MA33326B1 - Procédé pour la production de benzofuranes - Google Patents

Procédé pour la production de benzofuranes

Info

Publication number
MA33326B1
MA33326B1 MA34361A MA34361A MA33326B1 MA 33326 B1 MA33326 B1 MA 33326B1 MA 34361 A MA34361 A MA 34361A MA 34361 A MA34361 A MA 34361A MA 33326 B1 MA33326 B1 MA 33326B1
Authority
MA
Morocco
Prior art keywords
preparation
benzofuran
production
dronedarone
relates
Prior art date
Application number
MA34361A
Other languages
Arabic (ar)
English (en)
Inventor
Gerhard Kretzschmar
Volker Kraft
Thomas Olpp
Kai Rossen
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MA33326B1 publication Critical patent/MA33326B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/43—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention concerne la préparation de 2-alkyl-3-aroyl-5-nitrobenzofuranes par acylation de 2-(2-hydroxy-5-nitrophényl)-1-aryl-éthanones et traitement ultérieur des esters avec des associations de bases et d'acides protoniques ou d'acides de Lewis. Ce procédé peut s'utiliser pour la préparation de Dronédarone. L'invention concerne également des nouveaux intermédiaires pour la préparation de Dronédarone.
MA34361A 2009-05-27 2010-05-26 Procédé pour la production de benzofuranes MA33326B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09290395 2009-05-27
US24455009P 2009-09-22 2009-09-22
PCT/EP2010/057270 WO2010136500A1 (fr) 2009-05-27 2010-05-26 Procédé de préparation de benzofuranes

Publications (1)

Publication Number Publication Date
MA33326B1 true MA33326B1 (fr) 2012-06-01

Family

ID=41152122

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34361A MA33326B1 (fr) 2009-05-27 2010-05-26 Procédé pour la production de benzofuranes

Country Status (27)

Country Link
US (1) US8674121B2 (fr)
EP (1) EP2435398B1 (fr)
JP (1) JP2012528114A (fr)
KR (1) KR20120017459A (fr)
CN (1) CN102459146A (fr)
AR (1) AR076890A1 (fr)
AU (1) AU2010251974A1 (fr)
BR (1) BRPI1014547A2 (fr)
CA (1) CA2763472A1 (fr)
CO (1) CO6480944A2 (fr)
DK (1) DK2435398T3 (fr)
ES (1) ES2453977T3 (fr)
HR (1) HRP20140248T1 (fr)
IL (1) IL216321A0 (fr)
MA (1) MA33326B1 (fr)
MX (1) MX2011011994A (fr)
MY (1) MY155506A (fr)
NZ (1) NZ596624A (fr)
PL (1) PL2435398T3 (fr)
PT (1) PT2435398E (fr)
RU (1) RU2011153180A (fr)
SG (1) SG176211A1 (fr)
SI (1) SI2435398T1 (fr)
TW (1) TW201107303A (fr)
UY (1) UY32656A (fr)
WO (1) WO2010136500A1 (fr)
ZA (1) ZA201107655B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32657A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para la fabricación de productos intermedios de dronedarona
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
FR2958291B1 (fr) 2010-04-01 2013-07-05 Sanofi Aventis Procede de preparation de derives d'amino-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
HUP1000386A2 (en) 2010-07-22 2012-05-29 Sanofi Sa Novel process for producing dronedarone
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (fr) * 2012-01-20 2013-07-24 Sanofi Procédé de préparation de dronédarone à l'aide d'un réactif dibutylaminopropanol
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (fr) 2012-05-31 2013-12-05 Sanofi Procédé pour la préparation de dronédarone par réaction de grignard

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577441A (en) 1967-03-07 1971-05-04 Warner Lambert Pharmaceutical Nitro substituted benzofurans
US3657350A (en) 1967-05-09 1972-04-18 Sterling Drug Inc Process and compositions
FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
GB2344819A (en) * 1998-12-18 2000-06-21 Portela & Ca Sa 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones
FR2809397B1 (fr) 2000-05-24 2002-07-19 Rhodia Chimie Sa Procede de preparation d'un compose de type benzofuranne ou benzothiophene
FR2800067B1 (fr) 1999-10-21 2004-12-17 Rhodia Chimie Sa Intermediaires de fabrication d'un derive de type benzofurane ou benzothiophene nitre en position 5 et leurs utilisations
BR0014810A (pt) 1999-10-21 2002-06-11 Rhodia Chimie Sa Processo de preparação de um composto do tipo benzofurano ou benzotiofeno
CN1133613C (zh) * 1999-10-22 2004-01-07 河南省科学院化学研究所 一种合成多羟基去氧安息香及其衍生物的新方法
WO2001035955A1 (fr) * 1999-11-16 2001-05-25 Toray Industries, Inc. Derives de benzene et leur utilisation en tant que medicaments
FR2817865B1 (fr) 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
IL146389A0 (en) * 2001-11-08 2002-07-25 Isp Finetech Ltd Process for the preparation of dronedarone
FR2833259B1 (fr) 2001-12-10 2004-08-27 Oreal Procede de preparation de 2-arylbenzofuranes, composes intermediaires, 2-arylbenzofuranes et compositions les comprenant
GB0313915D0 (en) * 2003-06-16 2003-07-23 Smithkline Beecham Corp Compounds
US20080033209A1 (en) 2004-08-24 2008-02-07 Basf Aktiengsellschaft Method For High-Purity Quaternary Ammonium Compounds
GB0611210D0 (en) 2006-06-07 2006-07-19 Cambrex Karlskoga Ab Process
GB0719180D0 (en) 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
UY32657A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para la fabricación de productos intermedios de dronedarona

Also Published As

Publication number Publication date
AR076890A1 (es) 2011-07-13
NZ596624A (en) 2013-04-26
UY32656A (es) 2010-12-31
PL2435398T3 (pl) 2014-06-30
WO2010136500A1 (fr) 2010-12-02
IL216321A0 (en) 2012-01-31
EP2435398A1 (fr) 2012-04-04
MX2011011994A (es) 2011-12-08
JP2012528114A (ja) 2012-11-12
ZA201107655B (en) 2012-07-25
RU2011153180A (ru) 2013-07-10
TW201107303A (en) 2011-03-01
PT2435398E (pt) 2014-04-02
BRPI1014547A2 (pt) 2016-04-05
CA2763472A1 (fr) 2010-12-02
US8674121B2 (en) 2014-03-18
AU2010251974A1 (en) 2011-12-22
HRP20140248T1 (hr) 2014-06-20
SI2435398T1 (sl) 2014-04-30
DK2435398T3 (da) 2014-04-14
MY155506A (en) 2015-10-30
ES2453977T3 (es) 2014-04-09
KR20120017459A (ko) 2012-02-28
SG176211A1 (en) 2012-01-30
US20120065411A1 (en) 2012-03-15
CN102459146A (zh) 2012-05-16
EP2435398B1 (fr) 2014-01-22
CO6480944A2 (es) 2012-07-16
HK1167851A1 (en) 2012-12-14

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