MA45148A - Composés de carfilzomib pégylés - Google Patents

Composés de carfilzomib pégylés

Info

Publication number
MA45148A
MA45148A MA045148A MA45148A MA45148A MA 45148 A MA45148 A MA 45148A MA 045148 A MA045148 A MA 045148A MA 45148 A MA45148 A MA 45148A MA 45148 A MA45148 A MA 45148A
Authority
MA
Morocco
Prior art keywords
carfilzomib compounds
pegylated carfilzomib
pegylated
compounds
carfilzomib
Prior art date
Application number
MA045148A
Other languages
English (en)
Inventor
Shabbir T Anik
Irina DOTSENKO
Gary Luehr
Ge Peng
Pasit Phiasivongsa
Dante ROMANINI
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59062074&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA45148(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA45148A publication Critical patent/MA45148A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33396Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2230/00Compositions for preparing biodegradable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Polymers & Plastics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Detergent Compositions (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
MA045148A 2016-05-24 2017-05-23 Composés de carfilzomib pégylés MA45148A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662340926P 2016-05-24 2016-05-24
US201762485812P 2017-04-14 2017-04-14

Publications (1)

Publication Number Publication Date
MA45148A true MA45148A (fr) 2019-04-10

Family

ID=59062074

Family Applications (1)

Application Number Title Priority Date Filing Date
MA045148A MA45148A (fr) 2016-05-24 2017-05-23 Composés de carfilzomib pégylés

Country Status (26)

Country Link
US (3) US10517954B2 (fr)
EP (1) EP3464277B1 (fr)
JP (1) JP7142578B2 (fr)
KR (1) KR102492135B1 (fr)
CN (1) CN109415353B (fr)
AU (1) AU2017272101B2 (fr)
CA (1) CA3025170A1 (fr)
CL (1) CL2018003352A1 (fr)
CO (1) CO2018013112A2 (fr)
CR (1) CR20180602A (fr)
ES (1) ES2939849T3 (fr)
IL (1) IL263147B (fr)
MA (1) MA45148A (fr)
MX (1) MX386616B (fr)
MY (1) MY203143A (fr)
NZ (1) NZ748615A (fr)
PE (1) PE20190328A1 (fr)
PH (1) PH12018502473B1 (fr)
SA (1) SA518400493B1 (fr)
SG (2) SG11201810396QA (fr)
TN (1) TN2018000393A1 (fr)
TW (1) TWI759301B (fr)
UA (1) UA125254C2 (fr)
UY (1) UY37253A (fr)
WO (1) WO2017205392A1 (fr)
ZA (1) ZA201807890B (fr)

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TWI759301B (zh) 2016-05-24 2022-04-01 美商安美基公司 聚乙二醇化卡非佐米化合物
KR102612531B1 (ko) 2016-11-17 2023-12-12 코그니토 쎄라퓨틱스, 인코포레이티드 인지 기능 개선을 위한 시스템
KR102919070B1 (ko) 2017-06-30 2026-01-29 메사추세츠 인스티튜트 오브 테크놀로지 분지형 다관능성 거대단량체 및 관련 중합체 및 그의 용도
ES3058718T3 (en) 2017-10-10 2026-03-12 Massachusetts Inst Technology Systems for preventing, mitigating, and/or treating dementia
US10960225B2 (en) 2017-10-10 2021-03-30 Massachusetts Institute Of Technology Systems and methods for preventing, mitigating, and/or treating dementia via visual stimulation that binds higher order brain regions, reduces neurodegeneration and neuroinflammation, and improves cognitive function
JP2021503441A (ja) * 2017-11-16 2021-02-12 アムジエン・インコーポレーテツド Peg化されたカルフィルゾミブ化合物の安定組成物
EP3774986A1 (fr) * 2018-04-13 2021-02-17 Massachusetts Institute of Technology Promédicaments à brosse et leurs utilisations
US20220304993A1 (en) 2019-06-21 2022-09-29 Ascendis Pharma A/S Conjugates of an electron-donating nitrogen or tertiary amine comprising compounds
EP4045562A2 (fr) 2019-10-16 2022-08-24 Massachusetts Institute of Technology Promédicaments à brosse et leurs utilisations
JP2023510258A (ja) * 2020-01-10 2023-03-13 アムジエン・インコーポレーテツド 安定なシクロデキストリン不含カルフィルゾミブ処方物
WO2021222783A1 (fr) * 2020-05-01 2021-11-04 Angiex, Inc. Conjugués anticorps anti-tm4sf-médicament et leurs procédés d'utilisation
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WO2025035020A2 (fr) 2023-08-09 2025-02-13 Amgen Inc. Méthodes d'utilisation du carfilzomib
KR20250153899A (ko) 2024-04-18 2025-10-28 충남대학교산학협력단 카르필조밉을 포함하는 자가 나노유화 약물전달시스템 조성물 및 이의 제조방법

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JP6512183B2 (ja) 2016-06-30 2019-05-15 株式会社Soken 乗員検知システム及び乗員検知装置

Also Published As

Publication number Publication date
SA518400493B1 (ar) 2024-01-18
IL263147A (en) 2018-12-31
KR102492135B1 (ko) 2023-01-26
PH12018502473B1 (en) 2023-03-22
CA3025170A1 (fr) 2017-11-30
UA125254C2 (uk) 2022-02-09
ES2939849T3 (es) 2023-04-27
US10517954B2 (en) 2019-12-31
US20170340746A1 (en) 2017-11-30
JP2019519530A (ja) 2019-07-11
UY37253A (es) 2017-11-30
AU2017272101B2 (en) 2021-10-07
CN109415353B (zh) 2023-01-10
CL2018003352A1 (es) 2019-02-15
MY203143A (en) 2024-06-11
US10675353B2 (en) 2020-06-09
BR112018074078A2 (pt) 2019-06-04
EP3464277A1 (fr) 2019-04-10
PE20190328A1 (es) 2019-03-05
AU2017272101A1 (en) 2018-12-13
SG10201912278TA (en) 2020-02-27
SG11201810396QA (en) 2018-12-28
MX2018014498A (es) 2019-04-01
MX386616B (es) 2025-03-19
EP3464277B1 (fr) 2022-12-28
PH12018502473A1 (en) 2019-04-08
CO2018013112A2 (es) 2018-12-28
TWI759301B (zh) 2022-04-01
NZ748615A (en) 2022-11-25
ZA201807890B (en) 2019-08-28
JP7142578B2 (ja) 2022-09-27
KR20190010648A (ko) 2019-01-30
US20200069808A1 (en) 2020-03-05
US11077198B2 (en) 2021-08-03
IL263147B (en) 2022-04-01
TN2018000393A1 (en) 2020-06-15
CN109415353A (zh) 2019-03-01
TW201808345A (zh) 2018-03-16
CR20180602A (es) 2019-03-04
US20200376131A1 (en) 2020-12-03
WO2017205392A1 (fr) 2017-11-30

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