MA40709B1 - Dérivé du glucagon à stabilité améliorée - Google Patents
Dérivé du glucagon à stabilité amélioréeInfo
- Publication number
- MA40709B1 MA40709B1 MA40709A MA40709A MA40709B1 MA 40709 B1 MA40709 B1 MA 40709B1 MA 40709 A MA40709 A MA 40709A MA 40709 A MA40709 A MA 40709A MA 40709 B1 MA40709 B1 MA 40709B1
- Authority
- MA
- Morocco
- Prior art keywords
- glucagon
- glucagon derivative
- improved stability
- present
- peptide
- Prior art date
Links
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000051325 Glucagon Human genes 0.000 abstract 1
- 108060003199 Glucagon Proteins 0.000 abstract 1
- 108010063919 Glucagon Receptors Proteins 0.000 abstract 1
- 102100040890 Glucagon receptor Human genes 0.000 abstract 1
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229960004666 glucagon Drugs 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne un nouveau peptide dérivé du glucagon, ainsi qu'une composition destinée à la prévention ou au traitement de l'hypoglycémie et de l'obésité, comprenant le peptide en tant que principe actif. Le dérivé de glucagon de la présente invention présente une activité maintenue dans le temps contre les récepteurs du glucagon et présente des propriétés physiques améliorées en raison d'une modification de son point isoélectrique, et est ainsi capable d'améliorer l'utilisation conforme
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20140193800 | 2014-12-30 | ||
| PCT/KR2015/014422 WO2016108586A1 (fr) | 2014-12-30 | 2015-12-30 | Dérivé du glucagon à stabilité améliorée |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA40709A1 MA40709A1 (fr) | 2017-12-29 |
| MA40709B1 true MA40709B1 (fr) | 2019-07-31 |
Family
ID=56284642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA40709A MA40709B1 (fr) | 2014-12-30 | 2015-12-30 | Dérivé du glucagon à stabilité améliorée |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US11135271B2 (fr) |
| EP (2) | EP3241841A4 (fr) |
| JP (2) | JP6797122B2 (fr) |
| KR (1) | KR102291020B1 (fr) |
| CN (1) | CN107636009B (fr) |
| AR (1) | AR103322A1 (fr) |
| AU (1) | AU2015372818A1 (fr) |
| CL (1) | CL2017001718A1 (fr) |
| CO (1) | CO2017006308A2 (fr) |
| CR (1) | CR20170293A (fr) |
| DO (1) | DOP2017000156A (fr) |
| EA (1) | EA035527B1 (fr) |
| EC (1) | ECSP17040923A (fr) |
| ES (1) | ES2976562T3 (fr) |
| GT (1) | GT201700150A (fr) |
| HK (1) | HK1248713A1 (fr) |
| IL (2) | IL253206B (fr) |
| MA (1) | MA40709B1 (fr) |
| MX (1) | MX2017008569A (fr) |
| MY (1) | MY185334A (fr) |
| PE (2) | PE20171154A1 (fr) |
| PH (1) | PH12017501222B1 (fr) |
| SG (1) | SG11201705376SA (fr) |
| TN (1) | TN2017000271A1 (fr) |
| TW (1) | TW201639878A (fr) |
| UA (1) | UA126960C2 (fr) |
| WO (1) | WO2016108586A1 (fr) |
| ZA (1) | ZA201705015B (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20171154A1 (es) * | 2014-12-30 | 2017-08-16 | Hanmi Pharm Ind Co Ltd | Derivados de glucagon con estabilidad mejorada |
| EP4523705A3 (fr) * | 2015-06-30 | 2025-06-11 | Hanmi Pharm. Co., Ltd. | Dérivé de glucagon et composition comprenant un conjugué à action prolongée de celui-ci |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| SG11201805586SA (en) | 2015-12-31 | 2018-07-30 | Hanmi Pharmaceutical Co Ltd | Triple glucagon/glp-1/gip receptor agonist |
| EP3479841A4 (fr) | 2016-06-29 | 2020-03-04 | Hanmi Pharm. Co., Ltd. | Dérivé du glucagon, conjugué de celui-ci, composition le comprenant et utilisation thérapeutique de celui-ci |
| CN110545849A (zh) | 2017-02-03 | 2019-12-06 | 韩美药品株式会社 | 具有增加的持续性的生理活性物质的缀合物及其应用 |
| CN111511910B (zh) * | 2017-12-22 | 2024-11-08 | 韩美药品株式会社 | 具有新颖结构的治疗酶融合蛋白及其用途 |
| US20210030847A1 (en) * | 2018-01-23 | 2021-02-04 | Xeris Pharmaceuticals, Inc. | Treatment of post-bariatric hypoglycemia using mini-dose stable glucagon |
| KR20200078414A (ko) * | 2018-12-21 | 2020-07-01 | 한미약품 주식회사 | 인슐린 및 글루카곤을 포함하는 약학 조성물 |
| CN109836486B (zh) * | 2019-01-30 | 2020-09-08 | 北京双因生物科技有限公司 | 成纤维生长因子21变体、其融合蛋白及其用途 |
| KR20210144606A (ko) | 2020-05-22 | 2021-11-30 | 한미약품 주식회사 | 글루카곤 유도체의 지속형 결합체의 액상 제제 |
| EP4183407A4 (fr) * | 2020-07-15 | 2024-08-14 | Hanmi Pharm. Co., Ltd. | Utilisation thérapeutique d'un dérivé du glucagon ou d'un conjugué de celui-ci pour une maladie hépatique |
| CN117157094A (zh) | 2021-04-09 | 2023-12-01 | 韩美药品株式会社 | 包括胰高血糖素衍生物的用于预防或治疗慢性肾病的药物组合物 |
| KR20230095666A (ko) | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 간 표적 물질 및 이의 용도 |
| CN115536739B (zh) * | 2022-07-04 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5408037A (en) | 1991-01-17 | 1995-04-18 | Zymogenetics, Inc. | Methods for detecting glucagon antagonists |
| GB9423277D0 (en) | 1994-11-18 | 1995-01-11 | Univ Nottingham | Pulsed laser deposition of coatings |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| US6677136B2 (en) | 2000-05-03 | 2004-01-13 | Amgen Inc. | Glucagon antagonists |
| ATE408414T1 (de) | 2001-07-31 | 2008-10-15 | Us Gov Health & Human Serv | Glp 1 exendin 4 peptidanaloga und deren verwendungen |
| JP2006520818A (ja) | 2003-03-19 | 2006-09-14 | イーライ リリー アンド カンパニー | ポリエチレングリコール結合ｇｌｐ−１化合物 |
| US8263084B2 (en) | 2003-11-13 | 2012-09-11 | Hanmi Science Co., Ltd | Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate |
| ES2383300T3 (es) | 2003-11-13 | 2012-06-20 | Hanmi Holdings Co., Ltd | Fragmento Fc de IgG para un vehículo de fármacos y procedimiento para su preparación |
| JP2009534423A (ja) | 2006-04-20 | 2009-09-24 | アムジェン インコーポレイテッド | Ｇｌｐ−１化合物 |
| RU2477286C2 (ru) | 2007-01-05 | 2013-03-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | АНАЛОГИ ГЛЮКАГОНА, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ РАСТВОРИМОСТЬЮ В БУФЕРАХ С ФИЗИОЛОГИЧЕСКИМ ЗНАЧЕНИЕМ pH |
| JP2008169195A (ja) | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
| US20090098130A1 (en) | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| CA2677932A1 (fr) * | 2007-02-15 | 2008-08-21 | Indiana University Research And Technology Corporation | Co-agonistes des recepteurs du glucagon/glp-1 |
| EP2158214B1 (fr) | 2007-06-15 | 2011-08-17 | Zealand Pharma A/S | Analogues du glucagon |
| KR20100049032A (ko) | 2007-06-19 | 2010-05-11 | 오츠카 가가쿠 가부시키가이샤 | 당사슬 부가 ｇｌｐ―１ 펩티드 |
| EP2190872B1 (fr) | 2007-09-05 | 2018-03-14 | Novo Nordisk A/S | Dérivés de glucagon-like peptide-1 et leur utilisation pharmaceutique |
| EP2249853A4 (fr) | 2008-01-30 | 2012-12-26 | Univ Indiana Res & Tech Corp | Promédicaments peptidiques à base d' esters |
| CN102105159B (zh) | 2008-06-17 | 2015-07-08 | 印第安纳大学研究及科技有限公司 | 基于gip的混合激动剂用于治疗代谢紊乱和肥胖症 |
| US8450270B2 (en) | 2008-06-17 | 2013-05-28 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers |
| WO2010096052A1 (fr) * | 2009-02-19 | 2010-08-26 | Merck Sharp & Dohme Corp. | Analogues d'oxyntomoduline |
| EP2443146B1 (fr) | 2009-06-16 | 2016-10-05 | Indiana University Research And Technology Corporation | Composés de glucagon actifs sur le récepteur gip |
| AU2010272944B2 (en) | 2009-07-13 | 2015-11-19 | Zealand Pharma A/S | Acylated glucagon analogues |
| GB0917072D0 (en) | 2009-09-29 | 2009-11-11 | Univ Ulster | Peptide analogues of glucagon for diabetes therapy |
| US8703701B2 (en) * | 2009-12-18 | 2014-04-22 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| US20130157953A1 (en) | 2010-01-20 | 2013-06-20 | Zealand Pharma A/S | Treatment of cardiac conditions |
| EP2552951A1 (fr) | 2010-03-26 | 2013-02-06 | Novo Nordisk A/S | Nouveaux analogues du glucagon |
| JP6050746B2 (ja) | 2010-05-13 | 2016-12-21 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | Ｇタンパク質共役受容体活性を示すグルカゴンスーパーファミリーのペプチド |
| KR101382593B1 (ko) | 2010-07-21 | 2014-04-10 | 한미사이언스 주식회사 | 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물 |
| US8507428B2 (en) | 2010-12-22 | 2013-08-13 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting GIP receptor activity |
| WO2012150503A2 (fr) | 2011-05-03 | 2012-11-08 | Zealand Pharma A/S | Composés sélectifs de la signalisation d'agoniste mixte glu-glp-1 |
| DK2710031T3 (en) | 2011-05-18 | 2018-01-02 | Mederis Diabetes Llc | IMPROVED PEPTID MEDICINALS FOR INSULIN RESISTANCE |
| UA126465C2 (uk) | 2011-06-10 | 2022-10-12 | Ханмі Сайенс Ко., Лтд. | Пептид, що має активність оксинтомодуліну, та фармацевтична композиція для лікування ожиріння, яка його містить |
| RU2607365C2 (ru) * | 2011-06-17 | 2017-01-10 | Ханми Сайенс Ко., Лтд. | Конъюгат, содержащий оксинтомодулин и фрагмент иммуноглобулина, и его применение |
| WO2013004983A1 (fr) | 2011-07-04 | 2013-01-10 | Imperial Innovations Limited | Nouveaux composés et leurs effets sur le comportement alimentaire |
| JP6324315B2 (ja) * | 2011-11-17 | 2018-05-16 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | グルココルチコイド受容体の活性を示すグルカゴンスーパーファミリーのペプチド |
| CN104583232B (zh) | 2012-06-21 | 2018-04-13 | 印第安纳大学研究及科技有限公司 | 展现gip受体活性的胰高血糖素类似物 |
| PE20150863A1 (es) | 2012-06-21 | 2015-06-11 | Univ Indiana Res & Tech Corp | Analogos de glucagon que exhiben actividad de receptor de gip |
| KR101968344B1 (ko) | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
| AR094821A1 (es) | 2012-07-25 | 2015-09-02 | Hanmi Pharm Ind Co Ltd | Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada |
| AR092873A1 (es) | 2012-09-26 | 2015-05-06 | Cadila Healthcare Ltd | Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon |
| WO2014073842A1 (fr) | 2012-11-06 | 2014-05-15 | Hanmi Pharm. Co., Ltd. | Formulation liquide d'un conjugué protéique comprenant l'oxyntomoduline et un fragment d'immunoglobuline |
| KR101993393B1 (ko) * | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
| ES2906975T3 (es) | 2012-11-20 | 2022-04-21 | Eumederis Pharmaceuticals Inc | Productos farmacéuticos de péptidos mejorados |
| MX360816B (es) | 2012-11-20 | 2018-11-15 | Mederis Diabetes Llc | Productos farmacéuticos peptídicos mejorados para la resistencia a la insulina. |
| AU2013366692B2 (en) | 2012-12-21 | 2017-11-23 | Sanofi | Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists |
| EP2986313B1 (fr) * | 2013-04-18 | 2019-06-12 | Novo Nordisk A/S | Co-agonistes stables de récepteur de glucagon/glp1 à effet prolongé |
| US20160185837A1 (en) | 2013-08-16 | 2016-06-30 | Medimmune Limited | Gip and glp-1 receptor dual-agonists for the treatment of diabetes |
| WO2015086733A1 (fr) | 2013-12-13 | 2015-06-18 | Sanofi | Agonistes mixtes des récepteurs du glp-1/glucagon |
| AR100695A1 (es) | 2014-05-30 | 2016-10-26 | Hanmi Pharm Ind Co Ltd | Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón |
| TWI802396B (zh) | 2014-09-16 | 2023-05-11 | 南韓商韓美藥品股份有限公司 | 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途 |
| CN108271356A (zh) | 2014-09-24 | 2018-07-10 | 印第安纳大学研究及科技有限公司 | 肠降血糖素-胰岛素缀合物 |
| PE20171154A1 (es) | 2014-12-30 | 2017-08-16 | Hanmi Pharm Ind Co Ltd | Derivados de glucagon con estabilidad mejorada |
| KR102418477B1 (ko) * | 2014-12-30 | 2022-07-08 | 한미약품 주식회사 | 글루카곤 유도체 |
| EP4523705A3 (fr) | 2015-06-30 | 2025-06-11 | Hanmi Pharm. Co., Ltd. | Dérivé de glucagon et composition comprenant un conjugué à action prolongée de celui-ci |
| TW201718629A (zh) * | 2015-09-25 | 2017-06-01 | 韓美藥品股份有限公司 | 包含多個生理多肽及免疫球蛋白Ｆｃ區之蛋白質接合物 |
| SG11201805586SA (en) | 2015-12-31 | 2018-07-30 | Hanmi Pharmaceutical Co Ltd | Triple glucagon/glp-1/gip receptor agonist |
-
2015
- 2015-12-30 PE PE2017001168A patent/PE20171154A1/es unknown
- 2015-12-30 EP EP15875680.9A patent/EP3241841A4/fr not_active Withdrawn
- 2015-12-30 PH PH1/2017/501222A patent/PH12017501222B1/en unknown
- 2015-12-30 EA EA201791333A patent/EA035527B1/ru not_active IP Right Cessation
- 2015-12-30 PE PE2022001996A patent/PE20230304A1/es unknown
- 2015-12-30 CN CN201580077186.3A patent/CN107636009B/zh active Active
- 2015-12-30 WO PCT/KR2015/014422 patent/WO2016108586A1/fr not_active Ceased
- 2015-12-30 AU AU2015372818A patent/AU2015372818A1/en not_active Abandoned
- 2015-12-30 TN TN2017000271A patent/TN2017000271A1/en unknown
- 2015-12-30 SG SG11201705376SA patent/SG11201705376SA/en unknown
- 2015-12-30 CR CR20170293A patent/CR20170293A/es unknown
- 2015-12-30 HK HK18104685.2A patent/HK1248713A1/en unknown
- 2015-12-30 MY MYPI2017000967A patent/MY185334A/en unknown
- 2015-12-30 US US15/540,729 patent/US11135271B2/en active Active
- 2015-12-30 KR KR1020150189532A patent/KR102291020B1/ko active Active
- 2015-12-30 JP JP2017535417A patent/JP6797122B2/ja active Active
- 2015-12-30 TW TW104144427A patent/TW201639878A/zh unknown
- 2015-12-30 EP EP19172184.4A patent/EP3575314B1/fr active Active
- 2015-12-30 AR ARP150104340A patent/AR103322A1/es active IP Right Grant
- 2015-12-30 MX MX2017008569A patent/MX2017008569A/es unknown
- 2015-12-30 UA UAA201707040A patent/UA126960C2/uk unknown
- 2015-12-30 ES ES19172184T patent/ES2976562T3/es active Active
- 2015-12-30 MA MA40709A patent/MA40709B1/fr unknown
-
2017
- 2017-06-27 CO CONC2017/0006308A patent/CO2017006308A2/es unknown
- 2017-06-27 IL IL253206A patent/IL253206B/en unknown
- 2017-06-28 GT GT201700150A patent/GT201700150A/es unknown
- 2017-06-28 EC ECIEPI201740923A patent/ECSP17040923A/es unknown
- 2017-06-28 CL CL2017001718A patent/CL2017001718A1/es unknown
- 2017-06-29 DO DO2017000156A patent/DOP2017000156A/es unknown
- 2017-07-24 ZA ZA2017/05015A patent/ZA201705015B/en unknown
-
2020
- 2020-08-28 JP JP2020144259A patent/JP7079301B2/ja active Active
-
2021
- 2021-03-09 IL IL281375A patent/IL281375B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA40709A1 (fr) | Dérivé du glucagon à stabilité améliorée | |
| JOP20200011B1 (ar) | مركبات وتركيبات لمعالجة حالات مرضية مرتبطة بنشاط nlrp | |
| EA201792047A1 (ru) | Новые соединения | |
| CY1120213T1 (el) | Antαγωνιστες φθοριωμενης ιντεγκρινης | |
| EA201591176A1 (ru) | Композиции и способы с использованием пептидной метки, связывающейся с гиалуронаном | |
| EA201591839A1 (ru) | Терапевтические пептиды | |
| EA201692177A1 (ru) | Соединения и композиции в качестве агонистов toll-подобного рецептора 7 | |
| EA201590058A1 (ru) | Аналоги глюкагона | |
| EA201791617A1 (ru) | Аналоги амилина | |
| EA201290964A1 (ru) | Пептидные конъюгаты агонистов рецептора glp-1 и их применение | |
| MA37963A1 (fr) | Protéines de fusion pour traiter un syndrome métabolique | |
| EA201690606A1 (ru) | Аналоги глюкагона | |
| MX2021008663A (es) | Anticuerpos mejorados contra il-6. | |
| EA201890570A1 (ru) | [4-(1,3,3-триметил-2-оксо-3,4-дигидро-1h-хиноксалин-7-ил)фенокси]этилокси соединение или его соль | |
| TR201815173T4 (tr) | Peptit bileşimleri. | |
| FR3061856B1 (fr) | Utilisations therapeutiques d'une poudre d'insectes | |
| BR112016028227A2 (pt) | método para redução de imunogenicidade de proteína e peptídeo | |
| EA201490790A1 (ru) | Пептидные конъюгаты агониста рецептора гастрина и глюкагон подобного пептида 1 | |
| EA202190588A1 (ru) | Гетероароматические соединения в качестве ингибиторов ванина | |
| PE20160012A1 (es) | Tratamiento de enfermedades miopaticas y neurogenerativas por agregacion de proteina mediante administracion parenteral | |
| MX372787B (es) | Un polipeptido receptor del factor de crecimiento de fibroblasto soluble 3 (fgr3) para el uso en la prevencion o tratamiento de trastornos de retraso de crecimiento esqueletico. | |
| BR112018015367A2 (pt) | carreadores oromucosais de nanofibra para tratamento terapêutico | |
| CL2018001343A1 (es) | Lactoferrina para uso en el diagnóstico o el pronóstico de la enfermedad de alzheimer o en el diagnóstico de la enfermedad de parkinson | |
| EA201690191A1 (ru) | Фармацевтическая композиция для замедленного высвобождения ланреотида | |
| EA201991490A1 (ru) | Ароматические амиды карбоновых кислот в качестве антагонистов рецепторов брадикинина в1 |