MA34066B1 - Composes de la pyrrolopyrimidine utilises en tant qu'inhibiteurs des cdk4/6 - Google Patents

Composes de la pyrrolopyrimidine utilises en tant qu'inhibiteurs des cdk4/6

Info

Publication number
MA34066B1
MA34066B1 MA35209A MA35209A MA34066B1 MA 34066 B1 MA34066 B1 MA 34066B1 MA 35209 A MA35209 A MA 35209A MA 35209 A MA35209 A MA 35209A MA 34066 B1 MA34066 B1 MA 34066B1
Authority
MA
Morocco
Prior art keywords
cdk4
kinases
compounds
inhibitors
treatment
Prior art date
Application number
MA35209A
Other languages
Arabic (ar)
English (en)
Inventor
Christopher Thomas Brain
Young Shin Cho
John William Giraldes
Bharat Lagu
Julian Levell
Michael LUZZIO
Lawrence Blas Perez
Yaping Wang
Fan Yang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA34066B1 publication Critical patent/MA34066B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DE NOUVEAUX COMPOSÉS DE LA PYRROLOPYRIMIDINE RÉPONDANT À LA FORMULE (I), DANS LAQUELLE R1, R2Y, R4, R8- R11, A ET L SONT TELS QUE DÉFINIS DANS LA DESCRIPTION, AINSI QUE DES SELS DESDITS COMPOSÉS, NOTAMMENT DES SELS ACCEPTABLES SUR LE PLAN PHARMACEUTIQUE. LES COMPOSÉS DE LA PRÉSENTE INVENTION SONT DES INHIBITEURS DES KINASES CDK4/6 ET ILS PEUVENT S'AVÉRER UTILES POUR TRAITER LES MALADIES ET LES TROUBLES MÉDIÉS PAR CES KINASES, PAR EXEMPLE LES CANCERS, NOTAMMENT LE LYMPHOME À CELLULES DU MANTEAU, LE LIPOSARCOME, LE CANCER DU POUMON NON À PETITES CELLULES, LE MÉLANOME, LE CANCER DE L''SOPHAGE À CELLULES SQUAMEUSES ET LE CANCER DU SEIN. L'INVENTION CONCERNE ÉGALEMENT DES COMPOSITIONS PHARMACEUTIQUES COMPRENANT UN COMPOSÉ DE L'INVENTION, AINSI QUE DES MÉTHODES D'INHIBITION DE L'ACTIVITÉ DES KINASES CDK4/6 ET LE TRAITEMENT DES TROUBLES ASSOCIÉS AU MOYEN D'UN COMPOSÉ DE L'INVENTION, OU UNE COMPOSITION PHARMACEUTIQUE COMPRENANT UN COMPOSÉ DE L'INVENTION.
MA35209A 2010-02-19 2011-02-17 Composes de la pyrrolopyrimidine utilises en tant qu'inhibiteurs des cdk4/6 MA34066B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30624810P 2010-02-19 2010-02-19
US201161429372P 2011-01-03 2011-01-03
US201161429997P 2011-01-05 2011-01-05
PCT/EP2011/052353 WO2011101409A1 (fr) 2010-02-19 2011-02-17 Composés de la pyrrolopyrimidine utilisés en tant qu'inhibiteurs des cdk4/6

Publications (1)

Publication Number Publication Date
MA34066B1 true MA34066B1 (fr) 2013-03-05

Family

ID=44201966

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35209A MA34066B1 (fr) 2010-02-19 2011-02-17 Composes de la pyrrolopyrimidine utilises en tant qu'inhibiteurs des cdk4/6

Country Status (38)

Country Link
US (2) US8957074B2 (fr)
EP (1) EP2536730B1 (fr)
JP (1) JP5788415B2 (fr)
KR (1) KR101812357B1 (fr)
CN (1) CN102918043B (fr)
AR (1) AR080198A1 (fr)
AU (1) AU2011217286B2 (fr)
BR (1) BR112012020922B1 (fr)
CA (1) CA2790637C (fr)
CL (1) CL2012002270A1 (fr)
DK (1) DK2536730T3 (fr)
DO (1) DOP2012000225A (fr)
EA (1) EA022355B1 (fr)
EC (1) ECSP12012111A (fr)
ES (1) ES2548532T3 (fr)
GE (1) GEP20146146B (fr)
HN (1) HN2012001744A (fr)
HR (1) HRP20151071T1 (fr)
IL (1) IL221520A (fr)
MA (1) MA34066B1 (fr)
ME (1) ME02202B (fr)
MX (1) MX2012009613A (fr)
NI (1) NI201200135A (fr)
NZ (1) NZ601754A (fr)
PE (1) PE20121815A1 (fr)
PH (1) PH12012501649A1 (fr)
PL (1) PL2536730T3 (fr)
PT (1) PT2536730E (fr)
RS (1) RS54263B1 (fr)
SG (1) SG183218A1 (fr)
SI (1) SI2536730T1 (fr)
SM (1) SMT201500265B (fr)
TN (1) TN2012000413A1 (fr)
TW (1) TWI503322B (fr)
UA (1) UA108369C2 (fr)
UY (1) UY33227A (fr)
WO (1) WO2011101409A1 (fr)
ZA (1) ZA201206079B (fr)

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CA2790637C (fr) 2018-04-10
KR101812357B1 (ko) 2017-12-26
AU2011217286B2 (en) 2014-06-19
AR080198A1 (es) 2012-03-21
HRP20151071T1 (hr) 2015-11-06
BR112012020922A2 (pt) 2016-05-03
GEP20146146B (en) 2014-08-25

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