MA34340B1 - Composes heteroaryles contenant de l'azote - Google Patents

Composes heteroaryles contenant de l'azote

Info

Publication number
MA34340B1
MA34340B1 MA35502A MA35502A MA34340B1 MA 34340 B1 MA34340 B1 MA 34340B1 MA 35502 A MA35502 A MA 35502A MA 35502 A MA35502 A MA 35502A MA 34340 B1 MA34340 B1 MA 34340B1
Authority
MA
Morocco
Prior art keywords
containing nitrogen
compounds containing
heteroaryl compounds
medicines
esters
Prior art date
Application number
MA35502A
Other languages
English (en)
Inventor
Konrad Bleicher
Alexander Flohr
Zbinden Katrin Groebke
Felix Gruber
Matthias Koerner
Bernd Kuhn
Jens-Uwe Peters
Sarmiento Rosa Maria Rodriguez
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA34340B1 publication Critical patent/MA34340B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DE NOUVEAUX COMPOSÉS HÉTÉROARYLES CONTENANT DE L'AZOTE DE FORMULE (I) OÙ A1, A2, (A), R1, R2, R3, R4, R5 ET R6 SONT COMME DÉFINI DANS LA DESCRIPTION ET DANS LES REVENDICATIONS, AINSI QUE LEURS SELS PHYSIOLOGIQUEMENT ACCEPTABLES ET LEURS ESTERS. CES COMPOSÉS INHIBENT PDE10A ET PEUVENT ÊTRE UTILISÉS COMME MÉDICAMENTS.
MA35502A 2010-06-09 2011-06-06 Composes heteroaryles contenant de l'azote MA34340B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10165427 2010-06-09
PCT/EP2011/059234 WO2011154327A1 (fr) 2010-06-09 2011-06-06 Composés hétéroaryles contenant de l'azote

Publications (1)

Publication Number Publication Date
MA34340B1 true MA34340B1 (fr) 2013-06-01

Family

ID=44483879

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35502A MA34340B1 (fr) 2010-06-09 2011-06-06 Composes heteroaryles contenant de l'azote

Country Status (24)

Country Link
US (1) US8703768B2 (fr)
EP (1) EP2580207B1 (fr)
JP (1) JP5940523B2 (fr)
KR (1) KR101757959B1 (fr)
CN (1) CN102947292B (fr)
AR (1) AR081649A1 (fr)
BR (1) BR112012031343A2 (fr)
CA (1) CA2799022A1 (fr)
CL (1) CL2012003421A1 (fr)
CO (1) CO6620065A2 (fr)
CR (1) CR20120594A (fr)
EA (1) EA022075B1 (fr)
EC (1) ECSP12012330A (fr)
IL (1) IL223069A0 (fr)
MA (1) MA34340B1 (fr)
MX (1) MX2012013907A (fr)
NZ (1) NZ603230A (fr)
PE (1) PE20130279A1 (fr)
PH (1) PH12012502335A1 (fr)
SG (1) SG185655A1 (fr)
TW (1) TW201202221A (fr)
UA (1) UA108105C2 (fr)
WO (1) WO2011154327A1 (fr)
ZA (1) ZA201209119B (fr)

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CA2794801C (fr) 2010-04-07 2019-01-15 F. Hoffmann-La Roche Ag Composes pyrazol-4-yl-heterocyclyle-carboxamide et leurs procedes d'utilisation
WO2012112946A1 (fr) 2011-02-18 2012-08-23 Allergan, Inc. Dérivés de 6,7-dialkoxy-3-isoquinolinol substitués en tant qu'inhibiteurs de la phosphodiestérase 10 (pde10a)
EP2760857A1 (fr) 2011-09-27 2014-08-06 F.Hoffmann-La Roche Ag Composés de type pyrazol-4-yl-hétérocyclyl-carboxamide et leurs méthodes d'utilisation
EP2712862A1 (fr) * 2012-09-28 2014-04-02 Splicos Nouveaux composés anti-invasifs
WO2014058691A1 (fr) 2012-10-08 2014-04-17 Merck Sharp & Dohme Corp. Inhibiteurs d'activité d'irak4
WO2014071044A1 (fr) 2012-11-01 2014-05-08 Allergan, Inc. Dérivés de 6,7-dialcoxy-3-isoquinoline substitués à titre d'inhibiteurs de phosphodiestérase 10 (pde10a)
TR201904614T4 (en) 2013-02-27 2019-05-21 Mochida Pharm Co Ltd Novel pyrazole derivative.
RU2015147450A (ru) * 2013-04-29 2017-06-05 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ 2-ФЕНИЛ ИЛИ 2-ГЕТЕРОАРИЛ ИМИДАЗОЛ[1,2-a]ПИРИДИНА
GB201316600D0 (en) * 2013-09-18 2013-10-30 Redx Pharma Ltd Agricultural chemicals
US20160264536A1 (en) * 2013-10-23 2016-09-15 Takeda Pharmaceutical Company Limited Heterocyclic compound
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
WO2016120355A2 (fr) * 2015-01-30 2016-08-04 Basf Se Phénylpyrimidines herbicides
KR102551597B1 (ko) * 2015-02-06 2023-07-05 메르크 파텐트 게엠베하 Irak 억제제로서 피리다지논 매크로사이클 및 이의 용도
CN104610189A (zh) * 2015-02-10 2015-05-13 佛山市赛维斯医药科技有限公司 一类含环丙基脒结构sglt2/sglt1双靶点抑制剂及用途
CN104974075A (zh) * 2015-08-07 2015-10-14 新秀化学（烟台）有限公司 一种n, n-二(2,2,6,6-四甲基-4-哌啶基) -1,3-苯二甲酰胺的制备方法
IL311645B2 (en) * 2016-07-12 2025-11-01 Revolution Medicines Inc 2,5- disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines asallosteric shp2 inhibitors
EP3490985B1 (fr) 2016-07-26 2020-08-05 Basf Se Composés de pyrimidine herbicides
WO2018019767A1 (fr) 2016-07-27 2018-02-01 Basf Se Composés herbicides de pyridine
BR112018077223A2 (pt) 2016-07-27 2019-04-09 Basf Se compostos de pirimidina, uso de compostos de pirimidina, composições herbicidas, método para controlar vegetação indesejada e uso das composições herbicidas
EP3490380A1 (fr) 2016-07-28 2019-06-05 Basf Se Composés herbicides de pyrimidine
CN110446709B (zh) 2017-01-23 2023-09-12 锐新医药公司 作为变构shp2抑制剂的二环化合物
CA3051054A1 (fr) 2017-01-23 2018-07-26 Revolution Medicines, Inc. Composes de pyridine utilises en tant qu'inhibiteurs allosteriques de shp2
BR112020007058A2 (pt) 2017-10-12 2020-10-06 Revolution Medicines, Inc. compostos de piridina, pirazina, e triazina como inibidores de shp2 alostéricos
BR112020009757A2 (pt) 2017-12-15 2020-11-03 Revolution Medicines, Inc. compostos policíclicos como inibidores alostéricos de shp2
WO2019121352A1 (fr) 2017-12-20 2019-06-27 Basf Se Composés herbicides de pyrimidine
WO2019121374A1 (fr) 2017-12-20 2019-06-27 Basf Se Composés herbicides de pyrimidine
KR102725178B1 (ko) * 2017-12-20 2024-11-04 피아이 인더스트리스 엘티디. 살충제로서의 피라졸로피리딘-디아미드 용도 및 그의 제조 방법
US11389987B2 (en) 2018-06-29 2022-07-19 Synthes Gmbh Hybrid saw blade
WO2020058062A1 (fr) 2018-09-19 2020-03-26 Bayer Aktiengesellschaft Hydrazides de phénylpyrimidine substitués à action herbicide
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JP2023537271A (ja) 2020-07-24 2023-08-31 イニファーム，インク． チオフェンｈｓｄ１７ｂ１３阻害剤とその使用
EP4190402B1 (fr) 2020-07-30 2025-08-27 FUJIFILM Corporation Composé hétérocyclique à teneur en azote ou sel de celui-ci, application de celui-ci, et intermédiaire de celui-ci
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Also Published As

Publication number Publication date
TW201202221A (en) 2012-01-16
CO6620065A2 (es) 2013-02-15
ECSP12012330A (es) 2012-12-28
ZA201209119B (en) 2015-05-27
CA2799022A1 (fr) 2011-12-15
EA201291282A1 (ru) 2013-06-28
PE20130279A1 (es) 2013-03-08
US20110306589A1 (en) 2011-12-15
CN102947292A (zh) 2013-02-27
UA108105C2 (ru) 2015-03-25
CR20120594A (es) 2013-01-03
HK1178900A1 (en) 2013-09-19
JP2013528193A (ja) 2013-07-08
IL223069A0 (en) 2013-02-03
AR081649A1 (es) 2012-10-10
PH12012502335A1 (en) 2013-02-11
MX2012013907A (es) 2012-12-17
NZ603230A (en) 2013-09-27
CL2012003421A1 (es) 2013-07-26
US8703768B2 (en) 2014-04-22
CN102947292B (zh) 2015-08-19
EP2580207A1 (fr) 2013-04-17
JP5940523B2 (ja) 2016-06-29
EP2580207B1 (fr) 2017-09-27
WO2011154327A1 (fr) 2011-12-15
SG185655A1 (en) 2012-12-28
EA022075B1 (ru) 2015-10-30
BR112012031343A2 (pt) 2016-11-01
KR20130112858A (ko) 2013-10-14
KR101757959B1 (ko) 2017-07-14

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