MA47106A - Formulations d'anticorps anti-tnf alpha - Google Patents

Formulations d'anticorps anti-tnf alpha

Info

Publication number
MA47106A
MA47106A MA047106A MA47106A MA47106A MA 47106 A MA47106 A MA 47106A MA 047106 A MA047106 A MA 047106A MA 47106 A MA47106 A MA 47106A MA 47106 A MA47106 A MA 47106A
Authority
MA
Morocco
Prior art keywords
tnf alpha
antibody formulations
alpha antibody
formulations
tnf
Prior art date
Application number
MA047106A
Other languages
English (en)
Inventor
Joy Brennan
William J Callahan
Rahul Rajan Kaushik
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA47106A publication Critical patent/MA47106A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA047106A 2016-12-21 2017-12-20 Formulations d'anticorps anti-tnf alpha MA47106A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662437640P 2016-12-21 2016-12-21

Publications (1)

Publication Number Publication Date
MA47106A true MA47106A (fr) 2019-10-30

Family

ID=61006357

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047106A MA47106A (fr) 2016-12-21 2017-12-20 Formulations d'anticorps anti-tnf alpha

Country Status (4)

Country Link
US (3) US20200087390A1 (fr)
EP (3) EP3824906A1 (fr)
MA (1) MA47106A (fr)
WO (1) WO2018119142A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3824906A1 (fr) 2016-12-21 2021-05-26 Amgen Inc. Formulations d'anticorps anti-tnf alpha
CN114286690A (zh) * 2019-04-23 2022-04-05 赛诺菲 稳定的低粘度抗体配制品及其用途
US11655302B2 (en) 2019-06-10 2023-05-23 Sanofi Anti-CD38 antibodies and formulations
WO2023018870A1 (fr) * 2021-08-12 2023-02-16 Amgen Inc. Formulations d'anticorps

Family Cites Families (669)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945098A (en) 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
US5919452A (en) 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
US6284471B1 (en) 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
US7192584B2 (en) 1991-03-18 2007-03-20 Centocor, Inc. Methods of treating psoriasis with anti-TNF antibodies
US5656272A (en) 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
US5698195A (en) 1991-03-18 1997-12-16 New York University Medical Center Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
US6270766B1 (en) 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
ATE357221T1 (de) 1994-04-22 2007-04-15 Astellas Pharma Inc Kolon-spezifisches arzneistofffreisetzungssystem
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
DE122004000004I1 (de) 1996-02-09 2004-08-12 Abott Biotechnology Ltd Humane Antikörper welche an Humanen TNFalpha binden.
GB9610992D0 (en) 1996-05-24 1996-07-31 Glaxo Group Ltd Concentrated antibody preparation
JP2000516594A (ja) 1996-07-26 2000-12-12 スミスクライン・ビーチャム・コーポレイション 免疫細胞介在全身性疾患の改良された治療法
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
DE59804785D1 (de) 1997-11-22 2002-08-22 Roche Diagnostics Gmbh Verbessertes Verfahren zur Stabilisierung von Proteinen
AU742250B2 (en) 1997-12-26 2001-12-20 Astellas Pharma Inc. Sustained release medicinal compositions
DE19814084B4 (de) 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
DK2272870T3 (da) 1998-06-09 2013-08-05 Csl Behring Ag Fremgangsmåde til fremstilling af immunoglobuliner med henblik på intravenøs indgivelse og andre immunoglobulin-lignende produkter.
GB9812545D0 (en) 1998-06-10 1998-08-05 Celltech Therapeutics Ltd Biological products
CN1291979C (zh) 1998-07-23 2006-12-27 安斯泰来制药有限公司 咪唑化合物及其作为腺苷脱氨酶抑制剂的用途
GB9824632D0 (en) 1998-11-10 1999-01-06 Celltech Therapeutics Ltd Biological compounds
PT1142905E (pt) 1999-01-13 2006-10-31 Astellas Pharma Inc Novo composto de depsipeptido
CA2796140A1 (fr) 1999-03-25 2000-09-28 Jochen Salfeld Anticorps humains de liaison de l'il-12 humaine et methodes de production connexes
ES2338210T3 (es) 1999-11-11 2010-05-05 Astellas Pharma Inc. Metaloproteasa novedosa que tiene actividad agrecanasa.
AU2207801A (en) 1999-12-22 2001-07-03 Oxford Glycosciences (Uk) Limited Substances
WO2001062914A1 (fr) 2000-02-25 2001-08-30 Oxford Glycosciences (Uk) Ltd. Proteine bcmp 84 associee au cancer du sein
DE60130910T2 (de) 2000-04-17 2008-07-10 Ucb Pharma, S.A. Enamin-derivate als zell-adhäsionsmoleküle
JP2001322933A (ja) 2000-05-15 2001-11-20 Ucb Sa Ｃｄ４０シグナル遮断剤
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
DE60129736T2 (de) 2000-12-18 2008-04-17 Astellas Pharma Inc. Neue aggrecanase
WO2002053544A1 (fr) 2000-12-29 2002-07-11 Darwin Discovery Ltd. Utilisations pharmaceutiques et synthese de nicotinanilide-n-oxydes
CA2385745C (fr) 2001-06-08 2015-02-17 Abbott Laboratories (Bermuda) Ltd. Methodes pour administrer des anticorps anti-tnf.alpha.
GB0114644D0 (en) 2001-06-15 2001-08-08 Oxford Glycosciences Uk Ltd Protein
US7196080B2 (en) 2001-06-15 2007-03-27 Astellas Pharma Inc. Phenylpyridinecarbonylpiperazinederivative
MY143582A (en) 2001-06-26 2011-05-31 Amgent Fremont Inc Antibodies to opgl
US7858095B2 (en) 2001-07-24 2010-12-28 Astellas Us Llc Method for treating or preventing sclerotic disorders using CD-2 binding agents
TWI334439B (en) 2001-08-01 2010-12-11 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
WO2003018760A2 (fr) 2001-08-24 2003-03-06 Advanced Cell Technology, Inc. Essais de criblage pour l'identification d'agents induisant la differenciation, et production de cellules differenciees pour la therapie cellulaire
RU2305111C2 (ru) 2001-09-25 2007-08-27 Джуридикэл Фаундейшн Дзе Чемо-Серо-Терапьютик Рисерч Инститьют Рекомбинантное антитело против остеопонтина и его применение
IL161677A0 (en) 2001-11-08 2004-09-27 Protein Design Labs Stable liquid pharmaceutical formulation of igg antibodies
US7261892B2 (en) 2001-11-27 2007-08-28 Celltech R&D Limited Methods for diagnosis and treatment of epithelial-derived cancers
NZ533240A (en) 2001-11-27 2007-12-21 Oxford Glycosciences Uk Ltd Use of polypeptide for the treatment of epithelial-derived cancer
GB0129105D0 (en) 2001-12-05 2002-01-23 Celltech R&D Ltd Expression control using variable intergenic sequences
GB0207533D0 (en) 2002-04-02 2002-05-08 Oxford Glycosciences Uk Ltd Protein
GB0208089D0 (en) 2002-04-09 2002-05-22 Oxford Glycosciences Uk Ltd Protein
PL373763A1 (en) 2002-04-30 2005-09-19 Ucb, S.A. 2,6-quinolinyl and 2,6-naphthyl derivatives, processes for preparing them and their uses as vla-4 inhibitors
WO2003099226A2 (fr) 2002-05-28 2003-12-04 Celltech R & D Limited Isomeres de position de peg d'anticorps, compositions les comprenant, et leur utilisation
AU2003242163A1 (en) 2002-06-06 2003-12-22 Yamanouchi Pharmaceutical Co., Ltd. Novel oxidase
GB0214268D0 (en) 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
ATE386526T1 (de) 2002-07-02 2008-03-15 Ucb Farchim Sa Diarylmethylpiperazines als prophylaktische oder therapeutische mittel gegen virale myocarditis
AR040603A1 (es) 2002-07-19 2005-04-13 Abbott Lab S A El uso de un anticuerpo anti-tnfalfa neutralizador de alta afinidad en la fabricacion de un medicamento y conjunto de elementos
GB0218800D0 (en) 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
GB0222743D0 (en) 2002-10-01 2002-11-06 Celltech R&D Ltd Chemical compounds
MY150740A (en) 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
DE60334246D1 (de) 2002-11-21 2010-10-28 Celltech R & D Inc Modulieren von immunantworten
US9498530B2 (en) 2002-12-24 2016-11-22 Rinat Neuroscience Corp. Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
KR101026819B1 (ko) 2003-01-09 2011-04-04 아스테라스 세이야쿠 가부시키가이샤 피롤로피리다진 유도체
PT2404890T (pt) 2003-01-23 2017-10-23 Esperion Therapeutics Inc Compostos de hidroxilo e composições para gestão do colesterol e utilizações relacionadas
US20040230309A1 (en) 2003-02-14 2004-11-18 Depuy Spine, Inc. In-situ formed intervertebral fusion device and method
CA2519320A1 (fr) 2003-02-19 2004-09-02 Astellas Pharma Inc. Procede d'evaluation de l'effet antitumoral d'un inhibiteur d'histone desacetylase
US6805686B1 (en) 2003-05-06 2004-10-19 Abbott Laboratories Autoinjector with extendable needle protector shroud
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
EP1481683A1 (fr) 2003-05-30 2004-12-01 Yamanouchi Pharmaceutical Co. Ltd. Ligands ayant pour cible la P-selectine et compositions les comprenant
WO2004113348A1 (fr) 2003-06-20 2004-12-29 Celltech R & D Limited Derives de thienopyridone en tant qu'inhibiteurs de kinase
EP1641804A1 (fr) 2003-06-20 2006-04-05 Celltech R & D Limited Derives de thienopyridone en tant qu inhibiteurs de kinase
JPWO2005002590A1 (ja) 2003-07-01 2006-08-10 アステラス製薬株式会社 骨量増加誘導剤
AU2004253738A1 (en) 2003-07-01 2005-01-13 Ucb Pharma S.A. Modified antibody Fab fragments
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
CA2540881A1 (fr) 2003-10-24 2005-05-12 Celltech R & D Limited Utilisation de derives de thieno-pyridonone comme inhibiteurs de kinases
GB0325836D0 (en) 2003-11-05 2003-12-10 Celltech R&D Ltd Biological products
JPWO2005049087A1 (ja) 2003-11-20 2007-06-07 アステラス製薬株式会社 慢性骨盤痛症候群治療剤
AU2004292393C1 (en) 2003-11-21 2011-08-04 Ucb Pharma S.A. Method for the treatment of multiple sclerosis by inhibiting IL-17 activity
SI2177537T1 (sl) 2004-01-09 2012-01-31 Pfizer Protitielesa proti MAdCAM
JP2007104902A (ja) 2004-01-16 2007-04-26 Astellas Pharma Inc 関節リウマチ治療薬のスクリーニング法
JP2007104901A (ja) 2004-01-16 2007-04-26 Astellas Pharma Inc 関節リウマチ治療薬のスクリーニング法
US20190282622A1 (en) 2004-01-23 2019-09-19 Astellas Institute For Regenerative Medicine Modalities for the treatment of degenerative diseases of the retina
US7670624B2 (en) 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
TWI439284B (zh) 2004-04-09 2014-06-01 Abbvie Biotechnology Ltd 用於治療ＴＮＦα相關失調症之多重可變劑量療法
EP1736472A4 (fr) 2004-04-15 2007-10-31 Astellas Pharma Inc Dérivé de 2-aminopyridine
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
JP2007277093A (ja) 2004-06-21 2007-10-25 Astellas Pharma Inc 三環系化合物
JP2007269629A (ja) 2004-06-21 2007-10-18 Astellas Pharma Inc キナゾリン誘導体
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
ES2319797T3 (es) 2004-07-05 2009-05-12 Astellas Pharma Inc. Derivados de pirazolopiridina.
WO2006004191A1 (fr) 2004-07-05 2006-01-12 Astellas Pharma Inc. Derivés de pyrrolopyridazine qui inhibent la pde iv et le tnf alpha
WO2006038734A1 (fr) 2004-10-08 2006-04-13 Astellas Pharma Inc. Dérivés de la pyridazinone inhibiteurs de cytokines
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
GB0425569D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
GB0425972D0 (en) 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
NZ583153A (en) 2004-12-21 2011-06-30 Centocor Ortho Biotech Inc Anti-IL-12 antibodies, epitopes, compositions, methods and uses
JP2008529968A (ja) 2005-02-08 2008-08-07 国立循環器病センター総長 インスリン様成長因子−１（ｉｇｆ−１）を使用する慢性重症心不全を処置するための新規方法
US20090029970A1 (en) 2005-02-16 2009-01-29 Astellas Pharma Inc. Pain remedy containing rock inhibitor
GB0506912D0 (en) 2005-04-05 2005-05-11 Celltech R&D Ltd Biological products
AU2006246721B2 (en) 2005-05-16 2012-12-13 Abbvie Biotechnology Ltd Use of TNF inhibitor for treatment of erosive polyarthritis
BRPI0611243A2 (pt) 2005-06-09 2010-08-24 Ucb Pharma Sa composto, enanciâmeros, diastereoisâmeros do mesmo ou um sal farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, e, uso de um composto
ES2776657T3 (es) 2005-06-14 2020-07-31 Amgen Inc Formulaciones de proteínas autotamponantes
PT2452694T (pt) 2005-06-30 2019-02-21 Janssen Biotech Inc Anticorpos anti-il-23, composições, métodos e utilizações
GB0513852D0 (en) 2005-07-06 2005-08-10 Celltech R&D Ltd Biological products
GB0514779D0 (en) 2005-07-19 2005-08-24 Celltech R&D Ltd Biological products
ES2836764T3 (es) 2005-08-03 2021-06-28 Astellas Inst For Regenerative Medicine Métodos mejorados de reprogramación de células somáticas animales
CA2601869A1 (fr) 2005-08-12 2007-02-22 Astellas Pharma Inc. Procede servant a identifier une proteine cible d'un agent et procede servant a cribler un agent therapeutique pour le diabete utilisant la proteine cible
EP1754476A1 (fr) 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) pour le traitement de la myalgie, par exemple de la fibromyalgie
US20090042856A1 (en) 2005-09-01 2009-02-12 Astellas Pharma Inc Pyridazinone derivatives used for the treatment of pain
ES2382879T3 (es) 2005-09-14 2012-06-14 Ucb Pharma, S.A. Conjugado de anticuerpo - polímero de peine.
GB0520169D0 (en) 2005-10-04 2005-11-09 Celltech R&D Ltd Biological products
CA2626804A1 (fr) 2005-11-01 2007-08-09 Abbott Biotechnology Ltd. Methodes et compositions de diagnostic de la spondylarthrite ankylosante a l'aide de biomarqueurs
GB0523954D0 (en) 2005-11-24 2006-01-04 Ucb Celltech Bioassays
WO2007060411A1 (fr) 2005-11-24 2007-05-31 Ucb Pharma S.A. Anticorps anti-tnf alpha qui inhibent sélectivement le signal tnf alpha par le p55r
EP1790664A1 (fr) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Anticorps monoclonaux contre claudin-18 pour le traitement du cancer
JP5183484B2 (ja) 2005-12-09 2013-04-17 ユセベ ファルマ ソシエテ アノニム ヒトｉｌ−６に対して特異性を有する抗体分子
MX2008012896A (es) 2006-04-05 2008-10-14 Abbott Biotech Ltd Purificacion de anticuerpos.
WO2007120656A2 (fr) 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Utilisations et compositions pour le traitement de la polyarthrite rhumatoïde
EP2666472A3 (fr) 2006-04-10 2014-04-02 Abbott Biotechnology Ltd Utilisations et compositions pour le traitement de l'arthrite psoriasique
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
WO2007120626A2 (fr) 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Utilisations et compositions pour le traitement de la spondylarthrite ankylosante
EP2377925A1 (fr) 2006-04-14 2011-10-19 Advanced Cell Technology, Inc. Cellules formant colonie d'hemangio
US8808707B1 (en) 2006-05-08 2014-08-19 Wyeth Llc Pneumococcal dosing regimen
EP2025749B8 (fr) 2006-05-31 2012-05-23 Astellas Pharma Inc. Anticorps anti-ostéopontine humaine humanisés
WO2007141018A1 (fr) 2006-06-08 2007-12-13 Schwarz Pharma Ag Combinaison thérapeutique pour états médicaux douloureux
US20100021451A1 (en) 2006-06-08 2010-01-28 Wong Robert L Uses and compositions for treatment of ankylosing spondylitis
TWI392670B (zh) 2006-06-22 2013-04-11 Ucb Pharma Gmbh 經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
CN103316402A (zh) 2006-06-30 2013-09-25 艾伯维生物技术有限公司 自动注射装置
GB0613209D0 (en) 2006-07-03 2006-08-09 Ucb Sa Methods
AU2007279092B2 (en) 2006-07-24 2012-12-13 Ucb Pharma S.A. Substituted aniline derivatives
GB0614780D0 (en) 2006-07-25 2006-09-06 Ucb Sa Biological products
BRPI0715360B8 (pt) 2006-07-27 2022-01-04 Wyeth Corp método para a produção de uma proteína recombinante; método para a produção de uma proteína 2086 meningocócica recombinante (p2086); e composição
JPWO2008026781A1 (ja) 2006-08-31 2010-01-21 直人 奥 逆標的化脂質小胞体
EP2066645A2 (fr) 2006-09-12 2009-06-10 UCB Pharma S.A. Dérivés de 2 amino-pyrimidine en tant qu'antagonistes des récepteurs h4, leurs procédés de préparation et leur utilisation dans des compositions pharmaceutiques
BRPI0716762A2 (pt) 2006-09-13 2013-09-24 Abbott Lab melhorias da cultura celular
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
KR101251707B1 (ko) 2006-09-27 2013-04-11 콜리 파마슈티칼 게엠베하 면역 자극 활성이 증강된 소수성 Ｔ 유사체를 함유하는 ＣｐＧ 올리고뉴클레오티드 유사체
GB0619291D0 (en) 2006-09-29 2006-11-08 Ucb Sa Altered antibodies
US10068220B2 (en) 2006-10-11 2018-09-04 Visa International Service Association Systems and methods for brokered authentication express seller links
GB0620729D0 (en) 2006-10-18 2006-11-29 Ucb Sa Biological products
NZ576133A (en) 2006-10-27 2012-10-26 Abbott Biotech Ltd Crystalline anti-htnfalpha antibodies
WO2008064830A1 (fr) 2006-11-27 2008-06-05 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, leurs procédés de fabrication et leurs utilisations pharmaceutiques
WO2008064823A1 (fr) 2006-11-27 2008-06-05 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, procédés de préparation de ceux-ci et leurs utilisations
US20100179185A1 (en) 2006-11-30 2010-07-15 Ucb Pharma, S.A. Novel Aminothienopyridinone Derivatives Processes for Preparing Them and Pharmaceutical Compositions Thereof
WO2008074445A1 (fr) 2006-12-18 2008-06-26 Ucb Pharma, S.A. Nouveaux dérivés tricycliques et hétérocycliques, procédés destinés à les préparer et compositions pharmaceutiques les contenant
DK2115151T3 (en) 2006-12-28 2015-01-05 Janssen Biotech Inc PROCESSES AND VECTORS FOR GENERATING ASIALYLEREDE immunoglobulins
WO2008092084A2 (fr) 2007-01-26 2008-07-31 Centocor, Inc. Suspension non aqueuse injectable présentant une concentration élevée en agent thérapeutique
EP2982744A1 (fr) 2007-02-23 2016-02-10 Advanced Cell Technology, Inc. Procédés hautement efficaces pour reprogrammer des cellules différenciées et pour produire des animaux et des cellules souches embryonnaires à partir de cellules reprogrammées
US8147833B2 (en) 2007-02-23 2012-04-03 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
EP2125894B1 (fr) 2007-03-22 2018-12-19 Biogen MA Inc. Protéines de liaison, incluant des anticorps, dérivés d'anticorps et fragments d'anticorps, qui se lient spécifiquement à cd154 et leurs utilisations
US7935808B2 (en) 2007-03-30 2011-05-03 Abbott Laboratories Recombinant expression vector elements (rEVEs) for enhancing expression of recombinant proteins in host cells
EP2144877A1 (fr) 2007-04-04 2010-01-20 UCB Pharma, S.A. Nouveaux derives de pyridine, procedes de preparation et compositions pharmaceutiques associes
WO2008125210A1 (fr) 2007-04-12 2008-10-23 Ucb Pharma, S.A. Dérivés de quinoline et de naphtalène, procédés de préparation et utilisation de ceux-ci pour traiter des maladies inflammatoires
WO2008125215A1 (fr) 2007-04-12 2008-10-23 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, procédés de préparation et utilisations de ceux-ci
TW200904421A (en) 2007-05-03 2009-02-01 Astellas Pharma Inc New compounds
WO2008138592A1 (fr) 2007-05-14 2008-11-20 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, leurs méthodes de préparation et leurs utilisations
WO2008138591A2 (fr) 2007-05-14 2008-11-20 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, leurs méthodes de préparation et leurs utilisations
WO2008138615A1 (fr) 2007-05-16 2008-11-20 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, leurs méthodes de préparation et leurs utilisations
EP1997832A1 (fr) 2007-05-29 2008-12-03 Ganymed Pharmaceuticals AG Anticorps monoclonaux contre la claudine-18 pour le traitement contre le cancer
WO2008150491A2 (fr) 2007-05-31 2008-12-11 Abbott Laboratories Biomarqueurs prédictifs de la réactivité aux inhibiteurs tnfα dans des troubles auto-immuns
TW200911245A (en) 2007-06-07 2009-03-16 Astellas Pharma Inc Pyridone derivatives
BRPI0812461A2 (pt) 2007-06-08 2017-06-13 Biogen Idec Inc método de prever a resposta de um indivíduo a uma terapia, método de tratamento de um distúrbio imunológico, composição e kit
WO2008154543A2 (fr) 2007-06-11 2008-12-18 Abbott Biotechnology Ltd. Procédés de traitement de l'arthrite idiopathique juvénile
WO2009020654A1 (fr) 2007-08-08 2009-02-12 Abbott Laboratories Compositions et procédés permettant la cristallisation d'anticorps
WO2009032128A1 (fr) 2007-08-28 2009-03-12 Abbott Biotechnology Ltd. Compositions et procédés comprenant des protéines de liaison pour adalimumab
JP5592792B2 (ja) 2007-09-26 2014-09-17 ユセベ ファルマ ソシエテ アノニム 二重特異性抗体の融合体
US20100298289A1 (en) 2007-10-09 2010-11-25 Ucb Pharma, S.A. Heterobicyclic compounds as histamine h4-receptor antagonists
DK2209888T3 (da) 2007-10-12 2020-01-20 Astellas Inst For Regenerative Medicine Forbedrede fremgangsmåder til fremstilling af rpe-celler og sammensætninger af rpe-celler
CN101998965B (zh) 2007-11-01 2014-03-12 安斯泰来制药有限公司 免疫抑制性多肽与核酸
US7947495B2 (en) 2007-11-01 2011-05-24 Abbott Biotherapeutics Corp. Immunoglobulin display vectors
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
NZ622583A (en) 2007-11-30 2015-08-28 Abbvie Biotechnology Ltd Protein formulations and methods of making same
HUE032735T2 (en) 2007-12-14 2017-10-30 Bristol Myers Squibb Co Binding molecules for the human OX40 receptor
NZ600979A (en) 2008-01-15 2014-01-31 Abbott Lab Improved mammalian expression vectors and uses thereof
US7964608B2 (en) 2008-01-25 2011-06-21 High Point Pharmaceuticals, Llc Tricyclic compounds as modulators of TNF-α synthesis
GB0807413D0 (en) 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
CA3186451A1 (fr) 2008-05-06 2009-11-12 Astellas Institute For Regenerative Medicine Cellules formant des colonies hemangioblastiques et cellules hemangioblastiques non transplantables
KR20210003301A (ko) 2008-05-06 2021-01-11 아스텔라스 인스티튜트 포 리제너러티브 메디슨 다능성 줄기세포로부터 유도된 탈핵 적혈구계 세포를 생산하는 방법
SI2565191T1 (sl) 2008-05-14 2014-12-31 Astellas Pharma Inc. Derivati 4-(indol-7-ilkarbonilaminometil)cikloheksan karboksilne kisline kot EP4 receptorski antagonisti, uporabni za zdravljenje kronične ledvične odpovedi ali diabetične nefropatije
CN103800895B (zh) 2008-06-11 2016-12-28 弗雷森纽斯医疗护理德国有限责任公司 肝祖细胞的条件培养基
CA2728156A1 (fr) 2008-06-17 2009-12-23 Astellas Pharma Inc. Compose pyridone
CN102076358B (zh) 2008-06-27 2016-08-17 硕腾有限责任公司 新颖的佐剂组合物
SI2326371T1 (sl) 2008-07-18 2019-12-31 Ucb Biopharma Sprl Sistem za dajanje zdravila za bolnike z revmatoidnim artritisom
EP2166021A1 (fr) 2008-09-16 2010-03-24 Ganymed Pharmaceuticals AG Anticorps monoclonaux pour le traitement du cancer
LT2334705T (lt) 2008-09-26 2017-03-27 Ucb Biopharma Sprl Biologiniai produktai
TWI610936B (zh) 2008-10-20 2018-01-11 艾伯維有限公司 使用蛋白質ａ親和性層析進行抗體之分離及純化
TW201028433A (en) 2008-10-20 2010-08-01 Abbott Lab Viral inactivation during purification of antibodies
US20100119492A1 (en) 2008-10-31 2010-05-13 Synthes Usa, Llc Method and device for activating stem cells
CN104208714A (zh) 2008-11-18 2014-12-17 Ucb医药有限公司 含有2-氧代-1-吡咯烷衍生物的延长释放制剂
WO2010070971A1 (fr) 2008-12-16 2010-06-24 アステラス製薬株式会社 Animal modèle de maladie pour douleur chronique
EP2398498B1 (fr) 2009-02-17 2018-09-05 UCB Biopharma SPRL Molécules d'anticorps ayant une spécificité pour ox40 humain
GB0904214D0 (en) 2009-03-11 2009-04-22 Ucb Pharma Sa Biological products
KR101715418B1 (ko) 2009-04-03 2017-03-10 메리얼 인코포레이티드 뉴캐슬 질환 바이러스-벡터를 이용한 조류 백신
CA2758964A1 (fr) 2009-04-16 2010-10-21 Abbott Biotherapeutics Corp. Anticorps anti-tnf-.alpha. et leurs utilisations
CN102458517B (zh) 2009-04-29 2014-07-23 阿布维生物技术有限公司 自动注射装置
JP2012197228A (ja) 2009-07-27 2012-10-18 Kyoto Univ 肝炎の治療剤もしくは予防剤
ES2667258T3 (es) 2009-09-10 2018-05-10 Ucb Biopharma Sprl Anticuerpos multivalentes
US20110070227A1 (en) 2009-09-18 2011-03-24 Anna-Marie Novotney-Barry Treatment of Autoimmune and Inflammatory Diseases
IN2012DN02401A (fr) 2009-09-24 2015-08-21 Ucb Pharma Sa
WO2011036455A1 (fr) 2009-09-24 2011-03-31 Ucb Pharma S.A. Souche bactérienne pour l'expression de protéines recombinantes, ayant une degp à activité protéase déficiente et conservant une activité chaperonne et des gènes tsp et ptr inactivés
GB201005063D0 (en) 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
JP2012254939A (ja) 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物
KR20120102709A (ko) 2009-11-17 2012-09-18 어드밴스드 셀 테크놀로지, 인코포레이티드 인간 ｒｐｅ 세포의 생산 방법 및 인간 ｒｐｅ 세포의 제약 제제
GB0920127D0 (en) 2009-11-17 2009-12-30 Ucb Pharma Sa Antibodies
GB0920324D0 (en) 2009-11-19 2010-01-06 Ucb Pharma Sa Antibodies
US9096879B2 (en) 2009-11-24 2015-08-04 Biogen Ma Inc. Method of supplementing culture media to prevent undesirable amino acid substitutions
US20120253036A1 (en) 2009-12-11 2012-10-04 Yukinori Nagakura Agent for treating fibromyalgia
NZ600069A (en) 2009-12-15 2015-02-27 Abbvie Biotechnology Ltd Improved firing button for automatic injection device
MX346393B (es) 2009-12-17 2017-03-17 Centrexion Therapeutics Corp Nuevos antagonistas del receptor ccr2 y usos de los mismo.
NZ629256A (en) 2009-12-22 2016-02-26 Celldex Therapeutics Inc Vaccine compositions
CN104189912A (zh) 2009-12-22 2014-12-10 优时比制药有限公司 用于使非结晶形式的罗替戈汀的固体分散体稳定化的聚乙烯吡咯烷酮
GB201000467D0 (en) 2010-01-12 2010-02-24 Ucb Pharma Sa Antibodies
GB201000588D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201001791D0 (en) 2010-02-03 2010-03-24 Ucb Pharma Sa Process for obtaining antibodies
CA2791930A1 (fr) 2010-03-11 2011-09-15 Kerry Louise Tyson Anticorps pd-1
TW201134488A (en) 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
EP2371864A1 (fr) 2010-03-23 2011-10-05 Ganymed Pharmaceuticals AG Anticorps monoclonaux pour le traitement du cancer
ES2717883T3 (es) 2010-03-25 2019-06-26 Ucb Biopharma Sprl Moléculas de DVD-LG estabilizadas con disulfuro
GB201005064D0 (en) 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
PT3178851T (pt) 2010-03-31 2020-07-17 Boehringer Ingelheim Int Anticorpos anti-cd40
CN102958537B (zh) 2010-04-07 2015-09-16 Abbvie公司 TNF-α结合蛋白
JP5786020B2 (ja) 2010-04-16 2015-09-30 アボットジャパン株式会社 関節リウマチを診断する方法および試薬
NZ702172A (en) 2010-04-21 2016-03-31 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
MX355418B (es) 2010-05-04 2018-04-18 Five Prime Therapeutics Inc Anticuerpos que se unen a factor estimulante de colonias 1 (csf1r).
DK2571903T3 (da) 2010-05-17 2019-11-04 Emd Millipore Corp Polymerer, der reagerer på stimuli, til oprensning af biomolekyler
BR112012030337B1 (pt) 2010-05-28 2021-04-27 Coley Pharmaceutical Group, Inc Vacina compreendendo um ou mais oligonucleotídeo(s) de cpg isolado(s) ou um agonista de tlr e colesterol, e uso da mesma
HUE039740T2 (hu) 2010-06-03 2019-01-28 Abbvie Biotechnology Ltd Alkalmazások és készítmények hidradenitis suppurativa (HS) kezelésére
EP2582700B1 (fr) 2010-06-17 2016-11-02 Respivert Limited Formulations respiratoires contenant inhibiteurs de p38 mapk
PT2582391T (pt) 2010-06-18 2019-01-11 Xbiotech Inc Tratamento da artrite
WO2012012803A2 (fr) 2010-07-23 2012-01-26 Advanced Cell Technology, Inc. Procédés de détection de sous-populations rares de cellules et compositions de cellules très purifiées
GB201012603D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
GB201012784D0 (en) 2010-07-29 2010-09-15 Ucb Pharma Sa Method
GB201014033D0 (en) 2010-08-20 2010-10-06 Ucb Pharma Sa Biological products
RU2546873C2 (ru) 2010-09-10 2015-04-10 УАЙТ ЭлЭлСи Нелипидизированные варианты антигенов neisseria meningitidis orf2086
JP2013249256A (ja) 2010-09-15 2013-12-12 Astellas Pharma Inc 脂肪性肝疾患治療薬
UA112062C2 (uk) 2010-10-04 2016-07-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Cd33-зв'язувальний агент
UA118646C2 (uk) 2010-10-13 2019-02-25 Янссен Байотек, Інк. Виділене антитіло, яке специфіічно зв'язується з онкостатином м (оm) людини
SG190006A1 (en) 2010-11-04 2013-06-28 Boehringer Ingelheim Int Anti-il-23 antibodies
AU2011325974B2 (en) 2010-11-11 2016-10-27 Abbvie Biotechnology Ltd. Improved high concentration anti-TNFalpha antibody liquid formulations
EP2645997B1 (fr) 2010-12-02 2022-08-10 UCB Pharma GmbH Formulation de lacosamide en prise quotidienne unique
AR084210A1 (es) 2010-12-08 2013-05-02 Abbott Lab PROTEINAS DE UNION AL TNF-a
US10208349B2 (en) 2011-01-07 2019-02-19 Ucb Biopharma Sprl Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy
ME02734B (fr) 2011-01-14 2017-10-20 Ucb Biopharma Sprl Molécules d'anticorps se liant à il-17a et il-17f
EP3187216B1 (fr) 2011-01-24 2019-08-21 AbbVie Biotechnology Ltd. Dispositifs d'injection automatique présentant des surfaces de préhension surmoulées
US9170249B2 (en) 2011-03-12 2015-10-27 Momenta Pharmaceuticals, Inc. N-acetylhexosamine-containing N-glycans in glycoprotein products
TW201249867A (en) 2011-04-01 2012-12-16 Astellas Pharma Inc Novel anti-human il-23 receptor antibody
EP2702077A2 (fr) 2011-04-27 2014-03-05 AbbVie Inc. Procédé de contrôle du profil de galactosylation de protéines exprimées de manière recombinante
EP2714162B1 (fr) 2011-05-27 2020-01-01 Boehringer Ingelheim International GmbH Inhalateur et capsule pour inhalateur
ES2764079T3 (es) 2011-05-27 2020-06-02 Boehringer Ingelheim Animal Health Usa Inc Vacunas genéticas contra el virus Hendra y el virus Nipah
US9884152B2 (en) 2011-06-02 2018-02-06 Ucb Biopharma Sprl Auto-injector
UY34105A (es) 2011-06-03 2012-07-31 Lg Life Sciences Ltd Formulación líquida estable de etanercept
EP2729561A4 (fr) 2011-07-08 2015-06-24 Momenta Pharmaceuticals Inc Procédé de culture cellulaire
CN103827134A (zh) 2011-07-20 2014-05-28 泽普泰恩股份有限公司 多肽分离方法
CA2844927C (fr) 2011-08-12 2017-10-31 Merial Limited Conservation sous vide de produits biologiques, et en particulier de vaccins
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
LT2753355T (lt) 2011-09-08 2019-01-25 New York University Onkolitinis herpes simplex virusas ir jo terapinis panaudojimas
AU2012312052B2 (en) 2011-09-22 2017-06-08 Abbvie Inc. Automatic injection device
PT2750709T (pt) 2011-09-23 2018-11-22 Xbiotech Inc Tratamento da caquexia
JP2014528404A (ja) 2011-10-03 2014-10-27 レスピバート・リミテツド ｐ３８ＭＡＰキナーゼ阻害剤としての１−ピラゾリル−３−（４−（（２−アニリノピリミジン−４−イル）オキシ）ナフタレン−１−イル）尿素
EP2578582A1 (fr) 2011-10-03 2013-04-10 Respivert Limited 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napthtalèn-1-yl) urées comme inhibiteurs de la p38 MAP kinase
CN104011073B (zh) 2011-10-18 2017-08-25 科荣生生物科学公司 使用氨基酸稳定的依那西普制剂
US10493151B2 (en) 2011-10-18 2019-12-03 Coherus Biosciences, Inc. Etanercept formulations stabilized with sodium chloride
HK1200464A1 (en) 2011-10-24 2015-08-07 Abbvie Inc. Immunobinders directed against tnf
US20140288278A1 (en) 2011-10-31 2014-09-25 Joseph Nti-Gyabaah Chromatography process for resolving heterogeneous antibody aggregates
SI2776466T1 (sl) 2011-11-11 2017-12-29 Ucb Biopharma Sprl Protitelesa, ki se vežejo na albumin in njihovi vezavni fragmenti
UA112203C2 (uk) 2011-11-11 2016-08-10 Юсб Фарма С.А. Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини
TW202434266A (zh) 2011-11-14 2024-09-01 安斯泰來再生醫藥協會 人類rpe細胞之醫藥組合物及其用途
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
TW202537630A (zh) 2011-11-30 2025-10-01 美商安斯泰來再生醫藥協會 利用血管母細胞產生間葉基質細胞之方法
DE102011087676A1 (de) 2011-12-02 2013-06-06 Continental Automotive Gmbh Verfahren und Vorrichtung zur Überprüfung einer Lautsprecheranordnung
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
GB201203071D0 (en) 2012-02-22 2012-04-04 Ucb Pharma Sa Biological products
GB201203051D0 (en) 2012-02-22 2012-04-04 Ucb Pharma Sa Biological products
WO2013129454A1 (fr) 2012-02-28 2013-09-06 アステラス製薬株式会社 Nouvel anticorps anti-récepteur il-23 humain
DK2820640T3 (en) 2012-03-02 2016-09-05 Abbvie Inc AUTOMATIC INJECTION TRAINING DEVICE
JP2015509526A (ja) 2012-03-07 2015-03-30 カディラ ヘルスケア リミティド 医薬製剤
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
NZ629697A (en) 2012-03-15 2017-01-27 Janssen Biotech Inc Human anti-cd27 antibodies, methods and uses
PE20150323A1 (es) 2012-03-22 2015-03-05 Merial Ltd Virus de la enfermedad de marek modificado y vacunas elaboradas con el
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9505833B2 (en) 2012-04-20 2016-11-29 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
PT2844637T (pt) 2012-05-02 2018-04-17 Boehringer Ingelheim Int Inibidores de 3-haloalilamina substituídos de ssao e as suas utilizações
CA2871711A1 (fr) 2012-05-04 2013-11-07 Pfizer Inc. Regimes immunotherapeutiques bases sur des antigenes associes a la prostate et un vaccin
GB201208367D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
GB201208370D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Antibodies
WO2013174403A1 (fr) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer
WO2013176754A1 (fr) 2012-05-24 2013-11-28 Abbvie Inc. Nouvelle purification d'anticorps au moyen de chromatographie à interaction hydrophobe
US9550737B2 (en) 2012-06-11 2017-01-24 Ucb Biopharma Sprl TNF -α modulating benzimidazoles
WO2013186230A1 (fr) 2012-06-12 2013-12-19 Boehringer Ingelheim International Gmbh Formulation pharmaceutique destinée à un anticorps thérapeutique
SG11201407779YA (en) 2012-06-21 2015-02-27 Ucb Pharma Sa Pharmaceutical formulation
BR112015000675B1 (pt) 2012-07-13 2022-07-12 UCB Biopharma SRL Derivados de imidazopiridina como moduladores da atividade de tnf
GB201212513D0 (en) 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
JP2015180606A (ja) 2012-08-01 2015-10-15 アステラス製薬株式会社 抗癌剤の併用による癌治療方法
WO2014020171A1 (fr) 2012-08-03 2014-02-06 Boehringer Ingelheim International Gmbh Capacité tampon d'anticorps
JP6348492B2 (ja) 2012-08-10 2018-06-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ブルトン型チロシンキナーゼ（ｂｔｋ）阻害剤としてのヘテロ芳香族化合物
HK1211981A1 (en) 2012-09-02 2016-06-03 Abbvie Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
AU2013312300A1 (en) 2012-09-07 2015-04-16 Coherus Biosciences, Inc. Stable aqueous formulations of adalimumab
RS57013B1 (sr) 2012-09-11 2018-05-31 Coherus Biosciences Inc Korektno savijeni etanercept sa visokom čistoćom i odličnim prinosom
RU2648141C2 (ru) 2012-09-19 2018-03-22 Эббви Биотерапьютикс Инк. Способы идентификации антител с пониженной иммуногенностью
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
BR112015009624A2 (pt) 2012-11-02 2017-11-14 Pfizer inibidores de tirosina cinase de bruton
WO2014075697A1 (fr) 2012-11-13 2014-05-22 Biontech Ag Agents de traitement de maladies cancéreuses exprimant claudine
EP2920166B1 (fr) 2012-11-13 2016-11-02 Array Biopharma, Inc. Composes bicycliques a base d' uree, thiouree, guanidine ou cyanoguanidine utiles dans le traitement de la douleur
US9844594B2 (en) 2012-12-18 2017-12-19 Merck Sharp & Dohme Corp. Liquid formulations for an anti-TNF α antibody
WO2014094957A1 (fr) 2012-12-20 2014-06-26 Merck Patent Gmbh Copolymères destinés à la précipitation de protéine
KR101980989B1 (ko) 2012-12-20 2019-05-21 화이자 인코포레이티드 당접합 방법
CA3177929A1 (fr) 2012-12-21 2014-06-26 Astellas Institute For Regenerative Medicine Procedes de production de plaquettes a partir de cellules souches pluripotentes, et compositions associees
UA111305C2 (uk) 2012-12-21 2016-04-11 Пфайзер Інк. Конденсовані лактами арилу та гетероарилу
GB201223276D0 (en) 2012-12-21 2013-02-06 Ucb Pharma Sa Antibodies and methods of producing same
US9452138B2 (en) 2012-12-28 2016-09-27 Abbott Cardiovascular Systems Inc. Delivery of biologic therapeutics
EP2752426A1 (fr) 2013-01-03 2014-07-09 Covagen AG Composés de liaison d'albumine de sérum humain et leurs protéines de fusion
GB201300683D0 (en) 2013-01-15 2013-02-27 Apitope Int Nv Peptide
JP2016093104A (ja) 2013-02-19 2016-05-26 国立大学法人京都大学 抗ヒトＣＤ３ε抗体又はそのフラグメント、及びそれを有効成分とする免疫抑制剤
WO2014127785A1 (fr) 2013-02-20 2014-08-28 Ganymed Pharmaceuticals Ag Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer
WO2014129792A1 (fr) 2013-02-20 2014-08-28 사회복지법인 삼성생명공익재단 Composition pour le traitement de maladies inflammatoires du cerveau comprenant une cellule souche comme principe actif
GEP201706780B (en) 2013-03-14 2017-11-27 Boehringer Ingelheim Int Substituted 2-aza-bicyclo [2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014159579A1 (fr) 2013-03-14 2014-10-02 Abbvie Inc. Anticorps anti-tnfα ayant mutés et leurs procédés d'utilisation
WO2014151878A2 (fr) 2013-03-14 2014-09-25 Abbvie Inc. Procédés pour la modulation des profils de glycosylation de protéines de traitements à base de protéines recombinantes au moyen de monosaccharides et d'oligosaccharides
EP4292600A3 (fr) 2013-03-15 2024-04-10 Astellas Institute for Regenerative Medicine Photorécepteurs et progéniteurs de photorécepteurs produits à partir de cellules souches pluripotentes
JP2016512029A (ja) 2013-03-15 2016-04-25 ヤンセン バイオテツク，インコーポレーテツド 遺伝子組換えタンパク質中のｃ末端リジン、ガラクトース、及びシアル酸含量を制御する製造方法
EP2970378B1 (fr) 2013-03-15 2021-05-26 Biogen MA Inc. Chromatographie d'interaction hydrophobe pour protéines réalisée dans des conditions sans sel
WO2014146672A1 (fr) 2013-03-18 2014-09-25 Ganymed Pharmaceuticals Ag Thérapie comprenant des anticorps dirigés contre cldn 18.2 pour le traitement du cancer
NZ712903A (en) 2013-03-18 2018-07-27 Biocerox Prod Bv Humanized anti-cd134 (ox40) antibodies and uses thereof
JP2016000003A (ja) 2013-04-19 2016-01-07 アステラス製薬株式会社 新規抗ヒトｔｗｅａｋ抗体
JP6616284B2 (ja) 2013-04-23 2019-12-04 ザ ユニバーシティ コート オブ ザ ユニバーシティ オブ アバディーン 特異的結合分子の人工ライブラリー
EP2990055B1 (fr) 2013-04-26 2019-06-05 Kyoto University Composition comprenant un agoniste du récepteur 1 de la sphingosine-1-phosphate pour empêcher la formation et/ou l'expansion d'un anévrisme cérébral ou pour réduire un tel anévrisme
TW201446961A (zh) 2013-05-06 2014-12-16 Abbvie Inc 用於細胞培養之組合物及其使用方法
EP2803668A1 (fr) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Nouveau (cyano-dimethyl-methyl)-isoxazoles et - [1,3,4] thiadiazoles
EP2999459A1 (fr) 2013-05-22 2016-03-30 UCB Biopharma SPRL Procédés pour produire des particules contenant des protéines thérapeutiques
US20160129112A1 (en) 2013-05-28 2016-05-12 Momenta Pharmaceuticals, Inc. Pharmaceutical Compositions Comprising Pyrophosphate
AR096713A1 (es) 2013-06-25 2016-01-27 Cadila Healthcare Ltd Proceso de purificación para anticuerpos monoclonales
EP3019528A1 (fr) 2013-07-06 2016-05-18 Cadila Healthcare Limited Procédé amélioré de production d'anticorps monoclonaux
SG11201600067YA (en) 2013-07-23 2016-02-26 Biocon Ltd Methods for controlling fucosylation levels in proteins
EP3027416B1 (fr) 2013-07-28 2020-10-07 HP Scitex Ltd Support de média
LT3027603T (lt) 2013-08-02 2018-08-10 Pfizer Inc. Heterobicikloarilo rorc2 inhibitoriai ir jų panaudojimo būdai
GB201313888D0 (en) 2013-08-02 2013-09-18 Consort Medical Plc Assembly for an autoinjector device
AR097102A1 (es) 2013-08-02 2016-02-17 Pfizer Anticuerpo anti-cxcr4 y conjugados de anticuerpo y fármaco
ES2730978T3 (es) 2013-08-09 2019-11-13 Astellas Pharma Inc Anticuerpo anti-receptor de TSLP humana nuevo
US20160237399A1 (en) 2015-02-18 2016-08-18 Biogen Ma Inc. Control of Protein Glycosylation by Culture Medium Supplementation and Cell Culture Process Parameters
EP3916081A3 (fr) 2013-08-19 2022-03-23 Biogen MA Inc. Régulation de la glycosylation des protéines par supplémentation du milieu de culture et par les paramètres du procédé de culture cellulaire
SG10201801371PA (en) 2013-08-23 2018-04-27 Boehringer Ingelheim Rcv Gmbh Microparticles for cell disruption and/or biomolecule recovery
GB201315487D0 (en) 2013-08-30 2013-10-16 Ucb Pharma Sa Antibodies
US20160192626A1 (en) 2013-09-18 2016-07-07 Kyoto University Method For Creating Endometriotic Cells And Endometriosis Model Animal
EP3048899B1 (fr) 2013-09-25 2021-09-08 Bioverativ Therapeutics Inc. Procédés d'inactivation de virus sur colonne
WO2015057910A1 (fr) 2013-10-16 2015-04-23 Oncobiologics, Inc. Formulations de tampon pour stabilité d'anticorps améliorée
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9085618B2 (en) * 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
GB201320066D0 (en) 2013-11-13 2013-12-25 Ucb Pharma Sa Biological products
AU2014348676B2 (en) 2013-11-13 2020-06-18 Bristol-Myers Squibb Company Tumor necrosis factor-like ligand 1A specific antibodies and compositions and uses thereof
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
GB201321743D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321742D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321729D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321737D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321734D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321731D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321732D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321741D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321735D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321740D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321749D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
CN105814022B (zh) 2013-12-09 2018-09-28 Ucb生物制药私人有限公司 作为tnf活性调节剂的稠合的二环杂芳族衍生物
GB201321730D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321748D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321736D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321744D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321738D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321728D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321745D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321739D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321733D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
US9920052B2 (en) 2013-12-09 2018-03-20 Ucb Biopharma Sprl Imidazopyridine derivatives as modulators of TNF activity
GB201321746D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
CN104707146B (zh) * 2013-12-16 2019-04-16 浙江海正药业股份有限公司 一种含有阿达木单抗的药物组合物
CN114292331A (zh) 2013-12-24 2022-04-08 安斯泰来制药株式会社 抗人bdca-2抗体、其生产方法、多核苷酸、表达载体、宿主细胞及医药组合物
RS63295B1 (sr) 2013-12-24 2022-06-30 Janssen Pharmaceutica Nv Anti-vista antitela i fragmenti
US9758578B2 (en) 2013-12-26 2017-09-12 Mitsubishi Tanabe Pharma Corporation Human anti-IL-33 neutralizing monoclonal antibody
MX371453B (es) 2014-01-21 2020-01-29 Pfizer Polisacaridos capsulares de streptococcus pneumoniae y conjugados de los mismos.
WO2015110533A2 (fr) 2014-01-27 2015-07-30 Ucb Biopharma Sprl Auto-injecteur
CA2937967C (fr) 2014-01-29 2022-07-26 Neuropore Therapies, Inc. Amides heteroaryles comme inhibiteurs de l'agregation proteique
EA033604B1 (ru) 2014-01-31 2019-11-08 Boehringer Ingelheim Int Молекула анти-baff антитела, фармацевтическая композиция, содержащая эту молекулу, способы ее применения и кодирующий ее изолированный полинуклеотид
KR102382402B1 (ko) 2014-02-04 2022-04-01 바이오젠 엠에이 인코포레이티드 번역 후 변형을 강화시키기 위한 통류 방식 양이온 교환 크로마토그래피의 용도
EP3105222B1 (fr) 2014-02-14 2018-04-11 Respivert Limited Composés hétérocycliques aromatiques utilisés en tant que composés anti-inflammatoires
USRE47493E1 (en) 2014-02-20 2019-07-09 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
WO2015129858A1 (fr) 2014-02-28 2015-09-03 アステラス製薬株式会社 Nouvel anticorps bispécifique se liant au tlr2 humain et au tlr4 humain
US9135573B1 (en) 2014-03-17 2015-09-15 Linkedin Corporation Estimating reputation scores in reputation systems
AU2015232352B2 (en) 2014-03-17 2021-02-18 Mitsubishi Tanabe Pharma Corporation Antibody-fynomer conjugates
SG11201607794QA (en) 2014-03-19 2016-10-28 Boehringer Ingelheim Int Heteroaryl syk inhibitors
TW201623277A (zh) 2014-03-26 2016-07-01 安斯泰來製藥股份有限公司 醯胺化合物
CA2944330A1 (fr) 2014-04-02 2015-10-08 Intas Pharmaceuticals Limited Composition pharmaceutique liquide d'adalimumab
DK3126330T3 (en) 2014-04-04 2019-04-23 Pfizer BICYCLE-FUSED HETEROARYL OR ARYL COMPOUNDS AND USE THEREOF AS IRAC4 INHIBITORS
WO2015158776A1 (fr) 2014-04-15 2015-10-22 Boehringer Ingelheim International Gmbh Procédés, appareils et systèmes d'inactivation continue de virus pendant la fabrication de produit biologique
SG11201608080RA (en) 2014-04-17 2016-10-28 Boehringer Ingelheim Rcv Gmbh Recombinant host cell for expressing proteins of interest
KR102092225B1 (ko) 2014-04-30 2020-03-23 주식회사 엘지화학 고효율 분비능을 가지는 단백질 분비 인자 및 이를 포함하는 발현 벡터
JP6868394B2 (ja) 2014-05-16 2021-05-12 ファイザー・インク 二重特異性抗体
ES2607489T3 (es) 2014-05-23 2017-03-31 Ares Trading S.A. Composición farmacéutica líquida
EP2946766B1 (fr) 2014-05-23 2016-03-02 Ares Trading S.A. Composition pharmaceutique liquide
HUE029849T2 (en) 2014-05-23 2017-04-28 Ares Trading Sa Liquid pharmaceutical composition
GB201409558D0 (en) 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
ES2864079T3 (es) 2014-05-30 2021-10-13 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
EP3156071A4 (fr) 2014-06-10 2018-01-10 Meiji Seika Pharma Co., Ltd. Préparation aqueuse stable d'adalimumab
AP2016009605A0 (en) 2014-06-17 2016-12-31 Pfizer Substituted dihydroisoquinolinone compounds
TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
GB201412659D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
EP3708679A1 (fr) 2014-07-24 2020-09-16 Boehringer Ingelheim International GmbH Biomarqueurs utiles dans le traitement de maladies liées à l'il-23a
PT3178929T (pt) 2014-08-06 2021-09-02 Astellas Pharma Inc Novo anticorpo anti-ig(beta) humana
CR20170035A (es) 2014-08-06 2017-04-28 Pfizer Compuestos de imidazopiridazina
AR101479A1 (es) 2014-08-11 2016-12-21 Boehringer Ingelheim Int Derivados de 6-alquinil-piridina
NO2721710T3 (fr) 2014-08-21 2018-03-31
KR20190062617A (ko) 2014-09-03 2019-06-05 버베리안 노딕 에이/에스 면역 반응을 증대시키기 위한 방법 및 조성물
US10435464B1 (en) 2014-09-05 2019-10-08 Coherus Biosciences, Inc. Methods for making recombinant proteins
EP3189135B1 (fr) 2014-09-05 2021-06-02 Astellas Institute for Regenerative Medicine Cellules ganglionnaires de la rétine et leurs progénitrices
UA118610C2 (uk) 2014-09-12 2019-02-11 Бьорінгер Інгельхайм Інтернаціональ Гмбх Спіроциклічні інгібітори катепсину c
CN106714835A (zh) 2014-09-17 2017-05-24 默克专利股份公司 治疗骨转移疾病的方法、其药物以及预测治疗骨转移疾病的临床结果的方法
DK3197429T3 (da) 2014-09-25 2024-08-26 Boehringer Ingelheim Vetmedica Gmbh Kombinationsbehandling med sglt2-hæmmere og dopaminagonister til forebyggelse af metaboliske lidelser af dyr i hestefamilien
MA40759A (fr) 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
CN107108672B (zh) 2014-10-03 2019-11-08 Ucb生物制药私人有限公司 稠合的五环咪唑衍生物
HUP1400510A1 (hu) * 2014-10-28 2016-05-30 Richter Gedeon Nyrt Gyógyászati TNFalfa ellenes antitest készítmény
KR102265924B1 (ko) 2014-10-31 2021-06-15 삼성바이오에피스 주식회사 Pdk 불활성화에 의한 폴리펩타이드의 생산
EP3212199B1 (fr) 2014-10-31 2022-12-28 Fresenius Medical Care Deutschland GmbH Compositions pharmaceutiques contenant des stéviosides
EA032104B1 (ru) 2014-11-14 2019-04-30 Бёрингер Ингельхайм Интернациональ Гмбх Морфолин- и 1,4-оксазепан-амиды в качестве агонистов соматостатинового рецептора подтипа 4 (sstr4)
JP6475835B2 (ja) 2014-12-03 2019-02-27 サムスン ライフ パブリック ウェルフェア ファウンデーションＳａｍｓｕｎｇ Ｌｉｆｅ Ｐｕｂｌｉｃ Ｗｅｌｆａｒｅ Ｆｏｕｎｄａｔｉｏｎ ニューロピリン１（Ｎｅｕｒｏｐｉｌｉｎ １）に対する抗体およびその用途
KR20160068558A (ko) 2014-12-05 2016-06-15 삼성바이오에피스 주식회사 마우스 cmv 프로모터를 포함하는 융합 폴리뉴클레오타이드 및 이를 이용한 목적 폴리펩타이드의 생산 방법
SG11201704836XA (en) 2014-12-22 2017-07-28 Ucb Biopharma Sprl Protein manufacture
CA2970577A1 (fr) 2014-12-22 2016-06-30 Ares Trading S.A. Composition pharmaceutique liquide
IL252712B2 (en) 2014-12-22 2024-04-01 UCB Biopharma SRL Method of protein manufacture
EP3237000A1 (fr) * 2014-12-23 2017-11-01 Pfizer Inc Formulation d'anticorps aqueuse stable pour des anticorps anti tnf alpha
US10696735B2 (en) 2015-01-21 2020-06-30 Outlook Therapeutics, Inc. Modulation of charge variants in a monoclonal antibody composition
EP3250598A1 (fr) * 2015-01-28 2017-12-06 Mabxience S.A. Formulations pharmaceutiques pour des anticorps anti-tnf-alpha
EP3250570A1 (fr) 2015-01-30 2017-12-06 Pfizer Inc Modulateurs de pyrrolopyridine substituée par un méthoxy de rorc2 et leurs méthodes d'utilisation
GB201501613D0 (en) 2015-01-30 2015-03-18 Ucb Biopharma Sprl Treatment of autoimmune disorders with CD154 antibodies
US10385036B2 (en) 2015-01-30 2019-08-20 Pfizer Inc. Sulfonamide-substituted indole modulators of RORC2 and methods of use thereof
EP3053572A1 (fr) 2015-02-06 2016-08-10 Ares Trading S.A. Composition pharmaceutique liquide
EP3256160A1 (fr) * 2015-02-13 2017-12-20 Sanofi Formulation liquide stable pour des anticorps monoclonaux
KR20170138426A (ko) 2015-03-13 2017-12-15 삼성바이오에피스 주식회사 항-tnf-알파 폴리펩티드 조성물 및 그 용도
US11505784B2 (en) 2015-04-01 2022-11-22 Boehringer Ingelheim International Gmbh Cell culture medium
WO2016162819A1 (fr) * 2015-04-07 2016-10-13 Lupin Limited Composition pharmaceutique aqueuse stable d'anticorps anti-tnf alpha
EP3078675A1 (fr) 2015-04-10 2016-10-12 Ares Trading S.A. Régime de dosage à induction pour le traitement des maladies liées au tnf alpha
JP6921001B2 (ja) 2015-04-13 2021-08-18 ファイザー・インク Ｂ細胞成熟抗原を標的にするキメラ抗原受容体
EP3391905A1 (fr) 2015-04-14 2018-10-24 Boehringer Ingelheim International GmbH Traitement de l'asthme avec anticorps contre il-23a
EP3081227A1 (fr) 2015-04-15 2016-10-19 Institut National De La Recherche Agronomique Lactococcus lactis produisant du tslp ou il-25 et leurs utilisations comme probiotiques et thérapeutiques
WO2016165765A1 (fr) 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Procédés et compositions permettant de prédire l'efficacité thérapeutique des traitements contre le cancer et de pronostiquer un cancer
GB201506786D0 (en) 2015-04-21 2015-06-03 Ucb Biopharma Sprl Therapeutic use
CN107531791B (zh) 2015-04-28 2021-09-07 田边三菱制药株式会社 RGMa结合蛋白质及其使用
WO2016175230A1 (fr) 2015-04-28 2016-11-03 アステラス製薬株式会社 Composition pharmaceutique pour administration par voie orale
JP2018515082A (ja) 2015-04-30 2018-06-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 代謝障害を処置するための抗ａｐ２抗体及び抗原結合剤
IL255106B2 (en) 2015-05-04 2023-04-01 Pfizer Protein-polysaccharide conjugates of group b streptococcus, methods for preparing conjugates, immunogenic preparations containing conjugates and their uses
CN113940996A (zh) 2015-05-27 2022-01-18 Ucb生物制药私人有限公司 用于治疗神经系统疾病的方法
US20180291329A1 (en) 2015-05-29 2018-10-11 Biogen Ma Inc. Cell culture methods and systems
EP3303303A1 (fr) 2015-05-29 2018-04-11 Pfizer Inc Nouveaux composés hétérocycliques utilisés en tant qu'inhibiteurs de l'enzyme vanine-1
GB201509888D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
GB201509893D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
GB201509885D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
BR112017026191B1 (pt) 2015-06-17 2023-10-10 Pfizer Inc Compostos tricíclicos inibidores de fosfodiesterase, sua composição farmacêutica e uso dos mesmos
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
AR105025A1 (es) 2015-06-19 2017-08-30 Astellas Pharma Inc Compuesto de imidazodiazepina
US20170044265A1 (en) 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
US10548912B2 (en) 2015-07-03 2020-02-04 Astellas Pharma Europe Ltd. Dosage regimen for a tiacumicin compound
TN2017000543A1 (en) 2015-07-06 2019-04-12 Ucb Biopharma Sprl Tau-binding antibodies
MA41670A1 (fr) 2015-07-06 2018-05-31 Ucb Biopharma Sprl Anticorps se liant a tau
EP3325008B1 (fr) 2015-07-21 2025-09-10 Pfizer Inc. Compositions immunogènes contenant des antigènes saccharidiques capsulaires conjugués, kits comprenant ces compositions et leurs utilisations
AU2016297575B2 (en) 2015-07-23 2021-05-27 Boehringer Ingelheim International Gmbh Compound targeting IL-23A and B-cell activating factor (BAFF) and uses thereof
KR20180032585A (ko) 2015-08-04 2018-03-30 아스테라스 세이야쿠 가부시키가이샤 피페라진 유도체
WO2017031312A1 (fr) 2015-08-18 2017-02-23 Astellas Institute For Regenerative Medicine Formulations cliniques
EP3858825A1 (fr) 2015-08-27 2021-08-04 Pfizer Inc. Composés hétéroaryles bicycliques condensés en tant que modulateurs d'irak 4
CA2993996A1 (fr) 2015-09-01 2017-03-09 Boehringer Ingelheim International Gmbh Utilisation d'anticorps anti-cd40 pour le traitement de la nephrite lupique
RS65084B1 (sr) 2015-09-29 2024-02-29 Boehringer Ingelheim Animal Health Usa Inc Vakcine čestica sličnih virusu (vlp) parvovirusa pasa (cpv) i njihova upotreba
US20190048089A1 (en) 2015-09-30 2019-02-14 Janssen Biotech, Inc. Antagonistic Antibodies Specifically Binding Human CD40 and Methods of Use
DK3359688T3 (da) 2015-10-05 2021-08-23 Biogen Ma Inc Molekylære signaturer til anvendelse til diagnose og analyse af respons på behandling af autoimmune sygdomme
KR101949451B1 (ko) 2015-10-13 2019-05-10 주식회사 이노파마스크린 염증성 장 질환 및 아토피 피부염 치료용 조성물
EP3365335B1 (fr) 2015-10-23 2024-02-14 Array Biopharma, Inc. Composés de 2-pyridazin-3(2h)-one à substitution 2-aryle et 2-hétéroaryle utilisés en tant qu'inhibiteurs de fgfr tyrosine kinases
RU2754683C2 (ru) 2015-10-27 2021-09-06 Юсб Биофарма Срл Способы лечения с использованием анти-il-17a антител
MA43164A (fr) 2015-11-02 2018-09-12 Janssen Pharmaceutica Nv Anticorps anti-il1rap, molécules bispécifiques de liaison à un antigène liant il1rap et cd3 et leurs utilisations
HRP20211518T1 (hr) 2015-11-03 2021-12-24 UCB Biopharma SRL Postupak priprave brivaracetama
CA3006078A1 (fr) 2015-11-23 2017-06-01 Merial, Inc. Proteines de fusion de dmdv et e2 et leurs utilisations
TWI703160B (zh) 2015-11-30 2020-09-01 美商輝瑞股份有限公司 用於部位專一性接合之抗體和抗體片段
GB201521389D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
GB201521383D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl And Ucb Celltech Method
GB201521391D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521382D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521393D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
CN108368086B (zh) 2015-12-16 2021-01-08 勃林格殷格翰国际有限公司 可用于治疗自身免疫疾病的二吡唑基衍生物
GB201522391D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibody molecules
MX2018007520A (es) 2015-12-18 2018-08-01 Astellas Pharma Inc Composicion farmaceutica que comprende un anticuerpo receptor de linfopoyetina estromal timica antihumano.
EP3402789B1 (fr) 2016-01-13 2020-03-18 Boehringer Ingelheim International Gmbh Isoquinolones comme inhibiteurs de btk
EP3733201A1 (fr) 2016-01-19 2020-11-04 Pfizer Inc Vaccins contre le cancer
CN114681462A (zh) 2016-01-19 2022-07-01 詹森药业有限公司 包含btk抑制剂的配制品/组合物
WO2017125423A1 (fr) 2016-01-19 2017-07-27 Janssen Pharmaceutica Nv Formulations/compositions comprenant un inhibiteur de btk
EA201891641A1 (ru) 2016-01-21 2019-01-31 Пфайзер Инк. Химерные антигенные рецепторы, нацеленные на вариант iii рецептора эпидермального фактора роста
EP3405490B1 (fr) 2016-01-21 2021-10-20 Pfizer Inc. Anticorps mono et bispécifiques contre le variant iii du récepteur du facteur de croissance épidermique et contre le cd3, et leurs utilisations
US20170218092A1 (en) 2016-01-28 2017-08-03 Janssen Biotech, Inc. Bispecific Anti-TNF-Alpha/IL17A Antibodies and Anti-TNF-Alpha Antibodies and Methods of Their Use
TWI760322B (zh) 2016-01-29 2022-04-11 美商百靈佳殷格翰動物保健美國有限公司 重組腺病毒載體裝載之fmdv疫苗及其用途
US10465003B2 (en) 2016-02-05 2019-11-05 Janssen Biotech, Inc. Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes
US11338043B2 (en) 2016-02-08 2022-05-24 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting HER2 tumours and method for improving therapeutic index of antibody-conjugates
DE102016001407A1 (de) 2016-02-09 2017-08-24 Fresenius Medical Care Deutschland Gmbh Blutbehandlung mit Inaktivierung von freien Nukleinsäuren
GB201602938D0 (en) 2016-02-19 2016-04-06 Ucb Biopharma Sprl Protein purification
US10323042B2 (en) 2016-02-23 2019-06-18 Pfizer Inc. 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
GB201603104D0 (en) 2016-02-23 2016-04-06 Ucb Biopharma Sprl Therapeutic agents
RS60261B1 (sr) 2016-02-24 2020-06-30 Pfizer Pirazolo[1,5-a]pirazin-4-il derivativi kao jak-inhibitori
US10611800B2 (en) 2016-03-11 2020-04-07 Pfizer Inc. Human cytomegalovirus gB polypeptide
CN109311965B (zh) 2016-03-11 2023-07-18 勃林格殷格翰国际公司 在制造蛋白质期间连续灭活病毒的方法
ES2947570T3 (es) 2016-03-15 2023-08-11 Astellas Pharma Inc Comprimido
US10519479B1 (en) 2016-03-15 2019-12-31 Ares Trading S.A. Methods for modifying glycosylation using manganese
US10526631B1 (en) 2016-03-15 2020-01-07 Ares Trading S.A. Method of reducing serine for asparagine misincorporation
KR102023058B1 (ko) 2016-03-25 2019-09-19 사회복지법인 삼성생명공익재단 이중 이온 pH-민감성 공중합체를 이용한 허혈성 뇌질환 치료용 약물 전달체
KR20180124055A (ko) 2016-03-29 2018-11-20 아스테라스 세이야쿠 가부시키가이샤 급성 골수성 백혈병의 치료를 위한 병용 요법
US10654861B2 (en) 2016-04-01 2020-05-19 UCB Biopharma SRL Fused pentacyclic imidazole derivatives as modulators of TNF activity
CA3018907A1 (fr) 2016-04-01 2017-10-05 Ucb Biopharma Sprl Derives d'imidazole pentacycliques condenses utilises en tant que modulateurs de l'activite du tnf
BR112018069936A2 (pt) 2016-04-01 2019-02-05 Sanofi Sa derivados de imidazol pentacíclicos fundidos como moduladores de atividade do tnf
CA3018992A1 (fr) 2016-04-01 2017-10-05 Ucb Biopharma Sprl Derives d'imidazole hexacycliques condenses utilises en tant que modulateurs de l'activite du tnf
CN108883345B (zh) 2016-04-01 2022-09-13 Ucb生物制药私人有限公司 用于蛋白纯化的方法
ES2992002T3 (es) 2016-04-06 2024-12-05 Astellas Pharma Inc Moldeo tridimensional de elución rápida, filamento para moldeo tridimensional de elución rápida y material para moldeo tridimensional de elución rápida
US10485857B2 (en) 2016-04-07 2019-11-26 Boehringer Ingelheim Animal Health USA Inc. Heartworm vaccine, methods and uses thereof
US10538786B2 (en) 2016-04-13 2020-01-21 Janssen Pharmaceuticals, Inc. Recombinant arterivirus replicon systems and uses thereof
WO2017178377A1 (fr) 2016-04-13 2017-10-19 Ucb Biopharma Sprl Dérivés de tétrahydroisoquinoléine
WO2017178586A1 (fr) 2016-04-15 2017-10-19 Cellectis Méthode de mise au point par génie génétique de lymphocytes t hypersensibles à un promédicament spécifique pour une immunothérapie par expression génique
US11649283B2 (en) 2016-04-15 2023-05-16 Immunext, Inc. Anti-human vista antibodies and use thereof
KR20170122650A (ko) 2016-04-27 2017-11-06 사회복지법인 삼성생명공익재단 미숙아 뇌실내 출혈 치료를 위한 고효능 줄기세포 선별법
PE20181952A1 (es) 2016-04-27 2018-12-17 Pfizer Anticuerpos anti-ll-33, composiciones, metodos y usos de los mismos
JP7133544B2 (ja) 2016-05-01 2022-09-08 ユーシービー バイオファルマ エスアールエル 親和性を操作した血清タンパク質担体結合ドメイン
US11118208B2 (en) 2016-05-10 2021-09-14 Ares Trading S.A. Methods for modulating protein galactosylation profiles of recombinant proteins using peracetyl galactose
GB201608323D0 (en) 2016-05-12 2016-06-29 Ucb Biopharma Sprl Pharmaceutical compositions
GB201608797D0 (en) 2016-05-19 2016-07-06 Ucb Biopharma Sprl Therapeutic use
US20190336552A1 (en) 2016-05-30 2019-11-07 Astellas Pharma Inc. Genetically engineered vaccinia viruses
TW201808987A (zh) 2016-06-08 2018-03-16 健生生物科技公司 Ｇｍ－ｃｓｆ變體及使用方法
GB201610044D0 (en) 2016-06-08 2016-07-20 Ucb Biopharma Sprl Antibodies
GB201610198D0 (en) 2016-06-10 2016-07-27 Ucb Biopharma Sprl Anti-ige antibodies
BR112019000589A2 (pt) 2016-07-14 2019-04-24 Pfizer Inc. pirimidina carboxamidas como inibidores da enzima vanina-1
EP3484507A1 (fr) 2016-07-15 2019-05-22 Janssen Vaccines & Prevention B.V. Méthodes et compositions permettant l'induction d'une immunité protectrice contre l'infection par le virus de marburg
CN109563074B (zh) 2016-07-19 2021-09-28 安斯泰来制药株式会社 哌嗪衍生物
WO2018022851A1 (fr) 2016-07-28 2018-02-01 Mitobridge, Inc. Méthode de traitement de lésions rénales aiguës.
MX2019001153A (es) 2016-07-29 2019-06-10 Pfizer Peptidos ciclicos como antagonistas del receptor c5a.
WO2018030459A1 (fr) 2016-08-10 2018-02-15 アステラス製薬株式会社 Procédé de détection de gène hybride ｃｌｄｎ１８－ａｒｈｇａｐ６ ou de gène hybride ｃｌｄｎ１８－ａｒｈｇａｐ２６ du cancer du pancréas
AU2017313268C1 (en) 2016-08-17 2024-10-10 Boehringer Ingelheim International Gmbh Process for the preparation of highly concentrated liquid formulations containing biomolecules
WO2018035330A1 (fr) 2016-08-19 2018-02-22 Janssen Biotech, Inc. Méthodes de traitement de la maladie de crohn avec un anticorps anti-nkg2d
DK3510141T3 (da) 2016-09-12 2023-12-04 Ares Trading Sa Fremgangsmåder til modulering af fremstillingsprofiler af rekombinante proteiner
BR112019003320B1 (pt) 2016-09-15 2024-02-20 Boehringer Ingelheim International Gmbh Compostos de heteroaril carboxamida, sal farmaceuticamente aceitável dos mesmos, composição farmacêutica e seus usos como inibidores de ripk2
KR102546471B1 (ko) 2016-09-27 2023-06-21 프레제니우스 카비 도이치란트 게엠베하 액상의 약학 조성물
GB201616563D0 (en) 2016-09-29 2016-11-16 Ucb Biopharma Sprl Therapeutic agents
US10537590B2 (en) 2016-09-30 2020-01-21 Boehringer Ingelheim International Gmbh Cyclic dinucleotide compounds
KR101971323B1 (ko) 2016-10-17 2019-04-23 사회복지법인 삼성생명공익재단 면역질환 치료를 위한 고효능 줄기세포 선별방법
KR101971322B1 (ko) 2016-10-17 2019-04-23 사회복지법인 삼성생명공익재단 Ｓｏｃｓ의　발현　또는　활성　억제를　이용한　고효능 줄기세포 선별방법
HUE070615T2 (hu) 2016-10-17 2025-06-28 Pfizer Anti-EDB antitestek és antitest-gyógyszer konjugátumok
GB201617924D0 (en) 2016-10-24 2016-12-07 Ucb Biopharma Sprl Proteins and users
JPWO2018079570A1 (ja) 2016-10-26 2019-09-19 アステラス製薬株式会社 安定な医薬組成物
KR101837449B1 (ko) 2016-10-28 2018-03-12 삼성전자주식회사 마이크로 니들 패치, 마이크로 니들을 제조하는 방법 및 장치
EP3964197A1 (fr) 2016-10-31 2022-03-09 Fresenius Kabi Deutschland GmbH Composition pharmaceutique liquide
CN110062765A (zh) 2016-10-31 2019-07-26 维克特拉有限公司 包括il-13抗体的可吸入粉末组合物
SG10201912529SA (en) 2016-11-18 2020-02-27 Astellas Pharma Inc Novel anti-human muc1 antibody fab fragment
WO2018098213A1 (fr) 2016-11-23 2018-05-31 Wake Forest University Health Sciences Analyse d'image médicale à l'aide d'informations de déformation mécanique
GB201620948D0 (en) 2016-12-09 2017-01-25 Ucb Biopharma Sprl Therapeutic agents
CA3046432A1 (fr) 2016-12-13 2018-06-21 Astellas Pharma Inc. Anticorps anti-cd73 humain
GB201621728D0 (en) 2016-12-20 2017-02-01 Ucb Biopharma Sprl Methods
EP3824906A1 (fr) 2016-12-21 2021-05-26 Amgen Inc. Formulations d'anticorps anti-tnf alpha
TWI754702B (zh) 2016-12-28 2022-02-11 德商Ｕｃｂ製藥有限公司 （氮雜）吲哚－和苯並呋喃－３－磺醯胺類
US11413344B2 (en) 2017-01-20 2022-08-16 Pfizer Inc. Immunogenic compositions for use in pneumococcal vaccines
AU2018211735B2 (en) 2017-01-24 2021-08-12 Astellas Pharma Inc. Phenyldifluoromethyl-substituted prolinamide compound
BR112019015069A2 (pt) 2017-01-24 2020-03-03 Pfizer Inc. Derivados de caliqueamicina e conjugados de anticorpo-fármaco dos mesmos
ES2884145T3 (es) 2017-01-26 2021-12-10 UCB Biopharma SRL Derivados bicíclicos de bis-heteroarilo como moduladores de la agregación de proteínas
ES2882285T3 (es) 2017-01-26 2021-12-01 Ucb Biopharma Sprl Derivados de bis-heteroarilo como moduladores de la agregación de proteínas
EP3573658A4 (fr) 2017-01-30 2021-07-21 Janssen Biotech, Inc. Anticorps anti-tnf, compositions et méthodes pour le traitement du rhumatisme psoriasique actif
JOP20190186A1 (ar) 2017-02-02 2019-08-01 Astellas Pharma Inc مركب كينازولين
KR20190115042A (ko) 2017-02-07 2019-10-10 얀센 바이오테크 인코포레이티드 활성 강직성 척추염의 치료를 위한 항-tnf 항체, 조성물, 및 방법
KR20190117579A (ko) 2017-02-16 2019-10-16 엑스바이오테크, 인크. 화농성 한선염의 치료
JP7467119B2 (ja) 2017-02-17 2024-04-15 ロンザ リミテッド 発現困難タンパク質のための多部位ｓｓｉ細胞
EP3589323B1 (fr) 2017-03-01 2024-04-03 Janssen Sciences Ireland Unlimited Company Polythérapie pour le traitement de la tuberculose
EP3372242A1 (fr) 2017-03-06 2018-09-12 Ares Trading S.A. Composition pharmaceutique liquide
EP3372241A1 (fr) 2017-03-06 2018-09-12 Ares Trading S.A. Composition pharmaceutique liquide
IL269215B (en) 2017-03-10 2022-09-01 Pfizer Disubstituted imidazole[4,5-c]quinoline derivatives
JP6901292B2 (ja) 2017-03-15 2021-07-14 株式会社Adeka 水溶性組成物、その硬化物の製造方法、およびその硬化物、並びにアシルホスフィン酸塩
WO2018167176A1 (fr) 2017-03-15 2018-09-20 Ucb Biopharma Sprl Dérivés d'imidazole pentacycliques condensés utilisés en tant que modulateurs de l'activité du tnf
JP2020514370A (ja) 2017-03-17 2020-05-21 キュアバック アーゲー 組合せ抗癌療法のためのｒｎａワクチン及び免疫チェックポイント阻害剤
JOP20190218A1 (ar) 2017-03-22 2019-09-22 Boehringer Ingelheim Int مركبات ثنائية النيوكليوتيدات حلقية معدلة
CN110475567A (zh) 2017-03-31 2019-11-19 勃林格殷格翰国际有限公司 抗癌组合疗法
HRP20211927T1 (hr) 2017-04-25 2022-03-18 UCB Biopharma SRL Derivati spojenih pentacikličnih imidazola kao modulatori aktivnosti tnf
US20200048686A1 (en) 2017-04-26 2020-02-13 The Rna Medicines Company, Inc. Oligonucleotide binding agents
CN110785185B (zh) 2017-06-05 2024-05-24 詹森生物科技公司 具有非对称ch2-ch3区突变的工程化多特异性抗体和其他多聚体蛋白
PE20200340A1 (es) 2017-06-12 2020-02-14 Boehringer Ingelheim Int Compuestos heteroaromaticos como inhibidores de vanina
GB201709456D0 (en) 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
CR20200076A (es) 2017-07-14 2020-06-10 Pfizer ANTICUERPOS CONTRA MAdCAM
US20190048073A1 (en) 2017-07-20 2019-02-14 Pfizer Inc. Anti-gd3 antibodies and antibody-drug conjugates
SG11202000966XA (en) 2017-08-11 2020-02-27 Boehringer Ingelheim Int Integration sites in CHO cells
EP3668858A1 (fr) 2017-08-14 2020-06-24 Pfizer Inc Pyrazolo[1,5-a]pyrazin-4-yl et dérivés associés
WO2019035649A1 (fr) 2017-08-14 2019-02-21 주식회사 레고켐 바이오사이언스 Conjugués anticorps-médicament comprenant un anticorps contre egfrviii
JP7278261B2 (ja) 2017-08-23 2023-05-19 ノバルティス アーゲー マルチコピー遺伝子タンパク質発現系
EP3672611A4 (fr) 2017-08-25 2021-07-14 Janssen Biotech, Inc. DOMAINES DE TYPE III DE FIBRONECTINE LIANT FCyRII, LEURS CONJUGUÉS ET MOLÉCULES MULTISPÉCIFIQUES LES COMPRENANT
US20210130396A1 (en) 2017-08-30 2021-05-06 Ares Trading S.A. Method for purifying proteins
CN115920032A (zh) 2017-08-31 2023-04-07 田边三菱制药株式会社 含有il-33拮抗剂的子宫内膜异位症治疗剂
CA3074865A1 (fr) 2017-09-14 2019-03-21 Icagen, Inc. Procedes de detection utilisant la fluorescence x
TW201922780A (zh) 2017-09-25 2019-06-16 美商健生生物科技公司 以抗ｉｌ１２／ｉｌ２３抗體治療狼瘡之安全且有效之方法
KR102188572B1 (ko) 2017-09-25 2020-12-09 사회복지법인 삼성생명공익재단 뇌척수액을 포함하는 줄기세포 투여 제형 및 그의 제조방법
KR102403046B1 (ko) 2017-09-29 2022-05-30 재단법인 목암생명과학연구소 Bcma에 높은 친화도를 가지는 항-bcma 항체 및 이를 포함하는 암 치료용 약학적 조성물
US11364303B2 (en) 2017-09-29 2022-06-21 Pfizer Inc. Cysteine engineered antibody drug conjugates
US20190153096A1 (en) 2017-10-02 2019-05-23 Covagen Ag Cd3/cd33 bispecific binding molecules
US20190100587A1 (en) 2017-10-02 2019-04-04 Covagen Ag IgG1 Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS
CN111225685A (zh) 2017-10-13 2020-06-02 默克专利股份有限公司 Parp抑制剂和pd-1轴结合拮抗剂的组合
EP3694889A1 (fr) 2017-10-13 2020-08-19 Boehringer Ingelheim International GmbH Anticorps humains dirigés contre l'antigène thomsen-nouveau (tn)
AU2018348712B2 (en) 2017-10-13 2024-05-30 Boehringer Ingelheim International Gmbh Perfusion medium
CA3078155A1 (fr) 2017-10-19 2019-04-25 Debiopharm International S.A. Produit de combinaison pour le traitement du cancer
PE20201255A1 (es) 2017-10-27 2020-11-16 Pfizer Anticuerpos y conjugados de anticuerpo-farmaco especificos para cd123 y usos de los mismos
WO2019090329A1 (fr) 2017-11-06 2019-05-09 Janssen Biotech, Inc. Méthode sûre et efficace de traitement de l'arthrite psoriasique par un anticorps spécifique anti-il23
BR112020007884A2 (pt) 2017-11-20 2020-11-03 Janssen Pharmaceuticals, Inc. método de proporcionar uma administração segura de vetores adenovirais que codificam um antígeno de vírus zika
GB201719447D0 (en) 2017-11-23 2018-01-10 Ucb Biopharma Sprl Pharmaceutical composition
KR20190064293A (ko) 2017-11-30 2019-06-10 (주)메디노 미숙아 뇌실내 출혈 치료를 위한 고효능 줄기세포 선별법
BR112020010753A2 (pt) 2017-12-01 2020-11-24 The Regents Of The University Of California anticorpos anti-cxcr5 e composições e usos dos mesmos
GB201720975D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
GB201720970D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Antibodies
TW201938165A (zh) 2017-12-18 2019-10-01 美商輝瑞股份有限公司 治療癌症的方法及組合療法
MX2020006471A (es) 2017-12-19 2020-09-22 Janssen Sciences Ireland Unlimited Co Metodos y composiciones para inducir una respuesta inmune contra el virus de hepatitis b (hbv).
US11020476B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV)
CN111527214B (zh) 2017-12-20 2024-08-06 阿雷斯贸易股份有限公司 用聚醚离子载体调整蛋白质甘露糖基化状况的方法
EP3727374A4 (fr) 2017-12-21 2021-11-10 Merck Patent GmbH Association d'un anticorps anti-pd-l1 et d'un inhibiteur de l'ido1 pour le traitement du cancer
KR20200110356A (ko) 2018-01-15 2020-09-23 화이자 인코포레이티드 키메라 항원 수용체 면역요법을 4-1bb 효능제와 조합하여 투여하는 방법
CA3088764A1 (fr) 2018-01-15 2019-07-18 UCB Biopharma SRL Derives d'imidazole fusionnes utilises en tant qu'inhibiteurs d'il-17
PE20210708A1 (es) 2018-02-01 2021-04-16 Pfizer Anticuerpos especificos para cd70 y sus usos
IL276396B2 (en) 2018-02-01 2026-01-01 Pfizer Chimeric antigen receptors against CD70
TWI839347B (zh) 2018-02-27 2024-04-21 美商輝瑞大藥廠 抗體純化
EP3759129A1 (fr) 2018-02-28 2021-01-06 Pfizer Inc Variants d'il-15 et leurs utilisations
EP3759132A1 (fr) 2018-03-02 2021-01-06 Allogene Therapeutics, Inc. Récepteurs de cytokines chimériques inductibles
IL276896B2 (en) 2018-03-05 2024-06-01 Janssen Biotech Inc Methods of treating crohn's disease with anti-il23 specific antibody
IL277095B2 (en) 2018-03-07 2025-10-01 Pfizer Preparations containing anti-PD-1 antibody
WO2019177883A2 (fr) 2018-03-14 2019-09-19 Boehringer Ingelheim International Gmbh Utilisation d'anticorps anti-il-36 r pour le traitement d'une maladie intestinale inflammatoire
WO2019177888A1 (fr) 2018-03-14 2019-09-19 Boehringer Ingelheim International Gmbh Utilisation d'anticorps anti-il-36r pour le traitement du psoriasis pustuleux généralisé
CN111971291A (zh) 2018-03-27 2020-11-20 勃林格殷格翰国际有限公司 用作sting激动剂的含有2-氮杂-次黄嘌呤或6h-吡唑并[1,5-d][1,2,4]三嗪-7-酮的环状二核苷酸化合物
EP3774833A1 (fr) 2018-03-27 2021-02-17 Boehringer Ingelheim International GmbH Composés dinucléotidiques cycliques modifiés
KR102837419B1 (ko) 2018-04-20 2025-07-23 얀센 바이오테크 인코포레이티드 항-il12/il23 항체 조성물을 생성하기 위한 제조 방법에 있어서의 크로마토그래피 컬럼 적격성 평가
WO2019212253A1 (fr) 2018-05-02 2019-11-07 사회복지법인 삼성생명공익재단 Anticorps se liant de manière spécifique à c-met et utilisation associée
EP3790866A4 (fr) 2018-05-08 2022-03-02 Janssen Sciences Ireland Unlimited Company Dérivés de dihydropyrimidine et leurs utilisations dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b
JP2021523138A (ja) 2018-05-11 2021-09-02 ヤンセン バイオテツク，インコーポレーテツド Ｉｌ−２３抗体を使用してうつを治療する方法
CA3100157A1 (fr) 2018-05-16 2019-11-21 Janssen Biotech, Inc. Procedes de traitement de cancers et d'amelioration de l'efficacite d'agents therapeutiques de redirection de lymphocytes t
WO2019220412A2 (fr) 2018-05-18 2019-11-21 Janssen Biotech, Inc. Méthode sûre et efficace de traitement du lupus avec un anticorps anti-il12/il23
EP3569618A1 (fr) 2018-05-19 2019-11-20 Boehringer Ingelheim International GmbH Antagonisation d'anticorps cd73
EP3796983A2 (fr) 2018-05-23 2021-03-31 Pfizer Inc. Anticorps spécifiques de gucy2c et leurs utilisations
PL3797121T3 (pl) 2018-05-23 2024-09-23 Pfizer Inc. Przeciwciała swoiste dla CD3 i ich zastosowania
MX420253B (es) 2018-05-24 2025-02-10 Janssen Biotech Inc Anticuerpos anti-cd3 y usos de estos.
JOP20190116A1 (ar) 2018-05-24 2019-11-24 Janssen Biotech Inc الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها
PE20211916A1 (es) 2018-05-24 2021-09-28 Janssen Biotech Inc Agentes aglutinantes del psma y usos de estos
CA3099917A1 (fr) 2018-05-24 2019-11-28 Ares Trading S.A. Procede de regulation du degre d'afucosylation d'une composition de glycoproteines
WO2019231243A1 (fr) 2018-05-29 2019-12-05 사회복지법인 삼성생명공익재단 Cellule nourricière exprimant ox40l et procédé de culture de cellules tueuses naturelles l'utilisant
WO2019232110A1 (fr) 2018-05-30 2019-12-05 Mayne Pharma International Pty Ltd Inhibition de la voie hedgehog pour le traitement du carcinome basocellulaire à haut risque ou du syndrome de naevus du carcinome basocellulaire à haut risque
KR102286933B1 (ko) 2018-06-05 2021-08-06 사회복지법인 삼성생명공익재단 그레이브스 안병증 표현형 동물 모델, 그의 제조방법 및 그레이브스 안병증 치료물질 스크리닝 방법
CA3045370A1 (fr) 2018-06-08 2019-12-08 Pfizer Inc. Methodes de traitement de la maladie metabolique
TWI848953B (zh) 2018-06-09 2024-07-21 德商百靈佳殷格翰國際股份有限公司 針對癌症治療之多特異性結合蛋白
JP2021527082A (ja) 2018-06-11 2021-10-11 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ 新規な免疫チェックポイント阻害剤
GB201809700D0 (en) 2018-06-13 2018-08-01 Singapore Health Serv Pte Ltd IL-11 antibodies
GB201809699D0 (en) 2018-06-13 2018-08-01 Singapore Health Serv Pte Ltd IL-11 antibodies
CN112585128B (zh) 2018-06-18 2023-02-21 詹森药业有限公司 作为malt1抑制剂的吡唑衍生物
MX2020013699A (es) 2018-06-18 2021-05-12 Janssen Pharmaceutica Nv Derivados de pirazol como inhibidores de malt1.
EP3814326A4 (fr) 2018-06-26 2022-03-16 Janssen Sciences Ireland Unlimited Company Dérivés de dihydropyrimidine et leurs utilisations dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b
CA3103988A1 (fr) 2018-06-27 2020-01-02 Boehringer Ingelheim Rcv Gmbh & Co Kg Moyens et procedes d'augmentation de l'expression de proteines a l'aide de facteurs de transcription
JP7504808B2 (ja) 2018-06-29 2024-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 自己免疫疾患の処置における使用のための抗ｃｄ４０抗体
WO2020016838A2 (fr) 2018-07-18 2020-01-23 Janssen Biotech, Inc. Prédicteurs de réponse prolongée après le traitement avec un anticorps spécifique anti-il23
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
TWI803682B (zh) 2018-08-20 2023-06-01 美商輝瑞股份有限公司 抗－ｇｄｆ１５抗體、組成物及使用方法
US20200061015A1 (en) 2018-08-23 2020-02-27 Janssen Biotech, Inc. Lipase Degradation Resistant Surfactants for Use in Large Molecule Therapeutic Formulations
US11260119B2 (en) 2018-08-24 2022-03-01 Pfizer Inc. Escherichia coli compositions and methods thereof
JOP20210034A1 (ar) 2018-08-28 2021-02-25 Boehringer Ingelheim Int مركبات عطرية غير متجانسة كمثبطات Vanin
EP3848388B1 (fr) 2018-09-05 2025-08-20 LG Chem, Ltd. Polypeptide de fusion comprenant une région polypeptidique pouvant être o-glycosylée
AU2019336197A1 (en) 2018-09-07 2021-02-18 Pfizer Inc. Anti-avb8 antibodies and compositions and uses thereof

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WO2018119142A1 (fr) 2018-06-28
US20200087390A1 (en) 2020-03-19
US20250171527A1 (en) 2025-05-29
EP4467565A2 (fr) 2024-11-27
EP4467565A3 (fr) 2025-03-12
EP3824906A1 (fr) 2021-05-26
US20230151086A1 (en) 2023-05-18

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