MA34578B1 - Composés de tétrahydrofuranyl disubstitués en tant qu'antagonistes du récepteur de la bradykinine b1 - Google Patents
Composés de tétrahydrofuranyl disubstitués en tant qu'antagonistes du récepteur de la bradykinine b1Info
- Publication number
- MA34578B1 MA34578B1 MA35624A MA35624A MA34578B1 MA 34578 B1 MA34578 B1 MA 34578B1 MA 35624 A MA35624 A MA 35624A MA 35624 A MA35624 A MA 35624A MA 34578 B1 MA34578 B1 MA 34578B1
- Authority
- MA
- Morocco
- Prior art keywords
- tetrahydrofuranyl
- bradykinin
- receptor antagonists
- disubstituted compounds
- disubstituted
- Prior art date
Links
- 229940104754 Bradykinin B1 receptor antagonist Drugs 0.000 title 1
- -1 TETRAHYDROFURANYL Chemical class 0.000 title 1
- 239000003144 bradykinin B1 receptor antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne des composés de tétrahydrofuranyl disubstitués de formule générale I dans laquelle les variables R
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10173489 | 2010-08-20 | ||
| PCT/EP2011/064260 WO2012022795A1 (fr) | 2010-08-20 | 2011-08-19 | Composés de tétrahydrofuranyl disubstitués en tant qu'antagonistes du récepteur de la bradykinine b1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA34578B1 true MA34578B1 (fr) | 2013-10-02 |
Family
ID=44510978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA35624A MA34578B1 (fr) | 2010-08-20 | 2011-08-19 | Composés de tétrahydrofuranyl disubstitués en tant qu'antagonistes du récepteur de la bradykinine b1 |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US8937073B2 (fr) |
| EP (1) | EP2606042B1 (fr) |
| JP (1) | JP5727011B2 (fr) |
| KR (1) | KR101822371B1 (fr) |
| CN (1) | CN103068817B (fr) |
| AP (1) | AP2012006630A0 (fr) |
| AR (1) | AR082507A1 (fr) |
| AU (1) | AU2011290727B2 (fr) |
| BR (1) | BR112013003752A2 (fr) |
| CA (1) | CA2807086A1 (fr) |
| CL (1) | CL2013000310A1 (fr) |
| CO (1) | CO6680689A2 (fr) |
| CY (1) | CY1115933T1 (fr) |
| DK (1) | DK2606042T3 (fr) |
| EA (1) | EA022787B1 (fr) |
| EC (1) | ECSP13012495A (fr) |
| ES (1) | ES2525296T3 (fr) |
| GE (1) | GEP20146196B (fr) |
| HR (1) | HRP20141172T1 (fr) |
| IL (1) | IL224039A (fr) |
| MA (1) | MA34578B1 (fr) |
| ME (1) | ME01899B (fr) |
| MX (1) | MX352548B (fr) |
| MY (1) | MY156233A (fr) |
| NZ (1) | NZ607435A (fr) |
| PE (1) | PE20130810A1 (fr) |
| PH (1) | PH12013500330A1 (fr) |
| PL (1) | PL2606042T3 (fr) |
| PT (1) | PT2606042E (fr) |
| RS (1) | RS53622B1 (fr) |
| SG (1) | SG187835A1 (fr) |
| SI (1) | SI2606042T1 (fr) |
| TW (1) | TWI548632B (fr) |
| UA (1) | UA108765C2 (fr) |
| UY (1) | UY33565A (fr) |
| WO (1) | WO2012022795A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007034620A1 (de) * | 2007-07-25 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue B1-Antagonisten |
| ATE550321T1 (de) | 2007-08-29 | 2012-04-15 | Boehringer Ingelheim Int | Neue bradykinin b1-antagonisten |
| US8937073B2 (en) | 2010-08-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists |
| EP3200589B1 (fr) | 2014-09-10 | 2026-03-11 | Temple University Of The Commonwealth System Of Higher Education | Nouveaux modulateurs de l'activité du récepteur de 5-hydroxytryptamine 7 et leur procédé d'utilisation |
| US20180221365A1 (en) * | 2015-05-12 | 2018-08-09 | Temple University-Of The Commonwealth System Of Higher Education | Novel sigma-2 receptor binders and their method of use |
| WO2021198534A1 (fr) | 2020-04-04 | 2021-10-07 | Oxurion NV | Inhibiteurs de la kallicréine plasmique destinés à être utilisés dans le traitement d'une maladie à coronavirus |
| US11401303B2 (en) * | 2020-06-15 | 2022-08-02 | Taian City Qihang Biotechnology Co. | Synthetic peptide BRAP and application in preparation of anti-inflammatory drug for COVID-19 thereof |
| WO2023148016A1 (fr) | 2022-02-04 | 2023-08-10 | Oxurion NV | Biomarqueur pour la réponse à une thérapie par inhibiteur de la kallicréine plasmatique |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6919343B2 (en) | 2002-02-08 | 2005-07-19 | Merck & Co., Inc. | N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives |
| WO2003065789A2 (fr) | 2002-02-08 | 2003-08-14 | Merck & Co., Inc. | Derives de n-biphenylmethyl aminocycloalcanecarboxamide |
| EP1545538A2 (fr) * | 2002-08-29 | 2005-06-29 | Merck & Co., Inc. | Derives n-biarylmethyl aminocycloalcanecarboxamide |
| EP1654232A4 (fr) | 2003-08-07 | 2008-11-12 | Merck & Co Inc | N-(biarylmethyle) aminocyclopropanecarboxamides a substitution sulfonyle |
| CN1832922A (zh) * | 2003-08-07 | 2006-09-13 | 默克公司 | 磺酰基取代的n－(联芳基甲基)氨基环丙烷甲酰胺类 |
| DE602005012806D1 (en) * | 2004-03-02 | 2009-04-02 | Merck & Co Inc | Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten |
| US20060173023A1 (en) | 2005-02-01 | 2006-08-03 | Wood Michael R | 2-(Bicyclo)alkylamino-derivatives as mediators of chronic pain and inflammation |
| WO2008033564A1 (fr) * | 2006-09-15 | 2008-03-20 | Hydra Biosciences Inc. | Composés permettant de moduler la fonction du trpv3 |
| HUP0600809A3 (en) * | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them |
| DE102007034620A1 (de) | 2007-07-25 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue B1-Antagonisten |
| EP2025675A1 (fr) | 2007-08-14 | 2009-02-18 | Boehringer Ingelheim International GmbH | Arylsulfonamides ayant activité analgésique |
| ATE550321T1 (de) | 2007-08-29 | 2012-04-15 | Boehringer Ingelheim Int | Neue bradykinin b1-antagonisten |
| AR068509A1 (es) * | 2007-09-19 | 2009-11-18 | Jerini Ag | Antagosnistas del receptor de bradiquinina b1 |
| WO2010057899A1 (fr) | 2008-11-20 | 2010-05-27 | Boehringer Ingelheim International Gmbh | Dérivés de cycloalkylaminocarbonyle employés comme antagonistes du récepteur b1 de la bradykinine |
| WO2010097374A1 (fr) | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Composés servant d'antagonistes de bradykinine b1 |
| WO2010097372A1 (fr) | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Composés utilisés comme antagonistes de la bradykinine b1 |
| PE20121805A1 (es) * | 2010-02-23 | 2013-01-23 | Boehringer Ingelheim Int | Derivados de 6-oxo-1,6-dihidropiridazin-4-carboxamida n-sustituidas con anilino-(bencil o piridinilmetil)-carbamoilo como antagonistas del receptor de bradiquinina 1 (b1) |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| US8586604B2 (en) | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| US8937073B2 (en) | 2010-08-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists |
| WO2012022794A1 (fr) | 2010-08-20 | 2012-02-23 | Boehringer Ingelheim International Gmbh | Dérivés de pyridazine en tant qu'antagonistes du récepteur de la bradykinine b1 |
| AR082492A1 (es) | 2010-08-20 | 2012-12-12 | Allergan Inc | N-alquil-2-(1-(5-sustituido-2-(3-oxo-3-(trifluorometilsulfonamido)propil)bencil)pirrolidin-2-il)oxazol-4-carboxamida y su uso para preparar un medicamento util para tratar enfermedades o afecciones mediadas por receptor dp, fp, ep, ep, tp y/o ep |
-
2011
- 2011-08-12 US US13/208,567 patent/US8937073B2/en active Active
- 2011-08-19 GE GEAP201113031A patent/GEP20146196B/en unknown
- 2011-08-19 SI SI201130320T patent/SI2606042T1/sl unknown
- 2011-08-19 AP AP2012006630A patent/AP2012006630A0/xx unknown
- 2011-08-19 PT PT117486340T patent/PT2606042E/pt unknown
- 2011-08-19 PH PH1/2013/500330A patent/PH12013500330A1/en unknown
- 2011-08-19 UA UAA201303313A patent/UA108765C2/uk unknown
- 2011-08-19 JP JP2013524457A patent/JP5727011B2/ja active Active
- 2011-08-19 KR KR1020137004077A patent/KR101822371B1/ko not_active Expired - Fee Related
- 2011-08-19 HR HRP20141172AT patent/HRP20141172T1/hr unknown
- 2011-08-19 TW TW100129857A patent/TWI548632B/zh active
- 2011-08-19 DK DK11748634.0T patent/DK2606042T3/da active
- 2011-08-19 BR BR112013003752A patent/BR112013003752A2/pt not_active IP Right Cessation
- 2011-08-19 PL PL11748634T patent/PL2606042T3/pl unknown
- 2011-08-19 UY UY0001033565A patent/UY33565A/es not_active Application Discontinuation
- 2011-08-19 EA EA201201662A patent/EA022787B1/ru not_active IP Right Cessation
- 2011-08-19 NZ NZ607435A patent/NZ607435A/en not_active IP Right Cessation
- 2011-08-19 RS RS20140551A patent/RS53622B1/sr unknown
- 2011-08-19 MA MA35624A patent/MA34578B1/fr unknown
- 2011-08-19 ES ES11748634.0T patent/ES2525296T3/es active Active
- 2011-08-19 SG SG2013010764A patent/SG187835A1/en unknown
- 2011-08-19 CA CA2807086A patent/CA2807086A1/fr not_active Abandoned
- 2011-08-19 EP EP11748634.0A patent/EP2606042B1/fr active Active
- 2011-08-19 CN CN201180039753.8A patent/CN103068817B/zh not_active Expired - Fee Related
- 2011-08-19 ME MEP-2014-118A patent/ME01899B/me unknown
- 2011-08-19 AU AU2011290727A patent/AU2011290727B2/en not_active Ceased
- 2011-08-19 PE PE2013000265A patent/PE20130810A1/es not_active Application Discontinuation
- 2011-08-19 MY MYPI2013000537A patent/MY156233A/en unknown
- 2011-08-19 WO PCT/EP2011/064260 patent/WO2012022795A1/fr not_active Ceased
- 2011-08-19 MX MX2013001965A patent/MX352548B/es active IP Right Grant
- 2011-08-19 AR ARP110103036A patent/AR082507A1/es not_active Application Discontinuation
-
2012
- 2012-12-31 IL IL224039A patent/IL224039A/en active IP Right Grant
-
2013
- 2013-01-30 CL CL2013000310A patent/CL2013000310A1/es unknown
- 2013-02-28 CO CO13041062A patent/CO6680689A2/es active IP Right Grant
- 2013-03-15 EC ECSP13012495 patent/ECSP13012495A/es unknown
-
2014
- 2014-11-26 CY CY20141100985T patent/CY1115933T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA35086B1 (fr) | Compose de triazolopyridine | |
| MA35089B1 (fr) | Inhibiteurs de la production de leucotrienes de type benzodioxane | |
| MA35049B1 (fr) | Triazolopyridines | |
| MA37519B1 (fr) | Composés et compositions pour inhiber l'activité d'abl1, abl2 et bcr-abl1 | |
| MA35819B1 (fr) | Composés hétéroaryl pyridones et aza-pyridones en tant qu'inhibiteurs de l'activité btk | |
| MA35926B1 (fr) | Pyrrolidine-2-carboxamides substitués | |
| MA35664B1 (fr) | Nouveaux dérivés bicycliques de la dihydroisoquinoline-1-one | |
| CO6852084A2 (es) | Nuevos compuestos sustituidos con halógeno | |
| CR20130369A (es) | Novedosos derivados heterocíclicos | |
| EP2744808A4 (fr) | Composés tricycliques en tant qu'agents anticancéreux | |
| MA38645B1 (fr) | Nouveaux inhibiteurs de cyp17/antiandrogènes | |
| EP2685828A4 (fr) | Dérivés de 3-azabicyclo[3.1.0]hexane substitués utiles en tant qu'antagonistes de ccr2 | |
| UY34825A (es) | Síntesis de compuestos heterocíclicos | |
| MA37142A3 (fr) | Dérivés de dihydro-benzo-oxazine et de dihydro-pyrido-oxazine | |
| CR20130501A (es) | Derivados novedosos de cefalosporinas y composiciones farmacéuticas de estos | |
| MX2016007128A (es) | Compuestos del receptor 6 de quimiocina (ccr6). | |
| IN2014MN01521A (fr) | ||
| MA37943B1 (fr) | 2-oxo-2,3-dihydro-indoles destinés au traitement de troubles du snc | |
| EA201101675A1 (ru) | Спироэпоксиды как промежуточные продукты синтеза | |
| EA201170997A1 (ru) | Производные индола в качестве противораковых агентов | |
| MA37686A1 (fr) | Composés phénoxyéthyl pipéridine | |
| EA201591815A1 (ru) | Бицикло [2.2.2] кислоты - модуляторы gpr120 | |
| EP2757882A4 (fr) | Composés imidazopyridyliques utilisables en tant qu'inhibiteurs de l'aldostérone synthase | |
| EA201491251A1 (ru) | Соединение 2-(пиридин-2-ил)-1,7-диазаспиро[4.4]нонан-6-она в качестве модуляторов потенциалзависимых натриевых каналов | |
| MX390763B (es) | Compuestos de tetraciclina |