MA35194B1 - Derives de benzamide substitues - Google Patents

Derives de benzamide substitues

Info

Publication number
MA35194B1
MA35194B1 MA36585A MA36585A MA35194B1 MA 35194 B1 MA35194 B1 MA 35194B1 MA 36585 A MA36585 A MA 36585A MA 36585 A MA36585 A MA 36585A MA 35194 B1 MA35194 B1 MA 35194B1
Authority
MA
Morocco
Prior art keywords
disorders
halogen
lower alkoxy
substituted
diabetes
Prior art date
Application number
MA36585A
Other languages
English (en)
Inventor
Roger Norcross
Philippe Pflieger
Guido Galley
RENé TRUSSARDI
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46298391&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35194(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA35194B1 publication Critical patent/MA35194B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cette invention concerne des composés de formule (i), ou un sel d'addition d'acide pharmaceutiquement acceptable de ceux-ci, qui peuvent être utilisés pour traiter la dépression, les troubles de l'anxiété, le trouble bipolaire, les troubles déficitaires de l'attention avec hyperactivité (tdah), les troubles liés au stress, les troubles psychotiques, la schizophrénie, les maladies neurologiques, la maladie de parkinson, les troubles neurodégénératifs, la maladie d'alzheimer, l'épilepsie, la migraine, l'hypertension, la toxicomanie, les troubles métaboliques, les troubles du comportement alimentaire, le diabète, les complications du diabète, l'obésité, la dyslipidémie, les troubles de la consommation et de l'assimilation énergétique, les troubles et le dérèglement de l'homéostasie de la température corporelle, les troubles du sommeil et du rythme circadien, et les troubles cardiovasculaires. Dans la formule (i), r1 est un atome d'hydrogène, un halogène, un groupe cyano, alkyle inférieur, alkyle inférieur substitué par un atome d'halogène, alcoxy inférieur, alcoxy inférieur substitué par un atome d'halogène ou c(o)nh2, ou est un phényle éventuellement substitué par un halogène, un cyano ou un alcoxy inférieur substitué par un atome d'halogène, ou est un 2,2-difluorobenzo[d][l,3]
MA36585A 2011-06-10 2013-12-18 Derives de benzamide substitues MA35194B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11169441 2011-06-10
PCT/EP2012/060637 WO2012168265A1 (fr) 2011-06-10 2012-06-06 Dérivés de benzamide substitués

Publications (1)

Publication Number Publication Date
MA35194B1 true MA35194B1 (fr) 2014-06-02

Family

ID=46298391

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36585A MA35194B1 (fr) 2011-06-10 2013-12-18 Derives de benzamide substitues

Country Status (32)

Country Link
US (1) US9029370B2 (fr)
EP (1) EP2718271B1 (fr)
JP (1) JP5788087B2 (fr)
KR (1) KR101574906B1 (fr)
CN (1) CN103596937B (fr)
AR (1) AR086880A1 (fr)
AU (1) AU2012266462B2 (fr)
BR (1) BR112013030698B1 (fr)
CA (1) CA2834675C (fr)
CL (1) CL2013003485A1 (fr)
CO (1) CO6811866A2 (fr)
CY (1) CY1116769T1 (fr)
DK (1) DK2718271T3 (fr)
EA (1) EA022376B1 (fr)
EC (1) ECSP13013073A (fr)
ES (1) ES2546529T3 (fr)
HR (1) HRP20151201T1 (fr)
IL (1) IL229335A (fr)
MA (1) MA35194B1 (fr)
MX (1) MX354410B (fr)
MY (1) MY162461A (fr)
PE (1) PE20140968A1 (fr)
PH (1) PH12013502263A1 (fr)
PL (1) PL2718271T3 (fr)
PT (1) PT2718271E (fr)
RS (1) RS54415B1 (fr)
SG (1) SG194840A1 (fr)
SI (1) SI2718271T1 (fr)
TW (1) TWI445701B (fr)
UA (1) UA110388C2 (fr)
WO (1) WO2012168265A1 (fr)
ZA (1) ZA201308401B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9073911B2 (en) * 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
KR101631003B1 (ko) 2012-01-12 2016-06-15 에프. 호프만-라 로슈 아게 미량 아민 결합 수용체(taar)로서 헤테로환형 유도체
EA026062B1 (ru) * 2012-09-14 2017-02-28 Ф. Хоффманн-Ля Рош Аг Производные пиразолкарбоксамида в качестве модуляторов рецепторов следовых аминов (taar) для применения при лечении различных расстройств, таких как депрессия, диабет и болезнь паркинсона
HK1206714A1 (en) * 2012-09-17 2016-01-15 霍夫曼-拉罗奇有限公司 Triazole carboxamide derivatives
WO2014072257A1 (fr) * 2012-11-07 2014-05-15 F. Hoffmann-La Roche Ag Dérivés de pyrazine
WO2015165085A1 (fr) * 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Dérivés de morpholine-pyridine
KR101880841B1 (ko) * 2014-05-28 2018-07-20 에프. 호프만-라 로슈 아게 미량 아민 결합 수용체 1(taar1) 조절제로서 5-옥사-2-아자바이사이클로[2.2.2]옥탄-4-일 및 5-옥사-2-아자바이사이클로[2.2.1]헵탄-4-일 유도체
CN104478798B (zh) * 2014-12-18 2017-01-18 武汉华纳联合药业有限公司 N‑氨基烷基磺酰基‑3‑吡啶甲酰胺衍生物及其在制备治疗心脑血管病药物中的应用
MY195528A (en) * 2016-03-17 2023-01-30 Hoffmann La Roche 5-Ethyl-4-Methyl-Pyrazole-3-Carboxamide Derivative Having Activity as Agonist of Taar
CN114144412A (zh) * 2019-07-11 2022-03-04 豪夫迈·罗氏有限公司 用于制备经取代的吡唑衍生物的方法
MX2022010693A (es) * 2020-02-28 2022-09-26 Univ Texas Compuestos, composiciones y metodos para inhibidores de la proteina quinasa que interactua con el receptor i para el tratamiento de enfermedades.
WO2024118488A1 (fr) * 2022-11-28 2024-06-06 Sumitomo Pharma America, Inc. Composés de 2-phénylmorpholine et de 2-phényl(thio)morpholine et utilisations associées
WO2025165773A1 (fr) * 2024-02-01 2025-08-07 Board Of Regents, The University Of Texas System Inhibiteurs de la protéine kinase 1 interagissant avec des récepteurs pour le traitement d'une maladie
WO2025165774A1 (fr) * 2024-02-01 2025-08-07 Board Of Regents, The University Of Texas System Inhibiteurs de la protéine kinase 1 interagissant avec des récepteurs pour le traitement d'une maladie

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9425211D0 (en) 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
BR9813381A (pt) 1997-12-04 2000-10-03 Allergan Sales Inc "derivados de imidazol substituìdo possuindo atividade semelhante a agonista em receptores adrenérgicos alfa 2b ou 2b/2c"
US6841684B2 (en) 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
AR050865A1 (es) * 2004-09-09 2006-11-29 Sanofi Aventis Derivados de 2- morfolino-4-pirimidona
WO2008026046A1 (fr) 2006-08-30 2008-03-06 Pfizer Products Inc. Antagonistes à base de morpholine de la dopamine d3
CL2007003874A1 (es) * 2007-01-03 2008-05-16 Boehringer Ingelheim Int Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio
BRPI0806932A2 (pt) * 2007-02-02 2014-05-06 Novartis Ag Antagonista do receptor s1p1 de cromeno
MX2009008465A (es) 2007-02-15 2009-08-20 Hoffmann La Roche Nuevas 2-aminooxazolinas como ligandos de taar1.
AU2008281877A1 (en) 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag The use of benzamide derivatives for the treatment of CNS disorders
AR077969A1 (es) 2009-08-31 2011-10-05 Abbott Healthcare Products Bv Derivados de (tio)morfolina comomoduladores de s1p
CA2771822C (fr) 2009-09-04 2020-08-11 Daniel A. Erlanson Inhibiteurs de tyrosine kinase de bruton
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) * 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US9132136B2 (en) 2010-08-02 2015-09-15 Hoffmann-La Roche Inc. Pharmaceutical combination
US9073911B2 (en) * 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives

Also Published As

Publication number Publication date
US9029370B2 (en) 2015-05-12
MY162461A (en) 2017-06-15
SG194840A1 (en) 2013-12-30
UA110388C2 (xx) 2015-12-25
TWI445701B (zh) 2014-07-21
CA2834675C (fr) 2019-09-03
IL229335A0 (en) 2014-01-30
BR112013030698B1 (pt) 2022-05-31
TW201307308A (zh) 2013-02-16
EP2718271A1 (fr) 2014-04-16
KR101574906B1 (ko) 2015-12-04
MX2013014371A (es) 2014-01-31
HRP20151201T1 (hr) 2015-12-04
EA201391815A1 (ru) 2014-04-30
PL2718271T3 (pl) 2016-01-29
AU2012266462B2 (en) 2016-09-22
EA022376B1 (ru) 2015-12-30
SI2718271T1 (sl) 2015-11-30
PE20140968A1 (es) 2014-08-06
DK2718271T3 (en) 2015-08-24
IL229335A (en) 2016-11-30
AR086880A1 (es) 2014-01-29
US20120316165A1 (en) 2012-12-13
AU2012266462A1 (en) 2013-10-31
CL2013003485A1 (es) 2014-09-12
JP5788087B2 (ja) 2015-09-30
ES2546529T3 (es) 2015-09-24
WO2012168265A1 (fr) 2012-12-13
BR112013030698A2 (pt) 2016-12-06
NZ616820A (en) 2015-11-27
RS54415B1 (sr) 2016-04-28
HK1192562A1 (zh) 2014-08-22
PH12013502263A1 (en) 2016-06-29
CO6811866A2 (es) 2013-12-16
CY1116769T1 (el) 2017-03-15
PT2718271E (pt) 2015-10-29
ECSP13013073A (es) 2014-01-31
CN103596937B (zh) 2016-06-29
ZA201308401B (en) 2014-08-27
JP2014516067A (ja) 2014-07-07
CN103596937A (zh) 2014-02-19
KR20140028102A (ko) 2014-03-07
MX354410B (es) 2018-03-05
EP2718271B1 (fr) 2015-08-12
CA2834675A1 (fr) 2012-12-13

Similar Documents

Publication Publication Date Title
MA35192B1 (fr) Derives de pyrazole
MA32486B1 (fr) Derives de 4,5- dihydrooxazol-2-yle
MA35062B1 (fr) Dérivés d'amines hétérocycliques
MA31165B1 (fr) Nouvelles 2-aminooxazolines servant de ligands du taar1 pour des troubles du snc
TW200738645A (en) Use of 4-imidazole derivatives for CNS disorders
MX2012007409A (es) Derivados de benzamida sustituidos.
MX354815B (es) Derivados heterociclicos como receptores asociados con las aminas traza (taars).
TW200738690A (en) Use of 2-imidazoles for the treatment of CNS disorders
MX2015001108A (es) Derivados de triazol carboxamida.
MX2009003887A (es) Aminometil-2-imidazoles con afinidad con los receptores asociados a trazas de amina.
MX2012005363A (es) Derivados de oxazolina para el tratamiento de trastornos del sistema nervioso central (snc).
MX2009005920A (es) Nuevos 2-imidazoles como ligandos para receptores asociados con trazas de amina.
MA37944A1 (fr) Dérivés de pyrazole-carboxamide en tant que modulateurs de taar pour utilisation dans le traitement de plusieurs troubles, tels que la dépression, le diabète et la maladie de parkinson
MX2016016488A (es) Derivados de azetidina sustituidos como ligandos de receptores asociados a aminas en trazas (taar).
MX2009006215A (es) 4-imidazolinas como ligandos de aminas trazas.
MX377195B (es) Derivados de morfolina-piridina.
MX2009013745A (es) 4-imidazolinas y su uso como antidepresivos.
WO2007090720A3 (fr) Utilisation de 2-imidazoles pour le traitement de troubles du système nerveux central
MX349738B (es) Derivados de dihidrooxazol-2-amina.
MX2009004617A (es) 2-imidazoles sustituidos como moduladores de los receptores asociados con trazas de amina.
MX2015005721A (es) Derivados de pirazina.
MX2009005047A (es) 4-imidazoles sustituidos.
RU2010104632A (ru) 2-азетидинметанамины и 2-пирролидинметанамины в качестве лигандов taar