MA41200A - Procédé pour la préparation d'un composé diarylthiohydantoïne - Google Patents

Procédé pour la préparation d'un composé diarylthiohydantoïne

Info

Publication number: MA41200A
Authority: MA; Morocco
Prior art keywords: preparation; diarylthiohydantoin compound; diarylthiohydantoin; compound
Prior art date: 2014-12-19

Application number

MA041200A

Other languages

English (en)

Other versions

MA41200B1 (fr

Inventor

Cyril Ben Haim

Andras Horvath

Johan Erwin Edmond Weerts

Original Assignee

Aragon Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-12-19

Filing date

2015-12-17

Publication date

2017-10-25

2015-12-17 Application filed by Aragon Pharmaceuticals Inc filed Critical Aragon Pharmaceuticals Inc

2017-10-25 Publication of MA41200A publication Critical patent/MA41200A/fr

2019-05-31 Publication of MA41200B1 publication Critical patent/MA41200B1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/14—Phosphorus; Compounds thereof
- B01J27/186—Phosphorus; Compounds thereof with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
- B01J27/195—Phosphorus; Compounds thereof with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium with vanadium, niobium or tantalum
- B01J27/198—Vanadium
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/04—Mixing
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Materials Engineering (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

MA41200A 2014-12-19 2015-12-17 Procédé pour la préparation d'un composé diarylthiohydantoïne MA41200B1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201462094436P	2014-12-19	2014-12-19
EP15823875.8A EP3233803B1 (fr)	2014-12-19	2015-12-17	Procédé pour la préparation d'un composé diarylthiohydantoïne
PCT/US2015/066356 WO2016100652A2 (fr)	2014-12-19	2015-12-17	Procédé pour la préparation d'un composé diarylthiohydantoïne

Publications (2)

Publication Number	Publication Date
MA41200A true MA41200A (fr)	2017-10-25
MA41200B1 MA41200B1 (fr)	2019-05-31

Family

ID=55168400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA41200A MA41200B1 (fr)	2014-12-19	2015-12-17	Procédé pour la préparation d'un composé diarylthiohydantoïne

Country Status (33)

Country	Link
US (1)	US9688655B2 (fr)
EP (4)	EP3372585B1 (fr)
JP (2)	JP6681902B2 (fr)
KR (1)	KR102586059B1 (fr)
CN (2)	CN118638097A (fr)
AR (2)	AR103228A1 (fr)
AU (1)	AU2015364537B2 (fr)
BR (1)	BR112017013113B1 (fr)
CY (3)	CY1121684T1 (fr)
DK (3)	DK3233803T3 (fr)
EA (4)	EA201892486A1 (fr)
ES (3)	ES2827549T3 (fr)
HR (3)	HRP20190540T1 (fr)
HU (2)	HUE052475T2 (fr)
IL (1)	IL252843B2 (fr)
LT (3)	LT3233803T (fr)
MA (1)	MA41200B1 (fr)
MD (1)	MD3233803T2 (fr)
ME (1)	ME03420B (fr)
MX (1)	MX375467B (fr)
NZ (1)	NZ732766A (fr)
PH (1)	PH12017501152B1 (fr)
PL (3)	PL3372584T3 (fr)
PT (3)	PT3233803T (fr)
RS (3)	RS61060B9 (fr)
SG (4)	SG10201912811QA (fr)
SI (3)	SI3372585T1 (fr)
SM (3)	SMT202000618T1 (fr)
TR (1)	TR201904739T4 (fr)
TW (4)	TWI689494B (fr)
UA (1)	UA123201C2 (fr)
WO (1)	WO2016100652A2 (fr)
ZA (1)	ZA201704877B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3233823B1 (fr) *	2014-12-19	2019-01-30	Aragon Pharmaceuticals, Inc.	Procédés pour la préparation d'un composé diaryl-thiohydantoïne
ME03420B (fr) *	2014-12-19	2020-01-20	Aragon Pharmaceuticals Inc	Procédé pour la préparation d'un composé diarylthiohydantoïne
CN108069869B (zh) *	2016-11-09	2022-03-01	上海医药工业研究院	一种Apalutamide的制备方法及其中间体
TW201831461A (zh) *	2017-01-18	2018-09-01	台灣神隆股份有限公司	製備阿帕魯醯胺的方法
US10364245B2 (en)	2017-06-07	2019-07-30	Chiesi Farmaceutici S.P.A.	Kinase inhibitors
CN107501237B (zh) *	2017-08-17	2022-03-22	上海西浦医药科技有限公司	一种Apalutamide的合成方法
CN108383749B (zh) *	2018-01-30	2021-03-09	杭州科巢生物科技有限公司	阿帕鲁胺的合成方法及其中间体
US10513504B2 (en)	2018-03-08	2019-12-24	Apotex Inc.	Processes for the preparation of apalutamide and intermediates thereof
CN108314646B (zh) *	2018-04-11	2021-03-19	武汉慧敏科技中心	一种高分散双金属纳米材料制备泌尿生殖系统用药物中间体的方法
CN109651256A (zh) *	2018-11-20	2019-04-19	上海健康医学院	一种式（viii）的恩杂鲁胺的制备方法
CN110511206A (zh) *	2019-06-17	2019-11-29	扬子江药业集团江苏海慈生物药业有限公司	芳基-2-硫代海因类化合物中间体、其制备方法及应用
CN110511207A (zh) *	2019-06-17	2019-11-29	扬子江药业集团江苏海慈生物药业有限公司	芳基-2-硫代海因类化合物中间体、其制备方法及应用
CN113968815B (zh) *	2020-07-24	2025-11-18	苏州科伦药物研究有限公司	一种硫代二氮杂螺类化合物的合成方法、其中间体及其合成方法
WO2022049265A1 (fr)	2020-09-04	2022-03-10	Synthon B.V.	Procédé amélioré pour la préparation d'apalutamide
JP7815242B2 (ja) *	2020-11-20	2026-02-17	アムジエン・インコーポレーテツド	７－クロロ－６－フルオロ－１－（２－イソプロピル－４－メチルピリジン－３－イル）ピリド［２，３－ｄ］ピリミジン－２，４（１Ｈ，３Ｈ）－ジオンを調製するためのプロセス
CN113402466B (zh) *	2021-06-18	2022-08-16	南京方生和医药科技有限公司	一种阿帕鲁胺中间体及制备阿帕鲁胺的方法
CN113292535B (zh) *	2021-06-18	2022-07-01	南京方生和医药科技有限公司	一种制备阿帕鲁胺中间体及阿帕鲁胺的方法
CN115572264B (zh) *	2021-07-06	2025-12-05	山东新时代药业有限公司	一种恩杂鲁胺的制备方法
CN115850233B (zh) *	2021-09-24	2024-12-10	南京方生和医药科技有限公司	一种阿帕鲁胺的合成方法
CN116239536A (zh) *	2021-12-08	2023-06-09	山东新时代药业有限公司	一种阿帕鲁胺中间体化合物
CN117534652A (zh) *	2022-08-02	2024-02-09	黄冈人福药业有限责任公司	一种阿帕他胺的制备方法
CN115536634B (zh) *	2022-10-17	2024-06-11	上海博悦生物科技有限公司	一种阿帕他胺的合成方法
CN116332907A (zh) *	2023-03-16	2023-06-27	奥锐特药业股份有限公司	一种无定形阿帕他胺的制备方法
CN117645572A (zh) *	2023-11-23	2024-03-05	奥锐特药业股份有限公司	恩扎卢胺及其中间体的制备方法

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US20040077605A1 (en)	2001-06-20	2004-04-22	Salvati Mark E.	Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
TWI263640B (en) *	2001-12-19	2006-10-11	Bristol Myers Squibb Co	Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
EP2656842B1 (fr) *	2006-03-27	2016-08-10	The Regents of The University of California	Modulateur de récepteur androgène pour le traitement du cancer de la prostate et de maladies associées au récepteur androgène
US8461343B2 (en)	2007-03-27	2013-06-11	Sloan-Kettering Institute For Cancer Research	Synthesis of thiohydantoins
TWI445707B (zh) *	2008-05-16	2014-07-21	Takeda California Inc	葡萄糖激酶活化劑
US8722695B2 (en)	2009-12-11	2014-05-13	Autifony Therapeutics Limited	Imidazolidinedione derivatives
HUE037389T2 (hu) *	2010-02-16	2018-08-28	Aragon Pharmaceuticals Inc	Androgén receptor modulátorok és alkalmazásaik
ES2671343T3 (es) *	2010-02-24	2018-06-06	Medivation Prostate Therapeutics Llc	Procesos para la síntesis de compuestos de diariltiohidantoína y diarilhidantoína
WO2012119559A1 (fr)	2011-03-10	2012-09-13	Suzhou Kintor Pharmaceuticals,Inc.	Antagonistes des récepteurs d'androgènes et leurs utilisations
WO2013029338A1 (fr)	2011-09-01	2013-03-07	Glaxo Group Limited	Nouveaux composés
CN104379160A (zh) *	2012-03-29	2015-02-25	桑加特公司	双阿司匹林交联聚乙二醇化血红蛋白
CA2908326C (fr) *	2013-05-29	2017-09-12	Hinova Pharmaceuticals Inc.	Composes d'imidazolidinedione et leurs utilisations
ME03420B (fr) *	2014-12-19	2020-01-20	Aragon Pharmaceuticals Inc	Procédé pour la préparation d'un composé diarylthiohydantoïne

2015
- 2015-12-17 ME MEP-2019-86A patent/ME03420B/fr unknown
- 2015-12-17 LT LTEP15823875.8T patent/LT3233803T/lt unknown
- 2015-12-17 ES ES18169756T patent/ES2827549T3/es active Active
- 2015-12-17 EP EP18169895.2A patent/EP3372585B1/fr active Active
- 2015-12-17 RS RS20201378A patent/RS61060B9/sr unknown
- 2015-12-17 HU HUE18169756A patent/HUE052475T2/hu unknown
- 2015-12-17 PT PT15823875T patent/PT3233803T/pt unknown
- 2015-12-17 SG SG10201912811QA patent/SG10201912811QA/en unknown
- 2015-12-17 HR HRP20190540TT patent/HRP20190540T1/hr unknown
- 2015-12-17 MA MA41200A patent/MA41200B1/fr unknown
- 2015-12-17 PL PL18169756T patent/PL3372584T3/pl unknown
- 2015-12-17 CN CN202410667649.2A patent/CN118638097A/zh active Pending
- 2015-12-17 SI SI201531848T patent/SI3372585T1/sl unknown
- 2015-12-17 HR HRP20220750TT patent/HRP20220750T1/hr unknown
- 2015-12-17 ES ES15823875T patent/ES2718539T3/es active Active
- 2015-12-17 SI SI201531433T patent/SI3372584T1/sl unknown
- 2015-12-17 RS RS20190350A patent/RS58454B1/sr unknown
- 2015-12-17 SM SM20200618T patent/SMT202000618T1/it unknown
- 2015-12-17 SG SG10201912805SA patent/SG10201912805SA/en unknown
- 2015-12-17 SM SM20220242T patent/SMT202200242T1/it unknown
- 2015-12-17 PL PL18169895.2T patent/PL3372585T3/pl unknown
- 2015-12-17 EA EA201892486A patent/EA201892486A1/ru unknown
- 2015-12-17 PT PT181697566T patent/PT3372584T/pt unknown
- 2015-12-17 CN CN201580069602.5A patent/CN107108507B/zh active Active
- 2015-12-17 AU AU2015364537A patent/AU2015364537B2/en active Active
- 2015-12-17 BR BR112017013113-7A patent/BR112017013113B1/pt active IP Right Grant
- 2015-12-17 PL PL15823875T patent/PL3233803T3/pl unknown
- 2015-12-17 SG SG11201704969QA patent/SG11201704969QA/en unknown
- 2015-12-17 TR TR2019/04739T patent/TR201904739T4/tr unknown
- 2015-12-17 SG SG10201912802XA patent/SG10201912802XA/en unknown
- 2015-12-17 LT LTEP18169756.6T patent/LT3372584T/lt unknown
- 2015-12-17 HU HUE15823875A patent/HUE042409T2/hu unknown
- 2015-12-17 LT LTEP18169895.2T patent/LT3372585T/lt unknown
- 2015-12-17 EP EP18169756.6A patent/EP3372584B9/fr active Active
- 2015-12-17 DK DK15823875.8T patent/DK3233803T3/en active
- 2015-12-17 RS RS20220542A patent/RS63455B1/sr unknown
- 2015-12-17 EA EA201892485A patent/EA201892485A1/ru unknown
- 2015-12-17 MD MDE20170208T patent/MD3233803T2/ro unknown
- 2015-12-17 JP JP2017532725A patent/JP6681902B2/ja active Active
- 2015-12-17 DK DK18169895.2T patent/DK3372585T3/da active
- 2015-12-17 MX MX2017008179A patent/MX375467B/es active IP Right Grant
- 2015-12-17 KR KR1020177019551A patent/KR102586059B1/ko active Active
- 2015-12-17 PT PT181698952T patent/PT3372585T/pt unknown
- 2015-12-17 DK DK18169756.6T patent/DK3372584T5/da active
- 2015-12-17 IL IL252843A patent/IL252843B2/en unknown
- 2015-12-17 SI SI201530599T patent/SI3233803T1/sl unknown
- 2015-12-17 WO PCT/US2015/066356 patent/WO2016100652A2/fr not_active Ceased
- 2015-12-17 NZ NZ732766A patent/NZ732766A/en unknown
- 2015-12-17 EA EA201791390A patent/EA201791390A1/ru unknown
- 2015-12-17 ES ES18169895T patent/ES2919951T3/es active Active
- 2015-12-17 EP EP18170050.1A patent/EP3372586A1/fr not_active Withdrawn
- 2015-12-17 EP EP15823875.8A patent/EP3233803B1/fr active Active
- 2015-12-17 EA EA201892487A patent/EA201892487A1/ru unknown
- 2015-12-17 UA UAA201707588A patent/UA123201C2/uk unknown
- 2015-12-17 PH PH1/2017/501152A patent/PH12017501152B1/en unknown
- 2015-12-17 US US14/973,089 patent/US9688655B2/en active Active
- 2015-12-17 SM SM20190208T patent/SMT201900208T1/it unknown
- 2015-12-18 TW TW108131623A patent/TWI689494B/zh active
- 2015-12-18 TW TW108131622A patent/TWI703132B/zh active
- 2015-12-18 TW TW104142692A patent/TWI683810B/zh active
- 2015-12-18 TW TW108146841A patent/TWI753336B/zh active
- 2015-12-21 AR ARP150104237A patent/AR103228A1/es active IP Right Grant
2017
- 2017-07-18 ZA ZA2017/04877A patent/ZA201704877B/en unknown
2019
- 2019-04-10 CY CY20191100400T patent/CY1121684T1/el unknown
2020
- 2020-03-24 JP JP2020052658A patent/JP6903785B2/ja active Active
- 2020-11-02 CY CY20201101031T patent/CY1123611T1/el unknown
- 2020-11-20 HR HRP20201847TT patent/HRP20201847T2/hr unknown
2022
- 2022-06-10 CY CY20221100408T patent/CY1125243T1/el unknown
2024
- 2024-12-06 AR ARP240103372A patent/AR134579A2/es unknown

Also Published As

Publication number	Publication date
TW201639825A (zh)	2016-11-16
KR20170095976A (ko)	2017-08-23
RS61060B1 (sr)	2020-12-31
LT3372585T (lt)	2022-07-11
ES2919951T3 (es)	2022-07-29
UA123201C2 (uk)	2021-03-03
SI3233803T1 (sl)	2019-05-31
PH12017501152A1 (en)	2017-11-27
PL3372584T3 (pl)	2021-07-05
JP2018501237A (ja)	2018-01-18
SG10201912811QA (en)	2020-02-27
CN107108507B (zh)	2024-05-28
EP3372585A1 (fr)	2018-09-12
EP3372584B1 (fr)	2020-09-23
ZA201704877B (en)	2019-02-27
TWI703132B (zh)	2020-09-01
HRP20190540T1 (hr)	2019-06-14
TW201945343A (zh)	2019-12-01
ME03420B (fr)	2020-01-20
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EP3372584A1 (fr)	2018-09-12
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LT3233803T (lt)	2019-04-10
MD3233803T2 (ro)	2019-07-31
DK3372584T3 (da)	2021-01-04
EA201892485A1 (ru)	2019-07-31
PH12017501152B1 (en)	2022-04-29
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SG11201704969QA (en)	2017-07-28
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BR112017013113A2 (pt)	2017-12-26
US20160176845A1 (en)	2016-06-23
IL252843A0 (en)	2017-08-31
IL252843B2 (en)	2025-02-01
BR112017013113B1 (pt)	2023-11-21
CA2970937A1 (fr)	2016-06-23
TWI753336B (zh)	2022-01-21
AR134579A2 (es)	2026-01-28
PL3372585T3 (pl)	2022-10-10
SG10201912805SA (en)	2020-02-27
ES2718539T3 (es)	2019-07-02
JP6681902B2 (ja)	2020-04-15
LT3372584T (lt)	2020-12-10
EP3372584B9 (fr)	2021-03-31
MX2017008179A (es)	2017-09-18
EA201892486A1 (ru)	2019-07-31
JP2020114842A (ja)	2020-07-30
NZ732766A (en)	2023-07-28
HRP20201847T1 (hr)	2021-03-19
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WO2016100652A2 (fr)	2016-06-23
SMT201900208T1 (it)	2019-05-10
EP3233803A2 (fr)	2017-10-25
RS63455B1 (sr)	2022-08-31
CN107108507A (zh)	2017-08-29
KR102586059B1 (ko)	2023-10-05
DK3233803T3 (en)	2019-04-08
ES2827549T9 (es)	2021-07-02
AR103228A1 (es)	2017-04-26
WO2016100652A3 (fr)	2016-08-25
PT3372585T (pt)	2022-07-08
SMT202000618T1 (it)	2021-01-05
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MA41200B1 (fr)	2019-05-31
EA201791390A1 (ru)	2017-10-31
DK3372584T5 (da)	2021-05-17
TR201904739T4 (tr)	2019-05-21
PT3233803T (pt)	2019-05-20
CY1125243T1 (el)	2025-03-28

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