MA35191B1 - Spiro-[1,3]-oxazines et spiro-[1,4]-oxazepines en tant qu'inhibiteurs de baec1 et/ou bace2 - Google Patents

Spiro-[1,3]-oxazines et spiro-[1,4]-oxazepines en tant qu'inhibiteurs de baec1 et/ou bace2

Info

Publication number
MA35191B1
MA35191B1 MA36582A MA36582A MA35191B1 MA 35191 B1 MA35191 B1 MA 35191B1 MA 36582 A MA36582 A MA 36582A MA 36582 A MA36582 A MA 36582A MA 35191 B1 MA35191 B1 MA 35191B1
Authority
MA
Morocco
Prior art keywords
spiro
oxazepines
oxazines
bace2
baec1
Prior art date
Application number
MA36582A
Other languages
English (en)
Inventor
Robert Narquizian
Emmanuel Pinard
Wolfgang Wostl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46177417&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35191(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA35191B1 publication Critical patent/MA35191B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des spiro-[1,3]-oxazines et des spiro-[1,4]-oxazépines de formule (i) ayant une activité inhibitrice de bace1 et/ou bace2, leur fabrication, des compositions pharmaceutiques les contenant et leur utilisation en tant que substances thérapeutiquement actives. Les composés actifs de la présente invention sont utiles dans le traitement thérapeutique et/ou prophylactique par exemple de la maladie d'alzheimer et du diabète de type 2.
MA36582A 2011-05-27 2013-12-18 Spiro-[1,3]-oxazines et spiro-[1,4]-oxazepines en tant qu'inhibiteurs de baec1 et/ou bace2 MA35191B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11167835 2011-05-27
PCT/EP2012/059688 WO2012163790A1 (fr) 2011-05-27 2012-05-24 Spiro-[1,3]-oxazines et spiro-[1,4]-oxazépines en tant qu'inhibiteurs de baec1 et/ou bace2

Publications (1)

Publication Number Publication Date
MA35191B1 true MA35191B1 (fr) 2014-06-02

Family

ID=46177417

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36582A MA35191B1 (fr) 2011-05-27 2013-12-18 Spiro-[1,3]-oxazines et spiro-[1,4]-oxazepines en tant qu'inhibiteurs de baec1 et/ou bace2

Country Status (23)

Country Link
US (1) US9079919B2 (fr)
EP (1) EP2714697B1 (fr)
JP (1) JP2014515382A (fr)
KR (1) KR20140048137A (fr)
CN (1) CN103596961B (fr)
AU (1) AU2012264875B2 (fr)
BR (1) BR112013030281A2 (fr)
CA (1) CA2833813A1 (fr)
CL (1) CL2013003372A1 (fr)
CO (1) CO6801773A2 (fr)
CR (1) CR20130580A (fr)
EA (1) EA024286B1 (fr)
EC (1) ECSP13013048A (fr)
ES (1) ES2600636T3 (fr)
IL (1) IL229334A (fr)
MA (1) MA35191B1 (fr)
MX (1) MX2013013910A (fr)
PE (1) PE20141205A1 (fr)
PH (1) PH12013502262A1 (fr)
SG (1) SG194835A1 (fr)
UA (1) UA111847C2 (fr)
WO (1) WO2012163790A1 (fr)
ZA (1) ZA201308395B (fr)

Families Citing this family (25)

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ES2537898T3 (es) 2005-10-25 2015-06-15 Shionogi & Co., Ltd. Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1
AU2008245082B8 (en) 2007-04-24 2012-09-13 Shionogi & Co., Ltd. Aminodihydrothiazine derivatives substituted with a cyclic group
EP2151435A4 (fr) 2007-04-24 2011-09-14 Shionogi & Co Composition pharmaceutique pour le traitement de la maladie d'alzheimer
US8637504B2 (en) 2008-06-13 2014-01-28 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
WO2010047372A1 (fr) 2008-10-22 2010-04-29 塩野義製薬株式会社 2-aminopyridin-4-one et dérivé de 2-aminopyridine dont l'activité inhibe la bace1
WO2011044187A1 (fr) 2009-10-08 2011-04-14 Schering Corporation Composés de type dioxyde d'imino-thiadiazine utilisés en tant qu'inhibiteurs de bace, compositions en contenant et leur utilisation
WO2011044185A2 (fr) 2009-10-08 2011-04-14 Schering Corporation Composés hétérocycliques iminopentafluorosoufrés en tant qu'inhibiteurs de bace-1, compositions et leur utilisation
WO2011044184A1 (fr) 2009-10-08 2011-04-14 Schering Corporation Composés hétérocycliques de type imino-pentafluorosulfure utilisés en tant qu'inhibiteurs de bace1, compositions en contenant et leur utilisation
UA108363C2 (uk) 2009-10-08 2015-04-27 Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
RU2012129168A (ru) 2009-12-11 2014-01-20 Сионоги Энд Ко. Лтд. Производные оксазина
US9018219B2 (en) 2010-10-29 2015-04-28 Shionogi & Co., Ltd. Fused aminodihydropyrimidine derivative
CA2816285A1 (fr) 2010-10-29 2012-05-03 Shionogi & Co., Ltd. Derive de naphtyridine
WO2012138734A1 (fr) 2011-04-07 2012-10-11 Merck Sharp & Dohme Corp. Composés de dioxyde de thiadiazine condensés avec des dérivés oxacycliques en c5-c6 comme inhibiteurs de bace, compositions, et utilisation use
EP2694521B1 (fr) 2011-04-07 2015-11-25 Merck Sharp & Dohme Corp. Composés de dioxyde de thiadiazine fusionnée à la pyrrolidine en tant qu'inhibiteurs de bace, compositions et leur utilisation
WO2012147763A1 (fr) 2011-04-26 2012-11-01 塩野義製薬株式会社 Dérivé d'oxazine et inhibiteur de bace 1 le contenant
RU2014111055A (ru) 2011-08-22 2015-09-27 Мерк Шарп И Доум Корп. 2-спирозамещенные иминотиазины и их моно- и диоксиды в качестве ингибиторов bace, композиции и их применение
SG11201407796YA (en) 2012-05-30 2014-12-30 Comentis Inc Chromane compounds
JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
US9580396B2 (en) 2012-12-21 2017-02-28 Merck Sharp & Dohme Corp. C6-spiro iminothiadiazine dioxides as BACE inhibitors, compositions, and their use
AU2014223334C1 (en) 2013-03-01 2018-10-18 Amgen Inc. Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
EP2964644B1 (fr) 2013-03-08 2018-12-26 Amgen, Inc. Composés perfluorés à base de 1,3-oxazin-2-amine condensée avec un cyclopropyle en tant qu'inhibiteurs de la bêta-secrétase et leurs procédés d'utilisation
EP3043802B1 (fr) 2013-09-13 2018-04-18 Merck Sharp & Dohme Corp. Dioxydes d'iminothiazine spiro-c5 utilisés comme inhibiteurs de bace, compositions, et leur utilisation
MX381482B (es) 2014-08-08 2025-03-12 Amgen Inc Compuestos de tiazin-2-amina fusionados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso.
US10053453B2 (en) 2014-10-07 2018-08-21 Astrazeneca Ab Compounds and their use as BACE inhibitors
CA2979113A1 (fr) 2015-03-20 2016-09-29 F. Hoffmann-La Roche Ag Inhibiteurs de bace1

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Publication number Priority date Publication date Assignee Title
EP1501805A1 (fr) 2002-05-09 2005-02-02 Pharmacia Corporation Composes substitues de pyrazolyl utilises dans le traitement des inflammations
PE20060692A1 (es) * 2004-09-21 2006-07-19 Lilly Co Eli Inhibidores bace
CA2615656A1 (fr) * 2005-07-18 2007-01-25 Merck & Co., Inc. Inhibiteurs de spiropiperidine beta-secretase pour le traitement de la maladie d'alzheimer
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WO2008030412A2 (fr) 2006-09-07 2008-03-13 Merck & Co., Inc. Inhibiteurs de la spiropipéridine bêta-sécrétase pour le traitement de la maladie d'alzheimer
EP2151435A4 (fr) 2007-04-24 2011-09-14 Shionogi & Co Composition pharmaceutique pour le traitement de la maladie d'alzheimer
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UA103272C2 (uk) * 2009-12-11 2013-09-25 Ф. Хоффманн-Ля Рош Аг 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2
WO2011123674A1 (fr) * 2010-03-31 2011-10-06 Array Biopharma Inc. Composés pour traiter des maladies neurodégénératives
JP2012250933A (ja) * 2011-06-03 2012-12-20 Shionogi & Co Ltd オキサジン誘導体を含有するアルツハイマー症治療用または予防用医薬組成物

Also Published As

Publication number Publication date
PE20141205A1 (es) 2014-09-22
WO2012163790A1 (fr) 2012-12-06
IL229334A (en) 2017-02-28
US20120302549A1 (en) 2012-11-29
PH12013502262A1 (en) 2016-01-22
EP2714697A1 (fr) 2014-04-09
NZ616817A (en) 2015-12-24
US9079919B2 (en) 2015-07-14
CN103596961B (zh) 2016-09-28
EP2714697B1 (fr) 2016-08-31
ES2600636T3 (es) 2017-02-10
MX2013013910A (es) 2014-01-24
AU2012264875A1 (en) 2013-10-31
BR112013030281A2 (pt) 2016-11-29
ECSP13013048A (es) 2014-01-31
IL229334A0 (en) 2014-01-30
EA024286B1 (ru) 2016-09-30
CA2833813A1 (fr) 2012-12-06
UA111847C2 (uk) 2016-06-24
EA201391752A1 (ru) 2014-04-30
KR20140048137A (ko) 2014-04-23
CO6801773A2 (es) 2013-11-29
CL2013003372A1 (es) 2014-07-25
AU2012264875B2 (en) 2017-04-27
CN103596961A (zh) 2014-02-19
CR20130580A (es) 2013-12-09
ZA201308395B (en) 2014-07-30
JP2014515382A (ja) 2014-06-30
SG194835A1 (en) 2013-12-30

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