MA33829B1 - Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide tertiaires et leurs utilisations - Google Patents

Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide tertiaires et leurs utilisations

Info

Publication number
MA33829B1
MA33829B1 MA34972A MA34972A MA33829B1 MA 33829 B1 MA33829 B1 MA 33829B1 MA 34972 A MA34972 A MA 34972A MA 34972 A MA34972 A MA 34972A MA 33829 B1 MA33829 B1 MA 33829B1
Authority
MA
Morocco
Prior art keywords
hydroxyquinoline
carboxamide derivatives
novel tertiary
compounds
carboxamide
Prior art date
Application number
MA34972A
Other languages
Arabic (ar)
English (en)
Inventor
Stefania Gagliardi
Sordo Simone Del
Federico Mailland
Michela Legora
Original Assignee
Polichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42026678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33829(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Polichem Sa filed Critical Polichem Sa
Publication of MA33829B1 publication Critical patent/MA33829B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Cette invention concerne de nouveaux dérivés de 8-hydroxyquinoline- 7-carboxamide tertiaires de formule générale (i) et leurs sels pharmaceutiquement acceptables. Ces composés sont utiles en tant qu'agents antifongiques. Plus spécifiquement, ces composés ont été testés contre tricophyton rubrum, tricophyton mentagrophytes, aspergillus niger et scopulariopsis brevicaulis. Ils sont également actifs contre l'espèce candida, par exemple, candida albicans et candida glabrata.
MA34972A 2009-12-29 2012-06-15 Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide tertiaires et leurs utilisations MA33829B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09180902A EP2345643A1 (fr) 2009-12-29 2009-12-29 Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide et leurs utilisations
PCT/EP2010/070790 WO2011080264A1 (fr) 2009-12-29 2010-12-28 Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide tertiaires et leurs utilisations

Publications (1)

Publication Number Publication Date
MA33829B1 true MA33829B1 (fr) 2012-12-03

Family

ID=42026678

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34972A MA33829B1 (fr) 2009-12-29 2012-06-15 Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide tertiaires et leurs utilisations

Country Status (37)

Country Link
US (1) US8729098B2 (fr)
EP (2) EP2345643A1 (fr)
JP (1) JP5808754B2 (fr)
KR (1) KR101666505B1 (fr)
CN (2) CN105384685A (fr)
AU (1) AU2010338267B2 (fr)
BR (1) BR112012015728A2 (fr)
CA (1) CA2783213C (fr)
CL (1) CL2012001757A1 (fr)
CY (1) CY1116493T1 (fr)
DK (1) DK2519505T3 (fr)
DO (1) DOP2012000186A (fr)
EA (1) EA025563B1 (fr)
EC (1) ECSP12012007A (fr)
ES (1) ES2540327T3 (fr)
GE (1) GEP20156244B (fr)
GT (1) GT201200216A (fr)
HR (1) HRP20150749T1 (fr)
HU (1) HUE027220T2 (fr)
IL (1) IL220427A (fr)
MA (1) MA33829B1 (fr)
MX (1) MX2012007748A (fr)
MY (1) MY161869A (fr)
NI (1) NI201200114A (fr)
NZ (1) NZ600788A (fr)
PE (1) PE20130179A1 (fr)
PH (1) PH12012501326A1 (fr)
PL (1) PL2519505T3 (fr)
PT (1) PT2519505E (fr)
RS (1) RS54096B1 (fr)
SG (1) SG181586A1 (fr)
SI (1) SI2519505T1 (fr)
SM (1) SMT201500182B (fr)
TN (1) TN2012000320A1 (fr)
UA (1) UA107949C2 (fr)
WO (1) WO2011080264A1 (fr)
ZA (1) ZA201204347B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2345642A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Dérivés de 8-hydroxyquinoline-7-carboxamide secondaire pour une utilisation en tant qu'agents antifongiques
EP2345641A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide secondaire
JP6092261B2 (ja) * 2012-02-24 2017-03-08 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗ウイルス化合物
US9751838B2 (en) 2012-10-02 2017-09-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Tetrahydroquinoline derivatives and their use as Epac inhibitors
US8697753B1 (en) 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis
EP4699762A3 (fr) 2020-09-22 2026-04-22 Milwaukee Electric Tool Corporation Regroupement d'agrafes et d'agrafes
USD976093S1 (en) 2020-09-22 2023-01-24 Milwaukee Electric Tool Corporation Staple collation
EP4237201A4 (fr) 2020-10-30 2024-12-11 Milwaukee Electric Tool Corporation Dispositif d'entraînement d'élément de fixation motorisé

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US326328A (en) 1885-09-15 Broiler
US326330A (en) 1885-09-15 Harness-support
DE540842C (de) 1930-08-06 1931-12-28 Chinosol Fabrik Akt Ges Verfahren zur Darstellung der 8-Acetyloxychinolin-7-carbonsaeure
CA2215514A1 (fr) 1995-04-08 1996-10-17 Basf Aktiengesellschaft Compositions fongicides synergiques constituees de derives de quinoleine et en inhibiteurs de cytochrome b/c
US6194413B1 (en) * 1995-11-13 2001-02-27 Smithkline Beecham Corporation Hemoregulatory compounds
US6310211B1 (en) 1996-09-10 2001-10-30 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
KR20010015639A (ko) * 1997-09-30 2001-02-26 스즈키 다다시 술포닐 유도체
JP2001294572A (ja) * 2000-02-09 2001-10-23 Dai Ichi Seiyaku Co Ltd 新規スルホニル誘導体
EP1326611B1 (fr) 2000-10-12 2007-06-13 Merck & Co., Inc. Azanaphthalenylcarboxamides et polyazanaphthalenylcarboxamides utiles en tant qu'inhibiteurs de la vih integrase
PL360944A1 (en) 2000-10-12 2004-09-20 Merck & Co, Inc. Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
JP3616628B2 (ja) 2001-03-01 2005-02-02 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物
ATE404537T1 (de) 2002-08-13 2008-08-15 Shionogi & Co Heterocyclische verbindungen mit hiv-integrase- hemmender wirkung
WO2005033079A1 (fr) * 2003-09-30 2005-04-14 Eisai Co., Ltd. Agent antifongique a compose heterocyclique
FR2889192A1 (fr) * 2005-07-27 2007-02-02 Cytomics Systems Sa Composes antifongiques, compositions contenant ces composes et leurs utilisations
WO2008014307A2 (fr) * 2006-07-26 2008-01-31 Novartis Ag Inhibiteurs de l'undécaprényl pyrophosphate synthase
WO2009140215A2 (fr) * 2008-05-11 2009-11-19 Geraghty, Erin Procédé pour traiter des infections bactériennes résistant au médicament et d'autres infections par du clioquinol, de la phanquinone et des composés apparentés
EP2947082A1 (fr) * 2009-11-10 2015-11-25 Pfizer Inc INHIBITEURS DE N1-PYRAZOLOSPIROCÉTONE ACÉTYL-CoA CARBOXYLASE
TW201130842A (en) * 2009-12-18 2011-09-16 Incyte Corp Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
EP2345642A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Dérivés de 8-hydroxyquinoline-7-carboxamide secondaire pour une utilisation en tant qu'agents antifongiques
EP2345641A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide secondaire

Also Published As

Publication number Publication date
PE20130179A1 (es) 2013-02-24
ZA201204347B (en) 2013-09-25
PL2519505T3 (pl) 2015-11-30
CN102686566A (zh) 2012-09-19
IL220427A (en) 2015-04-30
BR112012015728A2 (pt) 2019-09-24
HK1178526A1 (en) 2013-09-13
PH12012501326A1 (en) 2015-04-01
UA107949C2 (xx) 2015-03-10
DK2519505T3 (en) 2015-06-29
EA025563B1 (ru) 2017-01-30
SMT201500182B (it) 2015-09-07
JP5808754B2 (ja) 2015-11-10
KR20120101563A (ko) 2012-09-13
AU2010338267A2 (en) 2012-07-26
NI201200114A (es) 2013-04-22
CA2783213A1 (fr) 2011-07-07
PT2519505E (pt) 2015-09-03
AU2010338267A1 (en) 2012-07-19
KR101666505B1 (ko) 2016-10-14
EP2519505A1 (fr) 2012-11-07
HRP20150749T1 (hr) 2015-08-14
ES2540327T3 (es) 2015-07-09
HUE027220T2 (hu) 2016-10-28
TN2012000320A1 (en) 2013-12-12
CY1116493T1 (el) 2017-03-15
EA201270670A1 (ru) 2013-03-29
CA2783213C (fr) 2017-09-12
AU2010338267B2 (en) 2014-03-27
EP2345643A1 (fr) 2011-07-20
SI2519505T1 (sl) 2015-08-31
EP2519505B1 (fr) 2015-05-27
CL2012001757A1 (es) 2013-03-22
MX2012007748A (es) 2012-08-03
NZ600788A (en) 2013-08-30
WO2011080264A1 (fr) 2011-07-07
ECSP12012007A (es) 2012-08-31
US20120309751A1 (en) 2012-12-06
DOP2012000186A (es) 2013-01-15
SG181586A1 (en) 2012-07-30
GEP20156244B (en) 2015-02-10
US8729098B2 (en) 2014-05-20
MY161869A (en) 2017-05-15
JP2013515755A (ja) 2013-05-09
CN105384685A (zh) 2016-03-09
RS54096B1 (sr) 2015-10-30
GT201200216A (es) 2014-12-26

Similar Documents

Publication Publication Date Title
MA33829B1 (fr) Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide tertiaires et leurs utilisations
EA201071329A1 (ru) Диамидные производные адамантана и их применение
EP2477985A4 (fr) Traitement du cancer
EA201101026A1 (ru) Ингибиторы бета-секретазы
UY31367A1 (es) Derivados de nicotinamida, su preparacion y su aplicacion en terapeutica
EA201100299A1 (ru) Органические соединения
CY1115043T1 (el) Φαρμακευτικο σκευασμα
CY1118093T1 (el) Φαρμακοτεχνικες μορφες που περιλαμβανουν παραγωγα 1-(bhta-d-γλυκοπυρανοζυλ)-2-θειενυλμεθυλβενζολιου ως αναστολεις sglt
UA107455C2 (uk) Похідні індолу як протиракові агенти
CR20110269A (es) Lactamas como inhibidores de beta secretasa
EA201001566A1 (ru) Новый класс спиропиперидинов для лечения нейродегенеративных заболеваний
UA104420C2 (uk) Застосування похідних глутарової кислоти або їх фармацевтично прийнятних солей як протиаритмічних засобів
MA33830B1 (fr) Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide secondaires
MA32165B1 (fr) Composition pharmaceutique
NI201200116A (es) Derivados secundarios de 8 - hidroxiquinolina - 7 - carboxamida útiles como agentes antifúngicos
MA32512B1 (fr) Derive de phenanthrenone, compositions et procedes
BR112012012905A2 (pt) derivados de difenil azepina como inibidores da reabsorção de monoamina
EA201190031A1 (ru) Производные сульфамоил-фенил-уреидо-бензаимидина в качестве противомалярийных агентов
EA202090677A1 (ru) Липидные композиции
TH127237A (th) อนุพันธ์เซคันดารี่ 8-ไฮดรอกซิควิโนลีน-7-คาร์บอกซาไมด์สำหรับการใช้เป็นสารต้านเชื้อรา