MA32104B1 - Dérivés d'oxime en tant qu'inhibiteurs de hsp90 - Google Patents

Dérivés d'oxime en tant qu'inhibiteurs de hsp90

Info

Publication number
MA32104B1
MA32104B1 MA33117A MA33117A MA32104B1 MA 32104 B1 MA32104 B1 MA 32104B1 MA 33117 A MA33117 A MA 33117A MA 33117 A MA33117 A MA 33117A MA 32104 B1 MA32104 B1 MA 32104B1
Authority
MA
Morocco
Prior art keywords
hsp90
inhibitors
compounds
oxime derivatives
methods
Prior art date
Application number
MA33117A
Other languages
Arabic (ar)
English (en)
Inventor
Young K Chen
Erick Wang Co
Prasuna Guntupalli
John David Lawson
Wolfgang Reinhard Ludwig Notz
Jeffrey A Stafford
Huong-Thu Ton-Nu
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MA32104B1 publication Critical patent/MA32104B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Urology & Nephrology (AREA)

Abstract

L'invention concerne des composés inhibiteurs de hsp90 répondant à la formule (i) dans laquelle les variables sont telles que définies par le présentes. L'invention concerne également des compositions pharmaceutiques, des kits et des articles de fabrication comportant de tels composés ; des procédés et des intermédiaires utiles pour préparer les composés, et des procédés d'utilisation desdits composés.
MA33117A 2008-02-01 2010-08-26 Dérivés d'oxime en tant qu'inhibiteurs de hsp90 MA32104B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2572508P 2008-02-01 2008-02-01
US10159508P 2008-09-30 2008-09-30
PCT/US2009/032728 WO2009097578A1 (fr) 2008-02-01 2009-01-30 Dérivés d'oxime en tant qu'inhibiteurs de hsp90

Publications (1)

Publication Number Publication Date
MA32104B1 true MA32104B1 (fr) 2011-02-01

Family

ID=40436400

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33117A MA32104B1 (fr) 2008-02-01 2010-08-26 Dérivés d'oxime en tant qu'inhibiteurs de hsp90

Country Status (26)

Country Link
US (4) US8071766B2 (fr)
EP (1) EP2252595B1 (fr)
JP (1) JP5524084B2 (fr)
KR (1) KR20100116206A (fr)
CN (1) CN101983191B (fr)
AR (1) AR071452A1 (fr)
AU (1) AU2009208947B2 (fr)
BR (1) BRPI0906598A2 (fr)
CA (1) CA2713658C (fr)
CL (1) CL2009000228A1 (fr)
CR (1) CR11659A (fr)
DO (1) DOP2010000236A (fr)
EA (1) EA019156B1 (fr)
EC (1) ECSP10010434A (fr)
ES (1) ES2475206T3 (fr)
GE (1) GEP20125718B (fr)
IL (1) IL207227A0 (fr)
MA (1) MA32104B1 (fr)
MX (1) MX2010008269A (fr)
MY (1) MY150596A (fr)
NZ (1) NZ587207A (fr)
PE (1) PE20091371A1 (fr)
SG (1) SG187502A1 (fr)
TW (1) TW200946531A (fr)
WO (1) WO2009097578A1 (fr)
ZA (1) ZA201005435B (fr)

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US8071766B2 (en) 2011-12-06
PE20091371A1 (es) 2009-10-03
US20090305998A1 (en) 2009-12-10
CA2713658A1 (fr) 2009-08-06
CL2009000228A1 (es) 2009-07-24
MX2010008269A (es) 2011-02-21
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US8618290B2 (en) 2013-12-31
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