MA37849A1 - Dérivés de diazépinone à utiliser pour le traitement du syndrome de l'x fragile, de la maladie de parkinson ou de la maladie du reflux - Google Patents

Dérivés de diazépinone à utiliser pour le traitement du syndrome de l'x fragile, de la maladie de parkinson ou de la maladie du reflux

Info

Publication number
MA37849A1
MA37849A1 MA37849A MA37849A MA37849A1 MA 37849 A1 MA37849 A1 MA 37849A1 MA 37849 A MA37849 A MA 37849A MA 37849 A MA37849 A MA 37849A MA 37849 A1 MA37849 A1 MA 37849A1
Authority
MA
Morocco
Prior art keywords
disease
parkinson
syndrome
treating fragile
diazepinone derivatives
Prior art date
Application number
MA37849A
Other languages
English (en)
Inventor
Dirk Behnke
David Carcache
Peter Ertl
Manuel Koller
David Orain
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47045285&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA37849(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA37849A1 publication Critical patent/MA37849A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'invention concerne un composé de formule (i) ou un sel de celui-ci, pour lequel les substituants sont tels que définis dans la description ; sa préparation, son utilisation en tant que médicament et des médicaments le comprenant.
MA37849A 2012-08-23 2013-08-21 Dérivés de diazépinone à utiliser pour le traitement du syndrome de l'x fragile, de la maladie de parkinson ou de la maladie du reflux MA37849A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1215033.0A GB201215033D0 (en) 2012-08-23 2012-08-23 Diazepinone derivatives
PCT/IB2013/056782 WO2014030128A1 (fr) 2012-08-23 2013-08-21 Dérivés de diazépinone à utiliser pour le traitement du syndrome de l'x fragile, de la maladie de parkinson ou de la maladie du reflux

Publications (1)

Publication Number Publication Date
MA37849A1 true MA37849A1 (fr) 2017-09-29

Family

ID=47045285

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37849A MA37849A1 (fr) 2012-08-23 2013-08-21 Dérivés de diazépinone à utiliser pour le traitement du syndrome de l'x fragile, de la maladie de parkinson ou de la maladie du reflux

Country Status (43)

Country Link
US (4) US8853203B2 (fr)
EP (1) EP2888259B1 (fr)
JP (2) JP6169699B2 (fr)
KR (1) KR102104149B1 (fr)
CN (1) CN104520298B (fr)
AP (1) AP2014008140A0 (fr)
AR (1) AR092212A1 (fr)
AU (1) AU2013307239B2 (fr)
BR (1) BR112015003281A8 (fr)
CA (1) CA2878564C (fr)
CL (1) CL2015000416A1 (fr)
CR (1) CR20150092A (fr)
CU (1) CU20150016A7 (fr)
CY (1) CY1120728T1 (fr)
DK (1) DK2888259T3 (fr)
EA (1) EA029493B1 (fr)
ES (1) ES2672737T3 (fr)
GB (1) GB201215033D0 (fr)
GT (1) GT201500039A (fr)
HR (1) HRP20180850T1 (fr)
HU (1) HUE037971T2 (fr)
IL (1) IL237062A (fr)
JO (1) JOP20130250B1 (fr)
LT (1) LT2888259T (fr)
MA (1) MA37849A1 (fr)
MX (1) MX365253B (fr)
MY (1) MY170103A (fr)
NO (1) NO2888259T3 (fr)
NZ (1) NZ703628A (fr)
PE (1) PE20150401A1 (fr)
PH (1) PH12015500373A1 (fr)
PL (1) PL2888259T3 (fr)
PT (1) PT2888259T (fr)
RS (1) RS57231B1 (fr)
SG (2) SG10201701333WA (fr)
SI (1) SI2888259T1 (fr)
TN (1) TN2014000528A1 (fr)
TR (1) TR201807174T4 (fr)
TW (1) TWI616444B (fr)
UA (1) UA114326C2 (fr)
UY (1) UY34986A (fr)
WO (1) WO2014030128A1 (fr)
ZA (1) ZA201409345B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201215033D0 (en) 2012-08-23 2012-10-10 Novartis Ag Diazepinone derivatives
CA3066711A1 (fr) 2017-07-31 2019-02-07 Novartis Ag Utilisation de mavoglurant dans la reduction de l'utilisation de cocaine ou dans la prevention d'une rechute dans l'utilisation de cocaine
CA3124931A1 (fr) 2019-01-29 2020-08-06 Novartis Ag Utilisation d'un antagoniste mglur5 pour le traitement d'une tolerance analgesique aux opioides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853851A (en) * 1972-01-26 1974-12-10 Ciba Geigy Corp Diazepinoisoquinolines
GB0128996D0 (en) 2001-12-04 2002-01-23 Novartis Ag Organic compounds
JP2006521358A (ja) * 2003-03-26 2006-09-21 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体のベンズアミドモジュレータ
GB0413605D0 (en) * 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
TW200811157A (en) * 2006-05-05 2008-03-01 Astrazeneca Ab mGluR5 modulators I
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
CA2784830C (fr) * 2009-12-18 2018-03-27 Sunovion Pharmaceuticals Inc. Composes pour le traitement des troubles medies par le recepteur metabotropique 5 du glutamate, et leurs methodes d'utilisation
JP6110787B2 (ja) 2011-05-10 2017-04-05 協和発酵キリン株式会社 ピリミドジアゼピノン化合物
GB201215033D0 (en) * 2012-08-23 2012-10-10 Novartis Ag Diazepinone derivatives

Also Published As

Publication number Publication date
BR112015003281A8 (pt) 2018-01-16
ES2672737T3 (es) 2018-06-15
UA114326C2 (uk) 2017-05-25
PT2888259T (pt) 2018-06-06
JOP20130250B1 (ar) 2021-08-17
US20140357625A1 (en) 2014-12-04
EP2888259B1 (fr) 2018-03-07
TW201412736A (zh) 2014-04-01
MY170103A (en) 2019-07-05
CN104520298A (zh) 2015-04-15
MX2015002367A (es) 2015-06-03
PH12015500373B1 (en) 2015-04-20
MX365253B (es) 2019-05-28
HUE037971T2 (hu) 2018-10-29
NO2888259T3 (fr) 2018-08-04
NZ703628A (en) 2018-05-25
SG10201701333WA (en) 2017-04-27
PE20150401A1 (es) 2015-04-16
CY1120728T1 (el) 2019-12-11
AP2014008140A0 (en) 2014-12-31
UY34986A (es) 2014-03-31
WO2014030128A1 (fr) 2014-02-27
CN104520298B (zh) 2016-10-19
CL2015000416A1 (es) 2015-04-24
JP2017226661A (ja) 2017-12-28
HRP20180850T1 (hr) 2018-06-29
RS57231B1 (sr) 2018-07-31
AU2013307239A1 (en) 2015-01-29
SG11201500068QA (en) 2015-05-28
AR092212A1 (es) 2015-04-08
EP2888259A1 (fr) 2015-07-01
DK2888259T3 (en) 2018-06-14
US20170305903A1 (en) 2017-10-26
CR20150092A (es) 2015-05-04
US20140057902A1 (en) 2014-02-27
KR20150044897A (ko) 2015-04-27
CA2878564C (fr) 2021-08-03
SI2888259T1 (en) 2018-07-31
US9650377B2 (en) 2017-05-16
GT201500039A (es) 2018-11-27
US20160159795A1 (en) 2016-06-09
ZA201409345B (en) 2015-12-23
HK1206008A1 (en) 2015-12-31
LT2888259T (lt) 2018-06-11
TN2014000528A1 (en) 2016-03-30
PL2888259T3 (pl) 2018-08-31
JP6169699B2 (ja) 2017-07-26
PH12015500373A1 (en) 2015-04-20
TR201807174T4 (tr) 2018-06-21
CU20150016A7 (es) 2015-07-30
IL237062A (en) 2016-11-30
US8853203B2 (en) 2014-10-07
JP2015526461A (ja) 2015-09-10
EA029493B1 (ru) 2018-04-30
BR112015003281A2 (pt) 2017-07-04
GB201215033D0 (en) 2012-10-10
AU2013307239B2 (en) 2015-12-24
TWI616444B (zh) 2018-03-01
EA201590415A1 (ru) 2015-06-30
KR102104149B1 (ko) 2020-04-24
CA2878564A1 (fr) 2014-02-27
US9284331B2 (en) 2016-03-15

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MA37849A1 (fr) Dérivés de diazépinone à utiliser pour le traitement du syndrome de l'x fragile, de la maladie de parkinson ou de la maladie du reflux
MA38857B1 (fr) Dérivés de 1-(pipérazin-1-yl)-2-([1,2,4]triazol-1-yl)-éthanone