MA39837B1 - Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1 - Google Patents

Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1

Info

Publication number
MA39837B1
MA39837B1 MA39837A MA39837A MA39837B1 MA 39837 B1 MA39837 B1 MA 39837B1 MA 39837 A MA39837 A MA 39837A MA 39837 A MA39837 A MA 39837A MA 39837 B1 MA39837 B1 MA 39837B1
Authority
MA
Morocco
Prior art keywords
thf
amines
pde1 inhibitors
quinazolin
halogenated
Prior art date
Application number
MA39837A
Other languages
English (en)
Inventor
Lars Kyhn Rasmussen
Morten Langgård
Jan Kehler
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MA39837B1 publication Critical patent/MA39837B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention concerne des quinazoline-thf-amines halogénées utilisées en tant qu'inhibiteurs de la pde1 ainsi que leur utilisation en tant que médicament, en particulier pour le traitement de troubles neurodégénératifs et de troubles psychiatriques.
MA39837A 2014-04-04 2015-03-27 Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1 MA39837B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201400194 2014-04-04
PCT/EP2015/056713 WO2015150254A1 (fr) 2014-04-04 2015-03-27 Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1

Publications (1)

Publication Number Publication Date
MA39837B1 true MA39837B1 (fr) 2020-05-29

Family

ID=52779655

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39837A MA39837B1 (fr) 2014-04-04 2015-03-27 Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1

Country Status (39)

Country Link
US (2) US10005764B2 (fr)
EP (1) EP3126354B1 (fr)
JP (1) JP6554116B2 (fr)
KR (1) KR20160138084A (fr)
CN (2) CN106132953B (fr)
AP (1) AP2016009521A0 (fr)
AR (1) AR101155A1 (fr)
AU (1) AU2015239696B2 (fr)
CA (1) CA2943011A1 (fr)
CL (1) CL2016002515A1 (fr)
CR (1) CR20160463A (fr)
CY (1) CY1122784T1 (fr)
DK (1) DK3126354T3 (fr)
DO (1) DOP2016000263A (fr)
EA (1) EA032579B1 (fr)
EC (1) ECSP16082599A (fr)
ES (1) ES2776359T3 (fr)
GE (2) GEP20186920B (fr)
GT (1) GT201600213A (fr)
HR (1) HRP20200369T1 (fr)
IL (1) IL248078B (fr)
JO (1) JO3628B1 (fr)
LT (1) LT3126354T (fr)
MA (1) MA39837B1 (fr)
MX (1) MX364519B (fr)
PE (1) PE20161380A1 (fr)
PH (1) PH12016501938A1 (fr)
PL (1) PL3126354T3 (fr)
PT (1) PT3126354T (fr)
RS (1) RS60017B1 (fr)
RU (1) RU2692808C2 (fr)
SG (1) SG11201608190YA (fr)
SI (1) SI3126354T1 (fr)
SM (1) SMT202000132T1 (fr)
SV (1) SV2016005297A (fr)
TW (1) TWI664178B (fr)
UA (1) UA119166C2 (fr)
WO (1) WO2015150254A1 (fr)
ZA (1) ZA201606566B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160138084A (ko) 2014-04-04 2016-12-02 하. 룬드벡 아크티에셀스카브 Pde1 저해제인 할로겐화된 퀴나졸린-thf-아민
KR102590848B1 (ko) 2016-12-28 2023-10-19 다트 뉴로사이언스, 엘엘씨 Pde2 억제제로서 치환된 피라졸로피리미디논 화합물
DK3717488T3 (da) * 2017-11-27 2021-12-13 Dart Neuroscience Llc Substituerede furanopyrimidinforbindelser som pde1-inhibitorer
MX2020012628A (es) 2018-05-25 2021-01-29 Intra Cellular Therapies Inc Compuestos organicos.
WO2020210614A1 (fr) 2019-04-12 2020-10-15 Intra-Cellular Therapies, Inc. Composés organiques
CN117105809B (zh) * 2023-10-20 2024-05-03 中国农业大学 一种苯甲酰苯胺化合物及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10042058A1 (de) * 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
GB0229281D0 (en) * 2002-12-16 2003-01-22 Novartis Ag Organic compounds
ZA200507979B (en) * 2003-03-03 2007-03-28 Vertex Pharma Inc Quinazolines useful as modulators of ion channels
GB0327319D0 (en) * 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
US20060019975A1 (en) * 2004-07-23 2006-01-26 Pfizer Inc Novel piperidyl derivatives of quinazoline and isoquinoline
US20060183763A1 (en) * 2004-12-31 2006-08-17 Pfizer Inc Novel pyrrolidyl derivatives of heteroaromatic compounds
WO2007096743A1 (fr) * 2006-02-23 2007-08-30 Pfizer Products Inc. Quinazolines substituées en tant qu'inhibiteurs de pde10
US20070265258A1 (en) * 2006-03-06 2007-11-15 Ruiping Liu Quinazoline derivatives as phosphodiesterase 10 inhibitors
WO2011036074A1 (fr) * 2009-09-24 2011-03-31 Basf Se Composés d'aminoquinazoline destinés à lutter contre des invertébrés nuisibles
US20130116241A1 (en) * 2011-11-09 2013-05-09 Abbvie Inc. Novel inhibitor compounds of phosphodiesterase type 10a
TW201609713A (zh) * 2013-12-19 2016-03-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之喹唑啉－ｔｈｆ－胺
TW201611834A (en) * 2014-02-07 2016-04-01 Lundbeck & Co As H Hexahydrofuropyrroles as PDE1 inhibitors
TW201625605A (zh) 2014-04-04 2016-07-16 賽諾菲公司 用於治療糖尿病、肥胖、血脂異常及相關病症之作為ｇｐｒ１１９調節劑的經取代之稠合雜環類
AR099937A1 (es) 2014-04-04 2016-08-31 Sanofi Sa Compuestos de isoindolinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados
DK3126330T3 (en) 2014-04-04 2019-04-23 Pfizer BICYCLE-FUSED HETEROARYL OR ARYL COMPOUNDS AND USE THEREOF AS IRAC4 INHIBITORS
CN106132958A (zh) 2014-04-04 2016-11-16 豪夫迈·罗氏有限公司 作为cb2激动剂的吡啶‑2‑酰胺类化合物
MX2016012690A (es) 2014-04-04 2017-04-27 Hoffmann La Roche Piridin-2-carboxamidas 5,6-disustituidas como agonistas del receptor cannabinoide.
KR20160138084A (ko) 2014-04-04 2016-12-02 하. 룬드벡 아크티에셀스카브 Pde1 저해제인 할로겐화된 퀴나졸린-thf-아민

Also Published As

Publication number Publication date
CN106132953A (zh) 2016-11-16
DOP2016000263A (es) 2016-11-30
AR101155A1 (es) 2016-11-30
RU2016138743A (ru) 2018-05-07
RU2692808C2 (ru) 2019-06-27
LT3126354T (lt) 2020-03-25
PH12016501938A1 (en) 2017-02-06
HRP20200369T1 (hr) 2020-08-07
IL248078B (en) 2018-11-29
AP2016009521A0 (en) 2016-10-31
EA201691773A1 (ru) 2017-01-30
US20190144434A1 (en) 2019-05-16
DK3126354T3 (da) 2020-03-09
JP6554116B2 (ja) 2019-07-31
ES2776359T3 (es) 2020-07-30
US10526319B2 (en) 2020-01-07
EA032579B1 (ru) 2019-06-28
PE20161380A1 (es) 2017-01-15
EP3126354B1 (fr) 2020-01-22
CR20160463A (es) 2017-03-06
MX2016012955A (es) 2016-12-07
US20170022186A1 (en) 2017-01-26
KR20160138084A (ko) 2016-12-02
PT3126354T (pt) 2020-03-17
ZA201606566B (en) 2017-11-29
SV2016005297A (es) 2016-11-30
SI3126354T1 (sl) 2020-04-30
GEP20186920B (en) 2018-11-12
GEAP201814286A (en) 2018-06-11
AU2015239696A1 (en) 2016-10-06
ECSP16082599A (es) 2017-02-24
US10005764B2 (en) 2018-06-26
GT201600213A (es) 2019-07-29
WO2015150254A1 (fr) 2015-10-08
UA119166C2 (uk) 2019-05-10
CN106132953B (zh) 2019-03-22
CL2016002515A1 (es) 2016-12-16
EP3126354A1 (fr) 2017-02-08
JP2017509680A (ja) 2017-04-06
AU2015239696B2 (en) 2019-10-24
PL3126354T3 (pl) 2020-06-15
JO3628B1 (ar) 2020-08-27
TW201620901A (zh) 2016-06-16
RS60017B1 (sr) 2020-04-30
CN109999039A (zh) 2019-07-12
SMT202000132T1 (it) 2020-05-08
SG11201608190YA (en) 2016-10-28
TWI664178B (zh) 2019-07-01
CY1122784T1 (el) 2021-05-05
MX364519B (es) 2019-04-30
RU2016138743A3 (fr) 2019-01-15
CA2943011A1 (fr) 2015-10-08

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