MA35210B1 - Polythérapie comportant un inhibiteur de cdk4/6 et un inhibiteur de pi3k à utiliser dans le traitement du cancer - Google Patents

Polythérapie comportant un inhibiteur de cdk4/6 et un inhibiteur de pi3k à utiliser dans le traitement du cancer

Info

Publication number
MA35210B1
MA35210B1 MA36616A MA36616A MA35210B1 MA 35210 B1 MA35210 B1 MA 35210B1 MA 36616 A MA36616 A MA 36616A MA 36616 A MA36616 A MA 36616A MA 35210 B1 MA35210 B1 MA 35210B1
Authority
MA
Morocco
Prior art keywords
inhibitor
cdk4
cancer
treatment
combination therapy
Prior art date
Application number
MA36616A
Other languages
English (en)
Inventor
Sunkyu Kim
Shivang Doshi
Kristy Haas
Steven Kovats
Alan Xizhong Huang
Yan Chen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46513871&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35210(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA35210B1 publication Critical patent/MA35210B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne une combinaison d'un inhibiteur de cdk4/6 et d'un inhibiteur de p3kinase pour le traitement du cancer.
MA36616A 2011-07-01 2013-12-26 Polythérapie comportant un inhibiteur de cdk4/6 et un inhibiteur de pi3k à utiliser dans le traitement du cancer MA35210B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161503642P 2011-07-01 2011-07-01
PCT/US2012/045199 WO2013006532A1 (fr) 2011-07-01 2012-07-02 Polythérapie comportant un inhibiteur de cdk4/6 et un inhibiteur de pi3k à utiliser dans le traitement du cancer

Publications (1)

Publication Number Publication Date
MA35210B1 true MA35210B1 (fr) 2014-06-02

Family

ID=46513871

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36616A MA35210B1 (fr) 2011-07-01 2013-12-26 Polythérapie comportant un inhibiteur de cdk4/6 et un inhibiteur de pi3k à utiliser dans le traitement du cancer

Country Status (23)

Country Link
US (2) US9271988B2 (fr)
EP (1) EP2726074B1 (fr)
JP (2) JP5832647B2 (fr)
KR (1) KR20140040770A (fr)
CN (1) CN103635189B (fr)
AU (3) AU2012279117A1 (fr)
BR (1) BR112013033940A2 (fr)
CA (1) CA2840754A1 (fr)
CL (1) CL2013003805A1 (fr)
CO (1) CO6842016A2 (fr)
EA (1) EA030465B1 (fr)
ES (1) ES2676180T3 (fr)
GT (1) GT201300320A (fr)
IL (1) IL229876B (fr)
MA (1) MA35210B1 (fr)
MX (1) MX359406B (fr)
MY (1) MY161237A (fr)
PE (1) PE20141381A1 (fr)
PH (1) PH12013502697A1 (fr)
TN (1) TN2013000508A1 (fr)
UA (1) UA114178C2 (fr)
WO (1) WO2013006532A1 (fr)
ZA (1) ZA201309241B (fr)

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US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
MX2010007419A (es) 2008-01-04 2010-11-12 Intellikine Inc Ciertas entidades quimicas, composiciones y metodos.
ES2637113T3 (es) 2011-01-10 2017-10-10 Infinity Pharmaceuticals, Inc. Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas
EP2726074B1 (fr) * 2011-07-01 2018-04-04 Novartis AG Polythérapie comportant un inhibiteur de cdk4/6 et un inhibiteur de pi3k à utiliser dans le traitement du cancer
MX2014011843A (es) * 2012-03-30 2014-12-10 Novartis Ag Compuestos para usarse en el tratamiento de neuroblastoma, sarcoma de ewing o rabdomiosarcoma.
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
AU2013296237B2 (en) 2012-08-03 2019-05-16 Foundation Medicine, Inc. Human papilloma virus as predictor of cancer prognosis
AU2013337717B2 (en) 2012-11-01 2018-10-25 Infinity Pharmaceuticals, Inc. Treatment of cancers using PI3 kinase isoform modulators
EP2742940B1 (fr) 2012-12-13 2017-07-26 IP Gesellschaft für Management mbH Sel de fumarate de (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-l-aza-bicyclo-[2.2.2]octane destinés à être administrés une fois par jour, deux fois par jour ou trois fois par jour
CA2906157C (fr) 2013-03-15 2022-05-17 G1 Therapeutics, Inc. Agents antineoplasiques et antiproliferatifs hautement actifs
ME03557B (fr) 2013-03-15 2020-07-20 G1 Therapeutics Inc Protection transitoire de cellules normales pendant une chimiothérapie
CN105828822B (zh) * 2013-08-14 2019-10-18 诺华股份有限公司 用于治疗癌症的组合疗法
WO2015160975A2 (fr) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Polythérapies
US20150320754A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
WO2015161288A1 (fr) 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Lactames tricycliques utilisés en tant qu'agents anti-néoplasiques et anti-prolifératifs
WO2016040848A1 (fr) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Traitement de tumeurs rb-négatives en utilisant des inhibiteurs de la topoisomérase en association avec des inhibiteurs des kinases cycline-dépendantes 4/6
EP3191098A4 (fr) 2014-09-12 2018-04-25 G1 Therapeutics, Inc. Combinaisons et régimes posologiques pour traiter des tumeurs rb-positives
AU2016287463B2 (en) 2015-07-02 2020-07-02 F. Hoffmann-La Roche Ag Benzoxazepin oxazolidinone compounds and methods of use
CN111848643A (zh) 2015-07-02 2020-10-30 豪夫迈·罗氏有限公司 苯并氧氮杂*噁唑烷酮化合物及其使用方法
WO2017037575A1 (fr) * 2015-08-28 2017-03-09 Novartis Ag Combinaison pharmaceutique comprenant l'inhibiteur de pi3k alpelisib et l'inhibiteur de cdk4/6 ribociclib et son utilisation dans le traitement/la prévention du cancer
US10690673B2 (en) 2016-03-29 2020-06-23 Mayo Foundation For Medical Education And Research Method of treating cancer metastasis by CDK 4/6 inhibitors
SG11201811237WA (en) 2016-06-24 2019-01-30 Infinity Pharmaceuticals Inc Combination therapies
WO2018017410A1 (fr) 2016-07-22 2018-01-25 Eli Lilly And Company Polythérapie à base d'abemaciclib et d'un inhibiteur double de kinase pi3 /mtor, destinée à être utilisée dans le traitement du cancer du sein
WO2018081211A1 (fr) * 2016-10-26 2018-05-03 Li George Y 7-cyclopentyl-n,n-diméthyl-2-((5- (pipérazin-1-yl)pyridin-2-yl)amino)-7h- pyrrolo[2,3-d]pyrimidine-6-carboxamide deutéré
KR20190092478A (ko) 2016-12-05 2019-08-07 쥐원 쎄라퓨틱스, 인크. 화학요법 레지멘 동안의 면역 반응의 보존
US11395821B2 (en) 2017-01-30 2022-07-26 G1 Therapeutics, Inc. Treatment of EGFR-driven cancer with fewer side effects
EP3738084A4 (fr) 2018-01-08 2021-11-17 G1 Therapeutics, Inc. Régimes de dosage supérieur de g1t38
KR20210031852A (ko) * 2018-03-05 2021-03-23 클리니쿰 레히츠 데어 이자르 데어 테크니쉔 우니베르지테트 뮌헨 종양 세포 붕괴성 아데노바이러스와 cdk4/6 억제제의 조합물에 의한 종양의 치료
CN111184863B (zh) * 2018-11-15 2023-06-16 江苏恒瑞医药股份有限公司 酪氨酸激酶抑制剂、cdk4/6抑制剂、serd联合在制备治疗肿瘤的药物中的用途
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
US20240307393A1 (en) * 2021-07-06 2024-09-19 National Cancer Center Pharmaceutical composition for cancer prevention or treatment, comprising cdk4/6 inhibitor and tricyclic antidepressant

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UY33227A (es) 2010-02-19 2011-09-30 Novartis Ag Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
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EP2726074B1 (fr) * 2011-07-01 2018-04-04 Novartis AG Polythérapie comportant un inhibiteur de cdk4/6 et un inhibiteur de pi3k à utiliser dans le traitement du cancer
EP2925365A1 (fr) * 2012-11-28 2015-10-07 Novartis AG Polythérapie

Also Published As

Publication number Publication date
EP2726074A1 (fr) 2014-05-07
BR112013033940A2 (pt) 2017-02-14
EA201490194A1 (ru) 2014-04-30
ES2676180T3 (es) 2018-07-17
MX2013015370A (es) 2014-02-11
JP5832647B2 (ja) 2015-12-16
JP2014518279A (ja) 2014-07-28
CN103635189B (zh) 2016-05-04
GT201300320A (es) 2016-03-01
AU2016202213A1 (en) 2016-05-05
AU2017232162B2 (en) 2019-03-07
CN103635189A (zh) 2014-03-12
ZA201309241B (en) 2014-08-27
EP2726074B1 (fr) 2018-04-04
US20140107114A1 (en) 2014-04-17
JP2016027043A (ja) 2016-02-18
US20160136171A1 (en) 2016-05-19
KR20140040770A (ko) 2014-04-03
AU2017232162A1 (en) 2017-10-12
EA030465B1 (ru) 2018-08-31
PE20141381A1 (es) 2014-10-21
CL2013003805A1 (es) 2014-08-08
TN2013000508A1 (en) 2015-03-30
AU2012279117A1 (en) 2014-01-09
PH12013502697A1 (en) 2014-02-10
IL229876B (en) 2018-10-31
MX359406B (es) 2018-09-27
CO6842016A2 (es) 2014-01-20
US10010552B2 (en) 2018-07-03
US9271988B2 (en) 2016-03-01
WO2013006532A1 (fr) 2013-01-10
UA114178C2 (uk) 2017-05-10
MY161237A (en) 2017-04-14
CA2840754A1 (fr) 2013-01-10

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