MA38413A1 - Anticorps pan-elr+ cxc chimiokine - Google Patents

Anticorps pan-elr+ cxc chimiokine

Info

Publication number
MA38413A1
MA38413A1 MA38413A MA38413A MA38413A1 MA 38413 A1 MA38413 A1 MA 38413A1 MA 38413 A MA38413 A MA 38413A MA 38413 A MA38413 A MA 38413A MA 38413 A1 MA38413 A1 MA 38413A1
Authority
MA
Morocco
Prior art keywords
elr
pan
cxc chemokine
chemokine antibody
antibody
Prior art date
Application number
MA38413A
Other languages
English (en)
Inventor
Catherine Brautigam Beidler
Kristine Kay Kikly
Beth Ann Strifler
Derrick Ryan Witcher
Jeffrey Streetman Boyles
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA38413A1 publication Critical patent/MA38413A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

L'invention concerne des anticorps qui se lient spécifiquement à sept chimiokines humaines elr
MA38413A 2013-03-15 2014-03-05 Anticorps pan-elr+ cxc chimiokine MA38413A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361792800P 2013-03-15 2013-03-15
PCT/US2014/020605 WO2014149733A1 (fr) 2013-03-15 2014-03-05 Anticorps pan-elr+ cxc chimiokine

Publications (1)

Publication Number Publication Date
MA38413A1 true MA38413A1 (fr) 2017-10-31

Family

ID=50343858

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38413A MA38413A1 (fr) 2013-03-15 2014-03-05 Anticorps pan-elr+ cxc chimiokine

Country Status (35)

Country Link
EP (4) EP2970447B1 (fr)
JP (1) JP6105146B2 (fr)
KR (1) KR101745230B1 (fr)
CN (2) CN105143259B (fr)
AP (1) AP2015008731A0 (fr)
AR (2) AR094960A1 (fr)
AU (1) AU2014237898B2 (fr)
CA (1) CA2901468C (fr)
CL (1) CL2015002531A1 (fr)
CY (1) CY1120459T1 (fr)
DK (1) DK2970447T3 (fr)
EA (1) EA029965B1 (fr)
ES (3) ES2769123T3 (fr)
HR (1) HRP20181047T1 (fr)
HU (1) HUE038834T2 (fr)
IL (2) IL241167B (fr)
JO (1) JO3580B1 (fr)
LT (1) LT2970447T (fr)
MA (1) MA38413A1 (fr)
ME (1) ME03094B (fr)
MX (1) MX364831B (fr)
MY (1) MY171213A (fr)
NZ (1) NZ711704A (fr)
PE (2) PE20151531A1 (fr)
PH (1) PH12015502090B1 (fr)
PL (1) PL2970447T3 (fr)
PT (1) PT2970447T (fr)
RS (1) RS57291B1 (fr)
SG (1) SG11201507686TA (fr)
SI (1) SI2970447T1 (fr)
TN (1) TN2015000377A1 (fr)
TR (1) TR201807613T4 (fr)
TW (1) TWI612059B (fr)
UA (1) UA116008C2 (fr)
WO (1) WO2014149733A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014267171A1 (en) * 2013-05-17 2015-12-10 Centre National De La Recherche Scientifique (Cnrs) Anti-CXCL1, CXCL7 and CXCL8 antibodies and their applications
WO2019036605A2 (fr) * 2017-08-17 2019-02-21 Massachusetts Institute Of Technology Agents de liaison à spécificité multiple de chimiokines cxc et leurs utilisations
KR20200108868A (ko) 2018-01-12 2020-09-21 브리스톨-마이어스 스큅 컴퍼니 암을 치료하기 위한 항-il-8 항체 및 항-pd-1 항체와의 조합 요법
KR102049180B1 (ko) * 2018-04-02 2019-11-26 고려대학교 산학협력단 체세포에서 유도 만능 줄기세포로의 역분화 유도용 조성물 및 이를 이용한 역분화 유도방법
TWI737000B (zh) * 2018-10-22 2021-08-21 美商美國禮來大藥廠 用於治療化膿性汗腺炎之泛-ｅｌｒ＋ｃｘｃ趨化介素抗體
CN114555792A (zh) 2019-10-15 2022-05-27 伊莱利利公司 重组改造的、脂肪酶/酯酶缺陷型哺乳动物细胞系
CN113087795B (zh) * 2019-12-23 2025-06-10 上海普铭生物科技有限公司 针对趋化因子cx3cl1的抗体及其应用
CA3167317C (fr) * 2020-02-12 2025-05-27 Eli Lilly And Company Cristallisation d'anticorps ou de fragments de liaison à l'antigène
TW202206457A (zh) * 2020-04-24 2022-02-16 美商美國禮來大藥廠 用於治療呼吸疾病之泛elr+ cxc趨化因子抗體
CN112358547A (zh) * 2020-09-30 2021-02-12 浙江大学 抗人cxcl-2单克隆抗体3-d3及其编码基因和应用
WO2023192478A1 (fr) 2022-04-01 2023-10-05 Bristol-Myers Squibb Company Polythérapie avec des anticorps anti-il-8 et des anticorps anti-pd-1 pour le traitement du cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040091503A1 (en) * 2002-08-20 2004-05-13 Genitrix, Llc Lectin compositions and methods for modulating an immune response to an antigen
WO2007107002A1 (fr) * 2006-03-22 2007-09-27 Osteopharm Inc. Marqueurs de diagnostic, de suivi et de pronostic d'ostéoporose et d'évaluation du risque d'ostéoporose et de fractures ostéoporotiques
CL2008001071A1 (es) * 2007-04-17 2009-05-22 Smithkline Beecham Corp Metodo para obtener anticuerpo penta-especifico contra il-8/cxcl8, gro-alfa/cxcl1, gro-beta/cxcl2), gro-gama/cxcl3 y ena-78/cxcl5 humanas; anticuerpo penta-especifico; proceso de produccion del mismo; vector, hbridoma o celela que lo comprende; composicion farmceutica; uso para tratar copd, otras enfermedades.
ES2672769T3 (es) * 2007-08-29 2018-06-18 Sanofi Anticuerpos anti-CXCR5 humanizados, derivados de los mismos y sus usos
GB0806812D0 (en) * 2008-04-15 2008-05-14 Univ Leuven Kath Citrullinated cytokines
KR20100133012A (ko) * 2008-05-14 2010-12-20 일라이 릴리 앤드 캄파니 항-ｃｘｃｒ4 항체
HRP20150162T1 (hr) * 2009-08-28 2015-05-08 Regeneron Pharmaceuticals, Inc. Antikin antitijela koja se vežu na višestruke cc kemokine
JP2011097867A (ja) * 2009-11-05 2011-05-19 Kurume Univ 脊柱靱帯骨化症のマーカーペプチド
EP2534256A4 (fr) * 2010-02-09 2013-07-24 Glaxosmithkline Llc Nouvelles utilisations
JP6211597B2 (ja) * 2012-05-01 2017-10-11 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ 新規抗体

Also Published As

Publication number Publication date
ES2675404T3 (es) 2018-07-11
EP3608336A1 (fr) 2020-02-12
TWI612059B (zh) 2018-01-21
AU2014237898B2 (en) 2016-05-05
AR125831A2 (es) 2023-08-16
DK2970447T3 (en) 2018-06-18
MX364831B (es) 2019-05-08
WO2014149733A1 (fr) 2014-09-25
CN105143259A (zh) 2015-12-09
PH12015502090B1 (en) 2020-07-08
ES2993153T3 (en) 2024-12-23
EA029965B1 (ru) 2018-06-29
HUE038834T2 (hu) 2018-11-28
CN109134652B (zh) 2022-05-24
CA2901468A1 (fr) 2014-09-25
PL2970447T3 (pl) 2018-10-31
TR201807613T4 (tr) 2018-06-21
IL269387A (en) 2019-11-28
IL241167B (en) 2019-10-31
EP3348569B1 (fr) 2019-11-27
EP3608336B1 (fr) 2024-10-02
CA2901468C (fr) 2018-02-20
KR20150119155A (ko) 2015-10-23
RS57291B1 (sr) 2018-08-31
EP2970447A1 (fr) 2016-01-20
TN2015000377A1 (en) 2017-01-03
NZ711704A (en) 2019-12-20
CN109134652A (zh) 2019-01-04
IL241167A0 (en) 2015-11-30
HRP20181047T1 (hr) 2018-08-24
AU2014237898A8 (en) 2015-08-27
HK1212714A1 (en) 2016-06-17
EP4467566A3 (fr) 2025-04-23
PT2970447T (pt) 2018-08-07
EP2970447B1 (fr) 2018-05-16
AP2015008731A0 (en) 2015-09-30
MY171213A (en) 2019-10-02
PH12015502090A1 (en) 2016-01-18
IL269387B (en) 2021-05-31
CY1120459T1 (el) 2019-07-10
MX2015013053A (es) 2016-05-18
BR112015020174A2 (pt) 2017-08-29
PE20151531A1 (es) 2015-10-28
EP3348569A1 (fr) 2018-07-18
CN105143259B (zh) 2018-09-21
JP2016512026A (ja) 2016-04-25
ES2769123T3 (es) 2020-06-24
SI2970447T1 (en) 2018-06-29
AU2014237898A1 (en) 2015-08-20
CL2015002531A1 (es) 2016-06-17
TW201520226A (zh) 2015-06-01
ME03094B (fr) 2019-01-20
EP4467566A2 (fr) 2024-11-27
JP6105146B2 (ja) 2017-03-29
KR101745230B1 (ko) 2017-06-08
EA201591514A1 (ru) 2016-03-31
UA116008C2 (uk) 2018-01-25
SG11201507686TA (en) 2015-10-29
PE20191480A1 (es) 2019-10-18
AR094960A1 (es) 2015-09-09
LT2970447T (lt) 2018-07-25
JO3580B1 (ar) 2020-07-05

Similar Documents

Publication Publication Date Title
MA38413A1 (fr) Anticorps pan-elr+ cxc chimiokine
FR23C1036I2 (fr) Anticorps qui se lient à il-23
UA113129C2 (xx) ЗЛИТА КОНСТРУКЦІЯ АНТИТІЛО ПРОТИ CD38 З ОСЛАБЛЕНИМ ІНТЕРФЕРОНОМ АЛЬФА-2b
EP3821005A4 (fr) Anticorps spécifiques de l'antigène trophoblaste 2 (trop2)
EP2953643A4 (fr) Anticorps cd47 n'induisant ni l'appauvrissement en globules rouges ni l'appauvrissement en plaquettes
EP3898698A4 (fr) Anticorps spécifiques à muc18
CA2924268C (fr) Anticorps anti-alpha-synucleine et leurs methodes d'utilisation
MX380520B (es) Anticuerpos receptores de antitransferina y métodos de uso.
EA202092435A2 (ru) Моноклональные антитела против bcma
EA201691266A1 (ru) Анти-cd3 антитела и способы применения
EP2961774A4 (fr) Anticorps d'alpha-synucléine et leurs utilisations
EA201691214A1 (ru) Антитела к cd33 и иммуноконъюгаты
UA120981C2 (uk) Антитіло, що зв'язується з il-8, та його застосування
EP3283110A4 (fr) Anticorps dirigés contre le récepteur de l'interleukine 36 (il-36r)
EA201590993A1 (ru) Гетеродимерные иммуноглобулины
EA201591750A1 (ru) Антитела против b7-h4 и иммуноконъюгаты
EP2771031A4 (fr) Anticorps humanisés qui reconnaissent l'alpha-synucléine
MA38322B1 (fr) Anticorps anti-il-17a et leur utilisation dans le traitement de troubles auto-immuns et inflammatoires
PE20150891A1 (es) Anticuerpos anti-receptor de il-13 alfa 2 y conjugados de anticuerpo farmaco
MA53322A (fr) Anticorps procoagulants améliorés
MA42440A (fr) Anticorps qui se lient à la sortiline et inhibent la liaison de la progranuline
IL284367A (en) Monoclonal antibodies that bind specifically to human trbv9
MX2015015232A (es) Anticuerpo monoclonal dirigido contra cxcr5.
EP3690051A4 (fr) Anticorps monoclonal anti-ckap4
EP2830663A4 (fr) Anticorps complètement humains qui se lient à vegfr2