MA39319A1 - Inhibiteur de la protéine de transfert d'ester de cholestéryle (cetp) et compositions pharmaceutiques comprenant ledit inhibiteur pour leur utilisation dans le traitement ou la prévention de maladies cardiovasculaires - Google Patents
Inhibiteur de la protéine de transfert d'ester de cholestéryle (cetp) et compositions pharmaceutiques comprenant ledit inhibiteur pour leur utilisation dans le traitement ou la prévention de maladies cardiovasculairesInfo
- Publication number
- MA39319A1 MA39319A1 MA39319A MA39319A MA39319A1 MA 39319 A1 MA39319 A1 MA 39319A1 MA 39319 A MA39319 A MA 39319A MA 39319 A MA39319 A MA 39319A MA 39319 A1 MA39319 A1 MA 39319A1
- Authority
- MA
- Morocco
- Prior art keywords
- inhibitor
- cardiovascular disease
- treatment
- cetp
- transfer protein
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne un inhibiteur de la protéine de transfert d'ester de cholestéryle (cetp) pour son utilisation dans le traitement de sujets souffrant de maladies cardiovasculaires ou présentant un risque accru de maladies cardiovasculaires, en particulier l'hyperlipidémie ou la dyslipidémie mixte. Un autre aspect de la présente invention concerne une composition pharmaceutique pour son utilisation dans le traitement de sujets souffrant de maladies cardiovasculaires ou présentant un risque accru de maladies cardiovasculaires, la composition comprenant une quantité thérapeutiquement efficace dudit inhibiteur de cetp.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/NL2014/050068 WO2015119495A1 (fr) | 2014-02-05 | 2014-02-05 | Inhibiteur de la protéine de transfert d'ester de cholestéryle (cetp) et compositions pharmaceutiques comprenant ledit inhibiteur pour leur utilisation dans le traitement ou la prévention de maladies cardiovasculaires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA39319A1 true MA39319A1 (fr) | 2017-07-31 |
Family
ID=50116144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA39319A MA39319A1 (fr) | 2014-02-05 | 2014-02-05 | Inhibiteur de la protéine de transfert d'ester de cholestéryle (cetp) et compositions pharmaceutiques comprenant ledit inhibiteur pour leur utilisation dans le traitement ou la prévention de maladies cardiovasculaires |
Country Status (33)
| Country | Link |
|---|---|
| US (6) | US10653692B2 (fr) |
| EP (1) | EP3102212B1 (fr) |
| JP (1) | JP6263271B2 (fr) |
| KR (1) | KR101967970B1 (fr) |
| CN (10) | CN119499252A (fr) |
| AP (1) | AP2016009359A0 (fr) |
| AR (1) | AR099299A1 (fr) |
| AU (1) | AU2014381733B2 (fr) |
| BR (1) | BR112016018077A8 (fr) |
| CA (1) | CA2938718C (fr) |
| CR (1) | CR20160353A (fr) |
| CY (1) | CY1121707T1 (fr) |
| DK (1) | DK3102212T3 (fr) |
| EA (1) | EA032689B1 (fr) |
| ES (1) | ES2710104T3 (fr) |
| HR (1) | HRP20190211T1 (fr) |
| HU (1) | HUE042932T2 (fr) |
| IL (1) | IL247037A (fr) |
| LT (1) | LT3102212T (fr) |
| MA (1) | MA39319A1 (fr) |
| ME (1) | ME03295B (fr) |
| MX (1) | MX369471B (fr) |
| PH (1) | PH12016501548B1 (fr) |
| PL (1) | PL3102212T3 (fr) |
| PT (1) | PT3102212T (fr) |
| RS (1) | RS58329B1 (fr) |
| SG (1) | SG11201605956RA (fr) |
| SI (1) | SI3102212T1 (fr) |
| SM (1) | SMT201900052T1 (fr) |
| TW (1) | TWI651086B (fr) |
| UA (1) | UA120922C2 (fr) |
| WO (1) | WO2015119495A1 (fr) |
| ZA (1) | ZA201605490B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119499252A (zh) * | 2014-02-05 | 2025-02-25 | 新阿姆斯特丹制药私人有限公司 | 用于治疗或预防心血管疾病的胆固醇酯转移蛋白抑制剂和含所述抑制剂的药物组合物 |
| MX376135B (es) * | 2014-08-28 | 2025-03-04 | Newamsterdam Pharma B V | Composicion farmaceutica y combinacion terapeutica que comprende un inhibidor de la proteina de transferencia de colesteril ester e inhibidores de hmg coa reductasa |
| AU2022223224A1 (en) * | 2021-02-18 | 2023-08-24 | Newamsterdam Pharma B.V. | Combination therapy of obicetrapib and ezetimibe for use in statin intolerant patients suffering from hyperlipidemia or mixed dyslipidaemia |
| ES2988112T3 (es) * | 2021-03-05 | 2024-11-19 | Newamsterdam Pharma B V | Obicetrapib para el tratamiento de demencias |
| US12006305B2 (en) | 2022-07-05 | 2024-06-11 | Newamsterdam Pharma B.V. | Salts of obicetrapib and processes for their manufacture and intermediates thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA90269C2 (ru) * | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| US20080269284A1 (en) * | 2004-06-24 | 2008-10-30 | Eli Lilly And Company | Compounds and Methods for Treating Dyslipidemia |
| CN101098690A (zh) * | 2004-12-06 | 2008-01-02 | 瑞莱恩特医药品有限公司 | 用于血脂治疗的ω-3脂肪酸和脂血异常剂 |
| JP4531027B2 (ja) * | 2005-09-29 | 2010-08-25 | 田辺三菱製薬株式会社 | 医薬組成物 |
| EA018734B1 (ru) * | 2006-10-10 | 2013-10-30 | Релайэнт Фармасьютикалз, Инк. | СТАТИН И ОМЕГА-3 ЖИРНЫЕ КИСЛОТЫ ДЛЯ СНИЖЕНИЯ УРОВНЕЙ Apo-B |
| JO3210B1 (ar) | 2011-10-28 | 2018-03-08 | Merck Sharp & Dohme | مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة |
| CN119499252A (zh) * | 2014-02-05 | 2025-02-25 | 新阿姆斯特丹制药私人有限公司 | 用于治疗或预防心血管疾病的胆固醇酯转移蛋白抑制剂和含所述抑制剂的药物组合物 |
| MX376135B (es) * | 2014-08-28 | 2025-03-04 | Newamsterdam Pharma B V | Composicion farmaceutica y combinacion terapeutica que comprende un inhibidor de la proteina de transferencia de colesteril ester e inhibidores de hmg coa reductasa |
-
2014
- 2014-02-05 CN CN202411508460.5A patent/CN119499252A/zh active Pending
- 2014-02-05 HR HRP20190211TT patent/HRP20190211T1/hr unknown
- 2014-02-05 CN CN202610211948.4A patent/CN121910736A/zh active Pending
- 2014-02-05 JP JP2016550780A patent/JP6263271B2/ja active Active
- 2014-02-05 AP AP2016009359A patent/AP2016009359A0/en unknown
- 2014-02-05 SM SM20190052T patent/SMT201900052T1/it unknown
- 2014-02-05 WO PCT/NL2014/050068 patent/WO2015119495A1/fr not_active Ceased
- 2014-02-05 LT LTEP14705225.2T patent/LT3102212T/lt unknown
- 2014-02-05 CN CN202110492605.7A patent/CN113332288B/zh active Active
- 2014-02-05 MA MA39319A patent/MA39319A1/fr unknown
- 2014-02-05 CN CN202011468410.0A patent/CN112755031A/zh active Pending
- 2014-02-05 RS RS20190122A patent/RS58329B1/sr unknown
- 2014-02-05 ES ES14705225T patent/ES2710104T3/es active Active
- 2014-02-05 AU AU2014381733A patent/AU2014381733B2/en active Active
- 2014-02-05 PT PT14705225T patent/PT3102212T/pt unknown
- 2014-02-05 CN CN201911087834.XA patent/CN110721187A/zh active Pending
- 2014-02-05 KR KR1020167024380A patent/KR101967970B1/ko active Active
- 2014-02-05 CR CR20160353A patent/CR20160353A/es unknown
- 2014-02-05 CN CN202610426925.5A patent/CN122163609A/zh active Pending
- 2014-02-05 CN CN202610426926.XA patent/CN122163610A/zh active Pending
- 2014-02-05 ME MEP-2019-27A patent/ME03295B/fr unknown
- 2014-02-05 US US15/117,154 patent/US10653692B2/en active Active
- 2014-02-05 CN CN202110492572.6A patent/CN113332287A/zh active Pending
- 2014-02-05 SI SI201431043T patent/SI3102212T1/sl unknown
- 2014-02-05 EA EA201691572A patent/EA032689B1/ru not_active IP Right Cessation
- 2014-02-05 CA CA2938718A patent/CA2938718C/fr active Active
- 2014-02-05 SG SG11201605956RA patent/SG11201605956RA/en unknown
- 2014-02-05 PL PL14705225T patent/PL3102212T3/pl unknown
- 2014-02-05 CN CN202610211947.XA patent/CN121818650A/zh active Pending
- 2014-02-05 MX MX2016010212A patent/MX369471B/es active IP Right Grant
- 2014-02-05 HU HUE14705225A patent/HUE042932T2/hu unknown
- 2014-02-05 UA UAA201609188A patent/UA120922C2/uk unknown
- 2014-02-05 DK DK14705225.2T patent/DK3102212T3/en active
- 2014-02-05 CN CN201480074940.3A patent/CN106232121A/zh active Pending
- 2014-02-05 EP EP14705225.2A patent/EP3102212B1/fr active Active
- 2014-02-05 BR BR112016018077A patent/BR112016018077A8/pt not_active Application Discontinuation
-
2015
- 2015-02-04 TW TW104103678A patent/TWI651086B/zh active
- 2015-02-05 AR ARP150100338A patent/AR099299A1/es not_active Application Discontinuation
-
2016
- 2016-08-01 IL IL247037A patent/IL247037A/en active IP Right Grant
- 2016-08-04 PH PH12016501548A patent/PH12016501548B1/en unknown
- 2016-08-08 ZA ZA2016/05490A patent/ZA201605490B/en unknown
-
2019
- 2019-01-17 CY CY20191100064T patent/CY1121707T1/el unknown
-
2020
- 2020-04-09 US US16/844,996 patent/US11013742B2/en active Active
-
2021
- 2021-04-09 US US17/226,655 patent/US11642344B2/en active Active
-
2023
- 2023-04-03 US US18/130,178 patent/US12186315B2/en active Active
-
2024
- 2024-12-04 US US18/968,973 patent/US20250228852A1/en not_active Abandoned
-
2025
- 2025-07-01 US US19/257,226 patent/US20260007669A1/en active Pending
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