MA33899B1 - Procedes et regimes a faible dose pour des troubles des globules rouges - Google Patents

Procedes et regimes a faible dose pour des troubles des globules rouges

Info

Publication number
MA33899B1
MA33899B1 MA35032A MA35032A MA33899B1 MA 33899 B1 MA33899 B1 MA 33899B1 MA 35032 A MA35032 A MA 35032A MA 35032 A MA35032 A MA 35032A MA 33899 B1 MA33899 B1 MA 33899B1
Authority
MA
Morocco
Prior art keywords
disorders
regimes
low dose
dose methods
fstale
Prior art date
Application number
MA35032A
Other languages
Arabic (ar)
English (en)
Inventor
Susan Perrine
Ronald J Berenson
Douglas V Faller
Original Assignee
Hemaquest Pharmaceuticals Inc
Univ Boston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemaquest Pharmaceuticals Inc, Univ Boston filed Critical Hemaquest Pharmaceuticals Inc
Publication of MA33899B1 publication Critical patent/MA33899B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention porte sur des procédés et des régimes à faibles doses pour augmenter les taux d'hémoglobine fstale dans des patients présentant des troubles des globules rouges, tels que la bêta-thalassémie, l'anémie falciforme, d'autres anémies, ou une perte de sang. Les taux d'hémoglobine fstale et totale et les comptages des globules rouges sont augmentés par l'administration de 2,2-diméthylbutyrate (dmb) seul ou en combinaison avec de l'hydroxyurée, de la décitabine ou un inhibiteur de hdac. Le traitement peut être poursuivi pendant au moins deux semaines.
MA35032A 2009-12-08 2010-12-08 Procedes et regimes a faible dose pour des troubles des globules rouges MA33899B1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US26772709P 2009-12-08 2009-12-08
US29565010P 2010-01-15 2010-01-15
US30637610P 2010-02-19 2010-02-19
US31209010P 2010-03-09 2010-03-09
US36732610P 2010-07-23 2010-07-23
US41136910P 2010-11-08 2010-11-08
PCT/US2010/059584 WO2011072086A1 (fr) 2009-12-08 2010-12-08 Procédés et régimes à faible dose pour traiter des troubles des globules rouges

Publications (1)

Publication Number Publication Date
MA33899B1 true MA33899B1 (fr) 2013-01-02

Family

ID=44145905

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35032A MA33899B1 (fr) 2009-12-08 2010-12-08 Procedes et regimes a faible dose pour des troubles des globules rouges

Country Status (7)

Country Link
US (1) US8618068B2 (fr)
EP (1) EP2509418A4 (fr)
CN (1) CN102802412A (fr)
IL (1) IL220040A0 (fr)
MA (1) MA33899B1 (fr)
TN (1) TN2012000270A1 (fr)
WO (1) WO2011072086A1 (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
EP2321642B1 (fr) 2008-08-04 2017-01-11 Natera, Inc. Procédés pour une classification d'allèle et une classification de ploïdie
WO2011041485A1 (fr) 2009-09-30 2011-04-07 Gene Security Network, Inc. Méthode non invasive de détermination d'une ploïdie prénatale
WO2011113013A2 (fr) 2010-03-11 2011-09-15 Hemaquest Pharmaceuticals, Inc. Procédés et compositions pour le traitement d'états viraux ou induits par des virus
WO2011146632A1 (fr) 2010-05-18 2011-11-24 Gene Security Network Inc. Procédés de classification de ploïdie prénatale non invasive
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20120016686A1 (en) * 2010-07-13 2012-01-19 Cerner Innovation, Inc. Inpatient blood management
CN103608466B (zh) 2010-12-22 2020-09-18 纳特拉公司 非侵入性产前亲子鉴定方法
RU2671980C2 (ru) 2011-02-09 2018-11-08 Натера, Инк. Способы неинвазивного пренатального установления плоидности
EP2714921A4 (fr) * 2011-05-26 2015-05-13 Univ Michigan Corépresseurs épigénétiques du gène de la gammaglobuline et leurs procédés d'utilisation
US20140271657A1 (en) * 2011-10-12 2014-09-18 Children's Medical Center Corporation Combinatorial compositions and methods of treating hemoglobinopathies
ITRM20120405A1 (it) 2012-08-09 2014-02-10 C N C C S Scarl Collezione Naziona Le Dei Compost Compounds for use in the treatment of disorders that are ameliorated by inhibition of hdac
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US20140065621A1 (en) * 2012-09-04 2014-03-06 Natera, Inc. Methods for increasing fetal fraction in maternal blood
CN109554350B (zh) 2012-11-27 2022-09-23 儿童医疗中心有限公司 用于胎儿血红蛋白再诱导的靶向bcl11a远端调控元件
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
CA2945962C (fr) 2014-04-21 2023-08-29 Natera, Inc. Detection de mutations et de la ploidie dans des segments chromosomiques
MX375592B (es) 2014-04-25 2025-03-06 The Children´S Medical Center Corp Composiciones y su uso para tratar hemoglobinopatias.
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
US11572543B2 (en) 2015-05-08 2023-02-07 The Children's Medical Center. Corporation Targeting BCL11A enhancer functional regions for fetal hemoglobin reinduction
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
WO2017165287A1 (fr) * 2016-03-22 2017-09-28 Balchem Corporation Compositions comprenant de la choline
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
JP7158104B2 (ja) 2016-07-15 2022-10-21 ビラクタ セラピューティクス，インク． Ｎｋ細胞ベースの療法で使用するためのｈｄａｃ阻害剤
WO2018067517A1 (fr) 2016-10-04 2018-04-12 Natera, Inc. Procédés pour caractériser une variation de nombre de copies à l'aide d'un séquençage de ligature de proximité
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
WO2018156418A1 (fr) 2017-02-21 2018-08-30 Natera, Inc. Compositions, procédés, et kits d'isolement d'acides nucléiques
US11261441B2 (en) 2017-03-29 2022-03-01 Bluebird Bio, Inc. Vectors and compositions for treating hemoglobinopathies
JP7136807B2 (ja) 2017-04-17 2022-09-13 ザ・ユニバーシティ・オブ・シカゴ ヒトの健康及び疾患の治療用途向けの短鎖脂肪酸の腸への送達用ポリマー材料
US11788087B2 (en) 2017-05-25 2023-10-17 The Children's Medical Center Corporation BCL11A guide delivery
CN109722414A (zh) * 2017-10-27 2019-05-07 博雅辑因（北京）生物科技有限公司 一种高效制备成熟红细胞的方法以及用于制备成熟红细胞的培养基
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
US12398389B2 (en) 2018-02-15 2025-08-26 Natera, Inc. Methods for isolating nucleic acids with size selection
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
WO2019213273A1 (fr) 2018-05-01 2019-11-07 The Children's Medical Center Corporation Administration et édition améliorées de bcl11a rnp/crispr à l'aide d'une 3xnls-cas9
WO2019213013A1 (fr) 2018-05-02 2019-11-07 The Children's Medical Center Corporation Microarn bcl11a améliorés pour le traitement d'hémoglobinopathies
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3937922A4 (fr) * 2019-03-14 2022-11-30 Hemoshear Therapeutics, Inc. Méthodes de traitement des acidémies organiques
AU2020283590A1 (en) 2019-05-31 2022-01-20 Viracta Subsidiary, Inc. Methods of treating virally associated cancers with histone deacetylase inhibitors
US12305235B2 (en) 2019-06-06 2025-05-20 Natera, Inc. Methods for detecting immune cell DNA and monitoring immune system
EP4041750A4 (fr) * 2019-10-07 2023-11-01 Viracta Subsidiary, Inc. Dosages pour le traitement de hdac à effets secondaires réduits
CN110827950B (zh) * 2019-11-25 2022-10-28 四川大学华西医院 麻醉药物用量的确定方法、模型的训练方法以及模型
US11938143B2 (en) 2021-10-19 2024-03-26 Akirabio, Inc. Compositions comprising 2′-deoxycytidine analogs and use thereof for the treatment of sickle cell disease, thalassemia, and cancers

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471513A (en) 1966-11-01 1969-10-07 Searle & Co 2-(2-carboxyethyl)-5-phenyl-1-pyrrole-butyric acid and congeners
BE789077A (fr) 1971-09-22 1973-01-15 Nitto Boseki Co Ltd Procede de preparation de derives de pyrimidine
FR2300551A2 (fr) 1975-02-17 1976-09-10 Fabre Sa Pierre Nouveaux
GB1498903A (en) 1974-03-25 1978-01-25 Fabre Sa Pierre Aromatic keto-acids and their derivatives
GB1484413A (en) 1974-04-18 1977-09-01 Kissei Pharmaceutical Aromatic amidocarboxylic acid derivatives
DE2456958A1 (de) 1974-12-03 1976-06-16 Basf Ag 3-(p-biphenylyl)-butyronitril und seine anwendung als arzneimittel
US4031243A (en) 1975-07-03 1977-06-21 Juste, S.A. Quimico-Farmaceutica 2-(4-Isobutyl phenyl)butyric acid, salts thereof, and pharmaceutical compositions containing the same
GB1518764A (en) 1976-03-17 1978-07-26 Soc D Etudes Prod Chimique Isobutyramides their preparation and therapeutic composititions containing them
US4176193A (en) 1977-03-17 1979-11-27 Societe D'etudes De Produits Chimiques Therapeutic isobutyramides
US4732914A (en) 1978-02-13 1988-03-22 The Upjohn Company Prostacyclin analogs
US4234599A (en) 1978-10-04 1980-11-18 Scott Eugene J Van Treatment of skin keratoses with α-hydroxy acids and related compounds
FR2508797B1 (fr) 1981-07-03 1986-03-14 Charles Chany Medicament comprenant le produit de la reaction d'un acide carboxylique en c1 a c6 sur un amino-acide basique
US4704402A (en) 1982-06-12 1987-11-03 University Of Pittsburgh Method of treating sickle cell anemia
GB2126082A (en) 1982-08-12 1984-03-21 Heinrich Schulze Pharmaceutical preparations having analgetic and cytostatic activity
US4894364A (en) 1983-10-26 1990-01-16 Greer Sheldon B Method and materials for sensitizing neoplastic tissue to radiation
US4851229A (en) 1983-12-01 1989-07-25 Alza Corporation Composition comprising a therapeutic agent and a modulating agent
US4671901A (en) 1984-01-26 1987-06-09 Oral-D Orally effective ion chelators
CA1249968A (fr) 1984-04-05 1989-02-14 Kazuo Kigasawa Base pour baume
US4747825A (en) 1984-06-29 1988-05-31 Ferring Laboratories, Inc. Apparatus and methodology for pulsed administration of growth promoting agents
US4613616A (en) 1984-07-20 1986-09-23 Research Corporation Polymeric iron chelators
JPS61155358A (ja) 1984-12-21 1986-07-15 Suntory Ltd ジアリール酪酸誘導体
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
US4735967A (en) 1985-05-28 1988-04-05 Neesby Torben E Method for desensitizing the gastrointestinal tract from food allergies
DE3534743A1 (de) 1985-09-28 1987-04-02 Beiersdorf Ag Hydrocortisondiester enthaltende o/w-creme
EP0224599A1 (fr) 1985-11-06 1987-06-10 National Patent Development Corporation Solution chimique à utiliser dans le traitement des dents
GB8607683D0 (en) 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4751244A (en) 1986-04-04 1988-06-14 Merck & Co., Inc. Compounds useful in treating sickle cell anemia
US4699926A (en) 1986-04-04 1987-10-13 Merck & Co., Inc. Compounds useful in treating sickle cell anemia
US4731381A (en) 1986-04-04 1988-03-15 Merck & Co., Inc. Method of treating a person for sickle cell anemia
US4948592A (en) 1986-05-09 1990-08-14 Alza Corporation Pulsed drug delivery
US4723958A (en) 1986-05-23 1988-02-09 Merck & Co., Inc. Pulsatile drug delivery system
US4822821A (en) 1986-10-10 1989-04-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
US5025029A (en) 1986-10-10 1991-06-18 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin
US4965251A (en) 1987-04-03 1990-10-23 The Board Of Regents Of The University Of Washington Pulse treatment of hemoglobinopathies with erythropoietin
US4820711A (en) 1987-05-15 1989-04-11 Pearlman Dale L Method for treating actinic keratosis with cytotoxic agents
US4853388A (en) 1987-05-15 1989-08-01 Pearlman Dale L Method for treating psoriasis with cytotoxic agents
US4849426A (en) 1987-05-15 1989-07-18 Pearlman Dale L Method for treating actinic keratosis with cytotoxic agents
FR2633929B2 (fr) 1987-09-25 1995-05-24 Picardie Universite Derives non toxiques de l'acide n-butyrique, presentant des actions therapeutiques retardees
US5032507A (en) 1987-11-13 1991-07-16 The Salk Institute For Biological Studies Potentiation of erythropoiesis
DE3742222A1 (de) 1987-12-12 1989-06-22 Basf Ag (2r)-aryloxy-3-n-butyroyloxy-propan-2-ole
ES2061963T3 (es) 1988-01-13 1994-12-16 Univ Arizona State Briostatinas inmunomoduladoras.
US4880624A (en) 1988-03-18 1989-11-14 The Board Of Trustees Of The University Of Illinois Volatile attractants for diabrotica species
US4958592A (en) 1988-08-22 1990-09-25 General Electric Company Resistance heater for diamond production by CVD
US4925873A (en) 1988-09-01 1990-05-15 E. R. Squibb & Sons, Inc. Method of treating skin injuries using thromboxane A2 receptor antagonists
US4997815A (en) 1988-11-01 1991-03-05 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin by treatment with activin and/or inhibin
EP0371789B1 (fr) 1988-11-29 1997-01-02 Children's Hospital Medical Center Of Northern California Médicament pour l'augmentation de l'hémoglobine foetale
US5137734A (en) 1989-03-22 1992-08-11 Dana Farber Cancer Institute Angiogenic monoglycerides
CA2038945A1 (fr) 1989-08-01 1991-02-02 Norman D. Weiner Liberation locale de peptides/proteines incluses dans des liposomes obtenus par deshydratation/rehydratation
US5039703A (en) 1989-11-16 1991-08-13 Breuer Richard I Method for treating inflammatory bowel disorders
GB8929070D0 (en) 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
US5674898A (en) 1990-03-05 1997-10-07 Genzyme Corporation Methods and therapeutic compositions for treating cystic fibrosis
US5258367A (en) 1990-06-29 1993-11-02 University Of Florida Uteroferrin and rose proteins for stimulating hematopoietic cells
SE9002732D0 (sv) 1990-08-24 1990-08-24 Kabivitrum Ab Product containing growth factor
US5216004A (en) 1990-09-13 1993-06-01 Children's Hospital Medical Center Of North California Method for preventing malaria
EP0548276A4 (en) 1990-09-13 1993-12-29 Children's Hospital Medical Center Of Northern California Method for increasing red blood cell production by treatment with activin or activin-related peptides
US5100647A (en) 1990-10-02 1992-03-31 The Trustees Of The University Of Pennsylvania Method and formulations for the therapy of cystic fibrosis, Bartter's syndrome and secretory diarrheas, and for diuretic treatment
US5674912A (en) 1991-03-01 1997-10-07 Warner-Lambert Company Sunscreen-wound healing compositions and methods for preparing and using same
US5270458A (en) 1991-04-02 1993-12-14 The Trustees Of Princeton University Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2
US5199942A (en) 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
EP0546261A3 (en) 1991-09-12 1993-08-11 American Cyanamid Company Method of treating latent herpes viral infections
US5635532A (en) 1991-10-21 1997-06-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia
WO1993007866A2 (fr) 1991-10-21 1993-04-29 Dvorit Samid Compositions et procedes de traitement et de prevention du cancer, du sida, et de l'anemie
US5605930A (en) 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
EP0583482B1 (fr) 1992-02-07 1999-12-29 Kaken Pharmaceutical Co., Ltd. Remede destine aux blessures ou aux hemorroides
CA2090283A1 (fr) 1992-02-28 1993-08-29 Nobuyuki Hamanaka Derives de l'acide phenoxyacetique
US5439939A (en) 1992-03-17 1995-08-08 Children's Hospital Medical Center Of Northern California Pharmaceutical compositions and methods using isobutyramide for treating betaglobin disorders
US7326535B2 (en) 1993-09-15 2008-02-05 Ortho Diagnostic Systems Inc. Immunoreactive peptides from Epstein-Barr virus
US5366996A (en) 1992-12-07 1994-11-22 Elford Howard L Method of treating hemoglobinopathies
US5403590A (en) 1992-12-21 1995-04-04 New England Deaconess Hospital Corporation Method of pulsatile drug infusion
WO1995011699A1 (fr) 1993-10-29 1995-05-04 The Trustees Of Boston University Compositions physiologiquement stables d'acide butyrique, de sels et de derives d'acide butyrique, utilisees comme agents antineoplasiques
US7888458B1 (en) 1993-11-30 2011-02-15 John B. Harley Diagnostics and therapy of epstein-barr virus in autoimmune disorders
US5780451A (en) 1994-04-01 1998-07-14 Abbott Laboratories Nutritional product for a person having ulcerative colitis
US5952314A (en) 1994-04-01 1999-09-14 Demichele; Stephen Joseph Nutritional product for a person having ulcerative colitis
IL110380A0 (en) 1994-07-20 1994-10-21 Agis Ind 1983 Ltd Antiviral topical pharmaceutical compositions
US6011000A (en) 1995-03-03 2000-01-04 Perrine; Susan P. Compositions for the treatment of blood disorders
AU6714396A (en) 1995-07-28 1997-02-26 Trustees Of Boston University Methods and compositions for treating cell proliferative disorders
US5883123A (en) 1995-10-06 1999-03-16 Vertex Pharmaceuticals, Inc. Butyrate prodrugs derived from lactic acid
US5912269A (en) 1996-04-30 1999-06-15 Vertex Pharmaceuticals, Inc. Butyrate prodrugs derived from lactic acid
US5763488A (en) 1995-10-30 1998-06-09 Vertex Pharmaceuticals Incorporated Methods and compositions using butyrate esters of threitol
US5846528A (en) 1996-01-18 1998-12-08 Avigen, Inc. Treating anemia using recombinant adeno-associated virus virions comprising an EPO DNA sequence
US6197743B1 (en) 1996-07-26 2001-03-06 The Trustees Of Boston University Compositions and methods for the treatment of viral disorders
US6403647B1 (en) * 1996-07-26 2002-06-11 Susan P. Perrine Pulsed administration of compositions for the treatment of blood disorders
US5939456A (en) 1996-07-26 1999-08-17 Perrine; Susan P. Pulsed administration of compositions for the treatment of blood disorders
AU3889197A (en) 1996-07-26 1998-02-20 Douglas V Faller Compositions comprising an inducing agent and an anti-viral agent for the treat ment of blood, viral and cellular disorders
US5939455A (en) 1997-03-11 1999-08-17 Beacon Laboratories, Inc. Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives
US6030961A (en) 1997-03-11 2000-02-29 Bar-Ilan Research & Development Co., Ltd. Oxyalkylene phosphate compounds and uses thereof
US6043389A (en) 1997-03-11 2000-03-28 Mor Research Applications, Ltd. Hydroxy and ether-containing oxyalkylene esters and uses thereof
US5932545A (en) 1997-03-17 1999-08-03 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy
US6231880B1 (en) * 1997-05-30 2001-05-15 Susan P. Perrine Compositions and administration of compositions for the treatment of blood disorders
CA2303268A1 (fr) 1997-06-13 1998-12-17 Scott Walsh Nanospheres therapeutiques
WO1999040883A2 (fr) 1998-02-11 1999-08-19 Faller Douglas V Compositions et techniques de traitement de la mucoviscidose
US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US8277810B2 (en) 2003-11-04 2012-10-02 Novartis Vaccines & Diagnostics, Inc. Antagonist anti-CD40 antibodies
DK1591109T3 (da) * 2004-04-30 2008-10-06 Topotarget Germany Ag Formulering, der omfatter histondeacetylaseinhibitorer, der udviser tofaset frigivelse
US20060069060A1 (en) 2004-09-27 2006-03-30 Sanjeev Redkar Salts of decitabine
FR2881746B1 (fr) 2005-02-07 2007-04-13 Centre Nat Rech Scient Epitopes t cd4+des antigenes de latence de type i et ii du virus epstein-barr aptes a etre reconnus par la majorite des individus de la population caucasienne et leurs applications
US20080075692A1 (en) * 2006-05-09 2008-03-27 Perrine Susan P Methods for treating blood disorders
US20080057086A1 (en) 2006-09-01 2008-03-06 Pharmion Corporation Colon-targeted oral formulations of cytidine analogs
JP5089335B2 (ja) 2007-10-29 2012-12-05 永大産業株式会社 難燃性パーティクルボードの製造方法
US20110086869A1 (en) 2009-09-24 2011-04-14 The Trustees Of Boston University Methods for treating viral disorders
WO2011113013A2 (fr) 2010-03-11 2011-09-15 Hemaquest Pharmaceuticals, Inc. Procédés et compositions pour le traitement d'états viraux ou induits par des virus

Also Published As

Publication number Publication date
US8618068B2 (en) 2013-12-31
CN102802412A (zh) 2012-11-28
WO2011072086A9 (fr) 2012-09-27
WO2011072086A1 (fr) 2011-06-16
EP2509418A1 (fr) 2012-10-17
IL220040A0 (en) 2012-07-31
TN2012000270A1 (en) 2013-12-12
US20110251149A1 (en) 2011-10-13
EP2509418A4 (fr) 2013-03-20

Similar Documents

Publication Publication Date Title
MA33899B1 (fr) Procedes et regimes a faible dose pour des troubles des globules rouges
Lightfoot et al. In the idiopathic inflammatory myopathies (IIM), do reactive oxygen species (ROS) contribute to muscle weakness?
AU2018253580A1 (en) Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
AU2016216625A1 (en) Dose escalation enzyme replacement therapy for treating acid sphingomyelinase deficiency
MX342423B (es) Metodos para usar inhibidores de cotransportadores 1 y 2 de glucosa y sodio.
MY153062A (en) Methods of treating gastrointestinal disorders independent of the intake of food
WO2007081744A3 (fr) Méthodes et compositions pour l&#39;administration de fer
MA38349A1 (fr) Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3)
BR0308290A (pt) Tratamento e prevenção de distúrbios inflamatórios
Ogłuszka et al. Interaction between iron and omega-3 fatty acids metabolisms: where is the cross-link?
Peng et al. The influence of gut microbiome on bone health and related dietary strategies against bone dysfunctions
EP2663193A1 (fr) Solution de monoxyde de carbone utilisable en vue du traitement d&#39;une maladie, notamment la drépanocytose
Rarinca et al. Relevance of diet in schizophrenia: a review focusing on prenatal nutritional deficiency, obesity, oxidative stress and inflammation
Carson et al. Transfusion strategies in hematologic and nonhematologic disease
EP2575456A4 (fr) Compositions et procédés destinés au traitement d&#39;ecchymoses
UA104741C2 (uk) Моноклональні антитіла проти феропортину 1 та варіанти їх застосування
Wong Hyperleukocytosis in acute myeloid leukemia patients is associated with high 30-day mortality which is not improved with leukapheresis
TW200740441A (en) Methods and reagents for the treatment of inflammatory disorders
AR059025A1 (es) Metodos para el tratamiento y prevencion de proliferacion de celulas anormales utilizando moleculas de fusion taci
WO2012075244A3 (fr) Utilisation d&#39;effecteurs de l&#39;hémoglobine pour améliorer la biodisponibilité de gaz thérapeutiques
Schmitt et al. Extreme anemia (hemoglobin 1.8 g/dL) secondary to colon cancer
Fernandez-Fresnedo et al. Relevance of chronic kidney disease classification (K/DOQI) in renal transplant patients
WO2011056978A3 (fr) Isomères s de l&#39;acide alpha-méthyl-hydrocinnamique pour le traitement de troubles sanguins
WO2005070077A3 (fr) Procedes d&#39;utilisation de zonisamide comme traitement auxiliaire pour des crises partielles
WO2008010008A3 (fr) Combinaisons cardiovasculaires faisant appel à des inhibiteurs de rennine-angiotensine