MA41389A1 - Utilisation de sulfones tricycliques en tant que modulateurs de rory - Google Patents

Utilisation de sulfones tricycliques en tant que modulateurs de rory

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Publication number
MA41389A1
MA41389A1 MA41389A MA41389A MA41389A1 MA 41389 A1 MA41389 A1 MA 41389A1 MA 41389 A MA41389 A MA 41389A MA 41389 A MA41389 A MA 41389A MA 41389 A1 MA41389 A1 MA 41389A1
Authority
MA
Morocco
Prior art keywords
modulators
rory
patient
formula
methods
Prior art date
Application number
MA41389A
Other languages
English (en)
Inventor
Jingwu Duan
T G Murali Dhar
David Marcoux
Qing Shi
Douglas G Batt
Qingjie Liu
Robert J Cherney
Lyndon A M Cornelius
Anurag S Srivastava
Bertrand Myra Beaudoin
Carolyn A Weigelt
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MA41389A1 publication Critical patent/MA41389A1/fr

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems

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Abstract

La présente invention concerne des modulateurs de ror? De formule (i) et de formule (ii) ou des stéréoisomères, des tautomères, ainsi que des sels, des solvates ou des promédicaments pharmaceutiquement acceptables correspondants, tous les substituants étant tels que définis dans la description. La présente invention concerne en outre des compositions pharmaceutiques les comprenant. Ces composés et ces compositions sont utiles dans des procédés de modulation de l'activité ror? Dans une cellule, et dans des procédés destinés à traiter un patient atteint d'une maladie ou d'un trouble, où ledit patient peut tirer un avantage thérapeutique de la modulation de l'activité ror?, par exemple, dans le cas de troubles auto-immuns et/ou inflammatoires.
MA41389A 2015-05-07 2016-05-06 Utilisation de sulfones tricycliques en tant que modulateurs de rory MA41389A1 (fr)

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PCT/US2016/031118 WO2016179460A1 (fr) 2015-05-07 2016-05-06 Utilisation de sulfones tricycliques en tant que modulateurs de rorγ

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016258087B2 (en) * 2015-05-07 2020-01-02 Bristol-Myers Squibb Company Tricyclic sulfones as RORϒ modulators
SG10201609616TA (en) * 2016-09-06 2018-04-27 Apple Inc Electronic device with cooling fan
JP2019529522A (ja) * 2016-10-10 2019-10-17 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＲＯＲγ調節因子としての三環式スルホン類
CN110049985B (zh) * 2016-10-13 2022-05-31 百时美施贵宝公司 作为RORγ调节剂的杂环砜类
DE102017010487A1 (de) * 2016-12-02 2018-06-07 Merck Patent Gmbh Monofluorierte cyclohexane
KR102829200B1 (ko) * 2018-05-17 2025-07-02 브리스톨-마이어스 스큅 컴퍼니 Ror 감마 조정제로서의 트리시클릭 술폰 화합물
IL279348B2 (en) * 2018-06-15 2026-01-01 Reata Pharmaceuticals Inc Decahydro-2h-naphth[1,2-d]imidazole compounds for inhibition of IL-17 and ROR-gamma
CN112996795B (zh) 2018-09-18 2024-11-12 尼坎治疗公司 作为src同源-2磷酸酶抑制剂的稠合的三环衍生物
WO2020231766A1 (fr) * 2019-05-13 2020-11-19 Bristol-Myers Squibb Company Agonistes de gammat ror
EP4093732A1 (fr) * 2020-01-24 2022-11-30 Bristol-Myers Squibb Company Sulfones tricycliques en tant que modulateurs de ror?
US11332442B2 (en) 2020-08-12 2022-05-17 Bristol-Myers Squibb Company Synthetic process
WO2022043284A1 (fr) * 2020-08-26 2022-03-03 F. Hoffmann-La Roche Ag Composés hétérocycliques utiles en tant qu'inhibiteurs de magl
WO2023232870A1 (fr) 2022-05-31 2023-12-07 Immunic Ag Modulateurs de rorg/rorgt pour le traitement d'infections virales de type covid-19

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005101838A2 (fr) 2004-04-13 2005-10-27 Incyte Corporation Utilisation de derives de piperazinylpiperidine comme antagonistes de recepteurs de chimiokines
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
EP1976843B1 (fr) * 2006-01-20 2013-09-04 Merck Sharp & Dohme Corp. Arylsulfones carbocycliques et heterocycliques en tant que inhibiteurs de gamma secretase
EP2178882B1 (fr) 2007-07-17 2013-04-17 Merck Sharp & Dohme Corp. Benzènesulfonyle-chromane, thiochromane, tétrahydronaphtalène et inhibiteurs de gamma-secrétase associés
KR20150013500A (ko) * 2012-05-08 2015-02-05 머크 샤프 앤드 돔 코포레이션 Ror감마 활성의 억제를 위한 비시클릭 술폰 화합물 및 질환의 치료
EP2669286A1 (fr) 2012-05-31 2013-12-04 Ares Trading S.A. Dérivés de spiro tétrahydro-benzothiophène utiles pour le traitement de maladies neuro-dégénératives
US10035790B2 (en) 2012-10-19 2018-07-31 Exelixis, Inc. RORγ modulators
JP6374889B2 (ja) 2013-03-08 2018-08-15 アムジエン・インコーポレーテツド β−セクレターゼ阻害剤としての過フッ素化シクロプロピル縮合１，３−オキサジン−２−アミン化合物、及び使用方法
US9663469B2 (en) 2013-09-09 2017-05-30 Bristol-Myers Squibb Company RORγ modulators
CN105555768B (zh) * 2013-09-20 2018-10-16 百时美施贵宝公司 RORγ调节剂
CN106132931B (zh) 2014-01-06 2019-08-02 百时美施贵宝公司 碳环砜RORγ调节剂
JP6530764B2 (ja) 2014-01-06 2019-06-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ＲＯＲγ調節因子としてのピロリジニルスルホン誘導体およびその使用
US9637455B2 (en) 2014-01-06 2017-05-02 Bristol-Myers Squibb Company Heterocyclic sulfone RORγ modulators
ES2704460T3 (es) 2014-01-06 2019-03-18 Bristol Myers Squibb Co Moduladores de ROR gamma de ciclohexilsulfona
AU2016258087B2 (en) * 2015-05-07 2020-01-02 Bristol-Myers Squibb Company Tricyclic sulfones as RORϒ modulators

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KR20180002811A (ko) 2018-01-08
KR102114536B1 (ko) 2020-05-22
AR104555A1 (es) 2017-07-26
TN2017000464A1 (en) 2019-04-12
PH12017502012A1 (en) 2018-04-02
BR112017023780A2 (pt) 2018-07-31
MA42049A (fr) 2021-03-17
US10273259B2 (en) 2019-04-30
US10711020B2 (en) 2020-07-14
CA2987759A1 (fr) 2016-11-10
AU2016258087B2 (en) 2020-01-02
UY36673A (es) 2016-11-30
US9815859B2 (en) 2017-11-14
MX2017014189A (es) 2018-04-13
US20160326195A1 (en) 2016-11-10
HK1249500A1 (zh) 2018-11-02
MY190748A (en) 2022-05-12
CO2017012545A2 (es) 2018-05-10
IL255419A0 (en) 2017-12-31
JP2018515494A (ja) 2018-06-14
AU2016258087A1 (en) 2018-01-04
JP6553746B2 (ja) 2019-07-31
ES2887087T3 (es) 2021-12-21
EP3292101A1 (fr) 2018-03-14
EA033345B1 (ru) 2019-09-30
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CN107709295B (zh) 2021-05-04
TW201706244A (zh) 2017-02-16
US20180002358A1 (en) 2018-01-04
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