MA42592A - Utilisation de dérivés de 2-(pyrazolopyridin-3-yl) pyrimidine en tant qu'inhibiteurs de jak - Google Patents

Utilisation de dérivés de 2-(pyrazolopyridin-3-yl) pyrimidine en tant qu'inhibiteurs de jak

Info

Publication number: MA42592A
Authority: MA; Morocco
Prior art keywords: pyrazolopyridin; pyrimidine derivatives; jak inhibitors; jak; inhibitors
Prior art date: 2015-06-11

Application number

MA042592A

Other languages

English (en)

Inventor

Trias Cristina Esteve

Rodriguez Jacob Gonzalez

Moll Joan Taltavull

Juan Bernat Vidal

Original Assignee

Almirall Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-06-11

Filing date

2016-06-10

Publication date

2018-06-20

2016-06-10 Application filed by Almirall Sa filed Critical Almirall Sa

2018-06-20 Publication of MA42592A publication Critical patent/MA42592A/fr

Links

PWNLEGTUORZMTM-UHFFFAOYSA-N 3-pyrimidin-2-yl-1h-pyrazolo[4,3-b]pyridine Chemical class N1=CC=CN=C1C1=NNC2=CC=CN=C12 PWNLEGTUORZMTM-UHFFFAOYSA-N 0.000 title 1
229940122245 Janus kinase inhibitor Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Immunology (AREA)
Hematology (AREA)
Dermatology (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MA042592A 2015-06-11 2016-06-10 Utilisation de dérivés de 2-(pyrazolopyridin-3-yl) pyrimidine en tant qu'inhibiteurs de jak MA42592A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP15382305		2015-06-11

Publications (1)

Publication Number	Publication Date
MA42592A true MA42592A (fr)	2018-06-20

Family

ID=53476802

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA042592A MA42592A (fr)	2015-06-11	2016-06-10	Utilisation de dérivés de 2-(pyrazolopyridin-3-yl) pyrimidine en tant qu'inhibiteurs de jak

Country Status (22)

Country	Link
US (1)	US10759793B2 (fr)
EP (1)	EP3307272A1 (fr)
JP (1)	JP2018516954A (fr)
KR (1)	KR20180012854A (fr)
CN (1)	CN107667106A (fr)
AR (1)	AR104963A1 (fr)
AU (1)	AU2016275716C1 (fr)
BR (1)	BR112017025781A2 (fr)
CA (1)	CA2987328A1 (fr)
CL (1)	CL2017003107A1 (fr)
CO (1)	CO2017011996A2 (fr)
CR (1)	CR20170557A (fr)
EA (1)	EA035312B1 (fr)
HK (1)	HK1246667A1 (fr)
IL (1)	IL255668A (fr)
MA (1)	MA42592A (fr)
MX (1)	MX2017015029A (fr)
PE (1)	PE20180279A1 (fr)
PH (1)	PH12017502236A1 (fr)
SG (1)	SG10201911926UA (fr)
TW (1)	TW201705961A (fr)
WO (1)	WO2016198663A1 (fr)

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CN116327922A (zh)	2015-08-24	2023-06-27	葛兰素史密斯克莱知识产权（第2 号）有限公司	生物医药组合物
JP2019510743A (ja) *	2016-02-12	2019-04-18	ウニヴェルズィテートチューリッヒ	痛風、ざ瘡及び糖尿病の予防又は治療のためのジメチルフマレート（ｄｍｆ）
KR20240052871A (ko)	2016-04-27	2024-04-23	애브비 인코포레이티드	항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법
WO2018087527A1 (fr) *	2016-11-08	2018-05-17	Cancer Research Technology Limited	Dérivés de pyrimidinone en tant qu'inhibiteurs de cdc7
US20180235931A1 (en) *	2017-01-17	2018-08-23	Menlo Therapeutics Inc.	Use of neurokinin-1 antagonists as antitussives
TW201834649A (zh)	2017-03-02	2018-10-01	新加坡商亞獅康私人有限公司	癌症療法
US11311548B2 (en)	2017-03-02	2022-04-26	Aslan Pharmaceuticals Pte. Ltd.	Cancer therapy
US11957931B2 (en) *	2017-04-26	2024-04-16	Yale University	Compositions and methods for treating vitiligo
CN108514637A (zh) *	2018-05-07	2018-09-11	山东省眼科研究所	Stat3抑制剂s31-201在治疗干眼症中的应用
CN109810991B (zh) *	2019-03-02	2021-11-12	昆明理工大学	二氢蝶酸合酶基因folP的用途
US20230150970A1 (en) *	2020-03-27	2023-05-18	Dong-A St Co., Ltd.	Aminopyrimidine derivatives and their use as aryl hydrocarbon receptor modulators
CA3177477A1 (fr) *	2020-06-02	2021-12-09	Nerre Therapeutics Limited	Antagonistes du recepteur de la neurokinine (nk)-1 destines a etre utilises dans le traitement d'etats de fibrose pulmonaire favorises par une lesion mecanique des poumons
CN116847850A (zh) *	2021-02-02	2023-10-03	辉瑞公司	治疗慢性手部湿疹的给药方案
CA3207819A1 (fr)	2021-02-19	2022-08-25	Anjali Pandey	Inhibiteurs de tyk2 et leurs utilisations
JP2024507253A (ja)	2021-02-19	2024-02-16	スドーバイオサイエンシーズリミテッド	Ｔｙｋ２阻害剤およびその使用
JP2024508794A (ja)	2021-02-19	2024-02-28	スドーバイオサイエンシーズリミテッド	Ｔｙｋ２阻害剤およびその使用
EP4696710A3 (fr) *	2021-05-03	2026-05-06	Incyte Corporation	Inhibiteurs de la voie jak1 pour le traitement de prurigo nodularis
EP4376844A1 (fr) *	2021-07-30	2024-06-05	Eli Lilly and Company	Traitement de l'eczéma des mains à l'aide de baricitinib
US20230172937A1 (en)	2021-12-03	2023-06-08	Incyte Corporation	Topical formulations of ruxolitinib with an organic amine ph adjusting agent for treatment of skin diseases
WO2025095039A1 (fr) *	2023-10-31	2025-05-08	ティア・リサーチ・コンサルティング合同会社	Composition pharmaceutique pour maladies de la peau et procédé de recherche d'une nouvelle utilisation de médicament
CN119707992B (zh) *	2024-12-20	2025-12-09	杭州同舟生物技术有限公司	一种纳呋拉啡人工半抗原、人工抗原及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS54128591A (en)	1978-03-25	1979-10-05	Kyowa Hakko Kogyo Co Ltd	Cephalosporin analog
EP2338888A1 (fr) *	2009-12-24	2011-06-29	Almirall, S.A.	Dérivés d'imidazopyridine en tant qu'inhibiteurs JAK
UY33213A (es) *	2010-02-18	2011-09-30	Almirall Sa	Derivados de pirazol como inhibidores de jak
EP2397482A1 (fr)	2010-06-15	2011-12-21	Almirall, S.A.	Dérivés d'imidazolone d'hétéroaryle en tant qu'inhibiteurs de JAK
AR086042A1 (es) *	2011-04-28	2013-11-13	Galapagos Nv	Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica
WO2013025628A1 (fr) *	2011-08-15	2013-02-21	Ligand Pharmaceuticals Incorporated	Composés et procédés d'inhibition de janus kinase
EP2758389B1 (fr) *	2011-09-22	2017-06-07	Merck Sharp & Dohme Corp.	Carboxamides de pyrazole comme inhibiteurs de la janus kinase
WO2015086693A1 (fr) *	2013-12-11	2015-06-18	Almirall, S.A.	Dérivés de pyrazolopyrimidin-2-yle utilisés comme inhibiteurs de jak

2016
- 2016-06-08 TW TW105118168A patent/TW201705961A/zh unknown
- 2016-06-10 SG SG10201911926UA patent/SG10201911926UA/en unknown
- 2016-06-10 WO PCT/EP2016/063391 patent/WO2016198663A1/fr not_active Ceased
- 2016-06-10 MA MA042592A patent/MA42592A/fr unknown
- 2016-06-10 CR CR20170557A patent/CR20170557A/es unknown
- 2016-06-10 AR ARP160101733A patent/AR104963A1/es unknown
- 2016-06-10 MX MX2017015029A patent/MX2017015029A/es unknown
- 2016-06-10 US US15/735,235 patent/US10759793B2/en not_active Expired - Fee Related
- 2016-06-10 BR BR112017025781-5A patent/BR112017025781A2/pt not_active Application Discontinuation
- 2016-06-10 HK HK18106235.2A patent/HK1246667A1/zh unknown
- 2016-06-10 EA EA201792689A patent/EA035312B1/ru not_active IP Right Cessation
- 2016-06-10 KR KR1020187000866A patent/KR20180012854A/ko not_active Withdrawn
- 2016-06-10 AU AU2016275716A patent/AU2016275716C1/en not_active Ceased
- 2016-06-10 JP JP2017563955A patent/JP2018516954A/ja active Pending
- 2016-06-10 PE PE2017002479A patent/PE20180279A1/es unknown
- 2016-06-10 CN CN201680030333.6A patent/CN107667106A/zh active Pending
- 2016-06-10 EP EP16728326.6A patent/EP3307272A1/fr not_active Withdrawn
- 2016-06-10 CA CA2987328A patent/CA2987328A1/fr not_active Abandoned
2017
- 2017-11-14 IL IL255668A patent/IL255668A/en unknown
- 2017-11-27 CO CONC2017/0011996A patent/CO2017011996A2/es unknown
- 2017-12-05 CL CL2017003107A patent/CL2017003107A1/es unknown
- 2017-12-07 PH PH12017502236A patent/PH12017502236A1/en unknown

Also Published As

Publication number	Publication date
CO2017011996A2 (es)	2018-03-28
KR20180012854A (ko)	2018-02-06
EA201792689A1 (ru)	2018-07-31
US10759793B2 (en)	2020-09-01
CA2987328A1 (fr)	2016-12-15
MX2017015029A (es)	2018-04-13
EA035312B1 (ru)	2020-05-27
JP2018516954A (ja)	2018-06-28
PH12017502236A1 (en)	2018-06-11
AU2016275716A1 (en)	2017-12-07
BR112017025781A2 (pt)	2018-08-14
SG10201911926UA (en)	2020-01-30
CL2017003107A1 (es)	2018-04-02
CR20170557A (es)	2018-02-06
AU2016275716C1 (en)	2020-10-15
AR104963A1 (es)	2017-08-30
WO2016198663A1 (fr)	2016-12-15
NZ737314A (en)	2021-02-26
US20180162856A1 (en)	2018-06-14
IL255668A (en)	2018-01-31
TW201705961A (zh)	2017-02-16
AU2016275716B2 (en)	2020-01-23
EP3307272A1 (fr)	2018-04-18
CN107667106A (zh)	2018-02-06
HK1246667A1 (zh)	2018-09-14
PE20180279A1 (es)	2018-02-07

Publication	Publication Date	Title
MA51878A (fr)	2020-12-30	Composés d'aminothiazole en tant qu'inhibiteurs de c-kit
MA40587A (fr)	2017-06-28	Composés d'aminopyrimidinyle en tant qu'inhibiteurs de jak
MA43169A (fr)	2018-09-12	Composés hétérocycliques utilisés en tant qu'inhibiteurs de pi3k-gamma
MA55194A (fr)	2022-05-04	Composés hétérocycliques en tant qu'immunomodulateurs
MA53150A (fr)	2021-05-26	Composés de benzimidazole en tant qu'inhibiteurs de c-kit
MA40774A (fr)	2017-08-08	Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
IL255668A (en)	2018-01-31	2-(pyrazolopyridin-3-yl)pyrimidine derivatives as jak inhibitors
MA42990A (fr)	2021-03-31	Composés utiles en tant qu'immunomodulateurs
MA47013A (fr)	2018-08-29	Composés benzolactames utilisés en tant qu'inhibiteurs de protéine kinase
MA51438A (fr)	2021-04-14	Composés hétérocycliques utilisés en tant qu'inhibiteurs de lsd1
MA47460A (fr)	2019-12-18	Aminotriazolopyridines utilisées en tant qu'inhibiteurs de kinase
MA52063A (fr)	2021-05-26	Composés de n-((hét)arylméthyl)hétéroaryle-carboxamides en tant qu'inhibiteurs de la kallicréine plasmatique
MA41140A (fr)	2017-10-17	Dérivés de 2,4-dioxo-quinazoline-6-sulfonamide en tant qu'inhibiteurs de la parg
MA42659A (fr)	2018-06-27	Dérivés hétéroaryle utilisés en tant qu'inhibiteurs de parp
DK3521282T3 (da)	2021-09-27	Quinazolinderivater anvendt til behandling af hiv
DK3692039T3 (da)	2023-03-13	Enantiomerer af substituerede thiazoler som antivirale forbindelser
EP3509581A4 (fr)	2020-04-08	Formulations de (r
MA42919A (fr)	2018-08-01	Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
MA46981A (fr)	2019-10-09	Dérivés de benzimidazole en tant qu'inhibiteurs de bromodomaine
MA42918A (fr)	2018-08-01	Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
MA49956A (fr)	2020-07-01	Composés de pyrimidine utilisés en tant qu'inhibiteurs de kinase jak
DK3386991T3 (da)	2020-07-13	Polycykliske forbindelser som inhibitorer af bruton's tyrosinkinase
IL252089B (en)	2020-03-31	2-amino-6-(difluoromethyl)- 5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as bace1 inhibitors
EP3250035A4 (fr)	2019-02-27	Composés et leur utilisation en tant qu'inhibiteurs de bace1
EP3250367A4 (fr)	2019-01-09	Étalonnage d'agent