014071044A1 (fr) 2012-11-01 2014-05-08 Allergan, Inc. Dérivés de 6,7-dialcoxy-3-isoquinoline substitués à titre d'inhibiteurs de phosphodiestérase 10 (pde10a)
US20140142689A1 (en) 2012-11-21 2014-05-22 Didier De Canniere Device and method of treating heart valve malfunction
EP2958896B1 (fr) 2013-02-21 2017-08-30 Takeda Pharmaceutical Company Limited Procédé de production d'un composé de pyridazinone
US9464076B2 (en) 2013-03-15 2016-10-11 Daiichi Sankyo Company, Limited Benzothiophene derivative
US10039764B2 (en) 2013-07-12 2018-08-07 University Of South Alabama Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression
KR102323515B1 (ko) 2013-09-12 2021-11-05 얀센 바이오파마, 인코퍼레이트. 아자-피리돈 화합물 및 이의 용도
LT3030549T (lt) 2013-09-12 2019-06-25 Janssen Biopharma, Inc. Piridazinono junginiai ir jų panaudojimas
US9566443B2 (en) 2013-11-26 2017-02-14 Corquest Medical, Inc. System for treating heart valve malfunction including mitral regurgitation
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
ES2544869B2 (es) * 2014-03-04 2016-01-18 Universidade De Vigo Derivados de piridazin-3(2H)-ona inhibidores selectivos de la isoforma B de la monoaminooxidasa
CA2943024A1 (fr) * 2014-03-18 2015-09-24 Takeda Pharmaceutical Company Limited Dispersion solide
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones
US10842626B2 (en) 2014-12-09 2020-11-24 Didier De Canniere Intracardiac device to correct mitral regurgitation
EA036776B1 (ru) 2015-03-11 2020-12-21 Янссен Байофарма, Инк. Соединения азапиридона и способы их применения
WO2016191935A1 (fr) 2015-05-29 2016-12-08 Merck Sharp & Dohme Corp. Composés 6-alkyle dihydropyrazolopyrimidinone utilisés en tant qu'inhibiteurs de pde2
HK1244808A1 (zh) 2015-12-22 2018-08-17 江苏恒瑞医药股份有限公司 苯并哌啶类衍生物、其制备方法及其在医药上的应用
US10736894B2 (en) 2018-02-15 2020-08-11 Ovid Therapeutics Inc. Methods of treating developmental syndromes with PDE10A inhibitors
CN108498868B (zh) * 2018-04-03 2020-09-15 北京大学口腔医学院 具有细胞外基质电学拓扑特征的带电复合膜及其制备方法
CN110407806B (zh) * 2018-04-28 2021-08-17 深圳微芯生物科技股份有限公司 甲酰胺类化合物、其制备方法及其应用
WO2019241787A1 (fr) * 2018-06-15 2019-12-19 The Regents Of The University Of Colorado A Body Corporate Nouveaux inhibiteurs cycliques de la gmp-amp synthase (cgaz) et leur procédé d'utilisation
EP3856185A1 (fr) * 2018-09-28 2021-08-04 Takeda Pharmaceutical Company Limited Balipodect pour traiter ou prévenir des troubles du spectre autistique
MX2019008440A (es) 2019-07-15 2021-01-18 Dva Farma Mexicana S A De C V Composiciones de recubrimientos en pelicula para tabletas con brillantez incrementada, procedimiento de preparacion y aplicacion.
EP3805206A1 (fr) * 2019-10-08 2021-04-14 Novaled GmbH Composé et couche semiconductrice organique, dispositif électronique organique, dispositif d'affichage et dispositif d'éclairage le comprenant
GB202002926D0 (en) 2020-02-28 2020-04-15 Benevolentai Tech Limited Compositions and uses thereof
WO2026070814A1 (fr) * 2024-09-30 2026-04-02 大日本印刷株式会社 Composé de cristaux liquides polymérisable, son procédé de production, composition polymérisable, polymère, film de retard, son procédé de production, stratifié de transfert, élément optique, son procédé de production et dispositif d'affichage

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0011693A1 (fr) * 1978-10-03 1980-06-11 Ciba-Geigy Ag N-hétérocycles N-substitués par trifluorométhane-sulfonylaminophényle, leur préparation, compositions les contenant et leur utilisation pour la régulation de la croissance des plantes
FR2648135B1 (fr) * 1989-06-07 1991-09-27 Pf Medicament Derives de phenyl-1-dihydro-1,4 amino-3 oxo-4 pyridazines, leur preparation et leur application en therapeutique
GB9506382D0 (en) * 1995-03-29 1995-05-17 Boots Co Plc Pharmaceutical compositions
KR100657189B1 (ko) 1998-08-14 2006-12-14 니혼노야쿠가부시키가이샤 피리다지논 유도체 및 이를 함유하는 의약 조성물
US20070060606A1 (en) 1999-10-07 2007-03-15 Robertson Harold A Compounds and methods for modulating phosphodiesterase 10A
GB0013383D0 (en) * 2000-06-01 2000-07-26 Glaxo Group Ltd Therapeutic benzamide derivatives
ES2266258T3 (es) 2000-09-15 2007-03-01 Vertex Pharmaceuticals Incorporated Compuestos de pirazol utiles como inhibidores de proteina cinasas.
US7005432B2 (en) 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
EP1755611A1 (fr) 2004-06-07 2007-02-28 Pfizer Products Inc. Inhibition de la phosphodiesterase 10 dans le traitement des etats pathologiques associes a l'obesite et au syndrome metabolique
RU2346996C2 (ru) 2004-06-29 2009-02-20 ЮРОПИЭН НИКЕЛЬ ПиЭлСи Усовершенствованное выщелачивание основных металлов
EA012211B1 (ru) 2005-01-07 2009-08-28 Пфайзер Продактс Инк. Гетероароматические соединения хинолинов и их применение в качестве ингибиторов pde10
JP4890439B2 (ja) * 2005-03-07 2012-03-07 杏林製薬株式会社 ピラゾロピリジン−４−イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤
WO2008001182A1 (fr) 2006-06-26 2008-01-03 Pfizer Products Inc. Composés hétéroaryliques tricycliques comme inhibiteurs de pde10
TW200801513A (en) 2006-06-29 2008-01-01 Fermiscan Australia Pty Ltd Improved process
US20080090834A1 (en) 2006-07-06 2008-04-17 Pfizer Inc Selective azole pde10a inhibitor compounds
US8642660B2 (en) 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2010000020A1 (fr) 2008-06-30 2010-01-07 Cathrx Ltd Cathéter
TWI396689B (zh) 2008-11-14 2013-05-21 Amgen Inc 作為磷酸二酯酶１０抑制劑之吡衍生物
TW201030001A (en) 2008-11-14 2010-08-16 Amgen Inc Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors
KR101371881B1 (ko) * 2008-12-04 2014-03-07 에프. 호프만-라 로슈 아게 피리다진온 유도체
MY170610A (en) * 2009-02-05 2019-08-20 Takeda Pharmaceuticals Co Pyridazinone compounds
US9187455B2 (en) * 2009-02-23 2015-11-17 Hoffmann-La Roche Inc. Substituted pyridazines as PDE10A inhibitors
US8415381B2 (en) 2009-07-30 2013-04-09 Novartis Ag Heteroaryl compounds and their uses
US8883788B2 (en) * 2010-08-04 2014-11-11 Takeda Pharmaceutical Company Limited Fused heterocyclic ring compound
US9150588B2 (en) * 2010-08-10 2015-10-06 Takeda Pharmaceutical Company Limited Substituted pyridazin-4(1H)-ones as phosphodiesterase 10A inhibitors

Also Published As

Publication number Publication date
CR20110440A (es) 2012-02-13
PE20110991A1 (es) 2012-02-06
US8435995B2 (en) 2013-05-07
EP3006031A1 (fr) 2016-04-13
US8354411B2 (en) 2013-01-15
CN102365020A (zh) 2012-02-29
KR101730665B1 (ko) 2017-04-26
US9550756B2 (en) 2017-01-24
US20100197651A1 (en) 2010-08-05
EA201171004A1 (ru) 2012-03-30
AR075238A1 (es) 2011-03-16
US20120028951A1 (en) 2012-02-02
US8778944B2 (en) 2014-07-15
EP2393360A4 (fr) 2012-08-15
US20170114044A1 (en) 2017-04-27
UY32417A (es) 2010-08-31
BRPI1008498B1 (pt) 2020-02-11
US20120277430A1 (en) 2012-11-01
ME02337B (fr) 2016-06-20
AU2010211050A1 (en) 2011-09-08
RS54504B1 (sr) 2016-06-30
EA020690B1 (ru) 2015-01-30
MY170610A (en) 2019-08-20
CA2751565A1 (fr) 2010-08-12
PL2393360T3 (pl) 2016-04-29
HUE027478T2 (en) 2016-09-28
DOP2011000254A (es) 2011-09-30
WO2010090737A1 (fr) 2010-08-12
AU2010211050A2 (en) 2011-10-06
US20120277431A1 (en) 2012-11-01
TW201036958A (en) 2010-10-16
US8513251B2 (en) 2013-08-20
TWI457333B (zh) 2014-10-21
US20120277204A1 (en) 2012-11-01
CA2751565C (fr) 2017-05-16
SMT201600008B (it) 2016-02-25
EP2393360A1 (fr) 2011-12-14
TN2011000362A1 (en) 2013-03-27
EP2393360B1 (fr) 2015-11-04
HK1164642A1 (zh) 2012-09-28
AU2010211050B2 (en) 2016-05-12
IL214137A0 (en) 2011-08-31
IL214137A (en) 2015-07-30
BRPI1008498B8 (pt) 2021-05-25
GEP20146004B (en) 2014-01-10
HRP20160065T1 (hr) 2016-02-12
JO3114B1 (ar) 2017-09-20
JP5659166B2 (ja) 2015-01-28
SG173175A1 (en) 2011-09-29
NZ594851A (en) 2013-10-25
US20150099757A1 (en) 2015-04-09
ZA201106074B (en) 2012-10-31
KR20110120931A (ko) 2011-11-04
DK2393360T3 (en) 2016-02-01
US8916566B2 (en) 2014-12-23
MX2011008305A (es) 2012-08-15
CO6410258A2 (es) 2012-03-30
ECSP11011305A (es) 2011-11-30
BRPI1008498A2 (pt) 2015-08-25
SI2393360T1 (sl) 2016-02-29
JP2012516890A (ja) 2012-07-26
CN102365020B (zh) 2014-07-30
ES2561181T3 (es) 2016-02-24

Similar Documents

Publication Publication Date Title
MX2011008305A (es) Compuestos de piridazinona.
MA31574B1 (fr) Dérivés de pyrazole et leur utilisation comme inhibiteurs de raf
MA32903B1 (fr) Inhibiteurs de proteine-kinases
NZ594741A (en) Specific diarylhydantoin and diarylthiohydantoin compounds
MA32171B1 (fr) Compose heterocyclique
WO2005012269A8 (fr) Nouveau compose azole
MX2008010931A (es) Quinolonas utiles como inhibidores de sintasa de oxido nitrico inducibles.
MA31873B1 (fr) Inhibiteurs de la peptide déformylase
TN2011000654A1 (fr) Sulfonamides heterocycliques leurs utilisations et compositions pharmaceutiques les contenant
MA46286B1 (fr) Dérivé de pyrazolopyridine ayant un effet agoniste du récepteur glp-1
MA34342B1 (fr) Dérivés de la pipéridinone en tant qu'inhibiteurs de mdm2 pour le traitement du cancer
MA33418B1 (fr) Composé tétracyclique
TW200728305A (en) Spiropiperidine beta-sectetase inhibitors for the treatment of alzheimer's disease
MY151295A (en) Pyrimidyl indoline compound
WO2008030412A3 (fr) Inhibiteurs de la spiropipéridine bêta-sécrétase pour le traitement de la maladie d'alzheimer
MA32727B1 (fr) Pyrazolylaminopyridines au titre d'inhibiteurs de fak
TN2009000012A1 (en) Amino-piperidine derivatives as cetp inhibitors
MA33240B1 (fr) Inhibiteurs de bêta-sécrétase
PE20081596A1 (es) Derivados fluorinados de deferiprona
MX2010006063A (es) Derivados de 4-bencil-amino-pirrolidina 1,2-disustituida como inhibidores de la proteina de transferencia de colesteril-ester (cetp) utiles para el tratamiento de las enfermedades tales como hiperlipidemia o arterioesclerosis.
WO2008054698A3 (fr) Composés de spiropipéridine inhibiteurs de la bêta-sécrétase pour le traitement de la maladie d'alzheimer
MA30351B1 (fr) Composes de tetrahydropyridothienopyrimidine et leurs procedes d'utilisation
NO20092035L (no) Tiazolylforbindelser anvendbare som kinaseinhibitorer
PL1685142T3 (pl) Pochodne kwasu fosfinowego, inhibitory beta-sekterazy do leczenia choroby Alzheimera
MA33618B1 (fr) Agent thérapeutique destiné aux troubles de l'humeur