MA33465B1 - Nouveaux conjugues, leur preparation et leur application en therapeutique - Google Patents
Nouveaux conjugues, leur preparation et leur application en therapeutiqueInfo
- Publication number
- MA33465B1 MA33465B1 MA34580A MA34580A MA33465B1 MA 33465 B1 MA33465 B1 MA 33465B1 MA 34580 A MA34580 A MA 34580A MA 34580 A MA34580 A MA 34580A MA 33465 B1 MA33465 B1 MA 33465B1
- Authority
- MA
- Morocco
- Prior art keywords
- group
- alkyl
- preparation
- phenyl core
- therapeutic application
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 PHENYL CORE Chemical group 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- PSNOPSMXOBPNNV-VVCTWANISA-N cryptophycin 1 Chemical class C1=C(Cl)C(OC)=CC=C1C[C@@H]1C(=O)NC[C@@H](C)C(=O)O[C@@H](CC(C)C)C(=O)O[C@H]([C@H](C)[C@@H]2[C@H](O2)C=2C=CC=CC=2)C/C=C/C(=O)N1 PSNOPSMXOBPNNV-VVCTWANISA-N 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 239000004593 Epoxy Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D245/06—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Abstract
L'INVENTION EST RELATIVE À UN AGENT DE CIBLAGE AUQUEL EST ATTACHÉ AU MOINS UN DÉRIVÉ DE CRYPTOPHYCINE DE FORMULE (I) : DANS LAQUELLE : R1 REPRÉSENTE UN ATOME D'HALOGÈNE ET R2 REPRÉSENTE UN GROUPE -OH, UN GROUPE ACYLE DÉRIVÉ D'UN ACIDE AMINÉ AA OU UN GROUPE (C1-C4)ALCANOYLOXY; OU BIEN R1 ET R2 FORMENT ENSEMBLE UN MOTIF ÉPOXYDE; AA DÉSIGNE UN ACIDE AMINÉ NATUREL OU NON-NATUREL; R3 REPRÉSENTE UN GROUPE (C1-C6)ALKYLE; R4 ET R5 REPRÉSENTENT TOUS DEUX H OU FORMENT ENSEMBLE UNE DOUBLE LIAISON CH=CH ENTRE C13 ET C14; R6 ET R7 REPRÉSENTENT INDÉPENDAMMENT L'UN DE L'AUTRE H OU UN GROUPE (C1-C6)JALKYLE; R8 ET R9 REPRÉSENTENT INDÉPENDAMMENT L'UN DE L'AUTRE H OU UN GROUPE (C1-C6)ALKYLE; R10 REPRÉSENTE AU MOINS UN SUBSTITUANT DU NOYAU PHÉNYLE CHOISI PARMI : H, UN GROUPE OH, (C1-C4)ALCOXY, UN ATOME D'HALOGÈNE OU BIEN UN GROUPE -NH2, -NH(C1-C6)ALKYLE OU -N(C1- C6)ALKYLE2; R11 REPRÉSENTE AU MOINS UN SUBSTITUANT DU NOYAU PHÉNYLE CHOISI PARMI H OU UN GROUPE (C1- C4)ALKYLE; L'AGENT DE CIBLAGE ET LE DÉRIVÉ DE CRYPTOPHYCINE ÉTANT ATTACHÉS DE FAÇON COVALENTE, L'ATTACHEMENT SE SITUANT EN POSITION ORTHO (O), META (M) OU PARA (P) DU NOYAU PHÉNYLE PORTEUR DU MOTIF CR1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0903170A FR2947269B1 (fr) | 2009-06-29 | 2009-06-29 | Nouveaux composes anticancereux |
| FR0905651A FR2947271B1 (fr) | 2009-06-29 | 2009-11-25 | Nouveaux composes anticancereux |
| PCT/FR2010/050986 WO2011001052A1 (fr) | 2009-06-29 | 2010-05-20 | Nouveaux conjugues, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA33465B1 true MA33465B1 (fr) | 2012-07-03 |
Family
ID=41611078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA34580A MA33465B1 (fr) | 2009-06-29 | 2010-05-20 | Nouveaux conjugues, leur preparation et leur application en therapeutique |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8952147B2 (fr) |
| EP (1) | EP2448929A1 (fr) |
| JP (1) | JP5746692B2 (fr) |
| KR (1) | KR101770584B1 (fr) |
| CN (1) | CN102482238B (fr) |
| AR (1) | AR078131A1 (fr) |
| BR (1) | BRPI1015131A2 (fr) |
| CA (1) | CA2766762C (fr) |
| CL (1) | CL2011003229A1 (fr) |
| CO (1) | CO6430462A2 (fr) |
| CR (1) | CR20110670A (fr) |
| DO (1) | DOP2011000376A (fr) |
| EA (1) | EA024627B1 (fr) |
| EC (1) | ECSP11011553A (fr) |
| FR (2) | FR2947269B1 (fr) |
| HN (1) | HN2011003414A (fr) |
| IL (1) | IL217208A (fr) |
| MA (1) | MA33465B1 (fr) |
| MX (1) | MX2011013764A (fr) |
| MY (1) | MY156684A (fr) |
| NI (1) | NI201100219A (fr) |
| NZ (1) | NZ597136A (fr) |
| PE (1) | PE20121031A1 (fr) |
| SG (2) | SG177419A1 (fr) |
| SV (1) | SV2011004086A (fr) |
| TN (1) | TN2011000636A1 (fr) |
| TW (1) | TW201110986A (fr) |
| UY (1) | UY32745A (fr) |
| WO (1) | WO2011001052A1 (fr) |
| ZA (1) | ZA201109537B (fr) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3000520C (fr) | 2005-08-24 | 2023-04-04 | Immunogen, Inc. | Procede de preparation de conjugues maytansinoides-anticorps |
| SG10201810743WA (en) | 2009-06-03 | 2018-12-28 | Immunogen Inc | Conjugation methods |
| KR101763656B1 (ko) | 2009-06-29 | 2017-08-01 | 인사이트 홀딩스 코포레이션 | Ｐｉ3ｋ 저해물질로서의 피리미디논 |
| US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| EP2558463A1 (fr) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Dérivés condensés en tant qu'inhibiteurs de i3 |
| WO2011163195A1 (fr) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Dérivés condensés de pyrrole en tant qu'inhibiteurs de pi3k |
| EP3660016A1 (fr) | 2010-12-20 | 2020-06-03 | Incyte Holdings Corporation | N-(1-(phényl substitué)éthyl)-9h-purin-6-amines en tant qu'inhibiteurs de pi3k |
| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| WO2012135009A1 (fr) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Dérivés de pyrimidine-4,6-diamine en tant qu'inhibiteurs de pi3k |
| ME03353B (fr) | 2011-03-29 | 2019-10-20 | Immunogen Inc | Préparation de conjugués de maytansinoïde anticorps par procédé en une étape |
| PT3513793T (pt) | 2011-09-02 | 2021-05-10 | Incyte Holdings Corp | Heterociclilaminas como inibidores de pi3k |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| RU2661083C2 (ru) | 2012-10-04 | 2018-07-11 | Иммуноджен, Инк. | Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент - цитотоксический агент |
| DK3199552T3 (da) | 2012-11-20 | 2020-03-30 | Sanofi Sa | Anti-ceacam5-antistoffer og anvendelser heraf |
| AU2014286990A1 (en) | 2013-07-11 | 2016-02-11 | Novartis Ag | Lysine-specific chemoenzymatic protein modifications using microbial transglutaminase |
| WO2015191677A1 (fr) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Dérivés d'hétéroarylaminoalkylphényle bicycliques à titre d'inhibiteurs de pi3k |
| AU2015311987B2 (en) * | 2014-09-03 | 2020-06-04 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
| GB201416960D0 (en) | 2014-09-25 | 2014-11-12 | Antikor Biopharma Ltd | Biological materials and uses thereof |
| SG10201907576SA (en) | 2015-02-27 | 2019-09-27 | Incyte Corp | Salts of pi3k inhibitor and processes for their preparation |
| EP3069734A1 (fr) * | 2015-03-17 | 2016-09-21 | Exiris S.r.l. | Conjugués anticorps-médicament à base de cryptophycine avec de nouveaux lieurs auto-immolateurs |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| CN107029242A (zh) | 2015-11-03 | 2017-08-11 | 财团法人工业技术研究院 | 抗体药物复合物及其制造方法 |
| TWI714661B (zh) * | 2015-11-05 | 2021-01-01 | 法商賽諾菲公司 | 新穎念珠藻素化合物及接合物、其製備與其治療用途 |
| WO2017136769A1 (fr) * | 2016-02-04 | 2017-08-10 | Eisai R&D Management Co., Ltd. | Conjugués peptides-médicaments |
| KR20220150408A (ko) | 2016-11-14 | 2022-11-10 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
| WO2018178277A1 (fr) | 2017-03-29 | 2018-10-04 | Avicenna Oncology Gmbh | Nouveaux dérivés d'isocombrétaquinoléine cytotoxique ciblés et leurs conjugués |
| TN2019000303A1 (en) * | 2017-05-10 | 2021-05-07 | Sanofi Sa | Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation |
| CA3072399A1 (fr) | 2017-08-09 | 2019-02-14 | Helmholtz-Zentrum Fur Infektionsforschung Gmbh | Nouveaux derives de ratjadone cytotoxiques cibles et leurs conjugues |
| CA3085600A1 (fr) * | 2017-12-22 | 2019-06-27 | Cornell University | Ligands peptidiques marques par 18f utiles dans l'imagerie par tep et par luminescence cerenkov |
| SG11202011680YA (en) | 2018-06-01 | 2020-12-30 | Incyte Corp | Dosing regimen for the treatment of pi3k related disorders |
| US12097263B2 (en) | 2018-08-02 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US12370264B1 (en) | 2018-08-02 | 2025-07-29 | Dyne Therapeutics, Inc. | Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject |
| CA3108282A1 (fr) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Complexes de ciblage musculaire et leurs utilisations pour le traitement de dystrophinopathies |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| SG11202100928QA (en) | 2018-08-02 | 2021-02-25 | Dyne Therapeutics Inc | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| FR3085952B1 (fr) | 2018-09-17 | 2020-10-30 | Centre Nat Rech Scient | Conjugue anticorps-medicament comprenant des derives de quinoline |
| US11530204B2 (en) | 2019-09-30 | 2022-12-20 | The Regents Of The University Of Michigan | Biocatalytic synthesis of cryptophycin anticancer agents |
| AU2021379882A1 (en) | 2020-11-10 | 2023-06-29 | Sanofi | Ceacam5 antibody-drug conjugate formulation |
| EP4046996A1 (fr) | 2021-02-19 | 2022-08-24 | Universität Bielefeld | Composés de cryptophycine et leurs conjugués |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| US11633498B2 (en) | 2021-07-09 | 2023-04-25 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| JP2024525608A (ja) | 2021-07-09 | 2024-07-12 | ダイン セラピューティクス，インコーポレーテッド | ジストロフィン異常症を処置するための筋標的化複合体および製剤 |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11672872B2 (en) | 2021-07-09 | 2023-06-13 | Dyne Therapeutics, Inc. | Anti-transferrin receptor antibody and uses thereof |
| JP2024536382A (ja) | 2021-10-07 | 2024-10-04 | サノフイ | イミダゾ［４，５－ｃ］キノリン－４－アミン化合物及びそのコンジュゲート、それらの調製並びにそれらの治療用途 |
| IL316143A (en) | 2022-04-15 | 2024-12-01 | Dyne Therapeutics Inc | Muscle targeting complexes and formulations for the treatment of myotonic dystrophy |
| AU2024320501A1 (en) | 2023-08-04 | 2026-03-12 | Sanofi | Imidazo[4,5-d]pyridazine compounds and conjugates thereof, their preparation, and their therapeutic applications |
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|---|---|---|---|---|
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-
2009
- 2009-06-29 FR FR0903170A patent/FR2947269B1/fr not_active Expired - Fee Related
- 2009-11-25 FR FR0905651A patent/FR2947271B1/fr not_active Expired - Fee Related
-
2010
- 2010-05-20 MX MX2011013764A patent/MX2011013764A/es active IP Right Grant
- 2010-05-20 MA MA34580A patent/MA33465B1/fr unknown
- 2010-05-20 NZ NZ597136A patent/NZ597136A/en not_active IP Right Cessation
- 2010-05-20 KR KR1020117031276A patent/KR101770584B1/ko not_active Expired - Fee Related
- 2010-05-20 JP JP2012518108A patent/JP5746692B2/ja not_active Expired - Fee Related
- 2010-05-20 SG SG2011097193A patent/SG177419A1/en unknown
- 2010-05-20 EP EP10728799A patent/EP2448929A1/fr not_active Withdrawn
- 2010-05-20 MY MYPI2011006289A patent/MY156684A/en unknown
- 2010-05-20 SG SG10201607595WA patent/SG10201607595WA/en unknown
- 2010-05-20 CA CA2766762A patent/CA2766762C/fr not_active Expired - Fee Related
- 2010-05-20 WO PCT/FR2010/050986 patent/WO2011001052A1/fr not_active Ceased
- 2010-05-20 PE PE2011002178A patent/PE20121031A1/es not_active Application Discontinuation
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