MA34385B1 - Composés hétérocycliques condensés comme inhibiteurs de phosphodiestérases (pdes) - Google Patents

Composés hétérocycliques condensés comme inhibiteurs de phosphodiestérases (pdes)

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Publication number
MA34385B1
MA34385B1 MA35573A MA35573A MA34385B1 MA 34385 B1 MA34385 B1 MA 34385B1 MA 35573 A MA35573 A MA 35573A MA 35573 A MA35573 A MA 35573A MA 34385 B1 MA34385 B1 MA 34385B1
Authority
MA
Morocco
Prior art keywords
pdes
heterocyclic compounds
phosphodiesterase inhibitors
compounds condensed
condensed
Prior art date
Application number
MA35573A
Other languages
English (en)
Inventor
Takahiko Taniguchi
Masato Yoshikawa
Kasei Miura
Tomoaki Hasui
Eiji Honda
Keisuke Imamura
Makoto Kamata
Haruhi Kamisaki
John F Quinn
Joseph Raker
Fatoumata Camara
Yi Wang
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44317888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34385(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MA34385B1 publication Critical patent/MA34385B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne un composé qui a un effet d'inhibition de PDE et qui est utile comme agent de prévention ou de traitement de la schizophrénie etc., représenté par la formule (I).
MA35573A 2010-06-24 2011-06-22 Composés hétérocycliques condensés comme inhibiteurs de phosphodiestérases (pdes) MA34385B1 (fr)

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PCT/US2011/041443 WO2011163355A1 (fr) 2010-06-24 2011-06-22 Composés hétérocycliques condensés comme inhibiteurs de phosphodiestérases (pdes)

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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2811025C (fr) 2010-09-10 2018-07-17 Shionogi & Co., Ltd. Derive d'imidazole a heterocycle fusionne ayant un effet d'activation de l'ampk
MX2013009575A (es) 2011-02-18 2014-10-14 Exonhit Therapeutics Sa Derivados de 6, 7-dialcoxi-3-isoquinolinol sustituidos como inhibidores de fosfodiesterasa 10 (pdei0a).
MX348131B (es) * 2011-02-25 2017-05-26 Merck Sharp & Dohme Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos.
WO2012124782A1 (fr) 2011-03-16 2012-09-20 武田薬品工業株式会社 Composé hétérocyclique condensé
US9806270B2 (en) * 2011-03-25 2017-10-31 Udc Ireland Limited 4H-imidazo[1,2-a]imidazoles for electronic applications
TWI570122B (zh) * 2011-06-22 2017-02-11 武田藥品工業股份有限公司 稠合雜環化合物之結晶
WO2014071044A1 (fr) 2012-11-01 2014-05-08 Allergan, Inc. Dérivés de 6,7-dialcoxy-3-isoquinoline substitués à titre d'inhibiteurs de phosphodiestérase 10 (pde10a)
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
HRP20210403T1 (hr) 2015-04-29 2021-10-29 Janssen Pharmaceutica Nv Azabenzimidazoli i njihova uporaba kao modulatora ampa receptora
AR105025A1 (es) * 2015-06-19 2017-08-30 Astellas Pharma Inc Compuesto de imidazodiazepina
KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
AU2019211931B2 (en) * 2018-01-29 2023-08-10 Medshine Discovery Inc. Crystal form of 1H-imidazo[4,5-b]pyridine-2(3H)-one compound and preparation process therefor
EP3594205A1 (fr) 2018-07-09 2020-01-15 Abivax Dérivés phényl-n-aryl pour traiter une infection par le virus d'arn
EP3594206A1 (fr) 2018-07-09 2020-01-15 Abivax Dérivés de phenyl-n-quinoline pour traiter une infection par un virus à arn
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
AR119140A1 (es) 2019-06-13 2021-11-24 Pi Industries Ltd Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas
PL3999493T3 (pl) 2019-07-19 2024-04-22 Abivax Pochodne arylo-N-arylowe do leczenia zakażenia wirusem RNA
PE20221040A1 (es) * 2019-10-25 2022-06-17 Gilead Sciences Inc Compuestos moduladores de glp-1r
CA3168543A1 (fr) 2020-01-29 2021-08-05 Gilead Sciences, Inc. Composes modulateurs de glp-1r
EP3901152A1 (fr) * 2020-04-23 2021-10-27 F. Hoffmann-La Roche AG Nouveaux composés hétérocycliques pour le traitment des maladies cognitives
WO2022109182A1 (fr) 2020-11-20 2022-05-27 Gilead Sciences, Inc. Composés modulateurs de glp-1r polyhétérocycliques
EP4304711A1 (fr) 2021-03-11 2024-01-17 Gilead Sciences, Inc. Composés modulateurs de glp-1r
WO2022192430A1 (fr) 2021-03-11 2022-09-15 Gilead Sciences, Inc. Composés modulateurs de glp-1r
PL4271672T3 (pl) 2021-04-21 2026-04-20 Gilead Sciences, Inc. Karboksybenzimidazolowe związki modulujące glp-1r
EP4604945A2 (fr) * 2022-10-18 2025-08-27 Merck Sharp & Dohme LLC Nouveaux modulateurs de canaux kv3
WO2025070690A1 (fr) 2023-09-29 2025-04-03 第一三共株式会社 Dérivé de 3-phénylpropylamine

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE422799B (sv) * 1975-05-28 1982-03-29 Merck & Co Inc Analogiforfarande for framstellning av 1,3-dihydroimidazo (4,5-b)pyridin-2-oner
ATE201403T1 (de) * 1993-03-16 2001-06-15 Pfizer Naphtalinderivate
US5597826A (en) 1994-09-14 1997-01-28 Pfizer Inc. Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist
CZ27399A3 (cs) 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
CZ2002233A3 (cs) * 1999-07-21 2002-04-17 Fujisawa Pharmaceutical Co., Ltd. Benzimidazolonové deriváty, způsob jejich výroby a farmaceutický prostředek
DE60118521T2 (de) 2000-01-07 2006-10-12 Universitaire Instelling Antwerpen Purin derivate, ihre herstellung und verwendung
WO2004043913A2 (fr) 2002-11-08 2004-05-27 Trimeris, Inc. Composes de benzimidazole a substitution hetero et utilisations antivirales de ces composes
WO2006038111A1 (fr) 2004-10-07 2006-04-13 Pfizer Products Inc. Derives de benzoimidazole utiles en tant qu'agents antiproliferatifs
EA012211B1 (ru) 2005-01-07 2009-08-28 Пфайзер Продактс Инк. Гетероароматические соединения хинолинов и их применение в качестве ингибиторов pde10
AU2007214709A1 (en) * 2006-02-15 2007-08-23 Sanofi-Aventis Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
WO2008001182A1 (fr) 2006-06-26 2008-01-03 Pfizer Products Inc. Composés hétéroaryliques tricycliques comme inhibiteurs de pde10
US20080090834A1 (en) 2006-07-06 2008-04-17 Pfizer Inc Selective azole pde10a inhibitor compounds
ES2383370T3 (es) 2006-10-19 2012-06-20 Signal Pharmaceuticals Llc Compuestos de heteroarilo, sus composiciones y uso de los mismos como inhibidores de proteína quinasa
JP5313883B2 (ja) 2007-04-18 2013-10-09 キッセイ薬品工業株式会社 含窒素縮合環誘導体、それを含有する医薬組成物及びその医薬用途
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
PE20110368A1 (es) 2008-08-18 2011-06-13 Univ Yale Moduladores de mif
US9643922B2 (en) 2008-08-18 2017-05-09 Yale University MIF modulators
TWI396689B (zh) 2008-11-14 2013-05-21 Amgen Inc 作為磷酸二酯酶１０抑制劑之吡衍生物
TW201030001A (en) 2008-11-14 2010-08-16 Amgen Inc Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors
MY170610A (en) 2009-02-05 2019-08-20 Takeda Pharmaceuticals Co Pyridazinone compounds
KR20130086343A (ko) 2010-06-24 2013-08-01 질랜드 파마 에이/에스 글루카곤 유사체
MX2012015292A (es) 2010-06-24 2013-05-30 Gilead Sciences Inc Pirazolo[1, 5]pirimidinas en la forma de agentes antivirales.
CA2811025C (fr) 2010-09-10 2018-07-17 Shionogi & Co., Ltd. Derive d'imidazole a heterocycle fusionne ayant un effet d'activation de l'ampk

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MX341446B (es) 2016-08-19
TW201213324A (en) 2012-04-01
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DOP2012000318A (es) 2013-02-15
CR20130024A (es) 2013-05-15
TWI546302B (zh) 2016-08-21
EA022705B1 (ru) 2016-02-29
US8940758B2 (en) 2015-01-27
AU2011270994A2 (en) 2013-03-14
US20130172328A1 (en) 2013-07-04
US20140228320A1 (en) 2014-08-14
US9226921B2 (en) 2016-01-05
CO6670576A2 (es) 2013-05-15
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AR081976A1 (es) 2012-10-31
UY33463A (es) 2012-01-31
PH12012502549A1 (en) 2022-03-21
IL223631A (en) 2016-11-30
PE20130346A1 (es) 2013-03-30
US20130303553A1 (en) 2013-11-14
BR112012032087A2 (pt) 2016-11-16
TN2012000614A1 (en) 2014-04-01
NZ605889A (en) 2014-10-31
CA2803156C (fr) 2019-01-08
CN103153995B (zh) 2016-08-10
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US8846713B2 (en) 2014-09-30
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