MA35014B1 - Sels de 2,3-dihydroimidazo [1,2-c]quinazoline substitués - Google Patents

Sels de 2,3-dihydroimidazo [1,2-c]quinazoline substitués

Info

Publication number
MA35014B1
MA35014B1 MA36288A MA36288A MA35014B1 MA 35014 B1 MA35014 B1 MA 35014B1 MA 36288 A MA36288 A MA 36288A MA 36288 A MA36288 A MA 36288A MA 35014 B1 MA35014 B1 MA 35014B1
Authority
MA
Morocco
Prior art keywords
dihydroimidazo
substituted
quinazoline
salts
quinazoline salts
Prior art date
Application number
MA36288A
Other languages
English (en)
Inventor
Jan Georg Peters
Hans-Christian Militzer
Hartwig Müller
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43984137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35014(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of MA35014B1 publication Critical patent/MA35014B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne : - un sel, le dihydrochlorure de 2-amino-N-[7-méthoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo- [1,2-c]quinazolin-5-yl]
MA36288A 2011-04-05 2012-03-29 Sels de 2,3-dihydroimidazo [1,2-c]quinazoline substitués MA35014B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11161111A EP2508525A1 (fr) 2011-04-05 2011-04-05 Sels de 2,3-dihydroimidazo[1,2-C]quinazoline substitutés
PCT/EP2012/055600 WO2012136553A1 (fr) 2011-04-05 2012-03-29 Sels de 2,3-dihydroimidazo[1,2-c]quinazoline substitués

Publications (1)

Publication Number Publication Date
MA35014B1 true MA35014B1 (fr) 2014-04-03

Family

ID=43984137

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36288A MA35014B1 (fr) 2011-04-05 2012-03-29 Sels de 2,3-dihydroimidazo [1,2-c]quinazoline substitués

Country Status (42)

Country Link
US (2) US10383876B2 (fr)
EP (2) EP2508525A1 (fr)
JP (2) JP5763834B2 (fr)
KR (1) KR101937501B1 (fr)
CN (1) CN103649091B (fr)
AP (1) AP3709A (fr)
AR (1) AR085718A1 (fr)
AU (1) AU2012238891B2 (fr)
BR (1) BR112013025549A2 (fr)
CA (1) CA2832123C (fr)
CL (1) CL2013002870A1 (fr)
CO (1) CO6781534A2 (fr)
CR (1) CR20130511A (fr)
CU (1) CU24208B1 (fr)
CY (1) CY1116231T1 (fr)
DK (1) DK2694508T3 (fr)
DO (1) DOP2013000223A (fr)
EA (1) EA023646B1 (fr)
EC (1) ECSP13013006A (fr)
ES (1) ES2529653T3 (fr)
GT (1) GT201300234A (fr)
HR (1) HRP20150138T1 (fr)
IL (1) IL228561A (fr)
JO (1) JO2958B1 (fr)
MA (1) MA35014B1 (fr)
ME (1) ME02021B (fr)
MX (1) MX336057B (fr)
MY (1) MY169452A (fr)
PE (1) PE20141038A1 (fr)
PH (1) PH12013502065A1 (fr)
PL (1) PL2694508T3 (fr)
PT (1) PT2694508E (fr)
RS (1) RS53811B1 (fr)
SG (1) SG193595A1 (fr)
SI (1) SI2694508T1 (fr)
SM (1) SMT201500037B (fr)
TN (1) TN2013000401A1 (fr)
TW (2) TWI592158B (fr)
UA (1) UA111604C2 (fr)
UY (1) UY33985A (fr)
WO (1) WO2012136553A1 (fr)
ZA (1) ZA201307105B (fr)

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AR064106A1 (es) 2006-12-05 2009-03-11 Bayer Schering Pharma Ag Derivados de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogenesis
EP2168583A1 (fr) 2008-09-24 2010-03-31 Bayer Schering Pharma Aktiengesellschaft Utilisation de 2,3-dihydroimidazo[1,2-c]quinazolines substituées pour le traitement du myélome
JO3733B1 (ar) 2011-04-05 2021-01-31 Bayer Ip Gmbh استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة
EP2508525A1 (fr) * 2011-04-05 2012-10-10 Bayer Pharma Aktiengesellschaft Sels de 2,3-dihydroimidazo[1,2-C]quinazoline substitutés
EA031493B9 (ru) 2013-04-08 2019-12-18 Байер Фарма Акциенгезельшафт Комбинация и фармацевтическая композиция для лечения или профилактики неходжкинской лимфомы (нхл)
AU2014280174A1 (en) 2013-06-14 2015-12-03 Bayer Pharma Aktiengesellschaft Anti-TWEAKR antibodies and uses thereof
CN103694319B (zh) * 2013-12-20 2018-02-27 深圳翰宇药业股份有限公司 一种布舍瑞林的纯化方法
EP3018131A1 (fr) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthèse de copanlisib et son sel de dichlorhydrate
EP3018127A1 (fr) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthèse de copanlisib et son sel de dichlorhydrate
CN107683138A (zh) * 2015-03-09 2018-02-09 拜耳制药股份公司 取代的2,3‑二氢咪唑并[1,2‑c]喹唑啉类化合物的用途
MX2017011635A (es) * 2015-03-09 2018-02-09 Bayer Pharma AG Combinaciones que contienen 2,3-dihidroimidazo[1,2-c]quinazolina sustituida.
CA2980390A1 (fr) 2015-03-23 2016-09-29 Bayer Pharma Aktiengesellschaft Anticorps anti-ceacam6 et leurs utilisations
WO2016162229A1 (fr) 2015-04-10 2016-10-13 Capsugel Belgium N.V. Formulations lipidiques d'acétate d'abiratérone
CN109072307A (zh) 2016-02-01 2018-12-21 拜耳制药股份公司 Copanlisib生物标志物
US20190038632A1 (en) 2016-02-01 2019-02-07 Bayer Pharma Aktiengesellschaft Copanlisib biomarkers
JOP20170053B1 (ar) 2016-03-02 2021-08-17 Eisai Randd Man Co Ltd مترافقات جسم مضاد وعقار أساسها إيريبولين وطرق استخدامها
EP3426657B1 (fr) * 2016-03-08 2022-07-13 Bayer Pharma Aktiengesellschaft 2-amino-n-[7-méthoxy-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamides
EP3219329A1 (fr) 2016-03-17 2017-09-20 Bayer Pharma Aktiengesellschaft Combinaisons de copanlisib
CN109729716B (zh) 2016-09-23 2022-03-15 拜耳制药股份公司 Pi3k-抑制剂的组合产品
CA3045041A1 (fr) 2016-12-14 2018-06-21 Tarveda Therapeutics, Inc. Conjugues ciblant hsp90 et formulations de ces derniers
US11684672B2 (en) 2017-02-24 2023-06-27 Bayer Pharma Aktiengesellschaft Combinations of copanlisib with anti-PD-1 antibody
CA3068324A1 (fr) 2017-06-28 2019-01-03 Bayer Consumer Care Ag Combinaison d'un inhibiteur de pi3k et d'un antagoniste du recepteur des androgenes
EP3498266A1 (fr) 2017-12-15 2019-06-19 Bayer Consumer Care AG Formulations de copanlisib
JP2020533292A (ja) 2017-09-08 2020-11-19 バイエル・コンシューマー・ケア・アクチェンゲゼルシャフトＢａｙｅｒ Ｃｏｎｓｕｍｅｒ Ｃａｒｅ ＡＧ コパンリシブの製剤
WO2019105734A1 (fr) 2017-11-28 2019-06-06 Bayer Consumer Care Ag Combinaisons de copanlisib
WO2019105835A1 (fr) 2017-11-29 2019-06-06 Bayer Consumer Care Ag Combinaisons de copanlisib et d'anetumab ravtansine
WO2019197269A1 (fr) 2018-04-11 2019-10-17 Bayer Aktiengesellschaft Combinaisons de copanlisib et de dérivés de triazolone ainsi que leur utilisation dans le traitement du cancer
EP3843743A1 (fr) 2018-08-28 2021-07-07 Bayer AS Combinaison d'inhibiteurs de pi3k et de conjugués de thorium ciblés
US20210369724A1 (en) * 2018-10-16 2021-12-02 Bayer Aktiengesellschaft Combination of atr kinase inhibitors with 2,3-dihydroimidazo[1,2-c]quinazoline compounds
CA3113770A1 (fr) * 2018-10-17 2020-04-23 Sandoz Ag Co-cristaux comprenant de la levothyroxine et un acide dicarboxylique
JP7195027B2 (ja) * 2018-12-27 2022-12-23 ホロスメディック 新規の化合物およびこれを含む抗癌活性増進用薬学組成物
WO2020164997A1 (fr) 2019-02-12 2020-08-20 Bayer Aktiengesellschaft Combinaison d'inhibiteurs de la pi3k
WO2023218032A1 (fr) 2022-05-13 2023-11-16 Synthon B.V. Formes solides de sels de copanlisib
WO2025053315A1 (fr) * 2023-09-08 2025-03-13 파로스젠 주식회사 Procédé de récupération et d'élimination du palladium au cours de la préparation d'un conjugué promédicament anticancéreux

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EP2168583A1 (fr) 2008-09-24 2010-03-31 Bayer Schering Pharma Aktiengesellschaft Utilisation de 2,3-dihydroimidazo[1,2-c]quinazolines substituées pour le traitement du myélome
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UA113280C2 (xx) 2010-11-11 2017-01-10 АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ
EP2508525A1 (fr) * 2011-04-05 2012-10-10 Bayer Pharma Aktiengesellschaft Sels de 2,3-dihydroimidazo[1,2-C]quinazoline substitutés
JO3733B1 (ar) * 2011-04-05 2021-01-31 Bayer Ip Gmbh استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة
EA031493B9 (ru) 2013-04-08 2019-12-18 Байер Фарма Акциенгезельшафт Комбинация и фармацевтическая композиция для лечения или профилактики неходжкинской лимфомы (нхл)
CN105934256B (zh) 2013-12-03 2019-12-27 拜耳制药股份公司 Pi3k-抑制剂的组合产品
EP3018131A1 (fr) 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthèse de copanlisib et son sel de dichlorhydrate
EP3018127A1 (fr) 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthèse de copanlisib et son sel de dichlorhydrate
MX2017011635A (es) 2015-03-09 2018-02-09 Bayer Pharma AG Combinaciones que contienen 2,3-dihidroimidazo[1,2-c]quinazolina sustituida.
CN107683138A (zh) * 2015-03-09 2018-02-09 拜耳制药股份公司 取代的2,3‑二氢咪唑并[1,2‑c]喹唑啉类化合物的用途

Also Published As

Publication number Publication date
AU2012238891B2 (en) 2016-12-01
PL2694508T3 (pl) 2015-04-30
KR101937501B1 (ko) 2019-01-10
CN103649091B (zh) 2016-06-22
IL228561A (en) 2015-10-29
PT2694508E (pt) 2015-02-10
US9636344B2 (en) 2017-05-02
ES2529653T3 (es) 2015-02-24
EP2508525A1 (fr) 2012-10-10
HRP20150138T1 (hr) 2015-05-08
JP5826961B2 (ja) 2015-12-02
HK1195907A1 (zh) 2014-11-28
EP2694508A1 (fr) 2014-02-12
NZ616198A (en) 2015-09-25
CA2832123A1 (fr) 2012-10-11
PH12013502065A1 (en) 2016-06-29
TWI592158B (zh) 2017-07-21
SG193595A1 (en) 2013-10-30
MX2013011583A (es) 2013-12-16
TW201249847A (en) 2012-12-16
TN2013000401A1 (en) 2015-03-30
US20160193219A1 (en) 2016-07-07
EA201391470A1 (ru) 2014-03-31
CL2013002870A1 (es) 2014-06-20
AP2013007219A0 (en) 2013-10-31
AU2012238891A1 (en) 2013-10-24
BR112013025549A2 (pt) 2016-12-27
IL228561A0 (en) 2013-12-31
CU20130133A7 (es) 2014-01-29
AR085718A1 (es) 2013-10-23
CN103649091A (zh) 2014-03-19
JP2014510119A (ja) 2014-04-24
SI2694508T1 (sl) 2015-03-31
UA111604C2 (uk) 2016-05-25
ECSP13013006A (es) 2013-12-31
MX336057B (es) 2016-01-07
US10383876B2 (en) 2019-08-20
JP5763834B2 (ja) 2015-08-12
DOP2013000223A (es) 2013-11-15
GT201300234A (es) 2015-01-16
RS53811B1 (sr) 2015-06-30
US20140072529A1 (en) 2014-03-13
DK2694508T3 (en) 2015-02-16
TW201637656A (zh) 2016-11-01
KR20140021637A (ko) 2014-02-20
CU24208B1 (es) 2016-11-29
EP2694508B1 (fr) 2014-11-19
CR20130511A (es) 2013-12-04
CA2832123C (fr) 2018-09-11
PE20141038A1 (es) 2014-09-05
TWI549954B (zh) 2016-09-21
CY1116231T1 (el) 2017-02-08
CO6781534A2 (es) 2013-10-31
JO2958B1 (en) 2016-03-15
ZA201307105B (en) 2014-11-26
MY169452A (en) 2019-04-11
SMT201500037B (it) 2015-05-05
EA023646B1 (ru) 2016-06-30
UY33985A (es) 2012-10-31
AP3709A (en) 2016-05-31
WO2012136553A1 (fr) 2012-10-11
JP2015164936A (ja) 2015-09-17
ME02021B (me) 2015-05-20

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