MA41125A - Dérivés de 6.7-cyclomorphinane et leur utilisation - Google Patents

Dérivés de 6.7-cyclomorphinane et leur utilisation

Info

Publication number
MA41125A
MA41125A MA041125A MA41125A MA41125A MA 41125 A MA41125 A MA 41125A MA 041125 A MA041125 A MA 041125A MA 41125 A MA41125 A MA 41125A MA 41125 A MA41125 A MA 41125A
Authority
MA
Morocco
Prior art keywords
cyclomorphinane
derivatives
cyclomorphinane derivatives
Prior art date
Application number
MA041125A
Other languages
English (en)
Inventor
Andrew Kassick
Dawit Tadesse
Laykea Tafesse
Original Assignee
Purdue Pharma Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Pharma Lp filed Critical Purdue Pharma Lp
Publication of MA41125A publication Critical patent/MA41125A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA041125A 2014-12-05 2015-12-02 Dérivés de 6.7-cyclomorphinane et leur utilisation MA41125A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462088300P 2014-12-05 2014-12-05

Publications (1)

Publication Number Publication Date
MA41125A true MA41125A (fr) 2017-10-10

Family

ID=56092474

Family Applications (1)

Application Number Title Priority Date Filing Date
MA041125A MA41125A (fr) 2014-12-05 2015-12-02 Dérivés de 6.7-cyclomorphinane et leur utilisation

Country Status (4)

Country Link
US (1) US10435406B2 (fr)
EP (1) EP3227293A4 (fr)
MA (1) MA41125A (fr)
WO (1) WO2016090158A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1254673A1 (zh) * 2015-12-17 2019-07-26 Trevena, Inc. 阿片受体配体和细胞色素p450抑制剂
US11214577B2 (en) * 2019-03-29 2022-01-04 Humanwell Pharmaceutical US Morphinans useful for treating medical disorders

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910920A (en) * 1973-11-07 1975-10-07 Bristol Myers Co 3,14,17-Substituted-6,7-tetramethylenemorphinans
US6277875B1 (en) 2000-07-17 2001-08-21 Andrew J. Holman Use of dopamine D2/D3 receptor agonists to treat fibromyalgia
NZ528241A (en) 2001-03-02 2004-08-27 Euro Celtique S N-but-3-enyl norbuprenorphine and methods of use
US6740641B2 (en) 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain
KR20050074462A (ko) 2002-09-25 2005-07-18 유로-셀티큐 에스.에이. Ｎ―치환 하이드로모르폰 및 그 용도
ATE444296T1 (de) 2002-10-25 2009-10-15 Euro Celtique Sa Analoga und prodrugs von buprenorphin
US7202259B2 (en) 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US6958398B1 (en) 2002-12-30 2005-10-25 Euro-Celtique S.A. Methods for making thebaine or its acid salts
GB0421687D0 (en) 2004-09-30 2004-11-03 Johnson Matthey Plc Preparation of opiate analgesics
ES2389456T3 (es) 2006-11-01 2012-10-26 Purdue Pharma Lp Compuestos de fenilpropionamida y uso de los mismos
CN101210016B (zh) * 2006-12-29 2011-07-20 中国科学院上海药物研究所 一类杂环并吗啡喃类化合物、制备方法及用途
AU2008331235C1 (en) 2007-11-30 2013-01-17 Purdue Pharma L.P. Benzomorphan Compounds
CN101481376A (zh) * 2008-01-10 2009-07-15 中国科学院上海药物研究所 一类杂环并14-羟基-吗啡喃类化合物、制备方法及用途
CA2731939C (fr) 2008-07-30 2017-05-23 Purdue Pharma L.P. Analogues de buprenorphine
MX2013003354A (es) 2010-09-21 2013-06-24 Purdue Pharma Lp Analogos de buprenorfina.
WO2013084060A1 (fr) 2011-12-08 2013-06-13 Purdue Pharma L.P. Analogues de buprénorphine quaternisés
US20150210646A1 (en) 2012-05-11 2015-07-30 Purdue Pharma L.P. Benzomorphan compounds as opioid receptors modulators
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
EP3333156A3 (fr) 2012-11-09 2018-09-26 Purdue Pharma L.P. Analogues de benzomorphane et leur utilisation
US9175000B2 (en) 2012-12-07 2015-11-03 Purdue Pharma L.P. Buprenorphine analogs
WO2014091297A1 (fr) 2012-12-14 2014-06-19 Purdue Pharma L.P. Morphinanes spirocycliques et leur utilisation
US8937084B2 (en) 2012-12-14 2015-01-20 Purdue Pharma L.P. Nitrogen containing morphinan derivatives and the use thereof
TWI513697B (zh) * 2012-12-14 2015-12-21 Purdue Pharma Lp 吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性
US8957084B2 (en) * 2012-12-28 2015-02-17 Purdue Pharma L.P. 7,8-cyclicmorphinan analogs
US8946255B2 (en) 2012-12-28 2015-02-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
US9056836B2 (en) 2013-01-31 2015-06-16 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
US20160333020A1 (en) 2013-12-26 2016-11-17 Purdue Pharma L.P. 7-beta analogs of orvinols
EP3087079B1 (fr) 2013-12-26 2019-04-03 Purdue Pharma LP Morphinanes oxabicyclo[2.2.2]octane modulateurs des récepteurs aux opiacés
EP3087078B1 (fr) 2013-12-26 2019-05-15 Purdue Pharma LP Analogues 7-bêta-alkyle d'orvinols
AU2014370062A1 (en) 2013-12-26 2016-08-11 Purdue Pharma L.P. Ring-contracted morphinans and the use thereof
WO2015097546A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Composés à base de propellane et utilisation de ces derniers en qualité de modulateurs de récepteurs d'opioïdes
US10550088B2 (en) 2013-12-27 2020-02-04 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
US9902726B2 (en) 2013-12-30 2018-02-27 Purdue Pharma L.P. Pyridone-sulfone morphinan analogs as opioid receptor ligands
CA2939501C (fr) 2014-02-12 2020-07-07 Purdue Pharma L.P. Derives d'isoquinoline et leur utilisation
CA2948144A1 (fr) 2014-05-06 2015-11-12 Purdue Pharma L.P. Analogues du benzomorphane et leur utilisation
JP2017521373A (ja) 2014-05-27 2017-08-03 パーデュー、ファーマ、リミテッド、パートナーシップ スピロ環モルフィナン及びその使用
MA40170A (fr) 2014-06-13 2017-04-19 Purdue Pharma Lp Dérivés hétérocycliques de morphinan et leur utilisation
EP3154972A4 (fr) 2014-06-13 2017-11-22 Purdue Pharma L.P. Dérivés d'azamophinan et leur utilisation
WO2016044546A1 (fr) 2014-09-17 2016-03-24 Purdue Pharma L.P. Analogues de benzomorphane et leur utilisation

Also Published As

Publication number Publication date
US10435406B2 (en) 2019-10-08
WO2016090158A1 (fr) 2016-06-09
US20180265510A1 (en) 2018-09-20
EP3227293A4 (fr) 2018-09-12
EP3227293A1 (fr) 2017-10-11

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