MA34169B1 - Dérivés d'acide 1-amino-2-cyclopropyléthylboronique - Google Patents

Dérivés d'acide 1-amino-2-cyclopropyléthylboronique

Info

Publication number
MA34169B1
MA34169B1 MA35323A MA35323A MA34169B1 MA 34169 B1 MA34169 B1 MA 34169B1 MA 35323 A MA35323 A MA 35323A MA 35323 A MA35323 A MA 35323A MA 34169 B1 MA34169 B1 MA 34169B1
Authority
MA
Morocco
Prior art keywords
cyclopropylethylboronic
amino
acid derivatives
relates
compositions
Prior art date
Application number
MA35323A
Other languages
English (en)
Inventor
Paul E Fleming
Jing Li
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44710349&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34169(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of MA34169B1 publication Critical patent/MA34169B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)

Abstract

La présente invention concerne des nouveaux composés utiles comme inhibiteurs du protéasome. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention et des procédés employant les compositions dans le traitement de diverses maladies.
MA35323A 2010-03-31 2011-03-30 Dérivés d'acide 1-amino-2-cyclopropyléthylboronique MA34169B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31946410P 2010-03-31 2010-03-31
PCT/US2011/030455 WO2011123502A1 (fr) 2010-03-31 2011-03-30 Dérivés d'acide 1-amino-2-cyclopropyléthylboronique

Publications (1)

Publication Number Publication Date
MA34169B1 true MA34169B1 (fr) 2013-04-03

Family

ID=44710349

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35323A MA34169B1 (fr) 2010-03-31 2011-03-30 Dérivés d'acide 1-amino-2-cyclopropyléthylboronique

Country Status (26)

Country Link
US (3) US8513218B2 (fr)
EP (1) EP2552216B1 (fr)
JP (1) JP5933523B2 (fr)
KR (1) KR20130036228A (fr)
CN (3) CN102892291A (fr)
AR (1) AR080863A1 (fr)
AU (1) AU2011235227B2 (fr)
CA (1) CA2794334C (fr)
CL (1) CL2012002733A1 (fr)
CO (1) CO6630162A2 (fr)
CR (1) CR20120529A (fr)
DO (1) DOP2012000257A (fr)
EA (1) EA029521B1 (fr)
EC (1) ECSP12012249A (fr)
MA (1) MA34169B1 (fr)
MX (1) MX2012011298A (fr)
NZ (1) NZ602622A (fr)
PE (1) PE20130383A1 (fr)
PH (1) PH12012501943A1 (fr)
RU (1) RU2012146101A (fr)
SG (1) SG184222A1 (fr)
TN (1) TN2012000465A1 (fr)
UA (1) UA110612C2 (fr)
UY (1) UY33314A (fr)
WO (1) WO2011123502A1 (fr)
ZA (2) ZA201207406B (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2623113B1 (fr) 2005-11-09 2017-05-31 Onyx Therapeutics, Inc. Composé pour l'inhibition d'enzymes
NZ597545A (en) 2006-06-19 2013-07-26 Proteolix Inc Peptide epoxyketones for proteasome inhibition
CA2701778C (fr) 2007-10-04 2018-09-11 Onyx Therapeutics, Inc. Inhibiteurs de protease epoxy-cetone peptidique cristalline, et synthese de ceto-epoxydes d'acides amines
SI2318419T2 (sl) 2008-06-17 2025-10-30 Takeda Pharmaceutical Company Limited Spojine boronat estra in njihovi farmacevtski sestavki
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
JP5675629B2 (ja) 2008-10-21 2015-02-25 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． ペプチドエポキシケトンを用いた併用療法
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
WO2011060179A1 (fr) 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Utilisation de peptides epoxycetones pour la suppression de la metastase
AU2011223795B2 (en) 2010-03-01 2015-11-05 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
AU2011235227B2 (en) 2010-03-31 2016-09-08 Millennium Pharmaceuticals, Inc. Derivatives of 1-amino-2-cyclopropylethylboronic acid
RU2599791C2 (ru) 2010-08-10 2016-10-20 Ремпекс Фармасьютикэлз, Инч. Циклические бороновые кислотно-эфирные производные и их использование в терапии
CN104039328B (zh) 2011-11-11 2018-10-09 米伦纽姆医药公司 对蛋白酶体抑制剂的反应的生物标记
EP2776586B1 (fr) 2011-11-11 2018-03-07 Millennium Pharmaceuticals, Inc. Biomarqueurs de la sensibilité vis-à-vis d'inhibiteurs du protéasome
SG10201605152SA (en) 2011-12-22 2016-08-30 Ares Trading Sa Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
WO2013112601A1 (fr) 2012-01-24 2013-08-01 Millennium Pharmaceuticals, Inc. Méthodes de traitement du cancer
WO2014011695A2 (fr) 2012-07-09 2014-01-16 Onyx Therapeutics, Inc. Promédicaments d'inhibiteurs d'époxy cétone protéase peptidique
CN109180780B (zh) * 2012-07-26 2022-03-18 圣特莱国际公司 多肽环氧酮化合物
AU2014204045B2 (en) 2013-01-04 2018-10-18 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US20160250238A1 (en) 2013-10-03 2016-09-01 Millennium Pharmaceuticals, Inc. Method for the Prophylaxis or Treatment of Systemic Lupus Erythematosus and/or Lupus Nephritis
ES2748434T3 (es) 2014-01-10 2020-03-16 Univ Cornell Dipéptidos como inhibidores de inmunoproteasomas humanos
WO2015171398A1 (fr) 2014-05-05 2015-11-12 Rempex Pharmaceuticals, Inc. Sels et polymorphes de dérivés cycliques d'ester d'acide boronique, et leurs utilisations thérapeutiques
US10385074B2 (en) 2014-05-05 2019-08-20 Rempex Pharmaceuticals, Inc. Synthesis of boronate salts and uses thereof
AU2015264418A1 (en) 2014-05-19 2016-11-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
UA121389C2 (uk) 2014-05-20 2020-05-25 Мілленніум Фармасьютікалз, Інк. Борвмісні інгібітори протеасом для застосування після первинної протиракової терапії
AU2015284307A1 (en) * 2014-07-01 2017-02-02 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2016022955A1 (fr) 2014-08-07 2016-02-11 Mayo Foundation For Medical Education And Research Composés et méthodes de traitement du cancer
US11202817B2 (en) 2014-08-18 2021-12-21 Cornell University Dipeptidomimetics as inhibitors of human immunoproteasomes
WO2016081297A1 (fr) 2014-11-18 2016-05-26 Rempex Pharmaceuticals, Inc. Dérivés d'esters d'acide boronique cycliques et leurs utilisations thérapeutiques
WO2016149393A1 (fr) 2015-03-17 2016-09-22 Rempex Pharmaceuticals, Inc. Dérivés d'acide boronique et leurs utilisations thérapeutiques
EP4006012A1 (fr) 2015-10-15 2022-06-01 Cornell University Inhibiteurs de protéasome et leurs utilisations
AU2017290060B2 (en) 2016-06-30 2021-07-22 Qpex Biopharma, Inc Boronic acid derivatives and therapeutic uses thereof
WO2018160717A1 (fr) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Composés et méthodes de traitement du cancer
BR112020007138B1 (pt) 2017-10-11 2023-03-21 Qpex Biopharma, Inc Derivados de ácido borônico, métodos de síntese, composição farmacêutica e uso dos mesmos
WO2019075252A1 (fr) 2017-10-11 2019-04-18 Cornell University Inhibiteurs peptidomimétiques du protéasome
US11243207B2 (en) 2018-03-29 2022-02-08 Mayo Foundation For Medical Education And Research Assessing and treating cancer
CN112424209A (zh) 2018-04-20 2021-02-26 Qpex生物制药有限公司 硼酸衍生物及其治疗用途
US12636297B2 (en) 2019-06-19 2026-05-26 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
US12637481B2 (en) 2020-03-18 2026-05-26 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
IL297458A (en) 2020-05-05 2022-12-01 Qpex Biopharma Inc Boronic acid derivatives and their synthesis, polymorphic forms and medicinal uses

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ203706A (en) 1982-04-22 1986-03-14 Squibb & Sons Inc Occlusive multi-layer wound dressing and hydrocolloidal granules for wound treatment
US4499082A (en) 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0315574A3 (fr) 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Inhibiteurs de la rénine
US5106948A (en) 1988-05-27 1992-04-21 Mao Foundation For Medical Education And Research Cytotoxic boronic acid peptide analogs
US5159060A (en) 1988-05-27 1992-10-27 Mayo Foundation For Medical Education And Research Cytotoxic boronic acid peptide analogs
DE3827340A1 (de) 1988-08-12 1990-02-15 Hoechst Ag Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen
EP0583536B1 (fr) 1992-08-14 1997-03-05 The Procter & Gamble Company Compositions détergents liquides contenant de l'acide borique
US5492900A (en) 1993-09-10 1996-02-20 Neutron Technology Corporation Method for enhancing the solubility of the boron delivery drug, boronophenylalanine (BPA)
US6060462A (en) 1993-10-20 2000-05-09 Dupont Pharmaceuticals Company Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
US5574017A (en) 1994-07-05 1996-11-12 Gutheil; William G. Antibacterial agents
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5614649A (en) 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
US6271199B2 (en) 1997-02-15 2001-08-07 Millennium Pharmaceuticals, Inc. Treatment of infarcts
AU9580098A (en) 1997-09-25 1999-04-12 Millennium Pharmaceuticals, Inc. Proteasome inhibitors, ubiquitin pathway inhibitors or agents that interfere with the activation of nf-(k)b via the ubiquitin proteasome pathway to treat inflammatory and autoimmune diseases
CA2314259A1 (fr) 1997-12-16 1999-06-24 Robert Siman Inhibiteurs de protease multicatalytique, utiles en tant qu'agents antitumoraux
US6169076B1 (en) 1999-03-31 2001-01-02 Glcosyn Pharmaceuticals, Inc. P-Boronophenylalanine complexes with fructose and related carbohydrates and polyols
WO2001002424A2 (fr) 1999-07-07 2001-01-11 Du Pont Pharmaceuticals Company Inhibiteurs de la protease du virus de l'hepatite c a base d'acide boronique peptide
US7122627B2 (en) * 1999-07-26 2006-10-17 Bristol-Myers Squibb Company Lactam inhibitors of Hepatitis C virus NS3 protease
AU2001229775A1 (en) 2000-02-29 2001-09-12 Bristol-Myers Squibb Company Low dose entecavir formulation and use
US6846806B2 (en) 2000-10-23 2005-01-25 Bristol-Myers Squibb Company Peptide inhibitors of Hepatitis C virus NS3 protein
CA2435146C (fr) 2001-01-25 2011-03-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Formulation de composes d'acide boronique
WO2003033507A1 (fr) 2001-10-12 2003-04-24 Kyorin Pharmaceutical Co., Ltd. Derives d'acide benzylmalonique et inhibiteurs de proteasomes les contenant
EP1463719A2 (fr) 2002-01-08 2004-10-06 Eisai Co., Ltd Analogues d'eponemycine et d'epoxomicine et leurs utilisations
US20060084592A1 (en) 2002-09-09 2006-04-20 Trigen Limited Peptide boronic acid inhibitors
TW200418791A (en) * 2003-01-23 2004-10-01 Bristol Myers Squibb Co Pharmaceutical compositions for inhibiting proteasome
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
TWI345465B (en) * 2003-08-14 2011-07-21 Cephalon Inc Proteasome inhibitors and methods of using the same
ES2899606T3 (es) 2004-03-30 2022-03-14 Millennium Pharm Inc Síntesis de compuestos de ésteres y ácidos borónicos
CN101247799B (zh) 2005-07-05 2013-03-27 塔夫茨大学信托人 成纤维细胞活化蛋白α的抑制剂
WO2007089618A2 (fr) 2006-01-27 2007-08-09 Phenomix Corporation Inhibiteurs de la sérine protéase de l'hépatite c et leurs utilisations
WO2009006473A2 (fr) 2007-07-05 2009-01-08 Trustees Of Tufts College Inhibiteurs promedicaments doux de proteasome polypeptidique et methodes d'utilisation associees
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
KR20140042933A (ko) 2007-08-06 2014-04-07 밀레니엄 파머슈티컬스 인코퍼레이티드 프로테아좀 억제제
SI2318419T2 (sl) * 2008-06-17 2025-10-30 Takeda Pharmaceutical Company Limited Spojine boronat estra in njihovi farmacevtski sestavki
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
AU2011235227B2 (en) 2010-03-31 2016-09-08 Millennium Pharmaceuticals, Inc. Derivatives of 1-amino-2-cyclopropylethylboronic acid

Also Published As

Publication number Publication date
MX2012011298A (es) 2012-11-06
US20110245203A1 (en) 2011-10-06
US8703743B2 (en) 2014-04-22
CR20120529A (es) 2013-01-11
CL2012002733A1 (es) 2013-01-25
CN106008570A (zh) 2016-10-12
US20140179631A1 (en) 2014-06-26
DOP2012000257A (es) 2012-11-15
AR080863A1 (es) 2012-05-16
WO2011123502A1 (fr) 2011-10-06
US20140011998A1 (en) 2014-01-09
CN107266485A (zh) 2017-10-20
CN102892291A (zh) 2013-01-23
JP2013523760A (ja) 2013-06-17
CO6630162A2 (es) 2013-03-01
UY33314A (es) 2011-10-31
SG184222A1 (en) 2012-10-30
EA029521B1 (ru) 2018-04-30
CA2794334A1 (fr) 2011-10-06
CA2794334C (fr) 2018-06-12
TN2012000465A1 (en) 2014-01-30
ZA201207406B (en) 2014-01-29
UA110612C2 (uk) 2016-01-25
EP2552216A1 (fr) 2013-02-06
AU2011235227A1 (en) 2012-10-18
EP2552216A4 (fr) 2013-07-31
US9023832B2 (en) 2015-05-05
US8513218B2 (en) 2013-08-20
PH12012501943A1 (en) 2017-08-23
NZ602622A (en) 2015-01-30
PE20130383A1 (es) 2013-04-24
ECSP12012249A (es) 2012-11-30
KR20130036228A (ko) 2013-04-11
ZA201308086B (en) 2015-03-25
AU2011235227B2 (en) 2016-09-08
RU2012146101A (ru) 2014-05-10
JP5933523B2 (ja) 2016-06-08
EP2552216B1 (fr) 2018-01-24
EA201290980A1 (ru) 2013-03-29

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