MA33598B1 - Nouvelles compositions de 1-[2-(2,4-diméthyl-phénylsulfanyl)-phényl]pipérazine - Google Patents

Nouvelles compositions de 1-[2-(2,4-diméthyl-phénylsulfanyl)-phényl]pipérazine

Info

Publication number
MA33598B1
MA33598B1 MA34709A MA34709A MA33598B1 MA 33598 B1 MA33598 B1 MA 33598B1 MA 34709 A MA34709 A MA 34709A MA 34709 A MA34709 A MA 34709A MA 33598 B1 MA33598 B1 MA 33598B1
Authority
MA
Morocco
Prior art keywords
phenylsulfane
phenylpiperazine
dimethyl
new formulations
formulations
Prior art date
Application number
MA34709A
Other languages
Arabic (ar)
English (en)
Inventor
Astrid-Maria Højer
Pernille Gundorf Drewes
Jens Kateb
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43628463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33598(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of MA33598B1 publication Critical patent/MA33598B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des compositions pharmaceutiques de 1-[2-(2,4-diméthyl-phénylsulfanyl)- phényl]pipérazine ainsi que leurs sels d'addition d'acide, conçues de sorte que la libération ne se produise pas dans l'estomac.
MA34709A 2009-08-24 2012-03-21 Nouvelles compositions de 1-[2-(2,4-diméthyl-phénylsulfanyl)-phényl]pipérazine MA33598B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23622309P 2009-08-24 2009-08-24
DKPA200900950 2009-08-24
PCT/DK2010/050216 WO2011023194A2 (fr) 2009-08-24 2010-08-23 Nouvelles compositions de 1-[2-(2,4-diméthyl-phénylsulfanyl)-phényl]pipérazine

Publications (1)

Publication Number Publication Date
MA33598B1 true MA33598B1 (fr) 2012-09-01

Family

ID=43628463

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34709A MA33598B1 (fr) 2009-08-24 2012-03-21 Nouvelles compositions de 1-[2-(2,4-diméthyl-phénylsulfanyl)-phényl]pipérazine

Country Status (32)

Country Link
US (3) US20120189697A1 (fr)
EP (1) EP2470166B1 (fr)
JP (1) JP2013502446A (fr)
KR (1) KR20120065328A (fr)
CN (1) CN102639117A (fr)
AU (1) AU2010289022B2 (fr)
BR (1) BR112012003280A2 (fr)
CA (1) CA2769872A1 (fr)
CL (1) CL2012000457A1 (fr)
CO (1) CO6612204A2 (fr)
CR (1) CR20120058A (fr)
DK (1) DK2470166T3 (fr)
DO (1) DOP2012000050A (fr)
EA (1) EA021321B1 (fr)
ES (1) ES2427628T3 (fr)
GE (1) GEP20135950B (fr)
HR (1) HRP20130819T1 (fr)
IL (1) IL217914A0 (fr)
MA (1) MA33598B1 (fr)
ME (1) ME01602B (fr)
MX (1) MX2012002199A (fr)
NZ (1) NZ598083A (fr)
PL (1) PL2470166T3 (fr)
PT (1) PT2470166E (fr)
RS (1) RS52959B (fr)
SG (1) SG178325A1 (fr)
SI (1) SI2470166T1 (fr)
SM (1) SMT201300108B (fr)
TN (1) TN2012000038A1 (fr)
UA (1) UA105057C2 (fr)
WO (1) WO2011023194A2 (fr)
ZA (1) ZA201201360B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200932233A (en) 2007-11-13 2009-08-01 Lundbeck & Co As H Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity
EP2564837B1 (fr) 2010-04-30 2019-01-30 Takeda Pharmaceutical Company Limited Comprimé à délitage intestinal
WO2011136376A1 (fr) * 2010-04-30 2011-11-03 武田薬品工業株式会社 Comprimé à délitage intestinal
CN104146953A (zh) * 2014-07-24 2014-11-19 李雪梅 一种氢溴酸沃替西汀注射液
CN104610195B (zh) * 2015-01-30 2017-06-27 上虞京新药业有限公司 沃替西汀的天冬氨酸盐或其水合物及其制备方法和用途
JO3456B1 (ar) 2015-05-13 2020-07-05 H Lundbeck As فيروتيوكسيتين بيروجلوتامات
EP3184104B1 (fr) 2015-12-23 2018-09-12 Hexal AG Composition pharmaceutique de bromhydrate vortioxetine qui est contenu dans une matrice d'oxyde de polyéthylène
EP3184102A1 (fr) 2015-12-23 2017-06-28 Hexal AG Composition pharmaceutique de bromhydrate vortioxetine comprenant un noyau inerte formé d'un composé à réaction acide
EP3478289A1 (fr) 2016-07-01 2019-05-08 H. Lundbeck A/S Schémas posologiques de la vortioxétine destinés à une apparition rapide de l'effet antidépresseur
WO2018065348A1 (fr) 2016-10-05 2018-04-12 Hexal Ag Nouveau comprimé à enrobage entérique comprenant de la vortioxétine
WO2020087031A1 (fr) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combinaison d'un inhibiteur de réabsorption spécifique de la sérotonine et d'un agoniste partiel du récepteur de la sérotonine 1a pour réduire la dyskinésie induite par l-dopa
CN112006995A (zh) * 2020-08-14 2020-12-01 石药集团中奇制药技术（石家庄）有限公司 一种氢溴酸伏硫西汀片的制备方法
CN113350348B (zh) * 2020-11-05 2022-03-01 东南大学 一种1-二苯甲基-4-甲基哌嗪类化合物在制备保护肠道屏障完整性药物中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9514842D0 (en) * 1995-07-20 1995-09-20 Smithkline Beecham Plc Novel formulation
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
US6866146B2 (en) 2001-10-09 2005-03-15 Christian M. Heesch Protective case for string instruments
KR20070087678A (ko) * 2004-12-20 2007-08-28 컬리지움 파마슈티칼, 인코포레이티드 수면 장애용 약제 조성물
WO2007040650A2 (fr) * 2005-05-12 2007-04-12 Abbott Laboratories Promoteurs d'apoptose
AU2006274565B2 (en) * 2005-08-02 2012-05-17 Lupin Limited Novel controlled release compositions of selective serotonin reuptake inhibitors
WO2007144005A1 (fr) * 2006-06-16 2007-12-21 H. Lundbeck A/S 1-[2-(2, 4-diméthylphénylsulfanyl)-phényl]pipérazine comme composé présentant une activité sur la sérotonine, 5-ht3 et 5-ht1a pour le traitement du déficit cognitif
TW200848411A (en) 2007-03-20 2008-12-16 Lundbeck & Co As H Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine
TW200932233A (en) * 2007-11-13 2009-08-01 Lundbeck & Co As H Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity

Also Published As

Publication number Publication date
HRP20130819T1 (en) 2013-09-30
WO2011023194A2 (fr) 2011-03-03
US20150150867A1 (en) 2015-06-04
DK2470166T3 (da) 2013-09-08
EP2470166A2 (fr) 2012-07-04
AU2010289022A1 (en) 2012-03-08
CN102639117A (zh) 2012-08-15
TN2012000038A1 (en) 2013-09-19
CO6612204A2 (es) 2013-02-01
ME01602B (me) 2014-09-20
NZ598083A (en) 2013-08-30
MX2012002199A (es) 2012-03-16
CL2012000457A1 (es) 2013-01-25
EA021321B1 (ru) 2015-05-29
BR112012003280A2 (pt) 2017-05-23
ZA201201360B (en) 2013-05-29
PT2470166E (pt) 2013-10-02
PL2470166T3 (pl) 2013-11-29
GEP20135950B (en) 2013-10-25
AU2010289022B2 (en) 2013-03-14
SI2470166T1 (sl) 2014-03-31
IL217914A0 (en) 2012-03-29
KR20120065328A (ko) 2012-06-20
US20120189697A1 (en) 2012-07-26
DOP2012000050A (es) 2012-07-31
EP2470166B1 (fr) 2013-08-14
JP2013502446A (ja) 2013-01-24
US20160256398A1 (en) 2016-09-08
SG178325A1 (en) 2012-03-29
CA2769872A1 (fr) 2011-03-03
UA105057C2 (uk) 2014-04-10
SMT201300108B (it) 2013-11-08
EA201290116A1 (ru) 2012-06-29
ES2427628T3 (es) 2013-10-31
CR20120058A (es) 2012-04-26
RS52959B (sr) 2014-02-28
WO2011023194A3 (fr) 2011-12-01

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