MA47106A - Formulations d'anticorps anti-tnf alpha - Google Patents

Formulations d'anticorps anti-tnf alpha

Info

Publication number
MA47106A
MA47106A MA047106A MA47106A MA47106A MA 47106 A MA47106 A MA 47106A MA 047106 A MA047106 A MA 047106A MA 47106 A MA47106 A MA 47106A MA 47106 A MA47106 A MA 47106A
Authority
MA
Morocco
Prior art keywords
tnf alpha
antibody formulations
alpha antibody
formulations
tnf
Prior art date
Application number
MA047106A
Other languages
English (en)
Inventor
Joy Brennan
William J Callahan
Rahul Rajan Kaushik
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA47106A publication Critical patent/MA47106A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA047106A 2016-12-21 2017-12-20 Formulations d'anticorps anti-tnf alpha MA47106A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662437640P 2016-12-21 2016-12-21

Publications (1)

Publication Number Publication Date
MA47106A true MA47106A (fr) 2019-10-30

Family

ID=61006357

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047106A MA47106A (fr) 2016-12-21 2017-12-20 Formulations d'anticorps anti-tnf alpha

Country Status (4)

Country Link
US (3) US20200087390A1 (fr)
EP (3) EP3558363A1 (fr)
MA (1) MA47106A (fr)
WO (1) WO2018119142A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018119142A1 (fr) 2016-12-21 2018-06-28 Amgen Inc. Formulations d'anticorps anti-tnf alpha
BR112021021099A2 (pt) * 2019-04-23 2021-12-14 Sanofi Sa Formulações de anticorpos estáveis, de baixa viscosidade, e usos das mesmas
US11655302B2 (en) 2019-06-10 2023-05-23 Sanofi Anti-CD38 antibodies and formulations
US20240343795A1 (en) * 2021-08-12 2024-10-17 Amgen Inc. Antibody formulations

Family Cites Families (669)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945098A (en) 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
US5919452A (en) 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
US5656272A (en) 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
US6284471B1 (en) 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
US5698195A (en) 1991-03-18 1997-12-16 New York University Medical Center Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies
US7192584B2 (en) 1991-03-18 2007-03-20 Centocor, Inc. Methods of treating psoriasis with anti-TNF antibodies
US6270766B1 (en) 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
ES2188657T3 (es) 1994-04-22 2003-07-01 Yamanouchi Pharma Co Ltd Sistema para la liberacion especifica en el colon de un farmaco.
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
MX336813B (es) 1996-02-09 2016-02-02 Abbvie Biotechnology Ltd Anticuerpos humanos que ligan el tnfa humano.
GB9610992D0 (en) 1996-05-24 1996-07-31 Glaxo Group Ltd Concentrated antibody preparation
JP2000516594A (ja) 1996-07-26 2000-12-12 スミスクライン・ビーチャム・コーポレイション 免疫細胞介在全身性疾患の改良された治療法
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
PT917879E (pt) 1997-11-22 2002-12-31 Roche Diagnostics Gmbh Processo melhorado para estabilizacao de proteinas
US6919372B1 (en) 1997-12-26 2005-07-19 Yamanouchi Pharmaceutical Co., Ltd. Sustained release pharmaceutical compositions
DE19814084B4 (de) 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
DK2270044T3 (en) 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
GB9812545D0 (en) 1998-06-10 1998-08-05 Celltech Therapeutics Ltd Biological products
EP1098885B9 (fr) 1998-07-23 2005-05-18 Fujisawa Pharmaceutical Co., Ltd. Composes d'imidazole et leur utilisation en tant qu'inhibiteurs d'adenosine deaminase
GB9824632D0 (en) 1998-11-10 1999-01-06 Celltech Therapeutics Ltd Biological compounds
DK1142905T3 (da) 1999-01-13 2006-09-18 Astellas Pharma Inc Hidtil ukendt depsipeptidforbindelse
HUP0200575A3 (en) 1999-03-25 2004-11-29 Abbott Gmbh & Co Kg Human antibodies that bind human il-12 and methods for producing
WO2007019398A1 (fr) 2005-08-03 2007-02-15 Advanced Cell Technology, Inc. Procedes ameliores de reprogrammation de cellules somatiques animales
US6716613B1 (en) 1999-11-11 2004-04-06 Yamanouchi Pharmaceutical Co., Ltd. Metalloprotease having aggrecanase activity
WO2001046392A2 (fr) 1999-12-22 2001-06-28 Oxford Glycosciences (Uk) Ltd. Substances
NZ520967A (en) 2000-02-25 2004-04-30 Oxford Glycosciences Uk Ltd Use of breast cancer associated membrane proteins (BCMP) for treatment, prophylaxis and diagnosis of breast cancer
DE60130910T2 (de) 2000-04-17 2008-07-10 Ucb Pharma, S.A. Enamin-derivate als zell-adhäsionsmoleküle
JP2001322933A (ja) 2000-05-15 2001-11-20 Ucb Sa Cd40シグナル遮断剤
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
ATE368735T1 (de) 2000-12-18 2007-08-15 Astellas Pharma Inc Neue aggrecanase
WO2002053544A1 (fr) 2000-12-29 2002-07-11 Darwin Discovery Ltd. Utilisations pharmaceutiques et synthese de nicotinanilide-n-oxydes
CA2817619A1 (fr) 2001-06-08 2002-12-08 Abbott Laboratories (Bermuda) Ltd. Methodes pour administrer des anticorps anti-tnf.alpha.
GB0114644D0 (en) 2001-06-15 2001-08-08 Oxford Glycosciences Uk Ltd Protein
DE60230266D1 (de) 2001-06-15 2009-01-22 Astellas Pharma Inc Phenylpyridincarbonyl piperazinderivate
EP2295081B1 (fr) 2001-06-26 2018-10-31 Amgen Inc. Anticorps OPGL
WO2003009740A2 (fr) 2001-07-24 2003-02-06 Biogen Idec Ma Inc. Methodes de traitement ou de prevention de troubles sclereux par l'usage d'agents se liant a cd2
TWI334439B (en) 2001-08-01 2010-12-11 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
MXPA04001725A (es) 2001-08-24 2005-04-11 Advanced Cell Tech Inc ANáLISIS DE SELECCION PARA IDENTIFICAR AGENTES INDUCTORES DE DIFERENCIACION Y PRODUCCION DE CELULAS DIFERENCIADAS PARA TERAPIA CELULAR.
US7241873B2 (en) 2001-09-25 2007-07-10 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Recombinant anti-osteopontin antibody and use thereof
IL161677A0 (en) 2001-11-08 2004-09-27 Protein Design Labs Stable liquid pharmaceutical formulation of igg antibodies
ES2394018T3 (es) 2001-11-27 2013-01-15 Ucb Pharma S.A. Procedimientos para el diagnóstico y el tratamiento de cánceres derivados de células epiteliales
US7261892B2 (en) 2001-11-27 2007-08-28 Celltech R&D Limited Methods for diagnosis and treatment of epithelial-derived cancers
GB0129105D0 (en) 2001-12-05 2002-01-23 Celltech R&D Ltd Expression control using variable intergenic sequences
GB0207533D0 (en) 2002-04-02 2002-05-08 Oxford Glycosciences Uk Ltd Protein
GB0208089D0 (en) 2002-04-09 2002-05-22 Oxford Glycosciences Uk Ltd Protein
US7638630B2 (en) 2002-04-30 2009-12-29 Ucb Pharma S.A. 2,6-quinolinyl and 2,6-naphthyl derivatives, processes for preparing them and their uses as VLA-4 inhibitors
WO2003099226A2 (fr) 2002-05-28 2003-12-04 Celltech R & D Limited Isomeres de position de peg d'anticorps, compositions les comprenant, et leur utilisation
CA2480619A1 (fr) 2002-06-06 2003-12-18 Masakatsu Kawakami Nouvelle oxydase
GB0214268D0 (en) 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
EP1521581B1 (fr) 2002-07-02 2008-02-20 UCB Farchim S.A. Diarylmethylpiperazines utiles comme agents prophylactiques ou therapeutiques de la myocardite virale
WO2004009776A2 (fr) 2002-07-19 2004-01-29 Abbott Biotechnology Ltd. Traitement de troubles en relation avec le tnf$g(a)
GB0218800D0 (en) 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
GB0222743D0 (en) 2002-10-01 2002-11-06 Celltech R&D Ltd Chemical compounds
MY150740A (en) 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
EP1572976B1 (fr) 2002-11-21 2010-09-15 Celltech R & D, Inc. Modulation de reponses immunitaires
US9498530B2 (en) 2002-12-24 2016-11-22 Rinat Neuroscience Corp. Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
DK1581535T5 (da) 2003-01-09 2009-12-21 Astellas Pharma Inc Pyrrolopyridazinderivater
ES2625429T3 (es) 2003-01-23 2017-07-19 Esperion Therapeutics Inc. Compuestos de hidroxilo y composiciones para el control del colesterol y utilizaciones correspondientes
EP1594423B1 (fr) 2003-02-14 2009-01-07 DePuy Spine, Inc. Dispositif et procede de fusion intervertebrale forme in-situ
EP1595952A4 (fr) 2003-02-19 2008-05-21 Astellas Pharma Inc Procede d'evaluation de l'effet antitumoral d'un inhibiteur d'histone desacetylase
US6805686B1 (en) 2003-05-06 2004-10-19 Abbott Laboratories Autoinjector with extendable needle protector shroud
EP1481683A1 (fr) 2003-05-30 2004-12-01 Yamanouchi Pharmaceutical Co. Ltd. Ligands ayant pour cible la P-selectine et compositions les comprenant
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
CA2528602A1 (fr) 2003-06-20 2004-12-29 Celltech R & D Limited Derives de thienopyridone en tant qu'inhibiteurs de kinase
CA2528603A1 (fr) 2003-06-20 2004-12-29 Celltech R & D Limited Derives de thienopyridone en tant qu'inhibiteurs de kinase
ES2551439T5 (es) 2003-07-01 2018-11-08 Ucb Biopharma Sprl Fragmentos Fab de anticuerpos modificados
EP1640010A1 (fr) 2003-07-01 2006-03-29 Astellas Pharma Inc. Agent d'induction de croissance dans la masse osseuse
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
JP2007509123A (ja) 2003-10-24 2007-04-12 セルテック アール アンド ディ リミテッド キナーゼ阻害剤としてのチエノ−ピリジノン誘導体
GB0325836D0 (en) 2003-11-05 2003-12-10 Celltech R&D Ltd Biological products
PT1685849E (pt) 2003-11-20 2012-02-15 Astellas Pharma Inc Inibidores de pde4 para o tratamento da cistite intersticial
HUE026260T2 (en) 2003-11-21 2016-06-28 Ucb Biopharma Sprl A method for treating multiple sclerosis by inhibiting IL-17 activity
MX370489B (es) 2004-01-09 2019-12-16 Pfizer Anticuerpos contra madcam.
JP2007104901A (ja) 2004-01-16 2007-04-26 Astellas Pharma Inc 関節リウマチ治療薬のスクリーニング法
JP2007104902A (ja) 2004-01-16 2007-04-26 Astellas Pharma Inc 関節リウマチ治療薬のスクリーニング法
US20190282622A1 (en) 2004-01-23 2019-09-19 Astellas Institute For Regenerative Medicine Modalities for the treatment of degenerative diseases of the retina
US7670624B2 (en) 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
TW201705980A (zh) 2004-04-09 2017-02-16 艾伯維生物技術有限責任公司 用於治療TNFα相關失調症之多重可變劑量療法
US20070265289A1 (en) 2004-04-15 2007-11-15 Yoshinori Okamoto 2-Aminopyrimidine Derivative
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
JP2007277093A (ja) 2004-06-21 2007-10-25 Astellas Pharma Inc 三環系化合物
JP2007269629A (ja) 2004-06-21 2007-10-18 Astellas Pharma Inc キナゾリン誘導体
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
DE602005011286D1 (en) 2004-07-05 2009-01-08 Astellas Pharma Inc Pyrazolopyridinderivate
WO2006004191A1 (fr) 2004-07-05 2006-01-12 Astellas Pharma Inc. Derivés de pyrrolopyridazine qui inhibent la pde iv et le tnf alpha
WO2006038734A1 (fr) 2004-10-08 2006-04-13 Astellas Pharma Inc. Dérivés de la pyridazinone inhibiteurs de cytokines
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
GB0425569D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
GB0425972D0 (en) 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
MY157915A (en) 2004-12-21 2016-08-15 Centocor Inc Anti-il-12 antibodies, epitopes, compositions, methods and uses.
JP2008529968A (ja) 2005-02-08 2008-08-07 国立循環器病センター総長 インスリン様成長因子−1(igf−1)を使用する慢性重症心不全を処置するための新規方法
WO2006088088A1 (fr) 2005-02-16 2006-08-24 Astellas Pharma Inc. Remède contre la douleur contenant un inhibiteur de la protéine rho-kinase
GB0506912D0 (en) 2005-04-05 2005-05-11 Celltech R&D Ltd Biological products
NZ595225A (en) 2005-05-16 2013-05-31 Abbott Biotech Ltd Use of tnf inhibitor for treatment of erosive polyarthritis
EA013080B1 (ru) 2005-06-09 2010-02-26 Юсб Фарма С.А. 2,6-хинолинильные производные, способы их получения и их применение
BRPI0611901A2 (pt) 2005-06-14 2012-08-28 Amgen, Inc composição, liofilizado, kit, e, processo para preparar uma composição
SI2452694T1 (sl) 2005-06-30 2019-05-31 Janssen Biotech, Inc. Protitelesa proti-IL-23, sestavki in postopki uporabe
GB0513852D0 (en) 2005-07-06 2005-08-10 Celltech R&D Ltd Biological products
GB0514779D0 (en) 2005-07-19 2005-08-24 Celltech R&D Ltd Biological products
EP2124062A1 (fr) 2005-08-12 2009-11-25 Astellas Pharma Inc. Procédé servant à identifier une protéine cible d'un agent et procédé servant à cribler un agent thérapeutique pour le diabète utilisant la protéine cible
EP1754476A1 (fr) 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) pour le traitement de la myalgie, par exemple de la fibromyalgie
WO2007026950A1 (fr) 2005-09-01 2007-03-08 Astellas Pharma Inc. Nouveaux composes
ES2382879T3 (es) 2005-09-14 2012-06-14 Ucb Pharma, S.A. Conjugado de anticuerpo - polímero de peine.
GB0520169D0 (en) 2005-10-04 2005-11-09 Celltech R&D Ltd Biological products
CN103336129A (zh) 2005-11-01 2013-10-02 阿布维生物技术有限公司 使用生物标志物诊断强直性脊柱炎的方法和组合物
EP1790664A1 (fr) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Anticorps monoclonaux contre claudin-18 pour le traitement du cancer
GB0523954D0 (en) 2005-11-24 2006-01-04 Ucb Celltech Bioassays
WO2007060411A1 (fr) 2005-11-24 2007-05-31 Ucb Pharma S.A. Anticorps anti-tnf alpha qui inhibent sélectivement le signal tnf alpha par le p55r
SI1960430T1 (sl) 2005-12-09 2015-01-30 Ucb Pharma, S.A. Molekule protiteles s specifiäśnostjo za äśloveĺ ki il-6
CN102887955A (zh) 2006-04-05 2013-01-23 艾博特生物技术有限公司 抗体纯化
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
US9399061B2 (en) 2006-04-10 2016-07-26 Abbvie Biotechnology Ltd Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis
WO2008063213A2 (fr) 2006-04-10 2008-05-29 Abbott Biotechnology Ltd. Compositions destinées au traitement de la polyarthrite psoriasique et leurs applications
WO2007120626A2 (fr) 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Utilisations et compositions pour le traitement de la spondylarthrite ankylosante
CN106434527A (zh) 2006-04-14 2017-02-22 安斯泰来再生医药协会 血管瘤集落形成细胞
US8808707B1 (en) 2006-05-08 2014-08-19 Wyeth Llc Pneumococcal dosing regimen
CA2653661A1 (fr) 2006-05-31 2007-12-06 Astellas Pharma Inc. Anticorps d'osteopontine anti-humains humanises
US20100021451A1 (en) 2006-06-08 2010-01-28 Wong Robert L Uses and compositions for treatment of ankylosing spondylitis
JP2009539792A (ja) 2006-06-08 2009-11-19 シュヴァルツ・ファーマ・アーゲー 疼痛の医学的状態のための治療組合せ
TWI392670B (zh) 2006-06-22 2013-04-11 Ucb Pharma Gmbh 經取代的2-胺基萘滿之於製造用於預防、減緩及/或治療各種類型疼痛之藥物上的用途
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
MX2008016335A (es) 2006-06-30 2009-01-21 Abbott Biotech Ltd Dispositivo automatico de inyeccion.
GB0613209D0 (en) 2006-07-03 2006-08-09 Ucb Sa Methods
AU2007279092B2 (en) 2006-07-24 2012-12-13 Ucb Pharma S.A. Substituted aniline derivatives
GB0614780D0 (en) 2006-07-25 2006-09-06 Ucb Sa Biological products
SG174013A1 (en) 2006-07-27 2011-09-29 Wyeth Corp High-cell density fed-batch fermentation process for producing recombinant protein
JPWO2008026781A1 (ja) 2006-08-31 2010-01-21 直人 奥 逆標的化脂質小胞体
US20100035863A1 (en) 2006-09-12 2010-02-11 Ucb Pharma, S.A. 2 Amino-Pyrimidine Derivatives As H4 Receptor Antagonists, Processes For Preparing Them And Their Use In Pharmaceutical Compositions
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
AU2007294731B2 (en) 2006-09-13 2014-04-17 Abbvie Inc. Cell culture improvements
PT2078080E (pt) 2006-09-27 2015-09-18 Coley Pharm Gmbh Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada
GB0619291D0 (en) 2006-09-29 2006-11-08 Ucb Sa Altered antibodies
US10068220B2 (en) 2006-10-11 2018-09-04 Visa International Service Association Systems and methods for brokered authentication express seller links
GB0620729D0 (en) 2006-10-18 2006-11-29 Ucb Sa Biological products
ES2442258T3 (es) 2006-10-27 2014-02-10 Abbvie Biotechnology Ltd Anticuerpos cristalinos anti-hTNF alfa
WO2008064830A1 (fr) 2006-11-27 2008-06-05 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, leurs procédés de fabrication et leurs utilisations pharmaceutiques
WO2008064823A1 (fr) 2006-11-27 2008-06-05 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, procédés de préparation de ceux-ci et leurs utilisations
WO2008064829A2 (fr) 2006-11-30 2008-06-05 Ucb Pharma, S.A. Nouveaux dérivés d'aminothiénopyridinone, procédés de préparation de ces dérivés et compositions pharmaceutiques à base de ceux-ci
WO2008074445A1 (fr) 2006-12-18 2008-06-26 Ucb Pharma, S.A. Nouveaux dérivés tricycliques et hétérocycliques, procédés destinés à les préparer et compositions pharmaceutiques les contenant
MX2009007139A (es) 2006-12-28 2009-10-08 Centocor Ortho Biotech Inc Metodos y vectores para generar inmunoglobulinas no sialiladas.
WO2008092084A2 (fr) 2007-01-26 2008-07-31 Centocor, Inc. Suspension non aqueuse injectable présentant une concentration élevée en agent thérapeutique
US8796021B2 (en) 2007-02-23 2014-08-05 Advanced Cell Technology, Inc. Blastomere culture to produce mammalian embryonic stem cells
US8147833B2 (en) 2007-02-23 2012-04-03 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
ME00832B (fr) 2007-03-22 2012-03-20 Ucb Biopharma Sprl Protéines de liaison, incluant des anticorps, dérivés d'anticorps et fragments d'anticorps, qui se lient spécifiquement à cd154 et leurs utilisations
NZ580378A (en) 2007-03-30 2012-11-30 Abbott Lab Recombinant expression vector elements (reves) for enhancing expression of recombinant proteins in host cells
WO2008122378A1 (fr) 2007-04-04 2008-10-16 Ucb Pharma, S.A. Nouveaux derives de pyridine, procedes de preparation et compositions pharmaceutiques associes
WO2008125210A1 (fr) 2007-04-12 2008-10-23 Ucb Pharma, S.A. Dérivés de quinoline et de naphtalène, procédés de préparation et utilisation de ceux-ci pour traiter des maladies inflammatoires
WO2008125215A1 (fr) 2007-04-12 2008-10-23 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, procédés de préparation et utilisations de ceux-ci
TW200904421A (en) 2007-05-03 2009-02-01 Astellas Pharma Inc New compounds
WO2008138591A2 (fr) 2007-05-14 2008-11-20 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, leurs méthodes de préparation et leurs utilisations
WO2008138592A1 (fr) 2007-05-14 2008-11-20 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, leurs méthodes de préparation et leurs utilisations
WO2008138615A1 (fr) 2007-05-16 2008-11-20 Ucb Pharma, S.A. Dérivés bicycliques et hétérobicycliques, leurs méthodes de préparation et leurs utilisations
EP1997832A1 (fr) 2007-05-29 2008-12-03 Ganymed Pharmaceuticals AG Anticorps monoclonaux contre la claudine-18 pour le traitement contre le cancer
WO2008150491A2 (fr) 2007-05-31 2008-12-11 Abbott Laboratories Biomarqueurs prédictifs de la réactivité aux inhibiteurs tnfα dans des troubles auto-immuns
US20100179137A1 (en) 2007-06-07 2010-07-15 Takashi Kamikubo Pyridone compound
US20100303813A1 (en) 2007-06-08 2010-12-02 Biogen Idec Ma Inc. Biomarkers for predicting anti-tnf responsiveness or non-responsiveness
WO2008154543A2 (fr) 2007-06-11 2008-12-18 Abbott Biotechnology Ltd. Procédés de traitement de l'arthrite idiopathique juvénile
WO2009020654A1 (fr) 2007-08-08 2009-02-12 Abbott Laboratories Compositions et procédés permettant la cristallisation d'anticorps
US8969024B2 (en) 2007-08-28 2015-03-03 Abbvie Biotechnology Ltd Compositions and methods comprising binding proteins for adalimumab
EP2535349A1 (fr) 2007-09-26 2012-12-19 UCB Pharma S.A. Fusions d'anticorps à double spécificité
US20100298289A1 (en) 2007-10-09 2010-11-25 Ucb Pharma, S.A. Heterobicyclic compounds as histamine h4-receptor antagonists
DK2209888T3 (da) 2007-10-12 2020-01-20 Astellas Inst For Regenerative Medicine Forbedrede fremgangsmåder til fremstilling af rpe-celler og sammensætninger af rpe-celler
US7947495B2 (en) 2007-11-01 2011-05-24 Abbott Biotherapeutics Corp. Immunoglobulin display vectors
EP2612867A1 (fr) 2007-11-01 2013-07-10 Perseid Therapeutics LLC Acides nucléiques et polypeptides immunosuppresseurs
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
US8420081B2 (en) 2007-11-30 2013-04-16 Abbvie, Inc. Antibody formulations and methods of making same
PT2594590E (pt) 2007-12-14 2015-01-14 Bristol Myers Squibb Co Moléculas de ligação ao recetor humano ox40
TWI478937B (zh) 2008-01-15 2015-04-01 Abbvie Inc 改良之哺乳動物表現載體及其用途
EA018462B1 (ru) 2008-01-25 2013-08-30 ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи ТРИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ КАК МОДУЛЯТОРЫ СИНТЕЗА TNF-α И КАК ИНГИБИТОРЫ PDE4
GB0807413D0 (en) 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
CA3186451A1 (fr) 2008-05-06 2009-11-12 Astellas Institute For Regenerative Medicine Cellules formant des colonies hemangioblastiques et cellules hemangioblastiques non transplantables
US20110086424A1 (en) 2008-05-06 2011-04-14 Advanced Cell Technology, Inc. Methods for producing enucleated erythroid cells derived from pluripotent stem cells
EP2565191B1 (fr) 2008-05-14 2014-10-08 Astellas Pharma Inc. Dérivés d'acide 4-(indol-7-ylcarbonylaminométhyl)cyclohexanecarboxylique comme antagonistes du récepteur EP4 utilisables pour le traitement de l'insuffisance rénale chronique ou de la néphropathie diabétique
BRPI0909866B1 (pt) 2008-06-11 2021-08-24 Fresenius Medical Care Deutschland Gmbh Método de produção de um meio condicionado de células progenitoras de fígado, meio condicionado e composição farmacêutica
MX2010014231A (es) 2008-06-17 2011-03-21 Astellas Pharma Inc Compuestos de piridona.
ES2569907T3 (es) 2008-06-27 2016-05-13 Zoetis Services Llc Composiciones adyuvantes novedosas
SMT201900652T1 (it) 2008-07-18 2020-01-14 Ucb Biopharma Sprl Sistemi per somministrare medicinale per pazienti con artrite reumatoide
EP2166021A1 (fr) 2008-09-16 2010-03-24 Ganymed Pharmaceuticals AG Anticorps monoclonaux pour le traitement du cancer
CA2737241C (fr) 2008-09-26 2017-08-29 Ucb Pharma S.A. Proteines de fusion d'anticorps multivalentes
NZ592095A (en) 2008-10-20 2013-01-25 Abbott Lab Isolation and purification of il-12 and tnf-alpha antibodies using protein a affinity chromatography
BRPI0920572A8 (pt) 2008-10-20 2015-10-27 Abbott Lab Inativação viral durante a purificação dos anticorpos
CN104357381A (zh) 2008-10-31 2015-02-18 辛西斯有限责任公司 用于活化干细胞的方法和装置
EP2358360B1 (fr) 2008-11-18 2016-09-14 UCB Biopharma SPRL Formules à libération prolongée comprenant un dérivé de 2-oxo-1-pyrrolidine
EP2327299B8 (fr) 2008-12-16 2012-06-27 Astellas Pharma Inc. Rongeur modèle de douleur musculaire chronique
NZ594315A (en) 2009-02-17 2013-05-31 Ucb Pharma Sa Antibody molecules having specificity for human ox40
GB0904214D0 (en) 2009-03-11 2009-04-22 Ucb Pharma Sa Biological products
EP2414386B1 (fr) 2009-04-03 2016-01-27 Merial Limited Vaccins aviaires transportés par le virus de la maladie de newcastle
PE20120835A1 (es) 2009-04-16 2012-07-23 Abbvie Biotherapeutics Inc Anticuerpos anti-tnf-alfa y sus usos
WO2010127146A1 (fr) 2009-04-29 2010-11-04 Abbott Biotechnology Ltd Dispositif d'injection automatique
JP2012197228A (ja) 2009-07-27 2012-10-18 Kyoto Univ 肝炎の治療剤もしくは予防剤
WO2011030107A1 (fr) 2009-09-10 2011-03-17 Ucb Pharma S.A. Anticorps multivalents
US20110070227A1 (en) 2009-09-18 2011-03-24 Anna-Marie Novotney-Barry Treatment of Autoimmune and Inflammatory Diseases
WO2011036455A1 (fr) 2009-09-24 2011-03-31 Ucb Pharma S.A. Souche bactérienne pour l'expression de protéines recombinantes, ayant une degp à activité protéase déficiente et conservant une activité chaperonne et des gènes tsp et ptr inactivés
US9109216B2 (en) 2009-09-24 2015-08-18 Ucb Pharma, S.A. Bacterial host strain
GB201005063D0 (en) 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
JP2012254939A (ja) 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物
GB0920127D0 (en) 2009-11-17 2009-12-30 Ucb Pharma Sa Antibodies
IL281453B (en) 2009-11-17 2022-07-01 Astellas Inst For Regenerative Medicine Methods for preparing human rpe cells and pharmaceutical preparations of human rpe cells
GB0920324D0 (en) 2009-11-19 2010-01-06 Ucb Pharma Sa Antibodies
US9096879B2 (en) 2009-11-24 2015-08-04 Biogen Ma Inc. Method of supplementing culture media to prevent undesirable amino acid substitutions
EP2510949A4 (fr) 2009-12-11 2013-11-13 Astellas Pharma Inc Agent thérapeutique pour la fibromyalgie
RU2582401C2 (ru) 2009-12-15 2016-04-27 Эббви Байотекнолоджи Лтд Усовершенствованная пусковая кнопка для автоматического инъекционного устройства
ES2674275T3 (es) 2009-12-17 2018-06-28 Centrexion Therapeutics Corporation Antagonistas del receptor CCR2 y usos de los mismos
LT3257504T (lt) 2009-12-22 2024-08-26 UCB Biopharma SRL Polivinilpirolidonas, skirtas nekristalinės formos kietos rotigotino dispersijos stabilizavimui
RU2581020C2 (ru) 2009-12-22 2016-04-10 Селлдекс Терапьютикс, Инк. Композиции вакцин
GB201000467D0 (en) 2010-01-12 2010-02-24 Ucb Pharma Sa Antibodies
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000588D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201001791D0 (en) 2010-02-03 2010-03-24 Ucb Pharma Sa Process for obtaining antibodies
EP2545078A1 (fr) 2010-03-11 2013-01-16 UCB Pharma, S.A. Anticorps pd-1
TW201134488A (en) 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
EP2371864A1 (fr) 2010-03-23 2011-10-05 Ganymed Pharmaceuticals AG Anticorps monoclonaux pour le traitement du cancer
GB201005064D0 (en) 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
ES2717883T3 (es) 2010-03-25 2019-06-26 Ucb Biopharma Sprl Moléculas de DVD-LG estabilizadas con disulfuro
HUE049849T2 (hu) 2010-03-31 2020-10-28 Boehringer Ingelheim Int Anti-CD40 antitestek
KR20130010123A (ko) 2010-04-07 2013-01-25 아비에 인코포레이티드 TNF-α 결합 단백질
WO2011129382A1 (fr) 2010-04-16 2011-10-20 Abbott Japan Co. Ltd. Procédés et réactifs pour diagnostiquer la polyarthrite rhumatoïde
JP5809242B2 (ja) 2010-04-21 2015-11-10 アッヴィ バイオテクノロジー リミテッド 治療薬の制御送達のための装着型自動注入装置
HRP20190047T1 (hr) 2010-05-04 2019-02-22 Five Prime Therapeutics, Inc. Protutijela koja se vežu na csf1r
WO2011146394A1 (fr) 2010-05-17 2011-11-24 Millipore Corporation Polymères répondant à des stimuli pour la purification de biomolécules
EP2575878B1 (fr) 2010-05-28 2018-06-13 Zoetis Belgium S.A. Vaccins comprenants cholestérole et cpg comme seules molécules adjuvantes-porteuses
EP2575884B1 (fr) 2010-06-03 2018-07-18 AbbVie Biotechnology Ltd Utilisations et compositions pour le traitement de l'hidrosadénite (hs)
WO2011158044A2 (fr) 2010-06-17 2011-12-22 Respivert Limited Formulations respiratoires et composés destinés à être utilisés dans ces formulations
EP2582391B1 (fr) 2010-06-18 2018-10-03 XBiotech, Inc Traitement de l'arthrite
WO2012012803A2 (fr) 2010-07-23 2012-01-26 Advanced Cell Technology, Inc. Procédés de détection de sous-populations rares de cellules et compositions de cellules très purifiées
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
GB201012603D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
GB201012784D0 (en) 2010-07-29 2010-09-15 Ucb Pharma Sa Method
GB201014033D0 (en) 2010-08-20 2010-10-06 Ucb Pharma Sa Biological products
AU2011300409B2 (en) 2010-09-10 2015-03-26 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
JP2013249256A (ja) 2010-09-15 2013-12-12 Astellas Pharma Inc 脂肪性肝疾患治療薬
UA112062C2 (uk) 2010-10-04 2016-07-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Cd33-зв'язувальний агент
KR101920250B1 (ko) 2010-10-13 2018-11-20 얀센 바이오테크 인코포레이티드 인간 온코스타틴 m 항체 및 이용 방법
MX2019000046A (es) 2010-11-04 2023-10-05 Boehringer Ingelheim Int Anticuerpos anti-il-23.
US8821865B2 (en) 2010-11-11 2014-09-02 Abbvie Biotechnology Ltd. High concentration anti-TNFα antibody liquid formulations
MX2013005974A (es) 2010-12-02 2013-07-29 Ucb Pharma Gmbh Formulacion de lacosamida de administracion una vez al dia.
AR084210A1 (es) 2010-12-08 2013-05-02 Abbott Lab PROTEINAS DE UNION AL TNF-a
US10208349B2 (en) 2011-01-07 2019-02-19 Ucb Biopharma Sprl Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy
ME02734B (fr) 2011-01-14 2017-10-20 Ucb Biopharma Sprl Molécules d'anticorps se liant à il-17a et il-17f
RU2727040C2 (ru) 2011-01-24 2020-07-17 Эббви Байотекнолоджи Лтд. Автоматические инъекционные устройства, имеющие наформованные поверхности захвата
EP2686671A4 (fr) 2011-03-12 2015-06-24 Momenta Pharmaceuticals Inc N-glycanes contenant de la n-acétylhexosamine dans des produits de glycoprotéines
TW201249867A (en) 2011-04-01 2012-12-16 Astellas Pharma Inc Novel anti-human il-23 receptor antibody
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
CA2837582C (fr) 2011-05-27 2021-03-02 Merial Limited Vaccins genetiques contre le virus hendra et le virus nipah
EP2714162B1 (fr) 2011-05-27 2020-01-01 Boehringer Ingelheim International GmbH Inhalateur et capsule pour inhalateur
WO2012164390A2 (fr) 2011-06-02 2012-12-06 Ucb Pharma S.A. Auto-injecteur
UY34105A (es) 2011-06-03 2012-07-31 Lg Life Sciences Ltd Formulación líquida estable de etanercept
CN103717729B (zh) 2011-07-08 2017-11-21 动量制药公司 细胞培养方法
CN103827134A (zh) 2011-07-20 2014-05-28 泽普泰恩股份有限公司 多肽分离方法
MX350096B (es) 2011-08-12 2017-08-25 Merial Inc Preservación asistida con vacío de productos biológicos, en particular de vacunas.
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
RS58146B1 (sr) 2011-09-08 2019-02-28 Univ New York Onkolitički herpes simpleks virus i njegova terapeutska upotreba
CN104080498B (zh) 2011-09-22 2016-08-24 艾伯维公司 自动注射装置
CN108404127B (zh) 2011-09-23 2025-12-12 埃克斯生物科技公司 恶病质治疗
EP2578582A1 (fr) 2011-10-03 2013-04-10 Respivert Limited 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napthtalèn-1-yl) urées comme inhibiteurs de la p38 MAP kinase
KR101995274B1 (ko) 2011-10-03 2019-07-02 레스피버트 리미티드 P38 map 키나제 저해제인 1-피라졸릴-3-(4-((2-아닐리노피리미딘-4-일)옥시)나프탈렌-1-일) 우레아
US10485869B2 (en) 2011-10-18 2019-11-26 Coherus Biosciences, Inc. Etanercept formulations stabilized with meglumine
BR112014009146A8 (pt) 2011-10-18 2017-06-20 Coherus Biosciences Inc formulações de etanercepte estabilizadas com aminoácidos
PE20141545A1 (es) 2011-10-24 2014-11-26 Abbvie Inc Inmunoenlazadores dirigidos contra el tnf
EP2773439A4 (fr) 2011-10-31 2015-07-01 Merck Sharp & Dohme Procédé de chromatographie permettant de décomposer des agrégats d'anticorps hétérogènes
UA112203C2 (uk) 2011-11-11 2016-08-10 Юсб Фарма С.А. Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини
WO2013068571A1 (fr) 2011-11-11 2013-05-16 Ucb Pharma S.A. Anticorps se liant à l'albumine et leurs fragments de liaison
IL287381B2 (en) 2011-11-14 2024-04-01 Astellas Inst For Regenerative Medicine Pharmaceutical preparations of human rpe cells and uses thereof
SI2785359T1 (sl) 2011-11-30 2018-11-30 Astellas Institute For Regenerative Medicine Mezenhimske stromalne celice in uporabe povezane z njimi
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
DE102011087676A1 (de) 2011-12-02 2013-06-06 Continental Automotive Gmbh Verfahren und Vorrichtung zur Überprüfung einer Lautsprecheranordnung
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
GB201203051D0 (en) 2012-02-22 2012-04-04 Ucb Pharma Sa Biological products
GB201203071D0 (en) 2012-02-22 2012-04-04 Ucb Pharma Sa Biological products
WO2013129454A1 (fr) 2012-02-28 2013-09-06 アステラス製薬株式会社 Nouvel anticorps anti-récepteur il-23 humain
AU2013204609B2 (en) 2012-03-02 2015-10-01 Abbvie Inc. Automatic injection training device
JP2015509526A (ja) 2012-03-07 2015-03-30 カディラ ヘルスケア リミティド 医薬製剤
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
NZ629697A (en) 2012-03-15 2017-01-27 Janssen Biotech Inc Human anti-cd27 antibodies, methods and uses
MY169061A (en) 2012-03-22 2019-02-12 Merial Inc Modified marek's disease virus, and vaccines made therefrom
WO2013158273A1 (fr) 2012-04-20 2013-10-24 Abbvie Inc. Procédés de modulation de la distribution de variant de lysine c-terminal
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158279A1 (fr) 2012-04-20 2013-10-24 Abbvie Inc. Procédés de purification de protéines pour réduire des espèces acides
AU2013255103B2 (en) 2012-05-02 2016-09-29 Syntara Limited Substituted 3-haloallylamine inhibitors of SSAO and uses thereof
RU2737765C2 (ru) 2012-05-04 2020-12-02 Пфайзер Инк. Простатоассоциированные антигены и иммунотерапевтические схемы на основе вакцин
GB201208370D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Antibodies
GB201208367D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
WO2013174403A1 (fr) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer
WO2013176754A1 (fr) 2012-05-24 2013-11-28 Abbvie Inc. Nouvelle purification d'anticorps au moyen de chromatographie à interaction hydrophobe
BR112014030940B1 (pt) 2012-06-11 2022-09-06 UCB Biopharma SRL Benzimidazóis que modulam tnf-alfa e composição farmacêutica compreendendo os mesmos
WO2013186230A1 (fr) 2012-06-12 2013-12-19 Boehringer Ingelheim International Gmbh Formulation pharmaceutique destinée à un anticorps thérapeutique
EA201590061A1 (ru) 2012-06-21 2015-05-29 Юсб Фарма С.А. Фармацевтическая композиция
GB201212513D0 (en) 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
CN104619709B (zh) 2012-07-13 2016-11-09 Ucb生物制药私人有限公司 作为tnf活性调节剂的咪唑并吡啶衍生物
JP2015180606A (ja) 2012-08-01 2015-10-15 アステラス製薬株式会社 抗癌剤の併用による癌治療方法
WO2014020171A1 (fr) 2012-08-03 2014-02-06 Boehringer Ingelheim International Gmbh Capacité tampon d'anticorps
SG11201500499TA (en) 2012-08-10 2015-03-30 Boehringer Ingelheim Int Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
HK1211981A1 (en) 2012-09-02 2016-06-03 Abbvie Inc. Methods to control protein heterogeneity
PE20150964A1 (es) 2012-09-07 2015-07-25 Coherus Biosciences Inc Formulaciones acuosas estables de adalimumab
SI2895188T1 (en) 2012-09-11 2018-05-31 Coherus Biosciences, Inc. CORRECTED QUALITY ETHANERCEPT WITH HIGH QUALITY AND EXCELLENT EXPERIENCE
KR20150056788A (ko) 2012-09-19 2015-05-27 애브비 바이오테라퓨틱스 인크. 면역원성이 감소된 항체의 동정 방법
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
KR101668574B1 (ko) 2012-11-02 2016-10-24 화이자 인코포레이티드 브루톤 티로신 키나제 억제제
RS55593B1 (sr) 2012-11-13 2017-06-30 Array Biopharma Inc Jedinjenja biciklične uree, tiouree, guanidina i cijanoguanidina korisna za lečenje bola
WO2014075697A1 (fr) 2012-11-13 2014-05-22 Biontech Ag Agents de traitement de maladies cancéreuses exprimant claudine
US9844594B2 (en) 2012-12-18 2017-12-19 Merck Sharp & Dohme Corp. Liquid formulations for an anti-TNF α antibody
US9926341B2 (en) 2012-12-20 2018-03-27 Merck Patent Gmbh Copolymers for protein precipitation
JP6502262B2 (ja) 2012-12-20 2019-04-17 ファイザー・インク 糖複合化方法
CA2896053A1 (fr) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Procedes de production de plaquettes a partir de cellules souches pluripotentes, et compositions associees
GB201223276D0 (en) 2012-12-21 2013-02-06 Ucb Pharma Sa Antibodies and methods of producing same
UA111305C2 (uk) 2012-12-21 2016-04-11 Пфайзер Інк. Конденсовані лактами арилу та гетероарилу
EP2938323A2 (fr) 2012-12-28 2015-11-04 Abbott Cardiovascular Systems, Inc. Compositions thérapeutiques contenant d'anticorps
EP2752426A1 (fr) 2013-01-03 2014-07-09 Covagen AG Composés de liaison d'albumine de sérum humain et leurs protéines de fusion
GB201300683D0 (en) 2013-01-15 2013-02-27 Apitope Int Nv Peptide
JP2016093104A (ja) 2013-02-19 2016-05-26 国立大学法人京都大学 抗ヒトCD3ε抗体又はそのフラグメント、及びそれを有効成分とする免疫抑制剤
US10493104B2 (en) 2013-02-20 2019-12-03 Samsung Life Public Welfare Foundation Composition for treating inflammatory brain diseases which includes stem cell as active ingredient
WO2014127785A1 (fr) 2013-02-20 2014-08-28 Ganymed Pharmaceuticals Ag Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer
HK1207960A1 (en) 2013-03-12 2016-02-19 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
WO2014159579A1 (fr) 2013-03-14 2014-10-02 Abbvie Inc. Anticorps anti-tnfα ayant mutés et leurs procédés d'utilisation
ES2845473T3 (es) 2013-03-14 2021-07-26 Boehringer Ingelheim Int (Bencil-ciano-metil)-amidas sustituidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico inhibidores de la catepsina- C
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9217168B2 (en) 2013-03-14 2015-12-22 Momenta Pharmaceuticals, Inc. Methods of cell culture
MX366910B (es) 2013-03-15 2019-07-30 Janssen Biotech Inc Metodos de fabricacion para controlar el contenido de lisina c-terminal, galactosa y acido sialico en proteinas recombinantes.
JP6592426B2 (ja) 2013-03-15 2019-10-16 バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. 無塩条件下で疎水性相互作用クロマトグラフィーを使用するタンパク質精製
EP4292600A3 (fr) 2013-03-15 2024-04-10 Astellas Institute for Regenerative Medicine Photorécepteurs et progéniteurs de photorécepteurs produits à partir de cellules souches pluripotentes
WO2014146672A1 (fr) 2013-03-18 2014-09-25 Ganymed Pharmaceuticals Ag Thérapie comprenant des anticorps dirigés contre cldn 18.2 pour le traitement du cancer
SG10201708048XA (en) 2013-03-18 2017-10-30 Biocerox Prod Bv Humanized anti-cd134 (ox40) antibodies and uses thereof
JP2016000003A (ja) 2013-04-19 2016-01-07 アステラス製薬株式会社 新規抗ヒトtweak抗体
JP6616284B2 (ja) 2013-04-23 2019-12-04 ザ ユニバーシティ コート オブ ザ ユニバーシティ オブ アバディーン 特異的結合分子の人工ライブラリー
WO2014175287A1 (fr) 2013-04-26 2014-10-30 国立大学法人 京都大学 Composition médicinale destinée à empêcher la formation et/ou l'expansion d'un anévrisme cérébral ou réduire un tel anévrisme
WO2014182658A1 (fr) 2013-05-06 2014-11-13 Abbvie Inc. Compositions pour culture cellulaire et procédés pour les utiliser
EP2803668A1 (fr) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Nouveau (cyano-dimethyl-methyl)-isoxazoles et - [1,3,4] thiadiazoles
JP2016519152A (ja) 2013-05-22 2016-06-30 ユーシービー バイオファルマ エスピーアールエル 治療用タンパク質を含む粒子を製造する方法
WO2014193821A1 (fr) 2013-05-28 2014-12-04 Momenta Pharmaceuticals, Inc. Compositions pharmaceutiques comprenant un pyrophosphate
TWI596107B (zh) 2013-06-25 2017-08-21 卡地拉保健有限公司 單株抗體之新穎純化方法
US20160215319A1 (en) 2013-07-06 2016-07-28 Cadila Helthcare Limited Improved process for production of monoclonal antibodies
SG11201600067YA (en) 2013-07-23 2016-02-26 Biocon Ltd Methods for controlling fucosylation levels in proteins
CN105745081B (zh) 2013-07-28 2019-10-25 惠普工业印刷有限公司 介质支承装置
CA2919790C (fr) 2013-08-02 2018-06-19 Pfizer Inc. Anticorps anti-cxcr4 et conjugues anticorps-medicaments
CA2919783C (fr) 2013-08-02 2018-02-06 Pfizer Inc. Inhibiteurs d'heterobicycloaryl rorc2 et ses methodes d'utilisation
GB201313888D0 (en) 2013-08-02 2013-09-18 Consort Medical Plc Assembly for an autoinjector device
UA119328C2 (uk) 2013-08-09 2019-06-10 Астеллас Фарма Інк. Антитіло до тslp-рецептора людини
US20160237399A1 (en) 2015-02-18 2016-08-18 Biogen Ma Inc. Control of Protein Glycosylation by Culture Medium Supplementation and Cell Culture Process Parameters
PL3036320T5 (pl) 2013-08-19 2024-06-10 Biogen Ma Inc. Kontrola glikozylacji białka poprzez parametry procesu suplementacji pożywki hodowlanej i hodowli komórkowej
US10076749B2 (en) 2013-08-23 2018-09-18 Boehringer Ingelheim Rcv Gmbh & Co Kg Microparticles for cell disruption and/or biomolecule recovery
GB201315487D0 (en) 2013-08-30 2013-10-16 Ucb Pharma Sa Antibodies
US20160192626A1 (en) 2013-09-18 2016-07-07 Kyoto University Method For Creating Endometriotic Cells And Endometriosis Model Animal
HUE057005T2 (hu) 2013-09-25 2022-04-28 Bioverativ Therapeutics Inc Oszlopon történõ vírusinaktiváló eljárások
EP3057616B1 (fr) 2013-10-16 2020-03-11 Outlook Therapeutics, Inc. Formulations de tampon pour stabilité d'anticorps améliorée
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
GB201320066D0 (en) 2013-11-13 2013-12-25 Ucb Pharma Sa Biological products
US9683998B2 (en) 2013-11-13 2017-06-20 Pfizer Inc. Tumor necrosis factor-like ligand 1A specific antibodies and compositions and uses thereof
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
GB201321738D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321748D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321749D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321745D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321743D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321731D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
ES2750236T3 (es) 2013-12-09 2020-03-25 UCB Biopharma SRL Derivados heteroaromáticos bicíclicos condensados como moduladores de la actividad del TNF
GB201321740D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321736D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321744D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321732D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321737D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321728D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321746D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321733D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
BR112016012243A2 (pt) 2013-12-09 2017-08-08 Ucb Biopharma Sprl Derivados de imidazopiridina como moduladores de atividade de tnf
GB201321739D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321742D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321729D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321741D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321730D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321734D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321735D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
CN104707146B (zh) * 2013-12-16 2019-04-16 浙江海正药业股份有限公司 一种含有阿达木单抗的药物组合物
WO2015097536A2 (fr) 2013-12-24 2015-07-02 Janssen Pharmaceutical Nv Anticorps et fragments anti-vista
CN109535254B (zh) 2013-12-24 2022-06-24 安斯泰来制药株式会社 抗人bdca-2抗体、其生产方法、多核苷酸、表达载体、宿主细胞及医药组合物
EP3088517B1 (fr) 2013-12-26 2023-11-01 Mitsubishi Tanabe Pharma Corporation Anticorps monoclonal neutralisant humain anti-il-33
PL3096786T3 (pl) 2014-01-21 2021-11-08 Pfizer Inc. Polisacharydy otoczkowe streptococcus pneumoniae i ich koniugaty
EP3099351B1 (fr) 2014-01-27 2019-11-06 UCB Biopharma SPRL Auto-injecteur
AP2016009347A0 (en) 2014-01-29 2016-07-31 Neuropore Therapies Inc Heteroarly amides as inhibitors of protein aggregation
EA033604B1 (ru) 2014-01-31 2019-11-08 Boehringer Ingelheim Int Молекула анти-baff антитела, фармацевтическая композиция, содержащая эту молекулу, способы ее применения и кодирующий ее изолированный полинуклеотид
WO2015120056A1 (fr) 2014-02-04 2015-08-13 Biogen Ma Inc. Chromatographie par échange cationique utilisée dans le mode de fixation par écoulement pour enrichir les modifications post-traductionnelles
PT3357919T (pt) 2014-02-14 2020-02-20 Respivert Ltd Compostos heterocíclicos aromáticos como compostos antiinflamatórios
USRE47493E1 (en) 2014-02-20 2019-07-09 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
RU2016134913A (ru) 2014-02-28 2018-03-30 Астеллас Фарма Инк. Новое биспецифическое антитело, связывающееся с tlr2 человека и tlr4 человека
US9135573B1 (en) 2014-03-17 2015-09-15 Linkedin Corporation Estimating reputation scores in reputation systems
CA2942546C (fr) 2014-03-17 2022-11-22 Mitsubishi Tanabe Pharma Corporation Conjugues anticorps-fynomer
AU2015233654B2 (en) 2014-03-19 2018-12-06 Boehringer Ingelheim International Gmbh Heteroaryl Syk inhibitors
TW201623277A (zh) 2014-03-26 2016-07-01 安斯泰來製藥股份有限公司 醯胺化合物
WO2015151115A1 (fr) 2014-04-02 2015-10-08 Intas Pharmaceuticals Limited Composition pharmaceutique liquide d'adalimumab
DK3126330T3 (en) 2014-04-04 2019-04-23 Pfizer BICYCLE-FUSED HETEROARYL OR ARYL COMPOUNDS AND USE THEREOF AS IRAC4 INHIBITORS
CN106456813B (zh) 2014-04-15 2020-06-30 勃林格殷格翰国际公司 在制造生物制品期间连续灭活病毒的方法、装置和系统
AU2015248807B2 (en) 2014-04-17 2021-07-22 Boehringer Ingelheim Rcv Gmbh & Co Kg Recombinant host cell for expressing proteins of interest
KR102092225B1 (ko) 2014-04-30 2020-03-23 주식회사 엘지화학 고효율 분비능을 가지는 단백질 분비 인자 및 이를 포함하는 발현 벡터
ES2936810T3 (es) 2014-05-16 2023-03-22 Pfizer Anticuerpos biespecíficos con interfaces CH1-CL de ingeniería
EP2946767B1 (fr) 2014-05-23 2016-10-05 Ares Trading S.A. Composition pharmaceutique liquide
PT2946765T (pt) 2014-05-23 2016-11-10 Ares Trading Sa Composição farmacêutica líquida
ES2572919T3 (es) 2014-05-23 2016-06-03 Ares Trading S.A. Composición farmacéutica líquida
GB201409558D0 (en) 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
ES2864079T3 (es) 2014-05-30 2021-10-13 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
KR20170018810A (ko) 2014-06-10 2017-02-20 메이지 세이카 파루마 가부시키가이샤 안정한 아달리무맙 수성 제제
TN2016000529A1 (en) 2014-06-17 2018-04-04 Pfizer Substituted dihydroisoquinolinone compounds
TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201412659D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
EP3708679A1 (fr) 2014-07-24 2020-09-16 Boehringer Ingelheim International GmbH Biomarqueurs utiles dans le traitement de maladies liées à l'il-23a
MD20170011A2 (ro) 2014-08-06 2017-08-31 Pfizer Inc. Compuşi imidazopiridazinici
IL250404B (en) 2014-08-06 2022-07-01 Astellas Pharma Inc Novel anti-human igbeta antibody
AR101479A1 (es) 2014-08-11 2016-12-21 Boehringer Ingelheim Int Derivados de 6-alquinil-piridina
NO2721710T3 (fr) 2014-08-21 2018-03-31
CA2960096A1 (fr) 2014-09-03 2016-03-10 Bavarian Nordic A/S Procedes et compositions pour augmenter des reponses immunitaires
US10435464B1 (en) 2014-09-05 2019-10-08 Coherus Biosciences, Inc. Methods for making recombinant proteins
EP3189135B1 (fr) 2014-09-05 2021-06-02 Astellas Institute for Regenerative Medicine Cellules ganglionnaires de la rétine et leurs progénitrices
EP3511331A1 (fr) 2014-09-12 2019-07-17 Boehringer Ingelheim International GmbH Inhibiteurs spirocycliques de la cathepsine c
EP3194972B1 (fr) 2014-09-17 2021-04-14 Merck Patent GmbH Méthode de traitement de maladies provoquées par des métastases osseuses, médicaments à cet effet, et méthode de prédiction du résultat clinique du traitement de maladies provoquées par des métastases osseuses
WO2016046150A1 (fr) 2014-09-25 2016-03-31 Boehringer Ingelheim Vetmedica Gmbh Polythérapie avec des inhibiteurs de sglt2 et des agonistes de la dopamine utilisée pour la prévention des troubles métaboliques chez des équidés
MA40759A (fr) 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
PE20170693A1 (es) 2014-10-03 2017-06-13 Ucb Biopharma Sprl Derivados de imidazol pentaciclicos fusionados
HUP1400510A1 (hu) * 2014-10-28 2016-05-30 Richter Gedeon Nyrt Gyógyászati TNFalfa ellenes antitest készítmény
KR102265924B1 (ko) 2014-10-31 2021-06-15 삼성바이오에피스 주식회사 Pdk 불활성화에 의한 폴리펩타이드의 생산
CN107073022B (zh) 2014-10-31 2020-12-29 弗雷森纽斯医疗护理德国有限责任公司 包含甜菊苷的药物组合物
BR112017009595A2 (pt) 2014-11-14 2017-12-19 Boehringer Ingelheim Int morfolina e 1,4-oxazepano amidas como agonistas do subtipo de receptor de somatostatina 4 (sstr4)
WO2016089126A1 (fr) 2014-12-03 2016-06-09 사회복지법인 삼성생명공익재단 Anticorps dirigé contre la neuropiline 1 et son utilisation
KR20160068558A (ko) 2014-12-05 2016-06-15 삼성바이오에피스 주식회사 마우스 cmv 프로모터를 포함하는 융합 폴리뉴클레오타이드 및 이를 이용한 목적 폴리펩타이드의 생산 방법
CA2970577A1 (fr) 2014-12-22 2016-06-30 Ares Trading S.A. Composition pharmaceutique liquide
CN107108691B (zh) 2014-12-22 2021-06-29 Ucb生物制药私人有限公司 蛋白质制造方法
EP3237432B1 (fr) 2014-12-22 2023-09-06 UCB Biopharma SRL Fabrication et purification de protéines
EP3237000A1 (fr) * 2014-12-23 2017-11-01 Pfizer Inc Formulation d'anticorps aqueuse stable pour des anticorps anti tnf alpha
WO2016118707A1 (fr) 2015-01-21 2016-07-28 Oncobiologics, Inc. Modulation de variants de charge dans une composition d'anticorps monoclonaux
US20180016333A1 (en) * 2015-01-28 2018-01-18 Mabxience, S.A. Pharmaceutical formulations for anti-tnf-alpha antibodies
GB201501613D0 (en) 2015-01-30 2015-03-18 Ucb Biopharma Sprl Treatment of autoimmune disorders with CD154 antibodies
WO2016120849A1 (fr) 2015-01-30 2016-08-04 Pfizer Inc. Modulateurs de pyrrolopyridine substituée par un méthoxy de rorc2 et leurs méthodes d'utilisation
US10385036B2 (en) 2015-01-30 2019-08-20 Pfizer Inc. Sulfonamide-substituted indole modulators of RORC2 and methods of use thereof
EP3053572A1 (fr) 2015-02-06 2016-08-10 Ares Trading S.A. Composition pharmaceutique liquide
SG11201706505PA (en) * 2015-02-13 2017-09-28 Sanofi Sa Stable liquid formulation for monoclonal antibodies
EP3268042B1 (fr) 2015-03-13 2024-11-27 Samsung Bioepis Co., Ltd. Composition contenant un polypeptide anti-tnf-alpha et utilisation
JP6744324B2 (ja) 2015-04-01 2020-08-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 細胞培養培地
WO2016162819A1 (fr) * 2015-04-07 2016-10-13 Lupin Limited Composition pharmaceutique aqueuse stable d'anticorps anti-tnf alpha
EP3078675A1 (fr) 2015-04-10 2016-10-12 Ares Trading S.A. Régime de dosage à induction pour le traitement des maladies liées au tnf alpha
US10294304B2 (en) 2015-04-13 2019-05-21 Pfizer Inc. Chimeric antigen receptors targeting B-cell maturation antigen
KR20170135972A (ko) 2015-04-14 2017-12-08 베링거 인겔하임 인터내셔날 게엠베하 질환을 치료하는 방법
WO2016165765A1 (fr) 2015-04-15 2016-10-20 Ganymed Pharmaceuticals Ag Procédés et compositions permettant de prédire l'efficacité thérapeutique des traitements contre le cancer et de pronostiquer un cancer
EP3081227A1 (fr) 2015-04-15 2016-10-19 Institut National De La Recherche Agronomique Lactococcus lactis produisant du tslp ou il-25 et leurs utilisations comme probiotiques et thérapeutiques
GB201506786D0 (en) 2015-04-21 2015-06-03 Ucb Biopharma Sprl Therapeutic use
JP6680297B2 (ja) 2015-04-28 2020-04-15 アステラス製薬株式会社 経口投与用医薬組成物
US10287346B2 (en) 2015-04-28 2019-05-14 Mitsubishi Tanabe Pharma Corporation RGMa binding protein and use thereof
TW201702271A (zh) 2015-04-30 2017-01-16 哈佛大學校長及研究員協會 治療代謝病症之抗-ap2抗體及抗原結合劑
MY182282A (en) 2015-05-04 2021-01-18 Pfizer Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof
JP6851322B2 (ja) 2015-05-27 2021-03-31 ユーシービー バイオファルマ エスアールエル 神経疾患を治療する方法
EP3303561A2 (fr) 2015-05-29 2018-04-11 Biogen MA Inc. Méthodes et systèmes de culture cellulaire
US10308615B2 (en) 2015-05-29 2019-06-04 Pfizer Inc. Heterocyclic compounds as inhibitors of Vanin-1 enzyme
GB201509885D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
GB201509888D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
GB201509893D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
CN107787322B (zh) 2015-06-17 2023-07-07 辉瑞大药厂 三环化合物以及它们作为磷酸二酯酶抑制剂的用途
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
AR105025A1 (es) 2015-06-19 2017-08-30 Astellas Pharma Inc Compuesto de imidazodiazepina
US20170044265A1 (en) 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
EA034885B1 (ru) 2015-07-03 2020-04-02 Астеллас Фарма Юэроп Лтд. Новая схема лечения тиакумициновым соединением
US10344081B2 (en) 2015-07-06 2019-07-09 Ucb Biopharma Sprl Tau-binding antibodies
WO2017005734A1 (fr) 2015-07-06 2017-01-12 Ucb Biopharma Sprl Anticorps se liant à tau
KR102225282B1 (ko) 2015-07-21 2021-03-10 화이자 인코포레이티드 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도
WO2017015433A2 (fr) 2015-07-23 2017-01-26 Boehringer Ingelheim International Gmbh Composé ciblant le facteur d'activation d'il-23 et des lymphocytes b (baff) et utilisations associées
EP3333165B1 (fr) 2015-08-04 2019-09-18 Astellas Pharma Inc. Dérivé de pipérazine
CN108697641A (zh) 2015-08-18 2018-10-23 安斯泰来再生医药协会 临床制剂
HUE053705T2 (hu) 2015-08-27 2021-07-28 Pfizer Biciklusos kondenzált heteroaril- vagy aril- vegyületek IRAK4 modulátorokként
CN107922501A (zh) 2015-09-01 2018-04-17 勃林格殷格翰国际有限公司 抗cd40抗体用于治疗狼疮性肾炎的用途
HUE065661T2 (hu) 2015-09-29 2024-06-28 Boehringer Ingelheim Animal Health Usa Inc Kutya parvovírus (CPV) vírusszerû részecske (VLP) vakcinák és alkalmazásuk
BR112018006251A2 (pt) 2015-09-30 2018-10-16 Janssen Biotech Inc anticorpos antagonistas que se ligam especificamente a cd40 humano e métodos de uso
DK3359688T3 (da) 2015-10-05 2021-08-23 Biogen Ma Inc Molekylære signaturer til anvendelse til diagnose og analyse af respons på behandling af autoimmune sygdomme
KR101949451B1 (ko) 2015-10-13 2019-05-10 주식회사 이노파마스크린 염증성 장 질환 및 아토피 피부염 치료용 조성물
US10208024B2 (en) 2015-10-23 2019-02-19 Array Biopharma Inc. 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
CN116059350A (zh) 2015-10-27 2023-05-05 Ucb生物制药有限责任公司 使用抗-il-17a/f抗体的治疗方法
EA201891084A1 (ru) 2015-11-02 2019-10-31 Антитела к il1rap, биспецифические антигенсвязывающие молекулы, которые связываются с il1rap и cd3, и их применение
EP3371150B1 (fr) 2015-11-03 2021-08-18 UCB Biopharma SRL Procede de preperation de brivaracetam
DK3380119T3 (da) 2015-11-23 2021-11-15 Boehringer Ingelheim Animal Health Usa Inc Fmdv- og e2-fusionsproteiner og anvendelser deraf
TWI812873B (zh) 2015-11-30 2023-08-21 美商輝瑞股份有限公司 用於部位專一性接合之抗體和抗體片段
GB201521389D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
GB201521391D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521382D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521383D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl And Ucb Celltech Method
GB201521393D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
LT3390390T (lt) 2015-12-16 2021-11-25 Boehringer Ingelheim International Gmbh Bipirazolilo dariniai, tinkami naudoti autoimuninių ligų gydymui
GB201522391D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibody molecules
SG10202012778YA (en) 2015-12-18 2021-01-28 Astellas Pharma Inc Pharmaceutical composition comprising anti-human tslp receptor antibody
US10570118B2 (en) 2016-01-13 2020-02-25 Boehringer Ingelheim International Gmbh Isoquinolones as BTK inhibitors
MX2018008771A (es) 2016-01-19 2018-11-09 Janssen Pharmaceutica Nv Formulaciones/composiciones que comprenden un inhibidor de btk.
MX2018008797A (es) 2016-01-19 2018-11-29 Pfizer Vacunas contra el cancer.
US20190290650A1 (en) 2016-01-19 2019-09-26 Janssen Pharmaceutic Nv Formulations/compositions comprising a btk inhibitor
CN109219618B (zh) 2016-01-21 2022-08-09 辉瑞大药厂 针对表皮生长因子受体变体iii和cd3的单特异性和双特异性抗体及其用途
TWI755547B (zh) 2016-01-21 2022-02-21 美商輝瑞股份有限公司 靶向表皮生長因子受體變異體iii之嵌合型抗原受體
MA46681A (fr) 2016-01-28 2019-09-11 Janssen Biotech Inc Anticorps bispécifiques anti-tnf-alpha/il-17a antibodies et anticorps anti-tnf-alpha et leurs procédés d'utilisation
TWI760322B (zh) 2016-01-29 2022-04-11 美商百靈佳殷格翰動物保健美國有限公司 重組腺病毒載體裝載之fmdv疫苗及其用途
US10465003B2 (en) 2016-02-05 2019-11-05 Janssen Biotech, Inc. Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes
EP3413915A1 (fr) 2016-02-08 2018-12-19 Synaffix B.V. Conjugués d'anticorps à indice thérapeutique amélioré permettant de cibler des tumeurs positives pour le her2 et méthode pour améliorer l'indice thérapeutique de conjugués d'anticorps
DE102016001407A1 (de) 2016-02-09 2017-08-24 Fresenius Medical Care Deutschland Gmbh Blutbehandlung mit Inaktivierung von freien Nukleinsäuren
GB201602938D0 (en) 2016-02-19 2016-04-06 Ucb Biopharma Sprl Protein purification
CN113332292A (zh) 2016-02-23 2021-09-03 辉瑞公司 6,7-二氢-5H-吡唑并[5,1-b][1,3]噁嗪-2-甲酰胺化合物
GB201603104D0 (en) 2016-02-23 2016-04-06 Ucb Biopharma Sprl Therapeutic agents
CN109071546B (zh) 2016-02-24 2021-03-02 辉瑞大药厂 作为jak抑制剂的吡唑并[1,5-a]吡嗪-4-基衍生物
US10611800B2 (en) 2016-03-11 2020-04-07 Pfizer Inc. Human cytomegalovirus gB polypeptide
CN109311965B (zh) 2016-03-11 2023-07-18 勃林格殷格翰国际公司 在制造蛋白质期间连续灭活病毒的方法
US10519479B1 (en) 2016-03-15 2019-12-31 Ares Trading S.A. Methods for modifying glycosylation using manganese
EP3431079B1 (fr) 2016-03-15 2023-06-07 Astellas Pharma Inc. Comprimé
US10526631B1 (en) 2016-03-15 2020-01-07 Ares Trading S.A. Method of reducing serine for asparagine misincorporation
KR102023058B1 (ko) 2016-03-25 2019-09-19 사회복지법인 삼성생명공익재단 이중 이온 pH-민감성 공중합체를 이용한 허혈성 뇌질환 치료용 약물 전달체
CA3018155A1 (fr) 2016-03-29 2017-10-05 Astellas Pharma Inc. Polytherapie pour le traitement de la leucemie myeloide aigue
MX2018011435A (es) 2016-04-01 2019-01-10 Ucb Biopharma Sprl Metodo para purificacion de proteinas.
EP3436460B1 (fr) 2016-04-01 2021-08-18 UCB Biopharma SRL Dérivés d'imidazole pentacyclique condensé comme modulateurs de l'activité du tnf
JP6968092B2 (ja) 2016-04-01 2021-11-17 ユーシービー バイオファルマ エスアールエル Tnf活性のモジュレーターとしての縮合五環式イミダゾール誘導体
EA201892144A1 (ru) 2016-04-01 2019-04-30 Юсб Байофарма Спрл Конденсированные гексациклические производные имидазола в качестве модуляторов активности tnf
JP6968091B2 (ja) 2016-04-01 2021-11-17 ユーシービー バイオファルマ エスアールエル Tnf活性のモジュレーターとしての縮合五環式イミダゾール誘導体
EP3441065B1 (fr) 2016-04-06 2024-10-09 Astellas Pharma Inc. Moulage tridimensionnel à élution rapide, filament pour moulage tridimensionnel à élution rapide et matériau pour moulage tridimensionnel à élution rapide
EP3439690A2 (fr) 2016-04-07 2019-02-13 Merial, Inc. Vaccin contre le ver du c ur, procédés et utilisations associés
CN108884050B (zh) 2016-04-13 2022-07-05 Ucb生物制药私人有限公司 四氢异喹啉衍生物
JP7250520B2 (ja) 2016-04-13 2023-04-03 ヤンセン ファーマシューティカルズ,インコーポレーテッド 組換えアルテリウイルスレプリコン系およびその使用
WO2017178586A1 (fr) 2016-04-15 2017-10-19 Cellectis Méthode de mise au point par génie génétique de lymphocytes t hypersensibles à un promédicament spécifique pour une immunothérapie par expression génique
KR20230119259A (ko) 2016-04-15 2023-08-16 이뮤넥스트, 인크. 항-인간 vista 항체 및 이의 용도
MX2018013038A (es) 2016-04-27 2019-03-28 Pfizer Anticuerpos anti-il-33, composiciones, metodos y usos de los mismos.
KR20170122650A (ko) 2016-04-27 2017-11-06 사회복지법인 삼성생명공익재단 미숙아 뇌실내 출혈 치료를 위한 고효능 줄기세포 선별법
CA3022494A1 (fr) 2016-05-01 2017-11-09 Ucb Biopharma Sprl Domaine de liaison a une proteine porteuse serique, avec affinite genetiquement modifiee
EP3455363B1 (fr) 2016-05-10 2021-12-08 Ares Trading S.A. Procédés de modulation des profils de galactosylation de protéines recombinantes au moyen de galactose de peracétyle
GB201608323D0 (en) 2016-05-12 2016-06-29 Ucb Biopharma Sprl Pharmaceutical compositions
GB201608797D0 (en) 2016-05-19 2016-07-06 Ucb Biopharma Sprl Therapeutic use
US20190336552A1 (en) 2016-05-30 2019-11-07 Astellas Pharma Inc. Genetically engineered vaccinia viruses
TW201808987A (zh) 2016-06-08 2018-03-16 健生生物科技公司 Gm-csf變體及使用方法
GB201610044D0 (en) 2016-06-08 2016-07-20 Ucb Biopharma Sprl Antibodies
GB201610198D0 (en) 2016-06-10 2016-07-27 Ucb Biopharma Sprl Anti-ige antibodies
WO2018011681A1 (fr) 2016-07-14 2018-01-18 Pfizer Inc. Nouveaux pyrimidine carboxamides utilisées comme inhibiteurs de l'enzyme vanin-1
EP3484507A1 (fr) 2016-07-15 2019-05-22 Janssen Vaccines & Prevention B.V. Méthodes et compositions permettant l'induction d'une immunité protectrice contre l'infection par le virus de marburg
WO2018016458A1 (fr) 2016-07-19 2018-01-25 アステラス製薬株式会社 Dérivé de pipérazine
WO2018022851A1 (fr) 2016-07-28 2018-02-01 Mitobridge, Inc. Méthode de traitement de lésions rénales aiguës.
US20190270778A1 (en) 2016-07-29 2019-09-05 Pfizer Inc. Cyclic Peptides As C5a Receptor Antagonists
JPWO2018030459A1 (ja) 2016-08-10 2019-06-13 アステラス製薬株式会社 膵がんでのcldn18−arhgap6融合遺伝子又はcldn18−arhgap26融合遺伝子の検出
WO2018033482A1 (fr) 2016-08-17 2018-02-22 Boehringer Ingelheim International Gmbh Procédé de préparation de formulations liquides hautement concentrées contenant des biomolécules
US20190292265A1 (en) 2016-08-19 2019-09-26 Janssen Biotech, Inc. Methods of Treating Crohn's Disease with an Anti-NKG2D Antibody
CA3034402A1 (fr) 2016-09-12 2018-03-15 Ares Trading S.A. Procedes pour la modulation de profils de production de proteines recombinantes
AU2017327539B2 (en) 2016-09-15 2020-12-24 Boehringer Ingelheim International Gmbh Heteroaryl carboxamide compounds as inhibitors of RIPK2
KR102546471B1 (ko) 2016-09-27 2023-06-21 프레제니우스 카비 도이치란트 게엠베하 액상의 약학 조성물
GB201616563D0 (en) 2016-09-29 2016-11-16 Ucb Biopharma Sprl Therapeutic agents
US10537590B2 (en) 2016-09-30 2020-01-21 Boehringer Ingelheim International Gmbh Cyclic dinucleotide compounds
ES3007557T3 (en) 2016-10-17 2025-03-20 Pfizer Anti-edb antibodies and antibody-drug conjugates
KR101971322B1 (ko) 2016-10-17 2019-04-23 사회복지법인 삼성생명공익재단 Socs의 발현 또는 활성 억제를 이용한 고효능 줄기세포 선별방법
KR101971323B1 (ko) 2016-10-17 2019-04-23 사회복지법인 삼성생명공익재단 면역질환 치료를 위한 고효능 줄기세포 선별방법
GB201617924D0 (en) 2016-10-24 2016-12-07 Ucb Biopharma Sprl Proteins and users
WO2018079570A1 (fr) 2016-10-26 2018-05-03 アステラス製薬株式会社 Composition pharmaceutique stable
KR101837449B1 (ko) 2016-10-28 2018-03-12 삼성전자주식회사 마이크로 니들 패치, 마이크로 니들을 제조하는 방법 및 장치
KR20190078572A (ko) 2016-10-31 2019-07-04 프레제니우스 카비 도이치란트 게엠베하 액상의 약학 조성물
EA201991096A1 (ru) 2016-10-31 2019-09-30 Вектура Лимитед Ингалируемая порошковая композиция, содержащая анти-il-13-антитело
TWI780082B (zh) 2016-11-18 2022-10-11 日商安斯泰來製藥股份有限公司 新穎抗人類MUC1抗體Fab片段
US10949973B2 (en) 2016-11-23 2021-03-16 Wake Forest University Health Sciences Medical image analysis using mechanical deformation information
GB201620948D0 (en) 2016-12-09 2017-01-25 Ucb Biopharma Sprl Therapeutic agents
RU2754058C2 (ru) 2016-12-13 2021-08-26 Астеллас Фарма Инк. Антитело к cd73 человека
GB201621728D0 (en) 2016-12-20 2017-02-01 Ucb Biopharma Sprl Methods
WO2018119142A1 (fr) 2016-12-21 2018-06-28 Amgen Inc. Formulations d'anticorps anti-tnf alpha
TWI754702B (zh) 2016-12-28 2022-02-11 德商Ucb製藥有限公司 (氮雜)吲哚-和苯並呋喃-3-磺醯胺類
BR112019014833A2 (pt) 2017-01-20 2020-04-14 Pfizer composições imunogênicas para uso em vacinas pneumococais
WO2018138591A1 (fr) 2017-01-24 2018-08-02 Pfizer Inc. Dérivés de calichéamicine et conjugués anticorps-médicaments de ceux-ci
SI3575284T1 (sl) 2017-01-24 2021-11-30 Astellas Pharma Inc. Spojina fenildifluorometil substituiranega prolinamida
EA201991755A1 (ru) 2017-01-26 2020-01-22 Юсб Байофарма Спрл Бициклические бисгетероарильные производные в качестве модуляторов агрегации белков
CN110198938B (zh) 2017-01-26 2023-03-14 Ucb生物制药私人有限公司 作为蛋白质聚集调节剂的双-杂芳基衍生物
WO2018140121A1 (fr) 2017-01-30 2018-08-02 Janssen Biotech, Inc. Anticorps anti-tnf, compositions et méthodes pour le traitement du rhumatisme psoriasique actif
JOP20190186A1 (ar) 2017-02-02 2019-08-01 Astellas Pharma Inc مركب كينازولين
MX2019009377A (es) 2017-02-07 2019-12-11 Janssen Biotech Inc Anticuerpos anti-tnf, composiciones y metodos para el tratamiento de la espondilitis anquilosante activa.
EP3582813A4 (fr) 2017-02-16 2020-12-30 XBiotech, Inc Traitement de l'hidradénite suppurative
JP7467119B2 (ja) 2017-02-17 2024-04-15 ロンザ リミテッド 発現困難タンパク質のための多部位ssi細胞
EP4417262A3 (fr) 2017-03-01 2024-11-27 Janssen Sciences Ireland Unlimited Company Polythérapie
EP3372242A1 (fr) 2017-03-06 2018-09-12 Ares Trading S.A. Composition pharmaceutique liquide
EP3372241A1 (fr) 2017-03-06 2018-09-12 Ares Trading S.A. Composition pharmaceutique liquide
WO2018163030A1 (fr) 2017-03-10 2018-09-13 Pfizer Inc. Dérivés d'imidazo [4,5-c] quinoléine substitués cycliques
WO2018167176A1 (fr) 2017-03-15 2018-09-20 Ucb Biopharma Sprl Dérivés d'imidazole pentacycliques condensés utilisés en tant que modulateurs de l'activité du tnf
JP6901292B2 (ja) 2017-03-15 2021-07-14 株式会社Adeka 水溶性組成物、その硬化物の製造方法、およびその硬化物、並びにアシルホスフィン酸塩
JP2020514370A (ja) 2017-03-17 2020-05-21 キュアバック アーゲー 組合せ抗癌療法のためのrnaワクチン及び免疫チェックポイント阻害剤
JOP20190218A1 (ar) 2017-03-22 2019-09-22 Boehringer Ingelheim Int مركبات ثنائية النيوكليوتيدات حلقية معدلة
WO2018178250A1 (fr) 2017-03-31 2018-10-04 Boehringer Ingelheim International Gmbh Polythérapie anticancéreuse
CA3058980A1 (fr) 2017-04-25 2018-11-01 Ucb Biopharma Sprl Derives d'imidazole pentacycliques fusionnes utilises en tant que modulateurs de l'activite du tnf
WO2018200788A1 (fr) 2017-04-26 2018-11-01 Beryllium, Llc Agents de liaison d'oligonucléotides
KR20200014379A (ko) 2017-06-05 2020-02-10 얀센 바이오테크 인코포레이티드 비대칭 ch2-ch3 영역 돌연변이를 갖는 조작된 다중특이성 항체 및 다른 다량체 단백질
AU2018285131B2 (en) 2017-06-12 2021-11-11 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as Vanin inhibitors
GB201709456D0 (en) 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
EP3652211A1 (fr) 2017-07-14 2020-05-20 Pfizer Inc. Anticorps dirigés contre madcam
WO2019018647A1 (fr) 2017-07-20 2019-01-24 Pfizer Inc. Anticorps anti-gd3 et conjugués anticorps-médicament
CA3068779A1 (fr) 2017-08-11 2019-02-14 Boehringer Ingelheim International Gmbh Sites d'integration dans des cellules cho
WO2019035649A1 (fr) 2017-08-14 2019-02-21 주식회사 레고켐 바이오사이언스 Conjugués anticorps-médicament comprenant un anticorps contre egfrviii
WO2019034973A1 (fr) 2017-08-14 2019-02-21 Pfizer Inc. Pyrazolo[1,5-a]pyrazin-4-yl et dérivés associés
WO2019038338A1 (fr) 2017-08-23 2019-02-28 Sandoz Ag Système d'expression de protéines à multiples copies géniques
JP7250766B2 (ja) 2017-08-25 2023-04-03 ヤンセン バイオテツク,インコーポレーテツド FCγRII結合フィブロネクチンIII型ドメイン、それらのコンジュゲート、及びそれらを含む多重特異性分子
JP2020531557A (ja) 2017-08-30 2020-11-05 アレス トレーディング ソシエテ アノニム タンパク質の精製方法
IL272864B2 (en) 2017-08-31 2024-03-01 Mitsubishi Tanabe Pharma Corp Il-33 antagonist-containing therapeutic agent for endometriosis
CA3074865A1 (fr) 2017-09-14 2019-03-21 Icagen, Inc. Procedes de detection utilisant la fluorescence x
KR102188572B1 (ko) 2017-09-25 2020-12-09 사회복지법인 삼성생명공익재단 뇌척수액을 포함하는 줄기세포 투여 제형 및 그의 제조방법
TW201922780A (zh) 2017-09-25 2019-06-16 美商健生生物科技公司 以抗il12/il23抗體治療狼瘡之安全且有效之方法
CN111201243B (zh) 2017-09-29 2023-08-11 财团法人牧岩生命科学研究所 对bcma具有高亲和力的抗bcma抗体和包含其的用于治疗癌症的药物组合物
US11364303B2 (en) 2017-09-29 2022-06-21 Pfizer Inc. Cysteine engineered antibody drug conjugates
US20190153096A1 (en) 2017-10-02 2019-05-23 Covagen Ag Cd3/cd33 bispecific binding molecules
US20190100587A1 (en) 2017-10-02 2019-04-04 Covagen Ag IgG1 Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS
WO2019073069A1 (fr) 2017-10-13 2019-04-18 Boehringer Ingelheim International Gmbh Anticorps humains dirigés contre l'antigène thomsen-nouveau (tn)
CA3078806A1 (fr) 2017-10-13 2019-04-18 Merck Patent Gmbh Combinaison d'un inhibiteur de parp et d'un antagoniste de liaison d'axe pd-1
US20200332251A1 (en) 2017-10-13 2020-10-22 Boehringer Ingelheim International Gmbh Perfusion medium
EP3697816A1 (fr) 2017-10-19 2020-08-26 Debiopharm International S.A. Produit de combinaison pour le traitement du cancer
MX2020004381A (es) 2017-10-27 2020-08-20 Pfizer Anticuerpos y conjugados de anticuerpo-farmaco especificos para cd123 y usos de los mismos.
JP2021502349A (ja) 2017-11-06 2021-01-28 ヤンセン バイオテツク,インコーポレーテツド 抗il23特異的抗体で乾癬性関節炎を治療する安全かつ有効な方法
WO2019099970A1 (fr) 2017-11-20 2019-05-23 Janssen Pharmaceuticals Inc. Procédé d'administration sûre de vecteurs adénoviraux codant pour un antigène du virus zika
GB201719447D0 (en) 2017-11-23 2018-01-10 Ucb Biopharma Sprl Pharmaceutical composition
KR20190064293A (ko) 2017-11-30 2019-06-10 (주)메디노 미숙아 뇌실내 출혈 치료를 위한 고효능 줄기세포 선별법
CN111615520A (zh) 2017-12-01 2020-09-01 辉瑞大药厂 抗cxcr5抗体及其组合物和用途
GB201720970D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Antibodies
GB201720975D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
TW201938165A (zh) 2017-12-18 2019-10-01 美商輝瑞股份有限公司 治療癌症的方法及組合療法
EA202091516A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv)
KR20200100745A (ko) 2017-12-19 2020-08-26 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 B형 간염 바이러스(hbv)에 대한 면역 반응 유도를 위한 방법 및 조성물
AU2018392658B2 (en) 2017-12-20 2024-07-25 Ares Trading S.A. Methods for modulating protein mannosylation profiles using maduramycin, narasin, or salinomycin
US20210002371A1 (en) 2017-12-21 2021-01-07 Brian A. Sherer Combination of an anti-pd-l1 antibody and ido1 inhibitor for the treatment of cancer
US11472794B2 (en) 2018-01-15 2022-10-18 UCB Biopharma SRL Fused imidazole derivatives as IL-17 modulators
CA3087481A1 (fr) 2018-01-15 2019-07-18 Pfizer Inc. Methodes d'administration d'immunotherapie par recepteur d'antigene chimerique en combinaison avec un agoniste de 4-1bb
CN112020518A (zh) 2018-02-01 2020-12-01 辉瑞公司 靶向cd70的嵌合抗原受体
PE20210708A1 (es) 2018-02-01 2021-04-16 Pfizer Anticuerpos especificos para cd70 y sus usos
TW202430218A (zh) 2018-02-27 2024-08-01 美商輝瑞大藥廠 抗體純化
AU2019228381B2 (en) 2018-02-28 2021-12-16 Pfizer Inc. IL-15 variants and uses thereof
CN111819192A (zh) 2018-03-02 2020-10-23 艾洛基治疗公司 可诱导的嵌合细胞激素受体
MX2020009265A (es) 2018-03-05 2020-10-01 Janssen Biotech Inc Metodos para tratar la enfermedad de crohn con un anticuerpo especifico anti-il23.
IL277095B2 (en) 2018-03-07 2025-10-01 Pfizer Preparations containing anti-PD-1 antibody
JP2021517577A (ja) 2018-03-14 2021-07-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 炎症性腸疾患の処置のための抗il−36r抗体の使用
BR112020016738A2 (pt) 2018-03-14 2020-12-15 Boehringer Ingelheim International Gmbh Uso de anticorpos anti-il-36r para o tratamento de psoríase pustular generalizada
WO2019185477A1 (fr) 2018-03-27 2019-10-03 Boehringer Ingelheim International Gmbh Composés dinucléotidiques cycliques contenant 2-aza-hypoxanthine ou 6h-pytazolo[1,5-d][1,2,4]triazine-7-one en tant qu'agonistes de sting
JP2021519279A (ja) 2018-03-27 2021-08-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 修飾環式ジヌクレオチド化合物
EP3781941B1 (fr) 2018-04-20 2026-01-14 Janssen Biotech, Inc. Qualification de colonnes de chromatographie pour la production de mélanges d'anticorps anti-tnf
WO2019212253A1 (fr) 2018-05-02 2019-11-07 사회복지법인 삼성생명공익재단 Anticorps se liant de manière spécifique à c-met et utilisation associée
KR20210006412A (ko) 2018-05-08 2021-01-18 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 디히드로피리미딘 유도체 및 hbv 감염 또는 hbv-유도성 질환의 치료에 있어서의 이의 용도
US20190345245A1 (en) 2018-05-11 2019-11-14 Janssen Biotech, Inc. Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody
UA130542C2 (uk) 2018-05-16 2026-03-18 Янссен Байотек, Інк. Антитіло до cd38 та терапевтичний засіб, який перенаправляє т-клітини, для лікування множинної мієломи у суб'єкта
EP3793521A4 (fr) 2018-05-18 2022-02-23 Janssen Biotech, Inc. Méthode sûre et efficace de traitement du lupus avec un anticorps anti-il12/il23
EP3569618A1 (fr) 2018-05-19 2019-11-20 Boehringer Ingelheim International GmbH Antagonisation d'anticorps cd73
MX2020012607A (es) 2018-05-23 2021-01-29 Pfizer Anticuerpos especificos para gucy2c y sus usos.
KR102602329B1 (ko) 2018-05-23 2023-11-16 화이자 인코포레이티드 Cd3에 특이적인 항체 및 이의 용도
JOP20190116A1 (ar) 2018-05-24 2019-11-24 Janssen Biotech Inc الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها
PE20211916A1 (es) 2018-05-24 2021-09-28 Janssen Biotech Inc Agentes aglutinantes del psma y usos de estos
CA3101271A1 (fr) 2018-05-24 2019-11-28 Janssen Biotech, Inc. Anticorps anti-cd3 et leurs utilisations
AU2019274782A1 (en) 2018-05-24 2020-12-03 Ares Trading S.A. Method for controlling the afucosylation level of a glycoprotein composition
WO2019231243A1 (fr) 2018-05-29 2019-12-05 사회복지법인 삼성생명공익재단 Cellule nourricière exprimant ox40l et procédé de culture de cellules tueuses naturelles l'utilisant
US20190365743A1 (en) 2018-05-30 2019-12-05 Hedgepath Pharmaceuticals, Inc. Hedgehog pathway inhibition for treatment of high-risk basal cell carcinoma or high-risk basal cell carcinoma nevus syndrome
WO2019235839A1 (fr) 2018-06-05 2019-12-12 사회복지법인 삼성생명공익재단 Modèle animal de phénotype d'ophtalmopathie de graves, son procédé d'élaboration et procédé de recherche par criblage d'une substance thérapeutique contre l'ophtalmopathie de graves
CA3045370A1 (fr) 2018-06-08 2019-12-08 Pfizer Inc. Methodes de traitement de la maladie metabolique
TWI848953B (zh) 2018-06-09 2024-07-21 德商百靈佳殷格翰國際股份有限公司 針對癌症治療之多特異性結合蛋白
CN113166972A (zh) 2018-06-11 2021-07-23 耶鲁大学 新型免疫检查点抑制剂
GB201809700D0 (en) 2018-06-13 2018-08-01 Singapore Health Serv Pte Ltd IL-11 antibodies
GB201809699D0 (en) 2018-06-13 2018-08-01 Singapore Health Serv Pte Ltd IL-11 antibodies
EP3810609B1 (fr) 2018-06-18 2024-06-12 Janssen Pharmaceutica NV Dérivés de la pyrazole comme inhibiteurs de la malt1
AU2019289222B2 (en) 2018-06-18 2023-07-13 Janssen Pharmaceutica Nv Pyrazole derivatives as MALT1 inhibitors
CN112513017A (zh) 2018-06-26 2021-03-16 爱尔兰詹森科学公司 二氢嘧啶衍生物及其在治疗hbv感染或hbv诱发疾病中的用途
JP7645076B2 (ja) 2018-06-27 2025-03-13 ベーリンガー インゲルハイム エルツェーファウ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 転写因子の使用によってタンパク質発現を増加させるための手段及び方法
WO2020006347A1 (fr) 2018-06-29 2020-01-02 Boehringer Ingelheim International Gmbh Anticorps anti-cd40 destinés à être utilisés dans le traitement d'une maladie auto-immune
US20200025776A1 (en) 2018-07-18 2020-01-23 Janssen Biotech, Inc. Sustained Response Predictors After Treatment With Anti-IL23 Specific Antibody
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
CN112912395B (zh) 2018-08-20 2024-08-23 辉瑞公司 抗gdf15抗体、组合物和使用方法
US20200061015A1 (en) 2018-08-23 2020-02-27 Janssen Biotech, Inc. Lipase Degradation Resistant Surfactants for Use in Large Molecule Therapeutic Formulations
US11260119B2 (en) 2018-08-24 2022-03-01 Pfizer Inc. Escherichia coli compositions and methods thereof
AU2019326933B2 (en) 2018-08-28 2024-12-05 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as Vanin inhibitors
EP3848388B1 (fr) 2018-09-05 2025-08-20 LG Chem, Ltd. Polypeptide de fusion comprenant une région polypeptidique pouvant être o-glycosylée
JP7654539B2 (ja) 2018-09-07 2025-04-01 ファイザー・インク 抗αvβ8抗体、組成物及びその使用

Also Published As

Publication number Publication date
US20230151086A1 (en) 2023-05-18
WO2018119142A1 (fr) 2018-06-28
US20250171527A1 (en) 2025-05-29
EP3824906A1 (fr) 2021-05-26
EP4467565A3 (fr) 2025-03-12
US20200087390A1 (en) 2020-03-19
EP3558363A1 (fr) 2019-10-30
EP4467565A2 (fr) 2024-11-27
US12247071B2 (en) 2025-03-11

Similar Documents

Publication Publication Date Title
MA49043A (fr) Formulation stable d'anticorps
EP3618871A4 (fr) Formulations d'anticorps anti-lag3 etco-formulations d'anticorps anti-lag3 et d'anticorps anti-pd-1
MA52884A (fr) Anticorps anti-il-11
MA53434A (fr) Anticorps anti-tigit
EP3484518A4 (fr) Conjugués d'adjuvant d'anticorps
MA56006A (fr) Formulations sous-cutanées d'anticorps her2
EP3359573A4 (fr) Marquage d'anticorps
MA46525A (fr) Anticorps anti-lag-3 et compositions
MA49034A (fr) Anticorps anti-lag3
EP3589313A4 (fr) Anticorps anti-tigit
MA44659A (fr) Anticorps anti-tim-3 et compositions
MA49726A (fr) Formulation d'anticorps anti-cgrp
EP3883970A4 (fr) Anticorps anti-b7-h3
MA47268A (fr) Anticorps anti-gpc3
MA44236A (fr) Anticorps anti-tgfbêta 2
EP3430731A4 (fr) Architecture d'iugw
MA44381A (fr) Format d'anticorps hétérodimères multispécifiques
MA49749A (fr) Anticorps anti-cd137
EP3496753A4 (fr) Formulation d'anticorps anti-pd-1
MA44054A (fr) Plateforme d'anticorps bispécifique
EP2968553A4 (fr) Formulations d'anticorps
MA54052A (fr) Formulation d'anticorps
EP3823978A4 (fr) Compositions d'anticorps anti-fcrn
EP3692072A4 (fr) Anticorps anti-hla-dq2.5
EP3617231A4 (fr) Anticorps anti-gpc-1