MA39189A1 - Dérivés de 1h-indazole et de 1h-indole antibactériens - Google Patents

Dérivés de 1h-indazole et de 1h-indole antibactériens

Info

Publication number
MA39189A1
MA39189A1 MA39189A MA39189A MA39189A1 MA 39189 A1 MA39189 A1 MA 39189A1 MA 39189 A MA39189 A MA 39189A MA 39189 A MA39189 A MA 39189A MA 39189 A1 MA39189 A1 MA 39189A1
Authority
MA
Morocco
Prior art keywords
antibacterials
indazole
indole
derivatives
formula
Prior art date
Application number
MA39189A
Other languages
English (en)
Inventor
Christian Hubschwerlen
Jean-Philippe Surivet
Jean-Christophe Gauvin
Azely Mirre
Etienne Ochala
Jean-Luc Specklin
Gaëlle Chapoux
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA39189A1 publication Critical patent/MA39189A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention porte sur des composés antibactériens de formule (i) dans laquelle x représente n ou ch; r
MA39189A 2013-12-19 2014-12-18 Dérivés de 1h-indazole et de 1h-indole antibactériens MA39189A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13198338 2013-12-19
PCT/EP2014/078384 WO2015091741A1 (fr) 2013-12-19 2014-12-18 Dérivés de 1h-indazole et de 1h-indole antibactériens

Publications (1)

Publication Number Publication Date
MA39189A1 true MA39189A1 (fr) 2017-06-30

Family

ID=49880464

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39189A MA39189A1 (fr) 2013-12-19 2014-12-18 Dérivés de 1h-indazole et de 1h-indole antibactériens

Country Status (22)

Country Link
US (1) US9624206B2 (fr)
EP (1) EP3083567B1 (fr)
JP (1) JP6407288B2 (fr)
KR (1) KR20160098503A (fr)
CN (1) CN105829288B (fr)
AR (1) AR100032A1 (fr)
AU (1) AU2014368619B2 (fr)
BR (1) BR112016014115A8 (fr)
CA (1) CA2933604A1 (fr)
CL (1) CL2016001524A1 (fr)
EA (1) EA030730B1 (fr)
ES (1) ES2666130T3 (fr)
IL (1) IL246201A0 (fr)
MA (1) MA39189A1 (fr)
MX (1) MX360983B (fr)
PH (1) PH12016501102A1 (fr)
PL (1) PL3083567T3 (fr)
SG (1) SG11201605014YA (fr)
TR (1) TR201807881T4 (fr)
TW (1) TW201609641A (fr)
WO (1) WO2015091741A1 (fr)
ZA (1) ZA201604968B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
AU2015261540A1 (en) 2014-05-16 2017-01-12 Idorsia Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
EP3221300B1 (fr) 2014-11-19 2019-03-20 Idorsia Pharmaceuticals Ltd Dérivés de benzothiazole antibactériens
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
US20190031676A1 (en) * 2015-08-28 2019-01-31 Idorsia Pharmaceuticals Ltd Antibacterial annulated pyrrolidin-2-one derivatives
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
KR20190009324A (ko) * 2016-05-17 2019-01-28 이도르시아 파마슈티컬스 리미티드 6-(부타-1,3-디인-1-일)벤조[d]티아졸 유도체
TW201906819A (zh) 2017-05-25 2019-02-16 日商大正製藥股份有限公司 新穎之咪唑衍生物
WO2019086452A1 (fr) * 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Composés hétéroaromatiques antibactériens
CN113666860B (zh) * 2020-05-14 2024-03-15 鲁南制药集团股份有限公司 一种7-乙基色醇的制备方法
CN119014415B (zh) * 2024-08-19 2025-09-05 浙江大学 1-甲氧基吲哚在驱避和/或杀灭害虫中的应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3000810T3 (en) 2002-03-13 2017-10-16 Array Biopharma Inc N3-ALKYLED BENZIMIDAZOLE DERIVATIVE AS MEK INHIBITOR
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
ES2400689T3 (es) 2004-10-18 2013-04-11 Amgen, Inc Compuestos de tiadiazol y métodos de uso
WO2006099972A1 (fr) 2005-03-23 2006-09-28 F. Hoffmann-La Roche Ag Derives d'acetylenyl-pyrazolo-pyrimidine comme antagonistes mglur2
TW201716375A (zh) 2007-06-12 2017-05-16 Achaogen Inc 抗菌劑
CA2760940A1 (fr) 2009-05-20 2010-11-25 Ardea Biosciences, Inc. Procedes pour moduler des taux d'acide urique
WO2011045703A2 (fr) * 2009-10-13 2011-04-21 Pfizer Inc. Dérivés d'acide hydroxamique à liaison c utiles comme agents antibactériens
US8664401B2 (en) 2009-12-16 2014-03-04 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
EA201390626A1 (ru) 2010-11-10 2013-12-30 Эйкеоджен, Инк. Производные гидроксамовой кислоты и применение указанных производных в лечении бактериальных инфекций
KR20120079015A (ko) 2011-01-03 2012-07-11 한미약품 주식회사 Ｇ 단백질-커플링된 수용체의 조절을 위한 신규한 비사이클릭 화합물
MX341977B (es) 2011-03-07 2016-09-07 Pfizer Derivados de fluoro-piridinona utiles como agentes antibacterianos.
SG193367A1 (en) 2011-04-08 2013-10-30 Pfizer Isoxazole derivatives useful as antibacterial agents
AU2012238379C1 (en) * 2011-04-08 2015-08-06 Pfizer Inc. Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
WO2013170030A1 (fr) 2012-05-09 2013-11-14 Achaogen, Inc. Agents antibactériens
WO2013170165A1 (fr) 2012-05-10 2013-11-14 Achaogen, Inc. Agents antibactériens
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
AU2015261540A1 (en) 2014-05-16 2017-01-12 Idorsia Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives

Also Published As

Publication number Publication date
ES2666130T3 (es) 2018-05-03
EA201600475A1 (ru) 2016-11-30
KR20160098503A (ko) 2016-08-18
TW201609641A (zh) 2016-03-16
EA030730B1 (ru) 2018-09-28
CN105829288A (zh) 2016-08-03
JP2017500336A (ja) 2017-01-05
CL2016001524A1 (es) 2017-01-27
CN105829288B (zh) 2019-01-15
CA2933604A1 (fr) 2015-06-25
US20170029411A1 (en) 2017-02-02
PH12016501102A1 (en) 2016-07-11
IL246201A0 (en) 2016-08-02
US9624206B2 (en) 2017-04-18
BR112016014115A2 (fr) 2017-08-08
WO2015091741A1 (fr) 2015-06-25
ZA201604968B (en) 2018-11-28
JP6407288B2 (ja) 2018-10-17
EP3083567A1 (fr) 2016-10-26
AU2014368619B2 (en) 2018-11-22
AU2014368619A1 (en) 2016-07-28
SG11201605014YA (en) 2016-07-28
AR100032A1 (es) 2016-09-07
PL3083567T3 (pl) 2018-08-31
TR201807881T4 (tr) 2018-06-21
EP3083567B1 (fr) 2018-03-07
MX2016007991A (es) 2016-10-07
MX360983B (es) 2018-11-22
BR112016014115A8 (pt) 2017-12-26

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