MA42049A - Sulfones tricycliques utiles commes modulateurs ror-gamma - Google Patents

Sulfones tricycliques utiles commes modulateurs ror-gamma

Info

Publication number
MA42049A
MA42049A MA042049A MA42049A MA42049A MA 42049 A MA42049 A MA 42049A MA 042049 A MA042049 A MA 042049A MA 42049 A MA42049 A MA 42049A MA 42049 A MA42049 A MA 42049A
Authority
MA
Morocco
Prior art keywords
sulphones
ror
tricyclic
useful
gamma modulators
Prior art date
Application number
MA042049A
Other languages
English (en)
Inventor
Douglas G Batt
Bertrand Myra Beaudoin
Robert J Cherney
Lyndon A M Cornelius
T G Murali Dhar
Jingwu Duan
Qingjie Liu
David Marcoux
Qing Shi
Anurag S Srivastava
Carolyn A Weigelt
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MA42049A publication Critical patent/MA42049A/fr

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    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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SG10201609616TA (en) * 2016-09-06 2018-04-27 Apple Inc Electronic device with cooling fan
EP3523279A1 (fr) * 2016-10-10 2019-08-14 Bristol-Myers Squibb Company Sulfones tricycliques en tant que modulateurs de ror gamma
KR102506326B1 (ko) * 2016-10-13 2023-03-03 브리스톨-마이어스 스큅 컴퍼니 Ror 감마 조정제로서의 헤테로시클릭 술폰
DE102017010487A1 (de) * 2016-12-02 2018-06-07 Merck Patent Gmbh Monofluorierte cyclohexane
CN112119060A (zh) * 2018-05-17 2020-12-22 百时美施贵宝公司 作为RORγ调节剂的三环砜化合物
US11993574B2 (en) 2018-06-15 2024-05-28 Reata Pharmaceuticals, Inc Pyrazole and imidazole compounds for inhibition of IL-17 and RORgamma
CR20210175A (es) 2018-09-18 2021-06-01 Nikang Therapeutics Inc Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2 (shp2)
US20230295087A1 (en) * 2019-05-13 2023-09-21 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
EP4093732A1 (fr) * 2020-01-24 2022-11-30 Bristol-Myers Squibb Company Sulfones tricycliques en tant que modulateurs de ror?
US11332442B2 (en) 2020-08-12 2022-05-17 Bristol-Myers Squibb Company Synthetic process
JP7785755B2 (ja) * 2020-08-26 2025-12-15 エフ． ホフマン－ラ ロシュ アーゲー Ｍａｇｌ阻害剤として有用な複素環化合物
WO2023232870A1 (fr) 2022-05-31 2023-12-07 Immunic Ag Modulateurs de rorg/rorgt pour le traitement d'infections virales de type covid-19

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JP6397488B2 (ja) 2013-09-20 2018-09-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＲＯＲγ調節因子
JP6476205B2 (ja) 2014-01-06 2019-02-27 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＲＯＲγ修飾因子としてのヘテロ環式スルホン
ES2704460T3 (es) 2014-01-06 2019-03-18 Bristol Myers Squibb Co Moduladores de ROR gamma de ciclohexilsulfona
EA030849B1 (ru) 2014-01-06 2018-10-31 Бристол-Маерс Сквибб Компани ПИРРОЛИДИНИЛСУЛЬФОНОВЫЕ МОДУЛЯТОРЫ RORγ
WO2015103508A1 (fr) 2014-01-06 2015-07-09 Bristol-Myers Squibb Company Composés sulfone carbocyclique servant de modulateurs de rorγ
AR104555A1 (es) * 2015-05-07 2017-07-26 Bristol Myers Squibb Co SULFONAS TRICÍCLICAS COMO MODULARES DE RORg

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US9815859B2 (en) 2017-11-14
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JP6553746B2 (ja) 2019-07-31
ES2887087T3 (es) 2021-12-21
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PH12017502012A1 (en) 2018-04-02
MA41389A1 (fr) 2018-06-29
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