MA38949A1 - Forme saline d'hydrochlorure pour inhibition d'ezh2 - Google Patents

Forme saline d'hydrochlorure pour inhibition d'ezh2

Info

Publication number
MA38949A1
MA38949A1 MA38949A MA38949A MA38949A1 MA 38949 A1 MA38949 A1 MA 38949A1 MA 38949 A MA38949 A MA 38949A MA 38949 A MA38949 A MA 38949A MA 38949 A1 MA38949 A1 MA 38949A1
Authority
MA
Morocco
Prior art keywords
dgat1
ezh2
hydrochloride
inhibition
saline form
Prior art date
Application number
MA38949A
Other languages
English (en)
Inventor
Kevin W Kuntz
Hyeong-Wook Choi
Steven Mathieu
Kristen Sanders
Arani Chanda
Original Assignee
Eisai R&D Man Co Ltd
Epizyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd, Epizyme Inc filed Critical Eisai R&D Man Co Ltd
Publication of MA38949A1 publication Critical patent/MA38949A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés qui sont des inhibiteurs d'acyl-coenzyme a: diacylglycérol transférase 1 (dgat1), des compositions pharmaceutiques les contenant, des procédés pour leur préparation, ainsi que leur utilisation en thérapie, seuls ou en combinaison avec des thérapies de gestion du poids ou autre thérapie de diminution des triglycérides pour la prévention ou le traitement de maladies liées à un dysfonctionnement de dgat1 ou dans lesquelles une modulation de l'activité de dgat1 peut avoir un bénéfice thérapeutique.
MA38949A 2013-10-16 2014-10-15 Forme saline d'hydrochlorure pour inhibition d'ezh2 MA38949A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361891786P 2013-10-16 2013-10-16
PCT/US2014/060724 WO2015057859A1 (fr) 2013-10-16 2014-10-15 Forme saline d'hydrochlorure pour inhibition d'ezh2

Publications (1)

Publication Number Publication Date
MA38949A1 true MA38949A1 (fr) 2017-07-31

Family

ID=52828660

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38949A MA38949A1 (fr) 2013-10-16 2014-10-15 Forme saline d'hydrochlorure pour inhibition d'ezh2

Country Status (24)

Country Link
US (3) US10040782B2 (fr)
EP (2) EP4324525A3 (fr)
JP (2) JP6608812B2 (fr)
KR (1) KR102142177B1 (fr)
CN (1) CN105829302B (fr)
AU (2) AU2014337300B2 (fr)
CA (1) CA2925889C (fr)
CL (1) CL2016000866A1 (fr)
DK (1) DK3057962T3 (fr)
EA (1) EA038869B1 (fr)
ES (1) ES2960953T3 (fr)
FI (1) FI3057962T3 (fr)
HU (1) HUE063984T2 (fr)
IL (1) IL244787B (fr)
LT (1) LT3057962T (fr)
MA (1) MA38949A1 (fr)
MX (1) MX2016004703A (fr)
MY (1) MY179802A (fr)
PE (1) PE20161273A1 (fr)
PL (1) PL3057962T3 (fr)
PT (1) PT3057962T (fr)
SG (2) SG10201901977XA (fr)
SI (1) SI3057962T1 (fr)
WO (1) WO2015057859A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3363B1 (ar) 2011-04-13 2019-03-13 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
IL296199B2 (en) 2012-04-13 2024-12-01 Eisai R&D Man Co Ltd Salt form of a human hi stone methyltransf erase ezh2 inhibitor
NZ706836A (en) 2012-10-15 2019-02-22 Epizyme Inc Methods of treating cancer
US10040782B2 (en) 2013-10-16 2018-08-07 Epizyme, Inc. Hydrochloride salt form for EZH2 inhibition
EP3888659A1 (fr) 2013-12-06 2021-10-06 Epizyme Inc Polythérapie pour le traitement du cancer
LT3157527T (lt) 2014-06-17 2023-07-25 Epizyme, Inc. Ezh2 inhibitoriai, skirti limfomos gydymui
CN106794177A (zh) 2014-10-16 2017-05-31 Epizyme股份有限公司 治疗癌症的方法
MX383484B (es) 2014-11-17 2025-03-11 Epizyme Inc Método para tratar el cáncer.
AU2016252546A1 (en) 2015-04-20 2017-11-02 Epizyme, Inc. Combination therapy for treating cancer
JP6890097B2 (ja) 2015-06-10 2021-06-18 エピザイム，インコーポレイティド リンパ腫を処置するためのｅｚｈ２阻害剤
WO2017035234A1 (fr) 2015-08-24 2017-03-02 Epizyme, Inc. Méthode de traitement du cancer
AU2017211331A1 (en) 2016-01-29 2018-06-07 Epizyme, Inc. Combination therapy for treating cancer
US11786533B2 (en) 2016-06-01 2023-10-17 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer
MA45406A (fr) 2016-06-17 2019-04-24 Epizyme Inc Inhibiteurs d'ezh2 pour traiter le cancer
BR112019014924A2 (pt) 2017-01-19 2020-03-31 St. Marianna University School Of Medicine Composição farmacêutica usada para o tratamento de mielopatia associada ao htlv-1
WO2018183885A1 (fr) 2017-03-31 2018-10-04 Epizyme, Inc. Multithérapie pour le traitement du cancer
EP3630080A4 (fr) 2017-06-02 2021-03-10 Epizyme, Inc. Utilisation d'inhibiteurs de ezh2 pour le traitement du cancer
CA3074720A1 (fr) 2017-09-05 2019-03-14 Epizyme, Inc. Polytherapie pour le traitement du cancer
JP2021531340A (ja) 2018-07-09 2021-11-18 フォンダシヨン、アジール、デ、アブグルスFondation Asile Des Aveugles 眼障害を治療するためのｐｒｃ２サブユニットの阻害
CN114555112A (zh) 2019-08-22 2022-05-27 朱诺治疗学股份有限公司 T细胞疗法和zeste增强子同源物2(ezh2)抑制剂的组合疗法及相关方法
AU2020408395A1 (en) * 2019-12-20 2022-07-07 Epizyme, Inc. Crystalline hydrobromide salt of a EZH2 inhibitor, its preparation and pharmaceutical composition useful for the treatment of cancer
US20250276079A1 (en) 2022-04-27 2025-09-04 Daiichi Sankyo Company, Limited COMBINATION OF ANTIBODY-DRUG CONJUGATE WITH EZH1 and/or EZH2 INHIBITOR

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0733729A (ja) 1993-07-26 1995-02-03 Kirin Brewery Co Ltd Ｎ−シアノ−ｎ′−置換−アリールカルボキシイミダミド化合物の製造法
RU2128644C1 (ru) 1993-12-27 1999-04-10 Эйсай Ко., Лтд. Производные антраниловой кислоты или их фармакологически приемлемые соли, промежуточные продукты для их получения и лекарственный препарат на их основе
DE19516776A1 (de) 1995-05-10 1996-11-14 Boehringer Ingelheim Int Chromatin-Regulatorgene
US5741819A (en) 1995-06-07 1998-04-21 3-Dimensional Pharmaceuticals, Inc. Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors
JP3906935B2 (ja) 1995-12-18 2007-04-18 杏林製薬株式会社 Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法
JP2002525352A (ja) 1998-09-30 2002-08-13 ザ、プロクター、エンド、ギャンブル、カンパニー ２−置換ケトアミド
UA71587C2 (uk) 1998-11-10 2004-12-15 Шерінг Акцієнгезелльшафт Аміди антранілової кислоти та їхнє застосування як лікарських засобів
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
ATE438624T1 (de) 2000-12-28 2009-08-15 Shionogi & Co 2-pyridonderivate mit affinität für den cannabinoid-typ-2-rezeptor
US7700293B2 (en) 2001-08-02 2010-04-20 The Regents Of The University Of Michigan Expression profile of prostate cancer
WO2003070277A1 (fr) 2002-02-19 2003-08-28 Shionogi & Co., Ltd. Antiprurigineux
TW200306155A (en) 2002-03-19 2003-11-16 Du Pont Benzamides and advantageous compositions thereof for use as fungicides
US7442685B2 (en) 2003-06-13 2008-10-28 The University Of North Carolina At Chapel Hill DOT1 histone methyltransferases as a target for identifying therapeutic agents for leukemia
US7563589B2 (en) 2004-06-01 2009-07-21 The University Of North Carolina At Chapel Hill Reconstituted histone methyltransferase complex and methods of identifying modulators thereof
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
DE602006019423D1 (de) 2005-06-02 2011-02-17 Univ North Carolina Reinigung, charakterisierung und wiederherstellung einer ubiquitin-e3-ligase
FR2889526B1 (fr) 2005-08-04 2012-02-17 Aventis Pharma Sa 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation
BRPI0618417A2 (pt) 2005-10-19 2012-07-31 Gruenenthal Chemie novos ligandos de receptores de vanilàide e seu uso para produzir medicamentos
AU2006306541B2 (en) 2005-10-21 2011-07-14 Merck Sharp & Dohme Corp. Potassium channel inhibitors
ATE547514T1 (de) 2005-10-28 2012-03-15 Univ North Carolina Protein-demethylasen mit einer jmjc-domäne
EP1966141A1 (fr) 2005-12-14 2008-09-10 Brystol-Myers Squibb Company Heterocycles a six elements utiles en tant qu inhibiteurs de serine protease
US8524467B2 (en) 2006-01-20 2013-09-03 The University Of North Carolina At Chapel Hill Diagnostic and therapeutic targets for leukemia
EP2018166A2 (fr) 2006-05-15 2009-01-28 Irm Llc Composés et compositions de téréphtalamate, et leur utilisation en tant qu'inhibiteurs de l'intégrase du vih
EP2040711A2 (fr) 2006-05-18 2009-04-01 Amphora Discovery Corporation Dérivés de 2-oxo-1,2-dihydroquinoline, compositions pharmaceutiques contenant ces composes, et leurs utilisation en tant qu'agents antiprolifératifs
US8022246B2 (en) 2006-10-10 2011-09-20 The Burnham Institute For Medical Research Neuroprotective compositions and methods
EP2114898A2 (fr) 2007-02-16 2009-11-11 Amgen Inc. Cétones d'hétérocyclyle contenant de l'azote et procédés d'utilisation
WO2008104077A1 (fr) 2007-02-28 2008-09-04 Methylgene Inc. Inhibiteurs à petite molécule de protéines arginine méthyltransférases (prmt)
WO2008113006A1 (fr) 2007-03-14 2008-09-18 Xenon Pharmaceuticals Inc. Procédés d'utilisation de composés à base de quinolinone dans le traitement des maladies ou des affections associées aux canaux sodiques
DE102007017884A1 (de) 2007-04-13 2008-10-16 Grünethal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
US20090012031A1 (en) 2007-07-03 2009-01-08 The Regents Of The University Of Michigan EZH2 Cancer Markers
WO2009058298A1 (fr) 2007-10-31 2009-05-07 Merck & Co., Inc. Antagonistes du récepteur p2x3 utilisés dans le traitement de la douleur
NZ586418A (en) 2007-12-19 2012-09-28 Cancer Rec Tech Ltd Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
WO2009124137A2 (fr) 2008-04-01 2009-10-08 Mount Sinai School Of Medicine Of New York University Procédé de suppression d’une transcription de gène par méthylation d’histone lysine
US20100113415A1 (en) 2008-05-29 2010-05-06 Rajapakse Hemaka A Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer
WO2010017355A2 (fr) 2008-08-08 2010-02-11 New York Blood Center Inhibiteurs à petite molécule d’assemblage et de maturation rétroviraux
FR2934995B1 (fr) 2008-08-14 2010-08-27 Sanofi Aventis Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique
WO2010111653A2 (fr) 2009-03-27 2010-09-30 The Uab Research Foundation Modulation de la traduction à médiation par les séquences ires
WO2011011366A2 (fr) 2009-07-20 2011-01-27 Constellation Pharmaceuticals Agents pour stimuler l'activité d'enzymes de modification par méthyle et procédés d'utilisation de ceux-ci
US8329149B2 (en) 2009-12-30 2012-12-11 Avon Products, Inc. Topical lightening composition and uses thereof
WO2011140325A1 (fr) 2010-05-07 2011-11-10 Glaxosmithkline Llc Indazoles
JP5889875B2 (ja) 2010-05-07 2016-03-22 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ アザインダゾール
MX2012012966A (es) 2010-05-07 2013-01-22 Glaxosmithkline Llc Indoles.
US9175331B2 (en) * 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
RU2765155C2 (ru) 2010-09-10 2022-01-26 Эпизайм, Инк. Ингибиторы ezh2 человека и способы их применения
WO2012068589A2 (fr) 2010-11-19 2012-05-24 Constellation Pharmaceuticals Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées
WO2012075080A1 (fr) 2010-12-01 2012-06-07 Glaxosmithkline Llc Indoles
KR20130124959A (ko) 2010-12-03 2013-11-15 에피자임, 인코포레이티드 히스톤 메틸전달효소의 7-데아자퓨린 조절제 및 그의 사용방법
EP2681216B1 (fr) 2011-02-28 2017-09-27 Epizyme, Inc. Composés hétéroaryles bicycliques substitués condensés en 6,5
TWI598336B (zh) 2011-04-13 2017-09-11 雅酶股份有限公司 經取代之苯化合物
JO3363B1 (ar) 2011-04-13 2019-03-13 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
AU2013232229B2 (en) 2012-03-12 2017-11-23 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
MX367793B (es) 2012-04-13 2019-09-06 Epizyme Inc Terapia de combinación para tratar cáncer.
IL296199B2 (en) 2012-04-13 2024-12-01 Eisai R&D Man Co Ltd Salt form of a human hi stone methyltransf erase ezh2 inhibitor
US9562041B2 (en) 2012-05-16 2017-02-07 Glaxosmithkline Llc Enhancer of zeste homolog 2 inhibitors
NZ706836A (en) 2012-10-15 2019-02-22 Epizyme Inc Methods of treating cancer
PE20150887A1 (es) 2012-10-15 2015-06-04 Epizyme Inc Compuestos de benceno sustituidos
CA2894222A1 (fr) 2012-12-21 2014-06-26 Epizyme, Inc. Composes heteroaryles bicycliques 1,4-pyridone
CA2894216A1 (fr) 2012-12-21 2014-06-26 Epizyme, Inc. Composes 1,4-pyridones
EP2970306A4 (fr) 2013-03-15 2016-08-03 Epizyme Inc Composés hétéroaryles bicycliques substitués condensés en 6,5
WO2014172044A1 (fr) 2013-03-15 2014-10-23 Epizyme, Inc. Composés de benzène substitués
EP3022195A2 (fr) 2013-07-19 2016-05-25 Epizyme, Inc. Composés hétéroaryles bicycliques substitués condensés en 6,5
WO2015010049A1 (fr) 2013-07-19 2015-01-22 Epizyme, Inc. Composés de benzène substitués
US10040782B2 (en) 2013-10-16 2018-08-07 Epizyme, Inc. Hydrochloride salt form for EZH2 inhibition

Also Published As

Publication number Publication date
AU2014337300B2 (en) 2019-01-03
PT3057962T (pt) 2023-11-07
US10710987B2 (en) 2020-07-14
NZ718201A (en) 2021-09-24
JP2019052181A (ja) 2019-04-04
PL3057962T3 (pl) 2024-01-29
IL244787A0 (en) 2016-04-21
CN105829302A (zh) 2016-08-03
ES2960953T3 (es) 2024-03-07
CL2016000866A1 (es) 2016-12-23
MX2016004703A (es) 2017-02-28
CA2925889A1 (fr) 2015-04-23
EP4324525A2 (fr) 2024-02-21
IL244787B (en) 2022-04-01
KR20160082993A (ko) 2016-07-11
US20210017163A1 (en) 2021-01-21
EP3057962B1 (fr) 2023-10-18
EA201690650A1 (ru) 2016-10-31
US20180282312A1 (en) 2018-10-04
SG10201901977XA (en) 2019-04-29
CN105829302B (zh) 2020-09-08
LT3057962T (lt) 2023-12-11
AU2019202246A1 (en) 2019-04-18
MY179802A (en) 2020-11-16
EP3057962A4 (fr) 2017-05-24
US20160237068A1 (en) 2016-08-18
HUE063984T2 (hu) 2024-02-28
CA2925889C (fr) 2020-09-29
US10040782B2 (en) 2018-08-07
AU2014337300A1 (en) 2016-04-14
JP6608812B2 (ja) 2019-11-20
WO2015057859A1 (fr) 2015-04-23
DK3057962T3 (da) 2023-11-06
KR102142177B1 (ko) 2020-08-07
SG11201602269QA (en) 2016-04-28
EP4324525A3 (fr) 2024-07-17
EA038869B1 (ru) 2021-10-29
PE20161273A1 (es) 2016-12-18
EP3057962A1 (fr) 2016-08-24
JP2016533349A (ja) 2016-10-27
SI3057962T1 (sl) 2024-01-31
FI3057962T3 (fi) 2023-11-03

Similar Documents

Publication Publication Date Title
MA38949A1 (fr) Forme saline d'hydrochlorure pour inhibition d'ezh2
MA49055B1 (fr) Dérivés d'imidazoles pentacycliques fusionnés en tant que modulateurs de l'activité de tnf
MA39753B1 (fr) Inhibiteurs de diacylglycérol acyltransférase pour le traitement de troubles métaboliques ou analogues
MA38380A1 (fr) Inhibiteurs quinazoline de l'activation des formes mutantes du récepteur de croissance épidermique (egfr)
MA45985A (fr) Inhibiteurs de diacylglycérol acyltransférase 2
MA40290A1 (fr) Agents immunorégulateurs
MX2014002459A (es) Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodos de uso de los mismos.
GEP20237541B (en) Methods for treating and/or preventing graft-versus-host disease and/or diffuse alveolar hemorrhage and/or veno-occlusive disease associated with hematopoietic stem cell transplant
EA200901166A1 (ru) Соединения и композиции в качестве модуляторов активности gpr 119
PH12012501480A1 (en) Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
MA42410B1 (fr) Oxystérols et leurs méthodes d'utilisation
PH12014500239A1 (en) Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
MA38810A1 (fr) Inhibiteurs de rorc2 méthodes d'utilisation associées
TW201613919A (en) Inhibitors of Bruton's tyrosine kinase
PH12017502049A1 (en) Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
MA38253A1 (fr) Compositions comprenant de la vortioxétine et du donépézil
MA37763B1 (fr) Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1
MA39447B1 (fr) Pirlindole ou ses sels pharmaceutiquement acceptables pour une utilisation en médecine
MA49839B1 (fr) Inhibiteurs bicycliques de la histone déacétylase
MA39448B1 (fr) (r)-pirlindole et ses sels pharmaceutiquement acceptables destinés à un usage médical
UA109359C2 (xx) Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном
MA38102A1 (fr) Nouveaux composés utilisés comme inhibiteurs de diacylglycérol acyltransférase
UA115079C2 (uk) Сполуки як інгібітори діацилгліцеринацилтрансферази
FR3038605B1 (fr) Diamines primaires vicinales associees a des motifs chelateurs de metaux et/ou de radicaux libres, actives contre les stress carbonyle et oxydant et leur utilisation
MA45990B1 (fr) Combinaison d'agonistes inverses du récepteur de l'histamine-3 avec des inhibiteurs de l'acétylcholinestérase