MA39688A - Composés hétéroaryle pour le traitement de maladies ophtalmiques - Google Patents

Composés hétéroaryle pour le traitement de maladies ophtalmiques

Info

Publication number
MA39688A
MA39688A MA039688A MA39688A MA39688A MA 39688 A MA39688 A MA 39688A MA 039688 A MA039688 A MA 039688A MA 39688 A MA39688 A MA 39688A MA 39688 A MA39688 A MA 39688A
Authority
MA
Morocco
Prior art keywords
rbp4
treatment
ophthalmic diseases
heteroaryl compounds
prophylaxis
Prior art date
Application number
MA039688A
Other languages
English (en)
Other versions
MA39688B1 (fr
Inventor
Yoshihiro Banno
Koichiro Fukuda
Masahiro Kamaura
Shigekazu Sasaki
Kazuaki Takami
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of MA39688A publication Critical patent/MA39688A/fr
Publication of MA39688B1 publication Critical patent/MA39688B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/46—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention porte sur un composé hétérocyclique ayant une action abaissant la rbp4 supérieure et utile comme médicament pour la prophylaxie ou le traitement d'une maladie ou d'un symptôme médié par une augmentation de rbp4 ou de rétinol fourni par rbp4. Composé représenté par la formule (i): dans laquelle chaque symbole est tel que défini dans la description, ou un sel de celui-ci a une action abaissant la rbp4 supérieure, et est utile comme médicament pour la prophylaxie ou le traitement d'une maladie ou d'un symptôme à médiation par une augmentation de rbp4 ou de rétinol fourni par rbp4.
MA39688A 2014-10-24 2015-10-22 Composés hétéroaryle pour le traitement de maladies ophtalmiques MA39688B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014217770 2014-10-24
PCT/JP2015/079782 WO2016063933A1 (fr) 2014-10-24 2015-10-22 Composé hétérocyclique

Publications (2)

Publication Number Publication Date
MA39688A true MA39688A (fr) 2017-08-30
MA39688B1 MA39688B1 (fr) 2021-02-26

Family

ID=55760964

Family Applications (2)

Application Number Title Priority Date Filing Date
MA053568A MA53568A (fr) 2014-10-24 2015-10-22 Médicaments pour le traitement de maladies ophtalmiques
MA39688A MA39688B1 (fr) 2014-10-24 2015-10-22 Composés hétéroaryle pour le traitement de maladies ophtalmiques

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA053568A MA53568A (fr) 2014-10-24 2015-10-22 Médicaments pour le traitement de maladies ophtalmiques

Country Status (38)

Country Link
US (4) US10214498B2 (fr)
EP (2) EP3848353A1 (fr)
JP (2) JP6588027B2 (fr)
KR (1) KR102490156B1 (fr)
CN (2) CN107108506B (fr)
AR (1) AR104342A1 (fr)
AU (2) AU2015336480B2 (fr)
BR (1) BR112017007138A2 (fr)
CA (1) CA2965465C (fr)
CL (1) CL2017000944A1 (fr)
CO (1) CO2017003699A2 (fr)
CR (1) CR20170160A (fr)
CY (1) CY1123842T1 (fr)
DK (1) DK3210973T3 (fr)
DO (1) DOP2017000098A (fr)
EA (1) EA033446B1 (fr)
EC (1) ECSP17026687A (fr)
ES (1) ES2848999T3 (fr)
HR (1) HRP20210320T1 (fr)
HU (1) HUE053443T2 (fr)
IL (2) IL285105B2 (fr)
LT (1) LT3210973T (fr)
MA (2) MA53568A (fr)
MX (2) MX2017004629A (fr)
MY (1) MY183209A (fr)
PE (1) PE20170669A1 (fr)
PH (1) PH12017500747A1 (fr)
PL (1) PL3210973T3 (fr)
PT (1) PT3210973T (fr)
RS (1) RS61504B1 (fr)
SG (1) SG11201702312UA (fr)
SI (1) SI3210973T1 (fr)
SM (1) SMT202100082T1 (fr)
TN (1) TN2017000097A1 (fr)
TW (2) TWI703131B (fr)
UA (1) UA121871C2 (fr)
WO (1) WO2016063933A1 (fr)
ZA (1) ZA201703344B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107108506B (zh) * 2014-10-24 2022-06-21 武田药品工业株式会社 杂环化合物
CA3057087A1 (fr) 2017-03-20 2018-09-27 The Broad Institute, Inc. Composes et procedes pour le traitement de maladies parasitaires
EP3638239A4 (fr) 2017-06-15 2021-03-10 Belite Bio, Inc Méthodes de traitement de maladies associées à rbp4 au moyen de triazolopyridines
WO2018232154A1 (fr) 2017-06-15 2018-12-20 Belite Bio, Inc Procédés de traitement de maladies métaboliques avec des pyrazoles bicycliques fusionnés
US12440486B2 (en) 2018-08-01 2025-10-14 The Trustees Of Columbia University In The City Of New York RBP4 antagonists for treatment and prevention of non-alcoholic fatty liver disease and gout
CN111690695A (zh) * 2020-05-19 2020-09-22 浙江工业大学 3-苯氨基丙羟肟酸的酶促微流控在线合成方法
CN111690698A (zh) * 2020-05-19 2020-09-22 浙江工业大学 两步串联流动合成3-（苯并[d][1,3]二氧-5-氨基）丙羟肟酸的方法
EP4340701A4 (fr) * 2021-05-21 2025-04-09 Belite Bio, LLC Marqueurs biologiques de la dégénérescence maculaire liée à l'âge
WO2022256301A1 (fr) * 2021-06-01 2022-12-08 Stargazer Pharmaceuticals, Inc. Méthodes et composés pour traiter des sujets atteints d'une maladie de stargardt
CN116286900B (zh) * 2022-10-28 2024-04-26 昆明理工大学 一种乙酸渗透酶A基因RkAcpa及其应用
CN116019791B (zh) * 2022-12-28 2025-12-16 浙江工业大学台州研究院 二苯醚类化合物在制备β-葡萄糖醛酸苷酶抑制剂中应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3625970A (en) 1968-04-17 1971-12-07 Cutter Lab 1-(disubstituted phenyl or benzyl)-1h-indazol-3-yloxyacetic acid
US5239080A (en) 1989-02-08 1993-08-24 Takeda Chemical Industries, Ltd. Oxazole compounds and their use as antidiabetic and bone-reduction inhibitory agents
EP0440183A1 (fr) * 1990-02-01 1991-08-07 Takeda Chemical Industries, Ltd. Composés à base d'oxazol, procédé pour leur préparation et leur utilisation
US6057338A (en) 1997-04-04 2000-05-02 Merck & Co., Inc. Somatostatin agonists
US6025372A (en) 1997-04-04 2000-02-15 Merck & Co., Inc. Somatostatin agonists
AU1285499A (en) 1997-10-30 1999-05-24 Merck & Co., Inc. Somatostatin agonists
AR035016A1 (es) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
WO2001025228A1 (fr) 1999-10-07 2001-04-12 Tadeka Chemical Industries, Ltd. Derives d'amines
ES2225252T3 (es) 1999-11-10 2005-03-16 Takeda Chemical Industries, Ltd. Compuestos n-heterociclicos de 5 miembros con actividad hipoglucemica e hipolipidemica.
GB0020351D0 (en) 2000-08-17 2000-10-04 Catalyst Biomedica Ltd Treatment of hyperproliferative diseases
DE10149568A1 (de) 2001-10-08 2003-04-24 Consequence Gmbh Verfahren zur Sequenzanalyse von Polypeptiden
WO2003042204A1 (fr) 2001-10-19 2003-05-22 Takeda Chemical Industries, Ltd. Derive d'amine
US20040214788A1 (en) 2003-03-11 2004-10-28 Raj Madhwa H.G. Treatment of prostate cancer
TW200505902A (en) 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
JP4767850B2 (ja) 2003-08-20 2011-09-07 エミスフィアー テクノロジーズ インコーポレイテッド グルカゴン様ペプチド（ｇｌｐ）−１化合物またはメラノコルチン４受容体（ｍｃ４）アゴニストペプチドの経口デリバリーのための化合物、方法および製剤
EP1692521A1 (fr) 2003-12-11 2006-08-23 Beth Israel Deaconess Medical Center, Inc. Utilisation de la proteine rbp 4 dans le traitement de la sensibilite/resistance insulinique, du diabete , et de l'obesite
WO2005120583A2 (fr) 2004-06-14 2005-12-22 Wisconsin Alumni Research Foundation Methode permettant de prevenir ou de traiter l'hypertrophie cardiaque
KR100862930B1 (ko) 2004-06-23 2008-10-13 시리온 테라퓨틱스, 인크. 레티닐 유도체를 사용하여 안 증상을 치료하기 위한 방법및 조성물
US20080033053A1 (en) 2004-07-22 2008-02-07 Wolfgang Curt D Cross-Reference To Related Applications
US7947267B2 (en) 2004-10-08 2011-05-24 Potentia Pharmaceuticals, Inc. Viral complement control proteins for eye disorders
MX2008016167A (es) 2006-06-22 2009-02-10 Sirion Therapeutics Inc Metodos y composiciones para el tratamiento de condiciones oftalmicas via modulacion de actividad de megalina.
US20090005381A1 (en) 2007-06-26 2009-01-01 Philip Manton Brown Methods of treating serotonin-mediated diseases and disorders
AU2008268409B2 (en) 2007-06-26 2013-12-05 Lexicon Pharmaceuticals, Inc. Compositions comprising tryptophan hydroxylase inhibitors
US7973079B2 (en) 2007-09-27 2011-07-05 Revision Therapeutics, Inc. Methods and compounds for treating retinol-related diseases
WO2009042444A2 (fr) 2007-09-27 2009-04-02 Sirion Therapeutics, Inc. Procédés et composés pour le traitement de maladies liées au rétinol
EP2202223B1 (fr) * 2007-10-18 2017-01-25 Takeda Pharmaceutical Company Limited Composé hétérocyclique en tant qu'agent diminuant les rpb4 sanguines
US8541388B2 (en) 2008-05-22 2013-09-24 Isis Pharmaceuticals, Inc. Methods for modulating expression of RBP4
BRPI0913291A2 (pt) * 2008-05-30 2019-01-15 Takeda Pharmaceuticals Co composto, pró-droga, medicamento, métodos para diminuir a proteína 4 ou tratamento de diabete em um mamífero, e, uso do composto
CA2758587A1 (fr) * 2009-04-13 2010-10-21 Irm Llc Compositions et procedes pour moduler la liaison du retinol a la proteine 4 de liaison au retinol (rbp4)
EP2419413B1 (fr) * 2009-04-16 2016-11-23 Takeda Pharmaceutical Company Limited Derives de n-acyl-n'-phenylpiperazine utiles, entres autres, pour la prevention ou le traitement du diabete
WO2011059776A2 (fr) 2009-10-28 2011-05-19 Revision Therapeutics, Inc Prophylaxie du cancer de la peau avec des rétinamides
AU2010327936B2 (en) 2009-12-11 2015-08-20 Nono Inc. Agents and methods for treating ischemic and other diseases
JP6155187B2 (ja) 2010-03-30 2017-06-28 ヴァーセオン コーポレイション トロンビンの阻害剤としての多置換芳香族化合物
EP2642998B1 (fr) 2010-11-24 2020-09-16 The Trustees of Columbia University in the City of New York Antagoniste rbp4 non rétinoïde pour le traitement de la dégénérescence maculaire liée à l'âge et de la maladie de stargardt
RS58718B1 (sr) 2011-05-12 2019-06-28 Proteostasis Therapeutics Inc Regulatori proteostaze
GB201205679D0 (en) 2012-03-30 2012-05-16 Dyson Technology Ltd A hand held appliance
WO2013166041A1 (fr) 2012-05-01 2013-11-07 The Trustees Of Columbia University In The City Of New York Ligands de la transthyrétine pouvant inhiber l'interaction de rbp4-ttr dépendante du rétinol pour le traitement de la dégénérescence maculaire liée à l'âge, de la maladie de stargardt et d'autres maladies de la rétine caractérisées par une accumulation excessive de lipofuscine
WO2014134127A1 (fr) 2013-02-26 2014-09-04 Northeastern University Nitro-esters cannabinergiques et analogues associés
WO2014160409A1 (fr) 2013-03-14 2014-10-02 The Trustees Of Columbia University In The City Of New York Antagonistes de rbp4 pour le traitement de la dégénérescence maculaire liée à l'âge et de la maladie de stargardt
WO2014153643A1 (fr) 2013-03-26 2014-10-02 The University Of British Columbia Compositions et procédés d'utilisation associés dans le traitement de l'aniridie
JP2017508798A (ja) 2014-03-07 2017-03-30 ザ ジョンズ ホプキンス ユニバーシティ ヒストンリジン特異的デメチラーゼ（ｌｓｄ１）およびヒストンデアセチラーゼ（ｈｄａｃ）の阻害剤
PE20171239A1 (es) 2014-10-24 2017-08-24 Bristol Myers Squibb Co Derivados de carbazol
AR102426A1 (es) 2014-10-24 2017-03-01 Bristol Myers Squibb Co Compuestos de indolcarboxamida como inhibidores de btk
CN107108506B (zh) 2014-10-24 2022-06-21 武田药品工业株式会社 杂环化合物
US11040976B2 (en) 2015-04-24 2021-06-22 President And Fellows Of Harvard College Substrate selective inhibitors of insulin-degrading enzyme (IDE) and uses thereof
US10189797B2 (en) 2015-12-30 2019-01-29 Duke University Chemical modulators of immune checkpoints and therapeutic use

Also Published As

Publication number Publication date
IL285105B (en) 2022-11-01
IL251695A0 (en) 2017-06-29
US10975043B2 (en) 2021-04-13
DK3210973T3 (da) 2021-02-08
MX2017004629A (es) 2017-06-30
IL251695B (en) 2021-08-31
PH12017500747B1 (en) 2017-10-30
IL285105B2 (en) 2023-03-01
TN2017000097A1 (en) 2018-07-04
CN107108506A (zh) 2017-08-29
UA121871C2 (uk) 2020-08-10
SI3210973T1 (sl) 2021-04-30
US20190119225A1 (en) 2019-04-25
JP2020007347A (ja) 2020-01-16
US10214498B2 (en) 2019-02-26
RS61504B1 (sr) 2021-03-31
MY183209A (en) 2021-02-18
EP3210973A4 (fr) 2018-04-25
US10544111B2 (en) 2020-01-28
PT3210973T (pt) 2021-02-12
CA2965465A1 (fr) 2016-04-28
PE20170669A1 (es) 2017-06-06
SMT202100082T1 (it) 2021-03-15
CR20170160A (es) 2017-06-15
AU2020204426B2 (en) 2022-02-03
CA2965465C (fr) 2023-08-01
HRP20210320T1 (hr) 2021-04-30
AU2015336480B2 (en) 2020-04-02
TWI749661B (zh) 2021-12-11
EP3210973B1 (fr) 2020-12-02
PH12017500747A1 (en) 2017-10-30
TW202042805A (zh) 2020-12-01
KR102490156B1 (ko) 2023-01-18
TWI703131B (zh) 2020-09-01
SG11201702312UA (en) 2017-05-30
PL3210973T3 (pl) 2021-06-28
JP6588027B2 (ja) 2019-10-09
AU2015336480A2 (en) 2017-06-01
AR104342A1 (es) 2017-07-12
CL2017000944A1 (es) 2018-01-12
WO2016063933A1 (fr) 2016-04-28
EA033446B1 (ru) 2019-10-31
JPWO2016063933A1 (ja) 2017-08-03
IL285105A (en) 2021-08-31
ECSP17026687A (es) 2017-09-29
KR20170067791A (ko) 2017-06-16
ES2848999T3 (es) 2021-08-13
MA53568A (fr) 2022-02-23
EP3210973A1 (fr) 2017-08-30
TW201714876A (zh) 2017-05-01
CY1123842T1 (el) 2022-05-27
JP6995094B2 (ja) 2022-02-21
EP3848353A1 (fr) 2021-07-14
HUE053443T2 (hu) 2021-06-28
US20210340114A1 (en) 2021-11-04
US20200157062A1 (en) 2020-05-21
CN115197160A (zh) 2022-10-18
BR112017007138A2 (pt) 2017-12-26
EA201790912A1 (ru) 2017-09-29
CN107108506B (zh) 2022-06-21
MX2021001188A (es) 2021-04-19
US20180237404A1 (en) 2018-08-23
MA39688B1 (fr) 2021-02-26
ZA201703344B (en) 2018-08-29
LT3210973T (lt) 2021-03-25
AU2015336480A1 (en) 2017-05-25
CO2017003699A2 (es) 2017-07-28
AU2020204426A1 (en) 2020-07-23
DOP2017000098A (es) 2017-07-15

Similar Documents

Publication Publication Date Title
MA39688B1 (fr) Composés hétéroaryle pour le traitement de maladies ophtalmiques
MA39246A1 (fr) Composé hétérocyclique fusionné
MA46337B1 (fr) Composé de pyridine
MA39247A1 (fr) 2-(4-guanidinophenyl)-2-oxo-ethyle substitues inhibiteurs d'enteropeptidase utiles pour le traitement ou la prevention, par ex. L'obesite, le diabete sucre, les troubles de l'alimentation, l'hyperlipidemie, l'hypertension, l'insuffisance cardiaque
MA52948B1 (fr) Composés
EA201692418A1 (ru) Замещенные индазольные соединения в качестве irak4 ингибиторов
MA47368B1 (fr) N-[4-fluoro-5-[[(2s,4s)-2-méthyl-4-[(5-méthyl-1,2,4-oxadiazol-3-yl)méthoxy]-1-pipéridyl]méthyl]thiazol-2-yl]acétamide utilisés en tant qu'inhibiteur d'oga
EA201892207A1 (ru) Индолкарбоксамидные соединения
EA201790271A1 (ru) Ингибиторы гликозидазы
MA38390B1 (fr) Composés tétrahydropyrrolothiazines
EA201691401A1 (ru) Индазольные соединения в качестве ингибиторов irak4
MA56553B1 (fr) Tétrahydropyranyl-amino-pyrrolopyrimidinone pour une utilisation dans un procédé de traitement d'un trouble médié par btk
EA201890594A1 (ru) Арильные, гетероарильные и гетероциклические соединения для лечения заболеваний
EA201991697A1 (ru) Сульфоксиминовые ингибиторы гликозидазы
EA201791070A1 (ru) Способы получения ингибиторов ask1
MA40060A (fr) Composés hétérocycliques et leur utilisation en tant qu'inhibiteurs gamma-t du récepteur orphelin apparenté aux récepteurs des rétinoïdes (ror) )
MX2019010085A (es) Inhibidores de la glicosidasa de sulfoximina.
MA38078A1 (fr) Dérivé de pyridine
MA40302B1 (fr) Dérivés de carbazole
EA201692433A1 (ru) Соединения ppar для применения при лечении фиброзных заболеваний
EA201992306A1 (ru) Ингибиторы ip6k
MA40895B1 (fr) Synthèse de copanlisib et son sel de dichlorhydrate
EA201790870A1 (ru) Трициклические атропоизомерные соединения
EA201990209A1 (ru) Способы лечения и предупреждения белой пятнистости маисовых культур
MA39305A3 (fr) Dérivés d'éthynyle