MA35460B1 - Composés et compositions en tant qu'inhibiteurs de kinase c-kit - Google Patents

Composés et compositions en tant qu'inhibiteurs de kinase c-kit

Info

Publication number
MA35460B1
MA35460B1 MA36864A MA36864A MA35460B1 MA 35460 B1 MA35460 B1 MA 35460B1 MA 36864 A MA36864 A MA 36864A MA 36864 A MA36864 A MA 36864A MA 35460 B1 MA35460 B1 MA 35460B1
Authority
MA
Morocco
Prior art keywords
compounds
kinase inhibitors
compositions
kit kinase
kit
Prior art date
Application number
MA36864A
Other languages
English (en)
Inventor
Valentina Molteni
Hank Michael James Petrassi
Xiaolin Li
Xiaodong Liu
Jon Loren
Juliet Nabakka
Bao Nguyen
Vince Yeh
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of MA35460B1 publication Critical patent/MA35460B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés de formules (i) et (ii), et leurs compositions pharmaceutiques, qui sont utiles comme inhibiteurs de protéine kinase, ainsi que des procédés d'utilisation de tels composés pour traiter, améliorer ou prévenir un état associé à une activité de kinase anormale ou dérégulée. Dans certains modes de réalisation, l'invention concerne des procédés d'utilisation de tels composés pour traiter, améliorer ou prévenir des maladies ou des troubles qui impliquent une activation anormale de la kinase c-kit ou des kinases c-kit et pdgfr (pdgfr±, pdgfr²).
MA36864A 2011-09-01 2014-03-28 Composés et compositions en tant qu'inhibiteurs de kinase c-kit MA35460B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161530038P 2011-09-01 2011-09-01
PCT/US2012/052802 WO2013033167A1 (fr) 2011-09-01 2012-08-29 Composés et compositions en tant qu'inhibiteurs de kinase c-kit

Publications (1)

Publication Number Publication Date
MA35460B1 true MA35460B1 (fr) 2014-09-01

Family

ID=46829904

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36864A MA35460B1 (fr) 2011-09-01 2014-03-28 Composés et compositions en tant qu'inhibiteurs de kinase c-kit

Country Status (30)

Country Link
US (3) US8569283B2 (fr)
EP (1) EP2751104B1 (fr)
JP (1) JP6134319B2 (fr)
KR (1) KR101962495B1 (fr)
CN (1) CN103797011B (fr)
AP (1) AP2014007493A0 (fr)
AR (1) AR087753A1 (fr)
AU (1) AU2012302042B2 (fr)
BR (1) BR112014004560A2 (fr)
CA (1) CA2845169C (fr)
CL (1) CL2014000492A1 (fr)
CO (1) CO6900141A2 (fr)
CR (1) CR20140107A (fr)
CU (1) CU20140024A7 (fr)
EA (1) EA026152B1 (fr)
ES (1) ES2761332T3 (fr)
GT (1) GT201400034A (fr)
IL (1) IL231227A0 (fr)
MA (1) MA35460B1 (fr)
MX (1) MX339937B (fr)
PE (1) PE20140909A1 (fr)
PH (1) PH12014500372A1 (fr)
PL (1) PL2751104T3 (fr)
PT (1) PT2751104T (fr)
SG (1) SG2014014369A (fr)
TN (1) TN2014000068A1 (fr)
TW (1) TW201313717A (fr)
UY (1) UY34301A (fr)
WO (1) WO2013033167A1 (fr)
ZA (1) ZA201401175B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9199981B2 (en) * 2011-09-01 2015-12-01 Novartis Ag Compounds and compositions as C-kit kinase inhibitors
WO2013033167A1 (fr) 2011-09-01 2013-03-07 Irm Llc Composés et compositions en tant qu'inhibiteurs de kinase c-kit
CN109568319A (zh) 2013-01-10 2019-04-05 普尔莫凯恩股份有限公司 非选择性激酶抑制剂
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
WO2015054574A1 (fr) 2013-10-11 2015-04-16 Zisman Lawrence S Formulations sèches de pulvérisation
US20150288928A1 (en) * 2014-04-08 2015-10-08 Sony Corporation Security camera system use of object location tracking data
CN105384738B (zh) * 2014-08-21 2017-08-29 上海科州药物研发有限公司 作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
EP4074378A1 (fr) 2015-07-02 2022-10-19 Janssen Sciences Ireland Unlimited Company Composés antibactériens
US10474987B2 (en) * 2015-08-05 2019-11-12 Whirlpool Corporation Object recognition system for an appliance and method for managing household inventory of consumables
WO2017214413A1 (fr) * 2016-06-08 2017-12-14 Chrysalis, Inc. Dérivés d'imidazo[1,2-a]pyridine utilisés en tant qu'inhibiteurs d'histone déméthylase
KR20190018681A (ko) 2016-06-16 2019-02-25 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 항균제로서의 헤테로고리 화합물
EA201990043A1 (ru) 2016-06-16 2019-05-31 Янссен Сайенсиз Айрлэнд Анлимитед Компани Антибактериальные соединения
EP3515446B1 (fr) 2016-09-19 2023-12-20 Novartis AG Combinaisons thérapeutiques comprenant un inhibiteur de raf et un inhibiteur d'erk
CN110087653A (zh) 2016-10-27 2019-08-02 普尔莫凯恩股份有限公司 用于治疗肺高血压的组合疗法
US20180162291A1 (en) * 2016-12-12 2018-06-14 Wipro Limited System and method of dynamically adjusting field of view of an image capturing device
EP4417262A3 (fr) 2017-03-01 2024-11-27 Janssen Sciences Ireland Unlimited Company Polythérapie
US11266653B2 (en) 2017-05-02 2022-03-08 Novartis Ag Combination therapy
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
KR102625224B1 (ko) * 2018-10-31 2024-01-15 주식회사 큐로젠 피라졸-온 유도체를 유효성분으로 포함하는 자가면역질환의 예방, 개선 또는 치료용 조성물
EP3942045A1 (fr) 2019-03-21 2022-01-26 Onxeo Molécule dbait associée à un inhibiteur de kinase pour le traitement du cancer
ES3025633T3 (en) 2019-05-13 2025-06-09 Novartis Ag New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
AU2020274564A1 (en) * 2019-05-13 2021-12-09 Novartis Ag Crystalline forms of N- (5- (5- ( (1R, 2S) -2-fluorocyclopropyl) -1, 2, 4-oxadiazol-3-yl) -2-methylphenyl) imidazo [1, 2-a] pyridine-3-carboxamide
WO2021035788A1 (fr) 2019-08-29 2021-03-04 中国科学院合肥物质科学研究院 Dérivé de pyrazole et son utilisation
KR102955654B1 (ko) 2019-09-13 2026-04-21 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 항균 화합물
EP4054579A1 (fr) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Méthodes pour le traitement de cancers qui ont acquis une résistance aux inhibiteurs de kinase
MX2022007044A (es) 2019-12-13 2022-06-24 Nippon Shinyaku Co Ltd Compuesto y composicion como inhibidor de cinasa del receptor de los factores de crecimiento derivados de las plaquetas (pdgf).
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
WO2022016021A1 (fr) 2020-07-15 2022-01-20 Third Harmonic Bio, Inc. Formes cristallines d'un inhibiteur sélectif de kinase c-kit
TW202237097A (zh) * 2020-11-19 2022-10-01 美商第三諧波生物公司 選擇性ｃ－ｋｉｔ激酶抑制劑之醫藥組合物及其製造及使用方法
KR20230157400A (ko) 2021-03-16 2023-11-16 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 항박테리아성 화합물
CA3212074A1 (fr) 2021-03-17 2022-09-22 Janssen Sciences Ireland Unlimited Company Composes antibacteriens
WO2022194905A1 (fr) 2021-03-17 2022-09-22 Janssen Sciences Ireland Unlimited Company Composés antibactériens
TW202325274A (zh) 2021-10-28 2023-07-01 愛爾蘭商健生科學愛爾蘭無限公司 抗菌化合物
WO2024089170A1 (fr) 2022-10-27 2024-05-02 Janssen Sciences Ireland Unlimited Company Composés antibactériens
WO2024118887A1 (fr) 2022-11-30 2024-06-06 Blueprint Medicines Corporation Dérivés de n-phényl-pyrazolo[1,5-a]pyridine-3-carboxamide utilisés en tant qu'inhibiteurs de kinase c-kit de type sauvage pour le traitement de l'urticaire
JP2025541190A (ja) * 2022-12-07 2025-12-18 サード ハーモニック バイオ， インコーポレイテッド Ｃ－ｋｉｔキナーゼ阻害剤としての化合物及び組成物
WO2024123966A1 (fr) * 2022-12-07 2024-06-13 Third Harmonic Bio, Inc. Composés et compositions utilisés en tant qu'inhibiteurs de c-kit kinase
WO2024223859A1 (fr) 2023-04-26 2024-10-31 Janssen Pharmaceutica Nv Composés antibactériens
WO2025072330A1 (fr) * 2023-09-26 2025-04-03 Arcus Biosciences, Inc. Composés inhibiteurs de kit et leurs procédés d'utilisation
WO2025256552A1 (fr) * 2024-06-11 2025-12-18 上海翰森生物医药科技有限公司 Inhibiteur de dérivé pyrazole, son procédé de préparation et son utilisation
WO2025256609A1 (fr) * 2024-06-13 2025-12-18 Third Harmonic Bio, Inc. Formes cristallines d'un inhibiteur sélectif de kinase c-kit
WO2025259929A1 (fr) * 2024-06-13 2025-12-18 Third Harmonic Bio, Inc. Composés et compositions utilisés en tant qu'inhibiteurs de kinase c-kit

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004001903A2 (fr) 2002-06-20 2003-12-31 Beacon Looms, Inc. Tricot electriquement conducteur
CA2514733A1 (fr) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Compositions pharmaceutiques a base d'un co-cristal
BRPI0515081B8 (pt) 2004-09-09 2021-05-25 Natco Pharma Ltd composto, processo para a preparação de um sal de guanidino trifluormetilaroil amida, processo para a preparação de um fenil amino pirido pirimidina, composições farmacêuticas e processos para preparar (3,5-bis trifluormetil)-n-[4-metil-3-(4-piridin-3-il-pirimidin-2-ilamino)-fenil]-benzamida
WO2006071940A2 (fr) 2004-12-23 2006-07-06 Deciphera Pharmaceuticals, Llc Modulateurs d'enzymes et traitements
US7754717B2 (en) * 2005-08-15 2010-07-13 Amgen Inc. Bis-aryl amide compounds and methods of use
AU2007317349B2 (en) * 2006-11-03 2011-10-20 Irm Llc Compounds and compositions as protein kinase inhibitors
MX2013005454A (es) * 2010-11-15 2013-06-24 Abbvie Inc Inhibidores de nampt y rock.
US20130023751A1 (en) 2011-07-18 2013-01-24 Samuel Victor Lichtenstein Water retention monitoring
JP2014525462A (ja) 2011-09-01 2014-09-29 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｐｄｇｆｒキナーゼ阻害剤としての化合物および組成物
US9199981B2 (en) 2011-09-01 2015-12-01 Novartis Ag Compounds and compositions as C-kit kinase inhibitors
BR112014003963A2 (pt) 2011-09-01 2017-03-21 Irm Llc compostos e composições como inibidores de quinase c-kit
WO2013033167A1 (fr) 2011-09-01 2013-03-07 Irm Llc Composés et compositions en tant qu'inhibiteurs de kinase c-kit

Also Published As

Publication number Publication date
EA026152B1 (ru) 2017-03-31
AR087753A1 (es) 2014-04-16
CN103797011B (zh) 2016-03-30
US20140228347A1 (en) 2014-08-14
GT201400034A (es) 2015-02-19
KR101962495B1 (ko) 2019-03-26
CL2014000492A1 (es) 2014-10-03
BR112014004560A2 (pt) 2017-04-04
SG2014014369A (en) 2014-09-26
MX2014002484A (es) 2014-11-25
PH12014500372A1 (en) 2014-04-07
PL2751104T3 (pl) 2020-04-30
PE20140909A1 (es) 2014-07-20
PT2751104T (pt) 2019-12-16
AU2012302042A1 (en) 2014-04-17
UY34301A (es) 2013-04-05
AU2012302042B2 (en) 2016-03-31
AP2014007493A0 (en) 2014-03-31
CA2845169C (fr) 2022-04-19
EP2751104B1 (fr) 2019-09-25
CO6900141A2 (es) 2014-03-20
TW201313717A (zh) 2013-04-01
US9023839B2 (en) 2015-05-05
US20140031333A1 (en) 2014-01-30
ES2761332T3 (es) 2020-05-19
TN2014000068A1 (en) 2015-07-01
ZA201401175B (en) 2015-01-28
CA2845169A1 (fr) 2013-03-07
EA201490545A1 (ru) 2014-07-30
US8569283B2 (en) 2013-10-29
MX339937B (es) 2016-06-17
CU20140024A7 (es) 2014-04-24
US20130059832A1 (en) 2013-03-07
CR20140107A (es) 2014-05-02
JP2014525448A (ja) 2014-09-29
US8754071B2 (en) 2014-06-17
KR20140075692A (ko) 2014-06-19
IL231227A0 (en) 2014-04-30
JP6134319B2 (ja) 2017-05-24
EP2751104A1 (fr) 2014-07-09
CN103797011A (zh) 2014-05-14
WO2013033167A1 (fr) 2013-03-07

Similar Documents

Publication Publication Date Title
MA34969B1 (fr) Composes et compositions en tant qu inibiteurs de trk
MA35459B1 (fr) Composés et compositions pouvant être utilisés en tant qu'inhibiteurs de la kinase c-kit
MA34948B1 (fr) Composes et procedes de modulation de kinase, et leurs indications
MA37739A1 (fr) Composés et compositions destinés à la modulation de l'activité de l'egfr
MA47043A1 (fr) Composés indole carboxamides utiles comme inhibiteurs de kinase
MA44312A (fr) Anticorps et leurs méthodes d'utilisation
MA40240A (fr) Composés hétéroaryle d'inhibition de la kinase
MA40290A1 (fr) Agents immunorégulateurs
MA30906B1 (fr) Composes et compositions en tant quinhibiteurs des proteines kinases
EA201490545A1 (ru) СОЕДИНЕНИЯ И КОМПОЗИЦИИ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ С-Kit
MA31167B1 (fr) Inhibiteurs de l'activite de akt
MA41179A (fr) Composés inhibiteurs de parg
BR112014004465A2 (pt) compostos e composições como inibidores de pdgfr cinase
MA30462B1 (fr) Composes de pyridylamide antagonistes des canaux calciques de type t
MA30772B1 (fr) Composes et compositions utilises en tant qu'inhibiteurs de proteine kinase
MX2009011951A (es) Compuestos y composiciones como inhibidores de cinasa c-kit y pdgfr.
MA33334B1 (fr) Derives de l-(piperidine-4-yl)-pyrazole servant de modulateurs de gpr 119
MA34474B1 (fr) Agonistes de gpr40
MX2009008099A (es) Compuestos para la prevencion y tratamiento de enfermedades cardiovasculares.
MA32729B1 (fr) Derives d'acide 1-amino-2-cyclobutylethylboronique
MA38076A1 (fr) Dérivés d'oxazolidin-2-one-pyrimidine
BR112014003963A2 (pt) compostos e composições como inibidores de quinase c-kit
MA38810B1 (fr) Inhibiteurs de rorc2 méthodes d'utilisation associées
BR112014004319A2 (pt) compostos e composições como inibidores de c-kit cinase
EP2563794A4 (fr) Inhibiteurs de l'activité protéine tyrosine kinase et leurs applications au traitement de troubles ophtalmiques