CU24208B1 - Sal de diclorhidrato de 2-amino-n-[7-metoxi-8-(3-morfolin-4-ilpropoxi)-2,3-dihidroimidazo-[1,2-c]quinazolin-5-il]pirimidin-5-carboxamida y método de preparación de la misma - Google Patents

Sal de diclorhidrato de 2-amino-n-[7-metoxi-8-(3-morfolin-4-ilpropoxi)-2,3-dihidroimidazo-[1,2-c]quinazolin-5-il]pirimidin-5-carboxamida y método de preparación de la misma

Info

Publication number
CU24208B1
CU24208B1 CUP2013000133A CU20130133A CU24208B1 CU 24208 B1 CU24208 B1 CU 24208B1 CU P2013000133 A CUP2013000133 A CU P2013000133A CU 20130133 A CU20130133 A CU 20130133A CU 24208 B1 CU24208 B1 CU 24208B1
Authority
CU
Cuba
Prior art keywords
dihydroimidazo
quinazolin
amino
ilpropoxi
diclorhydrate
Prior art date
Application number
CUP2013000133A
Other languages
English (en)
Other versions
CU20130133A7 (es
Inventor
Jan Georg Peters
Hans-Christian Militzer
Hartwig Müller
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43984137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24208(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of CU20130133A7 publication Critical patent/CU20130133A7/es
Publication of CU24208B1 publication Critical patent/CU24208B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Sal de diclorhidrato de 2-amino-n-[7-metoxi-8-(3-morfolin-4-ilpropoxi)-2,3-dihidroimidazo-[1,2-c]quinazolin-5-il]pirimidin-5-carboxamida de Fórmula (II): Espacio para Fórmula y métodos para preparar dicha sal de diclorhidrato.
CUP2013000133A 2011-04-05 2012-03-29 Sal de diclorhidrato de 2-amino-n-[7-metoxi-8-(3-morfolin-4-ilpropoxi)-2,3-dihidroimidazo-[1,2-c]quinazolin-5-il]pirimidin-5-carboxamida y método de preparación de la misma CU24208B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11161111A EP2508525A1 (en) 2011-04-05 2011-04-05 Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
PCT/EP2012/055600 WO2012136553A1 (en) 2011-04-05 2012-03-29 Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts

Publications (2)

Publication Number Publication Date
CU20130133A7 CU20130133A7 (es) 2014-01-29
CU24208B1 true CU24208B1 (es) 2016-11-29

Family

ID=43984137

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2013000133A CU24208B1 (es) 2011-04-05 2012-03-29 Sal de diclorhidrato de 2-amino-n-[7-metoxi-8-(3-morfolin-4-ilpropoxi)-2,3-dihidroimidazo-[1,2-c]quinazolin-5-il]pirimidin-5-carboxamida y método de preparación de la misma

Country Status (42)

Country Link
US (2) US10383876B2 (es)
EP (2) EP2508525A1 (es)
JP (2) JP5763834B2 (es)
KR (1) KR101937501B1 (es)
CN (1) CN103649091B (es)
AP (1) AP3709A (es)
AR (1) AR085718A1 (es)
AU (1) AU2012238891B2 (es)
BR (1) BR112013025549A2 (es)
CA (1) CA2832123C (es)
CL (1) CL2013002870A1 (es)
CO (1) CO6781534A2 (es)
CR (1) CR20130511A (es)
CU (1) CU24208B1 (es)
CY (1) CY1116231T1 (es)
DK (1) DK2694508T3 (es)
DO (1) DOP2013000223A (es)
EA (1) EA023646B1 (es)
EC (1) ECSP13013006A (es)
ES (1) ES2529653T3 (es)
GT (1) GT201300234A (es)
HR (1) HRP20150138T1 (es)
IL (1) IL228561A (es)
JO (1) JO2958B1 (es)
MA (1) MA35014B1 (es)
ME (1) ME02021B (es)
MX (1) MX336057B (es)
MY (1) MY169452A (es)
PE (1) PE20141038A1 (es)
PH (1) PH12013502065A1 (es)
PL (1) PL2694508T3 (es)
PT (1) PT2694508E (es)
RS (1) RS53811B1 (es)
SG (1) SG193595A1 (es)
SI (1) SI2694508T1 (es)
SM (1) SMT201500037B (es)
TN (1) TN2013000401A1 (es)
TW (2) TWI592158B (es)
UA (1) UA111604C2 (es)
UY (1) UY33985A (es)
WO (1) WO2012136553A1 (es)
ZA (1) ZA201307105B (es)

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EA031493B9 (ru) 2013-04-08 2019-12-18 Байер Фарма Акциенгезельшафт Комбинация и фармацевтическая композиция для лечения или профилактики неходжкинской лимфомы (нхл)
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CN103694319B (zh) * 2013-12-20 2018-02-27 深圳翰宇药业股份有限公司 一种布舍瑞林的纯化方法
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CN109729716B (zh) 2016-09-23 2022-03-15 拜耳制药股份公司 Pi3k-抑制剂的组合产品
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US11684672B2 (en) 2017-02-24 2023-06-27 Bayer Pharma Aktiengesellschaft Combinations of copanlisib with anti-PD-1 antibody
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JP2020533292A (ja) 2017-09-08 2020-11-19 バイエル・コンシューマー・ケア・アクチェンゲゼルシャフトＢａｙｅｒ Ｃｏｎｓｕｍｅｒ Ｃａｒｅ ＡＧ コパンリシブの製剤
WO2019105734A1 (en) 2017-11-28 2019-06-06 Bayer Consumer Care Ag Combinations of copanlisib
WO2019105835A1 (en) 2017-11-29 2019-06-06 Bayer Consumer Care Ag Combinations of copanlisib and anetumab ravtansine
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EP3843743A1 (en) 2018-08-28 2021-07-07 Bayer AS Combination of pi3k-inhibitors and targeted thorium conjugates
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JO3733B1 (ar) * 2011-04-05 2021-01-31 Bayer Ip Gmbh استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة
EA031493B9 (ru) 2013-04-08 2019-12-18 Байер Фарма Акциенгезельшафт Комбинация и фармацевтическая композиция для лечения или профилактики неходжкинской лимфомы (нхл)
CN105934256B (zh) 2013-12-03 2019-12-27 拜耳制药股份公司 Pi3k-抑制剂的组合产品
EP3018131A1 (en) 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
EP3018127A1 (en) 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
MX2017011635A (es) 2015-03-09 2018-02-09 Bayer Pharma AG Combinaciones que contienen 2,3-dihidroimidazo[1,2-c]quinazolina sustituida.
CN107683138A (zh) * 2015-03-09 2018-02-09 拜耳制药股份公司 取代的2,3‑二氢咪唑并[1,2‑c]喹唑啉类化合物的用途

Also Published As

Publication number Publication date
AU2012238891B2 (en) 2016-12-01
PL2694508T3 (pl) 2015-04-30
KR101937501B1 (ko) 2019-01-10
CN103649091B (zh) 2016-06-22
IL228561A (en) 2015-10-29
PT2694508E (pt) 2015-02-10
US9636344B2 (en) 2017-05-02
ES2529653T3 (es) 2015-02-24
EP2508525A1 (en) 2012-10-10
HRP20150138T1 (hr) 2015-05-08
JP5826961B2 (ja) 2015-12-02
HK1195907A1 (zh) 2014-11-28
EP2694508A1 (en) 2014-02-12
NZ616198A (en) 2015-09-25
CA2832123A1 (en) 2012-10-11
PH12013502065A1 (en) 2016-06-29
TWI592158B (zh) 2017-07-21
SG193595A1 (en) 2013-10-30
MX2013011583A (es) 2013-12-16
TW201249847A (en) 2012-12-16
TN2013000401A1 (en) 2015-03-30
US20160193219A1 (en) 2016-07-07
EA201391470A1 (ru) 2014-03-31
CL2013002870A1 (es) 2014-06-20
AP2013007219A0 (en) 2013-10-31
AU2012238891A1 (en) 2013-10-24
BR112013025549A2 (pt) 2016-12-27
IL228561A0 (en) 2013-12-31
CU20130133A7 (es) 2014-01-29
AR085718A1 (es) 2013-10-23
CN103649091A (zh) 2014-03-19
JP2014510119A (ja) 2014-04-24
SI2694508T1 (sl) 2015-03-31
MA35014B1 (fr) 2014-04-03
UA111604C2 (uk) 2016-05-25
ECSP13013006A (es) 2013-12-31
MX336057B (es) 2016-01-07
US10383876B2 (en) 2019-08-20
JP5763834B2 (ja) 2015-08-12
DOP2013000223A (es) 2013-11-15
GT201300234A (es) 2015-01-16
RS53811B1 (sr) 2015-06-30
US20140072529A1 (en) 2014-03-13
DK2694508T3 (en) 2015-02-16
TW201637656A (zh) 2016-11-01
KR20140021637A (ko) 2014-02-20
EP2694508B1 (en) 2014-11-19
CR20130511A (es) 2013-12-04
CA2832123C (en) 2018-09-11
PE20141038A1 (es) 2014-09-05
TWI549954B (zh) 2016-09-21
CY1116231T1 (el) 2017-02-08
CO6781534A2 (es) 2013-10-31
JO2958B1 (en) 2016-03-15
ZA201307105B (en) 2014-11-26
MY169452A (en) 2019-04-11
SMT201500037B (it) 2015-05-05
EA023646B1 (ru) 2016-06-30
UY33985A (es) 2012-10-31
AP3709A (en) 2016-05-31
WO2012136553A1 (en) 2012-10-11
JP2015164936A (ja) 2015-09-17
ME02021B (me) 2015-05-20

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