MA34008B1 - Composes en tant qu'antagonistes de la bradykinine b1 - Google Patents
Composes en tant qu'antagonistes de la bradykinine b1Info
- Publication number
- MA34008B1 MA34008B1 MA35153A MA35153A MA34008B1 MA 34008 B1 MA34008 B1 MA 34008B1 MA 35153 A MA35153 A MA 35153A MA 35153 A MA35153 A MA 35153A MA 34008 B1 MA34008 B1 MA 34008B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- bradykinin
- antagonists
- preparation
- salts
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 101800004538 Bradykinin Proteins 0.000 title 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 title 1
- 102100035792 Kininogen-1 Human genes 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/54—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
- C07C211/56—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La présente invention concerne les composés de formule générale (i) dans laquelle n, r1, r2, r3, r4, r5, r6, r7, r8, r9, r10, r11 et x sont tels que définis ci-dessous, leurs énantiomères, leurs diastéréomères, leurs mélanges et leurs sels, en particulier leurs sels physiologiquement acceptables contenant des bases ou des acides organiques ou inorganiques, lesquels présentent des propriétés précieuses, leur préparation, les médicaments contenant les composés pharmacologiquement actifs, leur préparation et leur utilisation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2010/052232 WO2010097372A1 (fr) | 2009-02-26 | 2010-02-23 | Composés utilisés comme antagonistes de la bradykinine b1 |
| PCT/EP2011/052512 WO2011104203A1 (fr) | 2010-02-23 | 2011-02-21 | Composés en tant qu'antagonistes de la bradykinine b1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA34008B1 true MA34008B1 (fr) | 2013-02-01 |
Family
ID=43981434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA35153A MA34008B1 (fr) | 2010-02-23 | 2011-02-21 | Composes en tant qu'antagonistes de la bradykinine b1 |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP2539323B3 (fr) |
| JP (1) | JP5603955B2 (fr) |
| KR (1) | KR101843341B1 (fr) |
| CN (2) | CN102781916B (fr) |
| AP (1) | AP3218A (fr) |
| AR (1) | AR080249A1 (fr) |
| AU (1) | AU2011219885C1 (fr) |
| CA (1) | CA2790952C (fr) |
| CY (1) | CY1116182T1 (fr) |
| DK (1) | DK2539323T6 (fr) |
| ES (1) | ES2531663T7 (fr) |
| IL (1) | IL220680A (fr) |
| MA (1) | MA34008B1 (fr) |
| MX (1) | MX2012009224A (fr) |
| NZ (1) | NZ601194A (fr) |
| PE (1) | PE20121805A1 (fr) |
| PL (1) | PL2539323T6 (fr) |
| PT (1) | PT2539323E (fr) |
| SG (1) | SG183336A1 (fr) |
| SI (1) | SI2539323T1 (fr) |
| TW (1) | TWI499589B (fr) |
| WO (1) | WO2011104203A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007034620A1 (de) | 2007-07-25 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue B1-Antagonisten |
| ATE550321T1 (de) | 2007-08-29 | 2012-04-15 | Boehringer Ingelheim Int | Neue bradykinin b1-antagonisten |
| PE20121805A1 (es) | 2010-02-23 | 2013-01-23 | Boehringer Ingelheim Int | Derivados de 6-oxo-1,6-dihidropiridazin-4-carboxamida n-sustituidas con anilino-(bencil o piridinilmetil)-carbamoilo como antagonistas del receptor de bradiquinina 1 (b1) |
| WO2012022794A1 (fr) * | 2010-08-20 | 2012-02-23 | Boehringer Ingelheim International Gmbh | Dérivés de pyridazine en tant qu'antagonistes du récepteur de la bradykinine b1 |
| US8937073B2 (en) * | 2010-08-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists |
| EP3870229A1 (fr) * | 2018-10-22 | 2021-09-01 | IOI Oleo GmbH | Additif pour une poudre destinée à être pressée pour former des pièces moulées |
| BR112021012909A2 (pt) * | 2019-01-04 | 2021-09-14 | Jiangsu Hengrui Medicine Co., Ltd. | Derivado de 6-oxo-1,6-di-hidropiridazina, método de preparação do mesmo e uso médico do mesmo |
| CN112996776B (zh) * | 2019-02-20 | 2024-03-15 | 福建盛迪医药有限公司 | 6-氧代-1,6-二氢哒嗪类前药衍生物、其制备方法及其在医药上的应用 |
| WO2021198534A1 (fr) | 2020-04-04 | 2021-10-07 | Oxurion NV | Inhibiteurs de la kallicréine plasmique destinés à être utilisés dans le traitement d'une maladie à coronavirus |
| WO2023148016A1 (fr) | 2022-02-04 | 2023-08-10 | Oxurion NV | Biomarqueur pour la réponse à une thérapie par inhibiteur de la kallicréine plasmatique |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6919343B2 (en) * | 2002-02-08 | 2005-07-19 | Merck & Co., Inc. | N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives |
| EP1545538A2 (fr) * | 2002-08-29 | 2005-06-29 | Merck & Co., Inc. | Derives n-biarylmethyl aminocycloalcanecarboxamide |
| EP1654232A4 (fr) * | 2003-08-07 | 2008-11-12 | Merck & Co Inc | N-(biarylmethyle) aminocyclopropanecarboxamides a substitution sulfonyle |
| DE602005012806D1 (en) * | 2004-03-02 | 2009-04-02 | Merck & Co Inc | Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten |
| EP1940392A2 (fr) | 2005-05-11 | 2008-07-09 | Nycomed GmbH | Combinaison d'un inhibiteur de pde4 et d'un derive de tetrahydrobiopterine |
| HUP0600809A3 (en) * | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them |
| WO2010097372A1 (fr) * | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Composés utilisés comme antagonistes de la bradykinine b1 |
| PE20121805A1 (es) | 2010-02-23 | 2013-01-23 | Boehringer Ingelheim Int | Derivados de 6-oxo-1,6-dihidropiridazin-4-carboxamida n-sustituidas con anilino-(bencil o piridinilmetil)-carbamoilo como antagonistas del receptor de bradiquinina 1 (b1) |
-
2011
- 2011-02-21 PE PE2012001250A patent/PE20121805A1/es not_active Application Discontinuation
- 2011-02-21 ES ES11705858.6T patent/ES2531663T7/es active Active
- 2011-02-21 DK DK11705858.6T patent/DK2539323T6/en active
- 2011-02-21 SG SG2012060620A patent/SG183336A1/en unknown
- 2011-02-21 MX MX2012009224A patent/MX2012009224A/es active IP Right Grant
- 2011-02-21 PL PL11705858T patent/PL2539323T6/pl unknown
- 2011-02-21 EP EP11705858.6A patent/EP2539323B3/fr active Active
- 2011-02-21 CN CN201180009563.1A patent/CN102781916B/zh not_active Expired - Fee Related
- 2011-02-21 AP AP2012006330A patent/AP3218A/xx active
- 2011-02-21 MA MA35153A patent/MA34008B1/fr unknown
- 2011-02-21 PT PT117058586T patent/PT2539323E/pt unknown
- 2011-02-21 NZ NZ601194A patent/NZ601194A/en not_active IP Right Cessation
- 2011-02-21 JP JP2012553341A patent/JP5603955B2/ja active Active
- 2011-02-21 CA CA2790952A patent/CA2790952C/fr not_active Expired - Fee Related
- 2011-02-21 CN CN201410206948.2A patent/CN103980258B/zh not_active Expired - Fee Related
- 2011-02-21 SI SI201130402T patent/SI2539323T1/sl unknown
- 2011-02-21 KR KR1020127021929A patent/KR101843341B1/ko not_active Expired - Fee Related
- 2011-02-21 WO PCT/EP2011/052512 patent/WO2011104203A1/fr not_active Ceased
- 2011-02-21 AU AU2011219885A patent/AU2011219885C1/en not_active Ceased
- 2011-02-22 TW TW100105851A patent/TWI499589B/zh active
- 2011-02-22 AR ARP110100542A patent/AR080249A1/es not_active Application Discontinuation
-
2012
- 2012-06-28 IL IL220680A patent/IL220680A/en not_active IP Right Cessation
-
2015
- 2015-03-02 CY CY20151100211T patent/CY1116182T1/el unknown
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