MA52948B1 - Composés - Google Patents

Composés

Info

Publication number
MA52948B1
MA52948B1 MA52948A MA52948A MA52948B1 MA 52948 B1 MA52948 B1 MA 52948B1 MA 52948 A MA52948 A MA 52948A MA 52948 A MA52948 A MA 52948A MA 52948 B1 MA52948 B1 MA 52948B1
Authority
MA
Morocco
Prior art keywords
compounds
compound
formula
relates
pharmaceutical salt
Prior art date
Application number
MA52948A
Other languages
English (en)
Other versions
MA52948A (fr
Inventor
Paul STUPPLE
Helen Lagiakos
Benjamin Morrow
Richard Foitzik
Catherine Hemley
Michelle Camerino
Ylva Bozikis
Scott Walker
Original Assignee
Ctxt Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ctxt Pty Ltd filed Critical Ctxt Pty Ltd
Publication of MA52948A publication Critical patent/MA52948A/fr
Publication of MA52948B1 publication Critical patent/MA52948B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un composé de formule (i), ou un sel pharmaceutique de celui-ci.
MA52948A 2018-06-20 2019-06-20 Composés MA52948B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1810092.5A GB201810092D0 (en) 2018-06-20 2018-06-20 Compounds
PCT/EP2019/066337 WO2019243491A1 (fr) 2018-06-20 2019-06-20 Composés

Publications (2)

Publication Number Publication Date
MA52948A MA52948A (fr) 2021-04-28
MA52948B1 true MA52948B1 (fr) 2024-02-29

Family

ID=63042663

Family Applications (1)

Application Number Title Priority Date Filing Date
MA52948A MA52948B1 (fr) 2018-06-20 2019-06-20 Composés

Country Status (41)

Country Link
US (3) US20200039945A1 (fr)
EP (2) EP4335439A3 (fr)
JP (2) JP2021529738A (fr)
KR (1) KR102868724B1 (fr)
CN (1) CN112334466B (fr)
AR (1) AR114972A1 (fr)
AU (2) AU2019289888A1 (fr)
BR (1) BR112020025869A2 (fr)
CA (1) CA3101238A1 (fr)
CL (1) CL2020003219A1 (fr)
CO (1) CO2020014586A2 (fr)
CR (1) CR20210032A (fr)
CU (1) CU20200096A7 (fr)
DK (1) DK3810602T3 (fr)
DO (1) DOP2020000249A (fr)
EA (1) EA202092451A1 (fr)
EC (1) ECSP20075270A (fr)
ES (1) ES2967983T3 (fr)
FI (1) FI3810602T3 (fr)
GB (1) GB201810092D0 (fr)
GE (2) GEP20227403B (fr)
HR (1) HRP20231467T1 (fr)
HU (1) HUE064744T2 (fr)
IL (1) IL279554B2 (fr)
LT (1) LT3810602T (fr)
MA (1) MA52948B1 (fr)
MD (1) MD3810602T2 (fr)
MX (1) MX2020012723A (fr)
MY (1) MY208377A (fr)
NI (1) NI202000092A (fr)
PE (1) PE20210181A1 (fr)
PH (1) PH12020500673A1 (fr)
PL (1) PL3810602T3 (fr)
PT (1) PT3810602T (fr)
PY (1) PY1948644A (fr)
RS (1) RS64932B1 (fr)
SG (1) SG11202010450VA (fr)
SI (1) SI3810602T1 (fr)
TW (1) TWI826471B (fr)
UY (1) UY38270A (fr)
WO (1) WO2019243491A1 (fr)

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EP3471271A1 (fr) 2017-10-16 2019-04-17 Acoustical Beauty Convolutions améliorées de signaux numériques utilisant une optimisation des exigences de bits d'un signal numérique cible
GB201810092D0 (en) 2018-06-20 2018-08-08 Ctxt Pty Ltd Compounds
PH12021553107A1 (en) * 2019-06-18 2022-08-01 Ctxt Pty Ltd Benzisoxazole sulfonamide derivatives
AU2020295006B2 (en) * 2019-06-19 2023-11-09 Ctxt Pty Ltd Cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives
JP7684945B2 (ja) * 2019-07-12 2025-05-28 キャノピー グロウス コーポレイション カンナビノイド誘導体
PT4181920T (pt) 2020-07-15 2025-11-04 Ctxt Pty Ltd Inibidor de kat6 e combinações para o tratamento do cancro da mama
US20240254139A1 (en) * 2021-05-21 2024-08-01 Aurigene Oncology Limited Fused isoxazolyl compounds as kat6a inhibitors
CN118382622A (zh) * 2021-07-05 2024-07-23 杭州英创医药科技有限公司 作为kat6抑制剂的化合物
JP2024529068A (ja) * 2021-08-10 2024-08-01 江蘇恒瑞医薬股▲ふん▼有限公司 スルファミド誘導体、その調製方法及びその医薬的使用
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WO2024201334A1 (fr) 2023-03-30 2024-10-03 Pfizer Inc. Kat6a en tant que biomarqueur prédictif pour un traitement avec un inhibiteur de kat6a et méthodes de traitement associées
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EP4702019A1 (fr) * 2023-04-25 2026-03-04 Insilico Medicine IP Limited Inhibiteur de lysine acétyltransférase 6a (kat6a) cristallin et ses utilisations
WO2025007873A1 (fr) * 2023-07-04 2025-01-09 上海齐鲁制药研究中心有限公司 Inhibiteur de kat6
AU2024325442A1 (en) * 2023-08-14 2026-03-26 Shanghai Henlius Biologics Co., Ltd. Sulfonamide compound, and preparation method therefor and use thereof
WO2025098417A1 (fr) * 2023-11-08 2025-05-15 再和医药科技（苏州）有限公司 Composé sulfonamide et son utilisation

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