MA38349A1 - Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3) - Google Patents

Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3)

Info

Publication number
MA38349A1
MA38349A1 MA38349A MA38349A MA38349A1 MA 38349 A1 MA38349 A1 MA 38349A1 MA 38349 A MA38349 A MA 38349A MA 38349 A MA38349 A MA 38349A MA 38349 A1 MA38349 A1 MA 38349A1
Authority
MA
Morocco
Prior art keywords
akr1c3
tetraeno
estra
carboxamide
beta
Prior art date
Application number
MA38349A
Other languages
English (en)
Inventor
Ulrich Bothe
Naomi Barak
Matthias Busemann
Oliver Martin Fischer
Andrea Rotgeri
Tobias Marquardt
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MA38349A1 publication Critical patent/MA38349A1/fr

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    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)

Abstract

L'invention concerne des inhibiteurs de l'akr1c3 suivant la formule (i) et des procédés pour les préparer, leur utilisation dans le traitement et/ou la prévention de maladies ainsi que leur utilisation pour fabriquer des médicaments destinés au traitement et/ou à la prévention de maladies, en particulier des troubles hémorragiques et de l'endométriose.
MA38349A 2013-02-21 2014-02-18 Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3) MA38349A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13156125 2013-02-21
PCT/EP2014/053094 WO2014128108A1 (fr) 2013-02-21 2014-02-18 Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3)

Publications (1)

Publication Number Publication Date
MA38349A1 true MA38349A1 (fr) 2017-02-28

Family

ID=47748503

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38349A MA38349A1 (fr) 2013-02-21 2014-02-18 Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3)

Country Status (28)

Country Link
US (1) US9714266B2 (fr)
EP (1) EP2958928B1 (fr)
JP (1) JP6254195B2 (fr)
KR (1) KR20150118153A (fr)
CN (1) CN105008382B (fr)
AP (1) AP3826A (fr)
AR (1) AR094852A1 (fr)
AU (1) AU2014220800A1 (fr)
BR (1) BR112015018071A2 (fr)
CA (1) CA2901632C (fr)
CL (1) CL2015002346A1 (fr)
CR (1) CR20150432A (fr)
CU (1) CU20150091A7 (fr)
EA (1) EA201500851A1 (fr)
ES (1) ES2678993T3 (fr)
GT (1) GT201500235A (fr)
HK (1) HK1211592A1 (fr)
IL (1) IL240191A0 (fr)
MA (1) MA38349A1 (fr)
MX (1) MX2015010876A (fr)
NI (1) NI201500115A (fr)
PE (1) PE20151754A1 (fr)
PH (1) PH12015501819A1 (fr)
SG (1) SG11201505875WA (fr)
TN (1) TN2015000362A1 (fr)
TW (1) TWI523862B (fr)
UY (1) UY35344A (fr)
WO (1) WO2014128108A1 (fr)

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Publication number Priority date Publication date Assignee Title
JP6407415B2 (ja) * 2014-09-11 2018-10-17 バイエル・ファルマ・アクティエンゲゼルシャフト ３−窒素または硫黄置換エストラ−１，３，５（１０），１６−テトラエンａｋｒ１ｃ３阻害剤
EP3401677A4 (fr) * 2016-01-05 2019-06-12 Hamamatsu Photonics K.K. Procédé d'observation de corps vivant et dispositif d'observation de corps vivant
US10167293B2 (en) 2016-05-26 2019-01-01 Bayer Pharma Aktiengesellschaft [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
CZ307437B6 (cs) 2016-06-07 2018-08-22 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
EP3269373A1 (fr) 2016-07-11 2018-01-17 Bayer Pharma Aktiengesellschaft Formes posologiques orales à faible dosage d'un inhibiteur de akr1c3 pour le traitement des maladies
US20200087284A1 (en) 2016-12-19 2020-03-19 Bayer Pharma Aktiengesellschaft [4-(phenylsulfonyl)piperazin-1-yl](1h-1, 2, 3-triazol-4-yl)methanones
US20200085791A1 (en) 2016-12-19 2020-03-19 Bayer Pharma Aktiengesellschaft [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones
TW201825478A (zh) 2016-12-19 2018-07-16 德商拜耳製藥公司 ［４－（苯基磺醯基）哌嗪－１－-基］（１ｈ－１，２，３－三唑－４-基）甲酮
EP3421483A1 (fr) 2017-06-29 2019-01-02 Bayer Pharma Aktiengesellschaft Nouveaux dérivés 17-beta-hétéroaryle des stéroïdes comme inhibiteurs de akr1c3
CN108159056A (zh) * 2018-02-09 2018-06-15 上海礼璞生物医药科技有限公司 孕激素在制备组蛋白去乙酰化酶抑制剂和气道周围胶原沉积抑制剂药物中的应用及抑制剂
CN110693892A (zh) * 2018-07-09 2020-01-17 深圳艾欣达伟医药科技有限公司 化合物用于制备预防、治疗或改善疼痛的药物的用途
CN117264008A (zh) * 2022-06-15 2023-12-22 中国科学院大连化学物理研究所 一种化合物及应用和抑制剂与药物

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AP2015008658A0 (en) 2015-08-31
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EP2958928B1 (fr) 2018-03-28
AR094852A1 (es) 2015-09-02
ES2678993T3 (es) 2018-08-21
CN105008382B (zh) 2018-01-30
HK1211592A1 (en) 2016-05-27
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CU20150091A7 (es) 2016-02-29
US20160024142A1 (en) 2016-01-28
CL2015002346A1 (es) 2015-12-28
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BR112015018071A2 (pt) 2017-07-18
UY35344A (es) 2014-09-30
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AU2014220800A1 (en) 2015-08-27
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