MA40775A - Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38 - Google Patents
Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38Info
- Publication number
- MA40775A MA40775A MA040775A MA40775A MA40775A MA 40775 A MA40775 A MA 40775A MA 040775 A MA040775 A MA 040775A MA 40775 A MA40775 A MA 40775A MA 40775 A MA40775 A MA 40775A
- Authority
- MA
- Morocco
- Prior art keywords
- naphtalén
- phenylureido
- pyridin
- oxy
- kinase
- Prior art date
Links
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 title 1
- 239000012826 P38 inhibitor Substances 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 229960004050 aminobenzoic acid Drugs 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
Classifications
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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| UA105763C2 (uk) | 2007-12-19 | 2014-06-25 | Кансер Рісерч Текнолоджі Лімітед | 8-ЗАМІЩЕНІ ПІРИДО[2,3-b]ПІРАЗИНИ ТА ЇХ ЗАСТОСУВАННЯ |
| NZ706154A (en) | 2010-02-01 | 2016-09-30 | Cancer Rec Tech Ltd | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy |
| JP2014528404A (ja) | 2011-10-03 | 2014-10-27 | レスピバート・リミテツド | p38MAPキナーゼ阻害剤としての1−ピラゾリル−3−(4−((2−アニリノピリミジン−4−イル)オキシ)ナフタレン−1−イル)尿素 |
| EP2578582A1 (fr) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napthtalèn-1-yl) urées comme inhibiteurs de la p38 MAP kinase |
| GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| EP2890695A2 (fr) | 2012-08-29 | 2015-07-08 | Respivert Limited | Inhibiteurs de kinase |
| EP2890460B1 (fr) | 2012-08-29 | 2017-02-22 | Respivert Limited | Inhibiteurs de kinases |
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| EP2925742B1 (fr) | 2012-11-16 | 2016-10-26 | Respivert Limited | Inhibiteurs de kinase |
| WO2014140582A1 (fr) | 2013-03-14 | 2014-09-18 | Respivert Limited | Inhibiteurs de kinases |
| MX363949B (es) * | 2013-04-02 | 2019-04-08 | Topivert Pharma Ltd | Inhibidor de quinasa. |
| US9771353B2 (en) | 2013-04-02 | 2017-09-26 | Topivert Pharma Limited | Kinase inhibitors based upon N-alkyl pyrazoles |
| GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| WO2015092423A1 (fr) | 2013-12-20 | 2015-06-25 | Respivert Limited | Dérivés d'urée utiles comme inhibiteurs de kinase |
| EP3105222B1 (fr) | 2014-02-14 | 2018-04-11 | Respivert Limited | Composés hétérocycliques aromatiques utilisés en tant que composés anti-inflammatoires |
| MA40774A (fr) * | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
| CA3015978A1 (fr) * | 2016-04-06 | 2017-10-12 | Topivert Pharma Limited | Inhibiteurs de kinase |
| JP2021501130A (ja) | 2017-10-05 | 2021-01-14 | フルクラム セラピューティクス,インコーポレイテッド | DUX4の発現を低減するためのp38阻害剤の使用 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| CA3122371A1 (fr) | 2018-12-07 | 2020-06-11 | University Of Maryland, Baltimore | Inhibiteurs de proteine kinase actives par le mitogene p38 de site non atp/catalytique |
| WO2021155100A1 (fr) * | 2020-01-29 | 2021-08-05 | Foghorn Therapeutics Inc. | Composés et leurs utilisations |
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| JP2024506041A (ja) * | 2021-02-08 | 2024-02-08 | ボシュ ヘルス アイルランド リミテッド | 潰瘍性大腸炎を予防、処置、または改善するためのアミセリモド |
| IL306101A (en) * | 2021-03-23 | 2023-11-01 | Gen1E Lifesciences Inc | Naphthyl-mutated p38 alpha mitogen-activated protein kinase inhibitors |
| EP4705280A1 (fr) * | 2023-05-02 | 2026-03-11 | Purdue Research Foundation | Composés à base de diaryle urée, compositions associées et procédés d'utilisation dans le traitement du diabète sucré et d'une maladie neurodégénérative |
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| GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| EP2890460B1 (fr) | 2012-08-29 | 2017-02-22 | Respivert Limited | Inhibiteurs de kinases |
| EP2890695A2 (fr) | 2012-08-29 | 2015-07-08 | Respivert Limited | Inhibiteurs de kinase |
| US9783556B2 (en) | 2012-08-29 | 2017-10-10 | Respivert Limited | Kinase inhibitors |
| GB201215357D0 (en) | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
| EP2925742B1 (fr) | 2012-11-16 | 2016-10-26 | Respivert Limited | Inhibiteurs de kinase |
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| EP3105222B1 (fr) | 2014-02-14 | 2018-04-11 | Respivert Limited | Composés hétérocycliques aromatiques utilisés en tant que composés anti-inflammatoires |
| EP3201189A1 (fr) | 2014-10-01 | 2017-08-09 | Respivert Limited | Dérivés de n-phényl-3-quinazolin-6-yl-benzamide en tant qu'inhibiteurs de kinase p38 |
| MA40774A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
-
2015
- 2015-09-30 MA MA040774A patent/MA40774A/fr unknown
- 2015-09-30 MA MA040775A patent/MA40775A/fr unknown
- 2015-10-01 EA EA201790660A patent/EA032694B1/ru not_active IP Right Cessation
- 2015-10-01 JP JP2017517316A patent/JP6608918B2/ja not_active Expired - Fee Related
- 2015-10-01 EA EA201790658A patent/EA035478B1/ru not_active IP Right Cessation
- 2015-10-01 MX MX2017004129A patent/MX373658B/es active IP Right Grant
- 2015-10-01 MX MX2017004128A patent/MX2017004128A/es unknown
- 2015-10-01 CA CA2961870A patent/CA2961870A1/fr active Pending
- 2015-10-01 BR BR112017006073A patent/BR112017006073A2/pt not_active Application Discontinuation
- 2015-10-01 AU AU2015326614A patent/AU2015326614B2/en not_active Ceased
- 2015-10-01 JP JP2017517315A patent/JP6662863B2/ja not_active Expired - Fee Related
- 2015-10-01 AU AU2015326543A patent/AU2015326543B2/en not_active Ceased
- 2015-10-01 WO PCT/GB2015/052876 patent/WO2016051187A1/fr not_active Ceased
- 2015-10-01 BR BR112017005531A patent/BR112017005531A2/pt not_active Application Discontinuation
- 2015-10-01 WO PCT/GB2015/052877 patent/WO2016051188A1/fr not_active Ceased
- 2015-10-01 EP EP15782018.4A patent/EP3201180A1/fr not_active Withdrawn
- 2015-10-01 US US14/872,807 patent/US9499486B2/en not_active Expired - Fee Related
- 2015-10-01 KR KR1020177010961A patent/KR20170063783A/ko not_active Withdrawn
- 2015-10-01 KR KR1020177011685A patent/KR20170057445A/ko not_active Ceased
- 2015-10-01 EP EP15782017.6A patent/EP3201179A1/fr not_active Withdrawn
- 2015-10-01 US US14/872,527 patent/US9751837B2/en not_active Expired - Fee Related
- 2015-10-01 CN CN201580053439.3A patent/CN106999478A/zh active Pending
- 2015-10-01 CN CN201580053462.2A patent/CN107001274A/zh active Pending
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2016
- 2016-10-12 US US15/291,359 patent/US9822076B2/en not_active Expired - Fee Related
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2017
- 2017-05-24 US US15/604,258 patent/US10125100B2/en active Active
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2018
- 2018-07-13 US US16/035,502 patent/US10392346B2/en active Active
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2019
- 2019-07-10 US US16/508,253 patent/US10941115B2/en not_active Expired - Fee Related
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