MA33561B1 - Dérivés d'isoxazolidine - Google Patents

Dérivés d'isoxazolidine

Info

Publication number: MA33561B1
Authority: MA; Morocco
Prior art keywords: isoxazolidine; relates; isoxazolidine derivatives; compounds; derivatives
Prior art date: 2009-09-11

Application number

MA34659A

Other languages

Arabic (ar)

English (en)

French (fr)

Inventor

Elisabetta Armani

Eleonora Ghidini

Ilaria Peretto

Andrea Virdis

Original Assignee

Chiesi Farma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-09-11

Filing date

2012-03-02

Publication date

2012-09-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41666572&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33561(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-03-02 Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa

2012-09-01 Publication of MA33561B1 publication Critical patent/MA33561B1/fr

Links

150000002546 isoxazolidines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
CIISBYKBBMFLEZ-UHFFFAOYSA-N 1,2-oxazolidine Chemical compound C1CNOC1 CIISBYKBBMFLEZ-UHFFFAOYSA-N 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000003862 glucocorticoid Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0068—Nitrogen and oxygen at position 16(17)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Steroid Compounds (AREA)

MA34659A 2009-09-11 2012-03-02 Dérivés d'isoxazolidine MA33561B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP09011665		2009-09-11
PCT/EP2010/005366 WO2011029547A2 (en)	2009-09-11	2010-09-01	Pregnane derivatives condensed in the 16, 17 position with an n-substituted isoxazolidine ring as anti-inflammatory agents

Publications (1)

Publication Number	Publication Date
MA33561B1 true MA33561B1 (fr)	2012-09-01

Family

ID=41666572

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA34659A MA33561B1 (fr)	2009-09-11	2012-03-02	Dérivés d'isoxazolidine

Country Status (27)

Country	Link
US (1)	US8637662B2 (es)
EP (2)	EP2993178A1 (es)
JP (1)	JP2013504524A (es)
KR (1)	KR101451486B1 (es)
CN (2)	CN105175479B (es)
AR (2)	AR078164A1 (es)
AU (1)	AU2010294598B2 (es)
BR (1)	BR112012005503B1 (es)
CA (1)	CA2773594C (es)
CL (1)	CL2012000450A1 (es)
CO (1)	CO6511204A2 (es)
EA (1)	EA025191B1 (es)
GE (1)	GEP20146135B (es)
IL (1)	IL218539A (es)
JO (1)	JO3760B1 (es)
MA (1)	MA33561B1 (es)
ME (1)	ME01331B (es)
MX (1)	MX2012002967A (es)
MY (1)	MY164842A (es)
NZ (1)	NZ598662A (es)
PE (1)	PE20120894A1 (es)
SG (2)	SG10201608490VA (es)
TN (1)	TN2012000077A1 (es)
TW (1)	TWI494318B (es)
UA (1)	UA108858C2 (es)
WO (1)	WO2011029547A2 (es)
ZA (1)	ZA201201705B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2010294598B2 (en) *	2009-09-11	2016-09-01	Chiesi Farmaceutici S.P.A.	Pregnane derivatives condensed in the 16, 17 position with an n-substituted isoxazolidine ring as anti-inflammatory agents
TW201139369A (en) *	2010-02-05	2011-11-16	Chiesi Farma Spa	Pyrrolidine derivatives
BR112013022890A2 (pt)	2011-03-15	2016-09-13	Chiesi Farma Spa	composto, composição farmacêutica, combinação e uso de um composto
MX345400B (es) *	2011-03-15	2017-01-30	Chiesi Farm Spa	Derivados de isoxazolidina.
CN103814043A (zh) *	2011-08-01	2014-05-21	奇斯药制品公司	在16，17位与吡咯烷环稠合的抗炎类固醇
US9155747B2 (en) *	2012-09-13	2015-10-13	Chiesi Farmaceutici S.P.A.	Isoxazolidine derivatives
PL3231444T3 (pl)	2014-05-12	2020-05-18	Verona Pharma Plc	Nowe leczenie
ES2802202T3 (es)	2014-09-03	2021-01-15	Rhizen Pharmaceuticals S A	Método de tratamiento y composiciones que comprenden un inhibidor dual de la quinasa PI3K delta-gama y un corticoesteroide
CN104262440B (zh) *	2014-09-10	2016-08-17	江西赣亮医药原料有限公司	一种16ɑ-羟基泼尼松龙的制备方法
CN109206471B (zh) *	2017-06-30	2022-07-12	天津药业研究院股份有限公司	一种哈西奈德的制备方法
CN109575096B (zh) *	2019-01-20	2021-01-01	湖南科瑞生物制药股份有限公司	一种制备16a-羟基泼尼松龙产品的新方法
CN112142820A (zh) *	2019-06-29	2020-12-29	天津药业研究院股份有限公司	曲安奈德的合成方法
CN117050128B (zh) *	2023-08-15	2026-04-24	黄冈人福药业有限责任公司	一种11β-羟基-孕甾-1,4,16-三烯-3,20-二酮-21-醋酸酯的制备方法和设备

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1131213B (de) *	1958-06-13	1962-06-14	Syntex Sa	Verfahren zur Herstellung neuer Pregnanverbindungen
US3048581A (en) *	1960-04-25	1962-08-07	Olin Mathieson	Acetals and ketals of 16, 17-dihydroxy steroids
BR6678983D0 (pt) *	1965-05-04	1973-09-18	Merck & Co Inc	Processo para preparar 21-fosfato esteroides
SE307576B (es) *	1966-01-27	1969-01-13	Bofors Ab
IL31997A (en) *	1968-05-03	1974-03-14	Lepetit Spa	Process for the preparation of pregnano(17alpha,16alpha-d)oxazolines and 16alpha,21-dihydroxy-17alpha-aminopregnanes
GB1302572A (es)	1969-05-05	1973-01-10
US3996359A (en) *	1972-05-19	1976-12-07	Ab Bofors	Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378110B (es) *	1972-05-19	1975-08-18	Bofors Ab
US4018774A (en) *	1976-02-13	1977-04-19	E. R. Squibb & Sons, Inc.	Steroidal [16α,17-d]isoxazolidines
DE3133631A1 (de) *	1981-08-21	1983-03-03	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue kortikoide ihre herstellung und verwendung
US5200518A (en) *	1991-02-21	1993-04-06	Kangweon National University	Anti-inflammatory carboxycyclic acetal pregnane derivatives
JP2749778B2 (ja) *	1994-09-05	1998-05-13	日清食品株式会社	トリアムシノロン誘導体
WO2005028495A1 (en) *	2003-09-24	2005-03-31	Glaxo Group Limited	Anti-inflammatory glucocorticoids
GB0415747D0 (en) *	2004-07-14	2004-08-18	Novartis Ag	Organic compounds
WO2006138212A1 (en) *	2005-06-14	2006-12-28	Gilead Sciences, Inc.	SUBSTITUTED PHENYLPHOSPHATES AS MUTUAL PRODRUGS OF STEROIDS AND β -AGONISTS FOR THE TREATMENT OF PULMONARY INFLAMMATION AND BRONCHOCONSTRICTION
WO2009085879A2 (en) *	2007-12-21	2009-07-09	Schering Corporation	C20-c21 substituted glucocorticoid receptor agonists
WO2009108118A1 (en) *	2008-02-27	2009-09-03	Astrazeneca Ab	16 alpha, 17 alpa-acetal glucocorticosteroidal derivatives and their use
AU2010294598B2 (en) *	2009-09-11	2016-09-01	Chiesi Farmaceutici S.P.A.	Pregnane derivatives condensed in the 16, 17 position with an n-substituted isoxazolidine ring as anti-inflammatory agents

2010
- 2010-09-01 AU AU2010294598A patent/AU2010294598B2/en not_active Ceased
- 2010-09-01 SG SG10201608490VA patent/SG10201608490VA/en unknown
- 2010-09-01 MX MX2012002967A patent/MX2012002967A/es active IP Right Grant
- 2010-09-01 EP EP15185573.1A patent/EP2993178A1/en not_active Withdrawn
- 2010-09-01 EP EP10754274.8A patent/EP2475676B1/en active Active
- 2010-09-01 KR KR1020127006312A patent/KR101451486B1/ko not_active Expired - Fee Related
- 2010-09-01 EA EA201290091A patent/EA025191B1/ru not_active IP Right Cessation
- 2010-09-01 CN CN201510690091.0A patent/CN105175479B/zh not_active Expired - Fee Related
- 2010-09-01 GE GEAP201012612A patent/GEP20146135B/en unknown
- 2010-09-01 CA CA2773594A patent/CA2773594C/en active Active
- 2010-09-01 CN CN201080040085.6A patent/CN102482318B/zh not_active Withdrawn - After Issue
- 2010-09-01 NZ NZ598662A patent/NZ598662A/en not_active IP Right Cessation
- 2010-09-01 JP JP2012528250A patent/JP2013504524A/ja active Pending
- 2010-09-01 WO PCT/EP2010/005366 patent/WO2011029547A2/en not_active Ceased
- 2010-09-01 PE PE2012000303A patent/PE20120894A1/es active IP Right Grant
- 2010-09-01 ME MEP-2012-28A patent/ME01331B/me unknown
- 2010-09-01 UA UAA201202764A patent/UA108858C2/ru unknown
- 2010-09-01 SG SG2012016473A patent/SG179055A1/en unknown
- 2010-09-01 BR BR112012005503-8A patent/BR112012005503B1/pt not_active IP Right Cessation
- 2010-09-01 MY MYPI2012001059A patent/MY164842A/en unknown
- 2010-09-08 JO JOP/2010/0313A patent/JO3760B1/ar active
- 2010-09-09 US US12/878,113 patent/US8637662B2/en not_active Expired - Fee Related
- 2010-09-09 TW TW099130461A patent/TWI494318B/zh not_active IP Right Cessation
- 2010-09-09 AR ARP100103307A patent/AR078164A1/es not_active Application Discontinuation
2012
- 2012-02-17 TN TNP2012000077A patent/TN2012000077A1/en unknown
- 2012-02-21 CL CL2012000450A patent/CL2012000450A1/es unknown
- 2012-03-01 CO CO12036474A patent/CO6511204A2/es not_active Application Discontinuation
- 2012-03-02 MA MA34659A patent/MA33561B1/fr unknown
- 2012-03-08 ZA ZA2012/01705A patent/ZA201201705B/en unknown
- 2012-03-08 IL IL218539A patent/IL218539A/en active IP Right Grant
2020
- 2020-02-17 AR ARP200100437A patent/AR118123A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN102482318B (zh)	2015-11-25
AR078164A1 (es)	2011-10-19
CA2773594C (en)	2018-09-25
BR112012005503A2 (pt)	2016-04-19
HK1166085A1 (zh)	2012-10-19
EP2475676B1 (en)	2020-05-27
IL218539A (en)	2015-09-24
WO2011029547A8 (en)	2011-06-16
TWI494318B (zh)	2015-08-01
KR20120055651A (ko)	2012-05-31
JO3760B1 (ar)	2021-01-31
PE20120894A1 (es)	2012-08-13
WO2011029547A3 (en)	2011-08-18
CN105175479A (zh)	2015-12-23
CN105175479B (zh)	2017-06-09
WO2011029547A2 (en)	2011-03-17
US20110065678A1 (en)	2011-03-17
ME01331B (me)	2013-12-20
US8637662B2 (en)	2014-01-28
AU2010294598B2 (en)	2016-09-01
UA108858C2 (xx)	2015-06-25
EP2475676A2 (en)	2012-07-18
MX2012002967A (es)	2012-04-30
AR118123A2 (es)	2021-09-22
EP2993178A1 (en)	2016-03-09
HK1218759A1 (zh)	2017-03-10
ZA201201705B (en)	2013-05-29
GEP20146135B (en)	2014-08-11
EA201290091A1 (ru)	2012-12-28
KR101451486B1 (ko)	2014-10-22
CA2773594A1 (en)	2011-03-17
SG179055A1 (en)	2012-04-27
MY164842A (en)	2018-01-30
CN102482318A (zh)	2012-05-30
IL218539A0 (en)	2012-05-31
SG10201608490VA (en)	2016-11-29
EA025191B1 (ru)	2016-11-30
JP2013504524A (ja)	2013-02-07
NZ598662A (en)	2014-03-28
TN2012000077A1 (en)	2013-09-19
CO6511204A2 (es)	2012-08-31
BR112012005503B1 (pt)	2021-10-13
AU2010294598A1 (en)	2012-04-05
TW201114776A (en)	2011-05-01
CL2012000450A1 (es)	2012-08-10

Publication	Publication Date	Title
MA33561B1 (fr)	2012-09-01	Dérivés d'isoxazolidine
MA33730B1 (fr)	2012-11-01	Procédés de synthèse pour des composés spiro-oxindoles
ATE514692T1 (de)	2011-07-15	Phenothiazin derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
MA32104B1 (fr)	2011-02-01	Dérivés d'oxime en tant qu'inhibiteurs de hsp90
EA201401193A1 (ru)	2015-08-31	Триарильные соединения и композиции, их содержащие
EA201000436A1 (ru)	2010-10-29	Стероидные [3,2-с]пиразольные соединения, обладающие глюкокортикоидной активностью
MA33220B1 (fr)	2012-04-02	Composition pharmaceutique a proprietes anti-inflammatoires
MA37798B1 (fr)	2018-11-30	4-méthyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphtalènes
MA30042B1 (fr)	2008-12-01	Composes calcilytiques
MA40875A (fr)	2017-09-06	2,4-diamino-quinoléine substituée servant de nouveaux agents anticancéreux
MX2011012669A (es)	2011-12-16	Nuevos agonistas del receptor de glucocorticoides.
MA33463B1 (fr)	2012-07-03	Compositions à dose pharmaceutique solide fixe comprenant de l'irbésartan et de l'amlodipine, leur préparation et leur application thérapeutique
MA32943B1 (fr)	2012-01-02	Piperidine spiro pyrrolidione et piperidinone substituees, leur preparation et leur utilisation therapeutique
MA34094B1 (fr)	2013-03-05	Dérivés de 3-(hétéroarylamino)-1,2,3,4-tétrahydro-9h-carbazole et leur utilisation comme modulateurs du récepteur de la prostaglandine d2
IL180495A (en)	2013-12-31	Benzyl triazolone compounds as non-nucleotide reverse transcriptase inhibitors
TN2013000313A1 (en)	2015-01-20	Isoxazolidine derivatives
EP1599201A4 (en)	2007-01-24	SELECTIVE NON-TTEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS
EA200970849A1 (ru)	2010-04-30	Трициклические производные изохинолина для лечения ожирения
MX2010001243A (es)	2010-03-11	Composicion anti-inflamatoria.
GEP20135733B (en)	2013-01-25	Novel diazeniumdiolate derivatives, their preparation method and pharmaceutical compositions containing them
MA20150350A1 (fr)	2015-10-30	Dérivés isoxazolidine
MX2009009831A (es)	2009-09-24	Nitrilos aromatizantes.
MA34746B1 (fr)	2013-12-03	Dérivés de diphénylamine : utilisations, procédés de synthèse et compositions pharmaceutiques
PT1853232E (pt)	2009-11-12	Forma cristalina estável de mesilato de bifeprunox, suas formas de dosagem e métodos para a sua utilização
EA200602049A1 (ru)	2007-06-29	Пролекарства стероидов с андрогенным действием