MA34054B1 - Bromhydrate d'agomelatine hydrate et sa preparation - Google Patents
Bromhydrate d'agomelatine hydrate et sa preparationInfo
- Publication number
- MA34054B1 MA34054B1 MA35191A MA35191A MA34054B1 MA 34054 B1 MA34054 B1 MA 34054B1 MA 35191 A MA35191 A MA 35191A MA 35191 A MA35191 A MA 35191A MA 34054 B1 MA34054 B1 MA 34054B1
- Authority
- MA
- Morocco
- Prior art keywords
- preparation
- bromhydrate
- agomelatin
- hydrate
- agomelatine
- Prior art date
Links
- BBYCMXWYKBBTJN-UHFFFAOYSA-N hypobromous acid;hydrate Chemical compound O.BrO BBYCMXWYKBBTJN-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- YJYPHIXNFHFHND-UHFFFAOYSA-N agomelatine Chemical compound C1=CC=C(CCNC(C)=O)C2=CC(OC)=CC=C21 YJYPHIXNFHFHND-UHFFFAOYSA-N 0.000 abstract 3
- 229960002629 agomelatine Drugs 0.000 abstract 3
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention porte sur un bromhydrate d'agomélatine hydraté de formule (i), dans laquelle x représente br, sur son procédé de préparation et son utilisation ainsi que sur une composition pharmaceutique le contenant. La solubilité du bromhydrate d'agomélatine hydraté obtenu par le présent procédé est considérablement supérieure à celle de l'agomélatine. Par conséquent, il est plus approprié pour la fabrication de formulations pharmaceutiques. En outre, le produit a une stabilité et une pureté supérieures. Le présent produit de haute pureté peut être obtenu par un procédé simple, plutôt qu'un procédé comprenant des étapes compliquées.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101262639A CN102190595A (zh) | 2010-03-17 | 2010-03-17 | 阿戈美拉汀溴化氢水合物及其制备方法 |
| PCT/CN2011/071912 WO2011113363A1 (fr) | 2010-03-17 | 2011-03-17 | Bromhydrate d'agomélatine hydraté et sa préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA34054B1 true MA34054B1 (fr) | 2013-03-05 |
Family
ID=44599557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA35191A MA34054B1 (fr) | 2010-03-17 | 2011-03-17 | Bromhydrate d'agomelatine hydrate et sa preparation |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US8729132B2 (fr) |
| EP (1) | EP2547650B1 (fr) |
| JP (1) | JP5634533B2 (fr) |
| KR (1) | KR101406736B1 (fr) |
| CN (2) | CN102190595A (fr) |
| AP (1) | AP3199A (fr) |
| AU (1) | AU2011229619B2 (fr) |
| BR (1) | BR112012023173B1 (fr) |
| CA (1) | CA2792430C (fr) |
| CL (1) | CL2012002541A1 (fr) |
| CR (1) | CR20120461A (fr) |
| CU (1) | CU20120136A7 (fr) |
| CY (1) | CY1117134T1 (fr) |
| DK (1) | DK2547650T3 (fr) |
| EA (1) | EA022066B1 (fr) |
| EC (1) | ECSP12012156A (fr) |
| ES (1) | ES2572427T3 (fr) |
| GE (1) | GEP20156232B (fr) |
| GT (1) | GT201200260A (fr) |
| HN (1) | HN2012001923A (fr) |
| HR (1) | HRP20151343T1 (fr) |
| HU (1) | HUE026673T2 (fr) |
| IL (1) | IL221783A (fr) |
| MA (1) | MA34054B1 (fr) |
| ME (1) | ME02309B (fr) |
| MX (1) | MX2012010594A (fr) |
| MY (1) | MY160337A (fr) |
| NI (1) | NI201200141A (fr) |
| NZ (1) | NZ602451A (fr) |
| PE (1) | PE20130014A1 (fr) |
| PH (1) | PH12012501756A1 (fr) |
| PL (1) | PL2547650T3 (fr) |
| PT (1) | PT2547650E (fr) |
| RS (1) | RS54449B1 (fr) |
| SG (1) | SG183869A1 (fr) |
| SI (1) | SI2547650T1 (fr) |
| TN (1) | TN2012000436A1 (fr) |
| UA (1) | UA105424C2 (fr) |
| WO (1) | WO2011113363A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07115742B2 (ja) | 1986-03-19 | 1995-12-13 | 株式会社石田衡器製作所 | 多方向仕分け装置 |
| JPH07115741B2 (ja) | 1986-03-19 | 1995-12-13 | 株式会社石田衡器製作所 | 多方向仕分け装置 |
| JPH07115739B2 (ja) | 1986-03-19 | 1995-12-13 | 株式会社石田衡器製作所 | 多方向仕分け装置 |
| JPH07115740B2 (ja) | 1986-03-19 | 1995-12-13 | 株式会社石田衡器製作所 | 多方向仕分け装置 |
| FR2978916B1 (fr) | 2011-08-10 | 2013-07-26 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
| EP2851363B1 (fr) * | 2012-05-14 | 2018-01-03 | Shanghai Righthand Pharmtech. Co., Ltd. | Composite à base de radical acide d'agomélatine et procédé de préparation et application associés |
| CN102718675B (zh) * | 2012-06-07 | 2015-03-25 | 上海右手医药科技开发有限公司 | 阿戈美拉汀甲磺酸复合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| EP1339707A2 (fr) * | 2000-10-30 | 2003-09-03 | Teva Pharmaceutical Industries Ltd. | Nouvelles formes de cristaux et solvates de chlorhydrate d'ondansetron et leurs procedes de preparation |
| FR2890562B1 (fr) * | 2005-09-09 | 2012-10-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles du sommeil chez le patient deprime |
| FR2899472B1 (fr) * | 2006-04-07 | 2008-09-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee |
| CN101481321B (zh) * | 2009-02-27 | 2012-04-18 | 上海医药工业研究院 | 阿戈美拉汀卤化氢复合物及其制备方法 |
| CN101585779B (zh) * | 2009-03-10 | 2014-04-02 | 上海医药工业研究院 | 阿戈美拉汀的晶型vi及其制备方法和应用 |
-
2010
- 2010-03-17 CN CN2010101262639A patent/CN102190595A/zh active Pending
-
2011
- 2011-03-17 SI SI201130723T patent/SI2547650T1/sl unknown
- 2011-03-17 AU AU2011229619A patent/AU2011229619B2/en not_active Ceased
- 2011-03-17 PT PT117556803T patent/PT2547650E/pt unknown
- 2011-03-17 CA CA2792430A patent/CA2792430C/fr active Active
- 2011-03-17 UA UAA201211719A patent/UA105424C2/uk unknown
- 2011-03-17 MX MX2012010594A patent/MX2012010594A/es active IP Right Grant
- 2011-03-17 PH PH1/2012/501756A patent/PH12012501756A1/en unknown
- 2011-03-17 HR HRP20151343TT patent/HRP20151343T1/hr unknown
- 2011-03-17 AP AP2012006493A patent/AP3199A/xx active
- 2011-03-17 US US13/635,087 patent/US8729132B2/en active Active
- 2011-03-17 SG SG2012065017A patent/SG183869A1/en unknown
- 2011-03-17 RS RS20150831A patent/RS54449B1/sr unknown
- 2011-03-17 ME MEP-2016-9A patent/ME02309B/me unknown
- 2011-03-17 NZ NZ602451A patent/NZ602451A/en not_active IP Right Cessation
- 2011-03-17 MY MYPI2012700614A patent/MY160337A/en unknown
- 2011-03-17 GE GEAP201112870A patent/GEP20156232B/en unknown
- 2011-03-17 MA MA35191A patent/MA34054B1/fr unknown
- 2011-03-17 PE PE2012001449A patent/PE20130014A1/es active IP Right Grant
- 2011-03-17 HU HUE11755680A patent/HUE026673T2/en unknown
- 2011-03-17 EA EA201201293A patent/EA022066B1/ru unknown
- 2011-03-17 BR BR112012023173-1A patent/BR112012023173B1/pt not_active IP Right Cessation
- 2011-03-17 JP JP2012557393A patent/JP5634533B2/ja not_active Expired - Fee Related
- 2011-03-17 WO PCT/CN2011/071912 patent/WO2011113363A1/fr not_active Ceased
- 2011-03-17 ES ES11755680T patent/ES2572427T3/es active Active
- 2011-03-17 PL PL11755680T patent/PL2547650T3/pl unknown
- 2011-03-17 CN CN201180024413.8A patent/CN102892749B/zh not_active Expired - Fee Related
- 2011-03-17 EP EP11755680.3A patent/EP2547650B1/fr active Active
- 2011-03-17 KR KR1020127026897A patent/KR101406736B1/ko not_active Expired - Fee Related
- 2011-03-17 DK DK11755680.3T patent/DK2547650T3/en active
-
2012
- 2012-08-31 TN TNP2012000436A patent/TN2012000436A1/en unknown
- 2012-09-04 IL IL221783A patent/IL221783A/en not_active IP Right Cessation
- 2012-09-11 CR CR20120461A patent/CR20120461A/es unknown
- 2012-09-12 NI NI201200141A patent/NI201200141A/es unknown
- 2012-09-13 CL CL2012002541A patent/CL2012002541A1/es unknown
- 2012-09-14 HN HN2012001923A patent/HN2012001923A/es unknown
- 2012-09-14 EC ECSP12012156 patent/ECSP12012156A/es unknown
- 2012-09-17 CU CU2012000136A patent/CU20120136A7/es unknown
- 2012-09-17 GT GT201200260A patent/GT201200260A/es unknown
-
2016
- 2016-01-18 CY CY20161100041T patent/CY1117134T1/el unknown
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