DOP2011000376A - Nuevos conjugados, su preparacion y su aplicacion en terapeutica - Google Patents
Nuevos conjugados, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- DOP2011000376A DOP2011000376A DO2011000376A DO2011000376A DOP2011000376A DO P2011000376 A DOP2011000376 A DO P2011000376A DO 2011000376 A DO2011000376 A DO 2011000376A DO 2011000376 A DO2011000376 A DO 2011000376A DO P2011000376 A DOP2011000376 A DO P2011000376A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- group
- alkyl
- alkyl group
- phenyl nucleus
- derivative
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- PSNOPSMXOBPNNV-VVCTWANISA-N cryptophycin 1 Chemical class C1=C(Cl)C(OC)=CC=C1C[C@@H]1C(=O)NC[C@@H](C)C(=O)O[C@@H](CC(C)C)C(=O)O[C@H]([C@H](C)[C@@H]2[C@H](O2)C=2C=CC=CC=2)C/C=C/C(=O)N1 PSNOPSMXOBPNNV-VVCTWANISA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D245/06—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La invención se refiere a un agente de selección de la diana al que está unido al menos un derivado de criptoficina de la fórmula (l), en la que: Rl representa un átomo de halógeno y R2 representa un grupo -OH, un grupo acilo derivado de un aminoácido AA o un grupo alcanoiloxi(C1-C4); o bien R1 y R2 forman conjuntamente un motivo epóxido; AA indica un aminoácido natural o no natural; R3 representa un grupo alquilo(C1-C6); R4 y R5 representan los dos H o forman conjuntamente un doble enlace CH=CH entre C13 y C14; R6 y R7 representan independientemente uno de otro H o un grupo alquilo(C1-C6); R8 y R9 representan independientemente uno de otro H o un grupo alquilo(C1-C6); R1O representa al menos un sustituyente del núcleo fenilo elegido entre: H, un grupo OH, alcoxi(C1-C4), un átomo de halógenoo bien un grupo -NH2, -NHalquilo(C1-C6) o -N(alquilo(C1-C6))2; R11 representa al menos un sustituyente del núcleo fenilo elegido entre H o un grupo alquilo(C1-C4); estando unidos el agente de selección de la diana y el derivado de criptoficina de forma covalente, situándose la unión en posición orto (o), meta (m) o para (p) del núcleo fenilo portador del motivo CRI.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0903170A FR2947269B1 (fr) | 2009-06-29 | 2009-06-29 | Nouveaux composes anticancereux |
| FR0905651A FR2947271B1 (fr) | 2009-06-29 | 2009-11-25 | Nouveaux composes anticancereux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2011000376A true DOP2011000376A (es) | 2012-01-15 |
Family
ID=41611078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2011000376A DOP2011000376A (es) | 2009-06-29 | 2011-12-05 | Nuevos conjugados, su preparacion y su aplicacion en terapeutica |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8952147B2 (es) |
| EP (1) | EP2448929A1 (es) |
| JP (1) | JP5746692B2 (es) |
| KR (1) | KR101770584B1 (es) |
| CN (1) | CN102482238B (es) |
| AR (1) | AR078131A1 (es) |
| BR (1) | BRPI1015131A2 (es) |
| CA (1) | CA2766762C (es) |
| CL (1) | CL2011003229A1 (es) |
| CO (1) | CO6430462A2 (es) |
| CR (1) | CR20110670A (es) |
| DO (1) | DOP2011000376A (es) |
| EA (1) | EA024627B1 (es) |
| EC (1) | ECSP11011553A (es) |
| FR (2) | FR2947269B1 (es) |
| HN (1) | HN2011003414A (es) |
| IL (1) | IL217208A (es) |
| MA (1) | MA33465B1 (es) |
| MX (1) | MX2011013764A (es) |
| MY (1) | MY156684A (es) |
| NI (1) | NI201100219A (es) |
| NZ (1) | NZ597136A (es) |
| PE (1) | PE20121031A1 (es) |
| SG (2) | SG10201607595WA (es) |
| SV (1) | SV2011004086A (es) |
| TN (1) | TN2011000636A1 (es) |
| TW (1) | TW201110986A (es) |
| UY (1) | UY32745A (es) |
| WO (1) | WO2011001052A1 (es) |
| ZA (1) | ZA201109537B (es) |
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| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
| TR201902180T4 (tr) | 2011-03-29 | 2019-03-21 | Immunogen Inc | Tek adimli bi̇r i̇şlem i̇le maytansi̇noi̇d anti̇kor konjugatlarinin hazirlanmasi |
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| RU2661083C2 (ru) | 2012-10-04 | 2018-07-11 | Иммуноджен, Инк. | Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент - цитотоксический агент |
| HRP20170743T1 (hr) | 2012-11-20 | 2017-07-28 | Sanofi | Anti-ceacam5 protutijela i njihova uporaba |
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| CN117980006A (zh) | 2021-07-09 | 2024-05-03 | 达因疗法公司 | 用于治疗肌养蛋白病的肌肉靶向复合物和制剂 |
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-
2009
- 2009-06-29 FR FR0903170A patent/FR2947269B1/fr not_active Expired - Fee Related
- 2009-11-25 FR FR0905651A patent/FR2947271B1/fr not_active Expired - Fee Related
-
2010
- 2010-05-20 EA EA201270096A patent/EA024627B1/ru not_active IP Right Cessation
- 2010-05-20 JP JP2012518108A patent/JP5746692B2/ja not_active Expired - Fee Related
- 2010-05-20 BR BRPI1015131-1A patent/BRPI1015131A2/pt not_active Application Discontinuation
- 2010-05-20 KR KR1020117031276A patent/KR101770584B1/ko not_active Expired - Fee Related
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