MA41169A - Composés antibactériens à large spectre d'activité - Google Patents

Composés antibactériens à large spectre d'activité

Info

Publication number: MA41169A
Authority: MA; Morocco
Prior art keywords: wide; antibacterial compounds; spectrum antibacterial; spectrum; compounds
Prior art date: 2014-12-17

Application number

MA041169A

Other languages

English (en)

Inventor

De Joannon Alessandra Capezzone

Claudia Cavarischia

Gaia Corso

Guido Furlotti

Barbara Garofalo

Tommaso Iacoangeli

Giorgina Mangano

Rosella Ombrato

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-12-17

Filing date

2015-12-13

Publication date

2017-10-24

2015-12-13 Application filed by Acraf filed Critical Acraf

2017-10-24 Publication of MA41169A publication Critical patent/MA41169A/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

MA041169A 2014-12-17 2015-12-13 Composés antibactériens à large spectre d'activité MA41169A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP14198414		2014-12-17

Publications (1)

Publication Number	Publication Date
MA41169A true MA41169A (fr)	2017-10-24

Family

ID=52338839

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA041169A MA41169A (fr)	2014-12-17	2015-12-13	Composés antibactériens à large spectre d'activité

Country Status (29)

Country	Link
US (1)	US10221144B2 (fr)
EP (1)	EP3233827B1 (fr)
JP (1)	JP6723242B2 (fr)
KR (1)	KR20170097069A (fr)
CN (1)	CN107108569A (fr)
AR (1)	AR102989A1 (fr)
AU (1)	AU2015366469B2 (fr)
BR (1)	BR112017011980A2 (fr)
CA (1)	CA2968455A1 (fr)
CY (1)	CY1123465T1 (fr)
DK (1)	DK3233827T3 (fr)
EA (1)	EA032384B1 (fr)
ES (1)	ES2850248T3 (fr)
GE (2)	GEAP201914540A (fr)
HK (1)	HK1245257A1 (fr)
HR (1)	HRP20201379T1 (fr)
HU (1)	HUE050749T2 (fr)
IL (1)	IL252432B (fr)
MA (1)	MA41169A (fr)
MD (1)	MD3233827T2 (fr)
MX (1)	MX2017007371A (fr)
PL (1)	PL3233827T3 (fr)
PT (1)	PT3233827T (fr)
RS (1)	RS60866B1 (fr)
SG (1)	SG11201704168QA (fr)
SI (1)	SI3233827T1 (fr)
SM (1)	SMT202000519T1 (fr)
UA (1)	UA121978C2 (fr)
WO (1)	WO2016096686A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MA41168A (fr) *	2014-12-17	2017-10-24	Acraf	Nouveaux composés antibactériens
MX2021006804A (es) *	2015-12-17	2023-01-13	Merck Patent Gmbh	Antagonistas policiclicos del receptor 7/8 tipo toll (tlr7/8) y uso de los mismos en el tratamiento de trastornos inmunitarios.
DK3468975T3 (da)	2016-06-08	2020-07-13	Acraf	Nye antibakterielle forbindelser
EP4198031A1 (fr)	2016-08-08	2023-06-21	Merck Patent GmbH	Antagonistes de tlr7/8 et leurs utilisations
WO2018109050A1 (fr)	2016-12-15	2018-06-21	F. Hoffmann-La Roche Ag	Procédé de préparation d'inhibiteurs de btk
CN108689876B (zh) *	2018-06-28	2020-11-27	苏州东南药业股份有限公司	一种8-(2-羟基苯甲酰胺基)辛酸钠的制备方法
CN113795482A (zh) *	2019-05-20	2021-12-14	广州龙沙制药有限公司	用于制备卡沙兰的方法
RU2748748C1 (ru) *	2020-06-25	2021-05-31	Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ)	Противотуберкулёзное средство на основе (Z)-3-(3,3-Диметил-2-оксобутилиден)-3,4-дигидро-2H-1,4-бензоксазин-2-она и способ его синтеза
CN114085194B (zh) *	2021-12-08	2023-07-18	青岛科技大学	一种2-(2-羟苯基)-4h-[1,3]-苯并噁嗪-4-酮制备方法

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JP2007502856A (ja) *	2003-05-16	2007-02-15	ファイザー・プロダクツ・インク	精神病性障害および抑うつ性障害の治療
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WO2010081874A1 (fr)	2009-01-15	2010-07-22	Glaxo Group Limited	Composés naphthyridine-2(1h)-one utiles comme antibactériens
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WO2012003418A2 (fr)	2010-07-02	2012-01-05	The University Of North Carolina At Chapel Hill	Ligands fonctionnellement sélectifs des récepteurs d2 de dopamine
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JP6030146B2 (ja) *	2011-11-08	2016-11-24	アクテリオンファーマシューティカルズリミテッドＡｃｔｅｌｉｏｎＰｈａｒｍａｃｅｕｔｉｃａｌｓＬｔｄ	２−オキソ−オキサゾリジン−３，５−ジイル抗生物質誘導体
EP2785721A1 (fr)	2011-11-30	2014-10-08	Actelion Pharmaceuticals Ltd.	Antibiotiques d'octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one 3,7-disubstituée
MA41168A (fr) *	2014-12-17	2017-10-24	Acraf	Nouveaux composés antibactériens

2015
- 2015-12-13 MA MA041169A patent/MA41169A/fr unknown
- 2015-12-14 SI SI201531377T patent/SI3233827T1/sl unknown
- 2015-12-14 EA EA201791219A patent/EA032384B1/ru not_active IP Right Cessation
- 2015-12-14 HK HK18104555.9A patent/HK1245257A1/zh unknown
- 2015-12-14 GE GEAP201914540A patent/GEAP201914540A/en unknown
- 2015-12-14 PT PT158084046T patent/PT3233827T/pt unknown
- 2015-12-14 ES ES15808404T patent/ES2850248T3/es active Active
- 2015-12-14 EP EP15808404.6A patent/EP3233827B1/fr active Active
- 2015-12-14 SG SG11201704168QA patent/SG11201704168QA/en unknown
- 2015-12-14 RS RS20201115A patent/RS60866B1/sr unknown
- 2015-12-14 PL PL15808404T patent/PL3233827T3/pl unknown
- 2015-12-14 WO PCT/EP2015/079528 patent/WO2016096686A1/fr not_active Ceased
- 2015-12-14 AR ARP150104058A patent/AR102989A1/es unknown
- 2015-12-14 US US15/533,594 patent/US10221144B2/en not_active Expired - Fee Related
- 2015-12-14 JP JP2017530230A patent/JP6723242B2/ja not_active Expired - Fee Related
- 2015-12-14 CN CN201580068670.XA patent/CN107108569A/zh active Pending
- 2015-12-14 MD MDE20170189T patent/MD3233827T2/ro not_active IP Right Cessation
- 2015-12-14 DK DK15808404.6T patent/DK3233827T3/da active
- 2015-12-14 GE GEAP201514540A patent/GEP20196991B/en unknown
- 2015-12-14 SM SM20200519T patent/SMT202000519T1/it unknown
- 2015-12-14 BR BR112017011980A patent/BR112017011980A2/pt not_active Application Discontinuation
- 2015-12-14 CA CA2968455A patent/CA2968455A1/fr not_active Abandoned
- 2015-12-14 UA UAA201705043A patent/UA121978C2/uk unknown
- 2015-12-14 KR KR1020177018182A patent/KR20170097069A/ko not_active Withdrawn
- 2015-12-14 HR HRP20201379TT patent/HRP20201379T1/hr unknown
- 2015-12-14 MX MX2017007371A patent/MX2017007371A/es unknown
- 2015-12-14 AU AU2015366469A patent/AU2015366469B2/en not_active Ceased
- 2015-12-14 HU HUE15808404A patent/HUE050749T2/hu unknown
2017
- 2017-05-22 IL IL252432A patent/IL252432B/en not_active IP Right Cessation
2020
- 2020-10-02 CY CY20201100925T patent/CY1123465T1/el unknown

Also Published As

Publication number	Publication date
EP3233827B1 (fr)	2020-07-08
DK3233827T3 (da)	2020-09-21
SI3233827T1 (sl)	2020-11-30
RS60866B1 (sr)	2020-11-30
HK1245257A1 (zh)	2018-08-24
EP3233827A1 (fr)	2017-10-25
WO2016096686A1 (fr)	2016-06-23
CN107108569A (zh)	2017-08-29
MX2017007371A (es)	2018-04-24
AR102989A1 (es)	2017-04-05
BR112017011980A2 (pt)	2017-12-26
HUE050749T2 (hu)	2021-01-28
MD3233827T2 (ro)	2020-11-30
CA2968455A1 (fr)	2016-06-23
UA121978C2 (uk)	2020-08-25
US20170369450A1 (en)	2017-12-28
PT3233827T (pt)	2020-09-28
EA201791219A1 (ru)	2018-01-31
SMT202000519T1 (it)	2020-11-10
KR20170097069A (ko)	2017-08-25
US10221144B2 (en)	2019-03-05
IL252432A0 (en)	2017-07-31
CY1123465T1 (el)	2022-03-24
ES2850248T3 (es)	2021-08-26
EA032384B1 (ru)	2019-05-31
JP2017537933A (ja)	2017-12-21
AU2015366469A1 (en)	2017-06-15
GEAP201914540A (en)	2019-02-11
IL252432B (en)	2020-06-30
AU2015366469B2 (en)	2019-06-27
SG11201704168QA (en)	2017-07-28
HRP20201379T1 (hr)	2020-11-27
GEP20196991B (en)	2019-07-10
JP6723242B2 (ja)	2020-07-15
PL3233827T3 (pl)	2020-11-30

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