MA42049A - Sulfones tricycliques utiles commes modulateurs ror-gamma - Google Patents

Sulfones tricycliques utiles commes modulateurs ror-gamma

Info

Publication number
MA42049A
MA42049A MA042049A MA42049A MA42049A MA 42049 A MA42049 A MA 42049A MA 042049 A MA042049 A MA 042049A MA 42049 A MA42049 A MA 42049A MA 42049 A MA42049 A MA 42049A
Authority
MA
Morocco
Prior art keywords
sulphones
ror
tricyclic
useful
gamma modulators
Prior art date
Application number
MA042049A
Other languages
English (en)
Inventor
Douglas G Batt
Bertrand Myra Beaudoin
Robert J Cherney
Lyndon A M Cornelius
T G Murali Dhar
Jingwu Duan
Qingjie Liu
David Marcoux
Qing Shi
Anurag S Srivastava
Carolyn A Weigelt
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MA42049A publication Critical patent/MA42049A/fr

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    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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MA042049A 2015-05-07 2016-05-06 Sulfones tricycliques utiles commes modulateurs ror-gamma MA42049A (fr)

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CN107709295B (zh) * 2015-05-07 2021-05-04 百时美施贵宝公司 作为RORγ调节剂的三环砜类
SG10201609616TA (en) * 2016-09-06 2018-04-27 Apple Inc Electronic device with cooling fan
US10968177B2 (en) 2016-10-10 2021-04-06 Bristol-Myers Squibb Company Tricyclic sulfones as RORγ modulators
WO2018071620A1 (fr) * 2016-10-13 2018-04-19 Bristol-Myers Squibb Company Sulfones hétérocycliques comme modulateurs de ror gamma
DE102017010487A1 (de) * 2016-12-02 2018-06-07 Merck Patent Gmbh Monofluorierte cyclohexane
KR102829200B1 (ko) * 2018-05-17 2025-07-02 브리스톨-마이어스 스큅 컴퍼니 Ror 감마 조정제로서의 트리시클릭 술폰 화합물
US11993574B2 (en) 2018-06-15 2024-05-28 Reata Pharmaceuticals, Inc Pyrazole and imidazole compounds for inhibition of IL-17 and RORgamma
JP7337174B2 (ja) 2018-09-18 2023-09-01 ニカング セラピューティクス， インコーポレイテッド Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての三置換ヘテロアリール誘導体
WO2020231766A1 (fr) * 2019-05-13 2020-11-19 Bristol-Myers Squibb Company Agonistes de gammat ror
US12570609B2 (en) 2020-01-24 2026-03-10 Bristol-Myers Squibb Company Tricyclic sulfones as ROR gamma modulators
US11332442B2 (en) 2020-08-12 2022-05-17 Bristol-Myers Squibb Company Synthetic process
WO2022043284A1 (fr) * 2020-08-26 2022-03-03 F. Hoffmann-La Roche Ag Composés hétérocycliques utiles en tant qu'inhibiteurs de magl
WO2023232870A1 (fr) 2022-05-31 2023-12-07 Immunic Ag Modulateurs de rorg/rorgt pour le traitement d'infections virales de type covid-19
PL453856A1 (pl) * 2025-11-25 2026-06-08 Anna Grzegorek Urządzenie stabilizująco-podtrzymujące do unieruchamiania psa w pozycji pionowej podczas zabiegów weterynaryjnych

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
ES2431524T3 (es) 2004-04-13 2013-11-26 Incyte Corporation Derivados de piperazinilpiperidina como antagonistas de los receptores de quimiocinas
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
AR059075A1 (es) * 2006-01-20 2008-03-12 Schering Corp Bencesulfonil - cromano , tiocromano tetrahidronaftaleno e inhibidores de gamma secretasa relacionados
US8618123B2 (en) 2007-07-17 2013-12-31 Merck Sharp & Dohme Corp. Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
CA2871504C (fr) * 2012-05-08 2020-07-21 Merck Sharp & Dohme Corp. Composes sulfone bicycliques utilises pour l'inhibition de l'activite rorg et le traitement d'une maladie
EP2669286A1 (fr) 2012-05-31 2013-12-04 Ares Trading S.A. Dérivés de spiro tétrahydro-benzothiophène utiles pour le traitement de maladies neuro-dégénératives
WO2014062938A1 (fr) 2012-10-19 2014-04-24 Bristol-Myers Squibb Company Modulateurs du récepteur gamma orphelin associé aux rétinoïdes (rory)
EP2964644B1 (fr) 2013-03-08 2018-12-26 Amgen, Inc. Composés perfluorés à base de 1,3-oxazin-2-amine condensée avec un cyclopropyle en tant qu'inhibiteurs de la bêta-secrétase et leurs procédés d'utilisation
WO2015035278A1 (fr) 2013-09-09 2015-03-12 Bristol-Myers Squibb Company Modulateurs de rorγ
WO2015042212A1 (fr) * 2013-09-20 2015-03-26 Bristol-Myers Squibb Company Modulateurs de rorγ
ES2669208T3 (es) 2014-01-06 2018-05-24 Bristol-Myers Squibb Company Derivados de pirrolidinilsulfona y su uso como moduladores de ROR gamma
EP3092215B1 (fr) 2014-01-06 2018-10-17 Bristol-Myers Squibb Company Composés cyclohéxyle sulfone servant de modulateurs de ror gamma
JP6476205B2 (ja) 2014-01-06 2019-02-27 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＲＯＲγ修飾因子としてのヘテロ環式スルホン
WO2015103508A1 (fr) 2014-01-06 2015-07-09 Bristol-Myers Squibb Company Composés sulfone carbocyclique servant de modulateurs de rorγ
CN107709295B (zh) * 2015-05-07 2021-05-04 百时美施贵宝公司 作为RORγ调节剂的三环砜类

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US20190241588A1 (en) 2019-08-08
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PH12017502012A1 (en) 2018-04-02
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BR112017023780A2 (pt) 2018-07-31
IL255419A0 (en) 2017-12-31
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CA2987759A1 (fr) 2016-11-10
EP3292101B1 (fr) 2021-07-28
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UY36673A (es) 2016-11-30
MA41389A1 (fr) 2018-06-29
ES2887087T3 (es) 2021-12-21
WO2016179460A1 (fr) 2016-11-10
MX2017014189A (es) 2018-04-13
HK1249500A1 (zh) 2018-11-02
US9815859B2 (en) 2017-11-14
CN107709295B (zh) 2021-05-04
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US20180002358A1 (en) 2018-01-04
US10711020B2 (en) 2020-07-14
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