MA42684A - Modulateurs deutérés du récepteur toll - Google Patents

Modulateurs deutérés du récepteur toll

Info

Publication number
MA42684A
MA42684A MA042684A MA42684A MA42684A MA 42684 A MA42684 A MA 42684A MA 042684 A MA042684 A MA 042684A MA 42684 A MA42684 A MA 42684A MA 42684 A MA42684 A MA 42684A
Authority
MA
Morocco
Prior art keywords
deuterated
modulators
toll receiver
toll
receiver
Prior art date
Application number
MA042684A
Other languages
English (en)
Inventor
Steven S Bondy
Ryan Mcfadden
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MA42684A publication Critical patent/MA42684A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA042684A 2015-08-26 2016-08-24 Modulateurs deutérés du récepteur toll MA42684A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562210281P 2015-08-26 2015-08-26

Publications (1)

Publication Number Publication Date
MA42684A true MA42684A (fr) 2018-07-04

Family

ID=56852420

Family Applications (1)

Application Number Title Priority Date Filing Date
MA042684A MA42684A (fr) 2015-08-26 2016-08-24 Modulateurs deutérés du récepteur toll

Country Status (7)

Country Link
US (1) US20210292327A1 (fr)
EP (1) EP3341373A1 (fr)
JP (1) JP2018525412A (fr)
AU (1) AU2016312508A1 (fr)
CA (1) CA2995004A1 (fr)
MA (1) MA42684A (fr)
WO (1) WO2017035230A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7381190B2 (ja) 2014-12-26 2023-11-15 エモリー・ユニバーシテイ Ｎ４－ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
PT3706762T (pt) 2017-12-07 2024-12-05 Univ Emory N4-hidroxicitidina e derivados e utilizações antivirais relacionadas com os mesmos
WO2020162705A1 (fr) 2019-02-08 2020-08-13 성균관대학교산학협력단 Complexe agoniste du récepteur de type toll 7 ou 8-cholestérol, et son utilisation
CA3170551A1 (fr) 2020-03-02 2021-09-10 Yong Taik Lim Nanoparticules mimetiques d'agent pathogene vivant basees sur un squelette de paroi cellulaire d'agent pathogene, et leur procede de production
US20230277525A1 (en) 2020-08-04 2023-09-07 Progeneer Inc Conjugate of functional drug and toll-like receptor 7 or 8 agonist of which active site is temporarily inactivated and use thereof
JP7690221B2 (ja) 2020-08-04 2025-06-10 プロジェニア インコーポレイテッド 動力学的に作用するアジュバントアンサンブル
US20230346924A1 (en) 2020-08-04 2023-11-02 Progeneer Inc. Mrna vaccine comprising adjuvant capable of kinetic control

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA014685B1 (ru) 2003-04-25 2010-12-30 Джилид Сайэнс, Инк. Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе
AU2005330489B2 (en) 2004-07-27 2011-08-25 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti HIV agents
TWI382019B (zh) 2005-08-19 2013-01-11 Array Biopharma Inc 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯
TW201402124A (zh) 2005-08-19 2014-01-16 Array Biopharma Inc 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯
CA2691444C (fr) 2007-06-29 2016-06-14 Gilead Sciences, Inc. Derives de purine et leur utilisation comme modulateurs du recepteur de type toll-7
EA019259B1 (ru) 2007-11-16 2014-02-28 Джилид Сайенсиз, Инк. Ингибиторы репликации вируса иммунодефицита человека
JP5465720B2 (ja) 2008-07-08 2014-04-09 インサイト・コーポレイション インドールアミン２，３−ジオキシゲナーゼの阻害剤としての１，２，５−オキサジアゾール
WO2010014913A1 (fr) 2008-08-01 2010-02-04 Ventirx Pharmaceuticals, Inc. Formulations d'agoniste des récepteurs de type toll et leur utilisation
RS53347B (sr) 2008-12-09 2014-10-31 Gilead Sciences, Inc. Modulatori toll-sličnih receptora
US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
CN105669553A (zh) 2009-08-18 2016-06-15 文蒂雷克斯药品公司 作为toll样受体调节剂的取代的苯并氮杂*
RU2016108987A (ru) 2009-08-18 2018-11-26 Вентиркс Фармасьютикалз, Инк. Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора
JP5694345B2 (ja) 2009-10-22 2015-04-01 ギリアード サイエンシーズ， インコーポレイテッド Ｔｏｌｌ様受容体の調節因子
WO2011139637A1 (fr) 2010-05-03 2011-11-10 Philadelphia Health & Education Corporation Modulateurs à petite molécule de stabilité de capside de vih-1 et procédés pour ceux-ci
TWI500617B (zh) 2010-05-31 2015-09-21 Ono Pharmaceutical Co Purine ketone derivatives
MX2012015097A (es) 2010-07-02 2013-05-28 Gilead Sciences Inc Derivados de acido naft-2-ilacetico para tratar sida.
EP2588455B1 (fr) 2010-07-02 2018-04-04 Gilead Sciences, Inc. Dérivés de l'acide 2-quinolinyl-acétique en tant que composés antiviraux hiv
EP3195868A3 (fr) 2010-10-01 2017-08-02 VentiRx Pharmaceuticals, Inc. Utilisation thérapeutique d'un agoniste de tlr, et polythérapie
CN103237549A (zh) 2010-10-01 2013-08-07 帆德制药股份有限公司 过敏性疾病的治疗方法
PY1153144A (es) 2010-12-10 2015-01-01 Gilead Sciences Inc Inhibidores macrocíclicos de virus flaviviridae
EP3208263A1 (fr) 2011-01-12 2017-08-23 VentiRx Pharmaceuticals, Inc. Benzoazépines substituées en tant que modulateurs de récepteurs de type toll
DK2663555T3 (en) 2011-01-12 2017-03-27 Ventirx Pharmaceuticals Inc SUBSTITUTED BENZOAZEPINS AS MODULATORS OF TOLL-LIKE RECEPTORS
JP5745102B2 (ja) 2011-02-12 2015-07-08 グローブイミューン，インコーポレイテッド 慢性ｂ型肝炎感染症のための酵母系免疫療法組成物
PT3590928T (pt) 2011-04-08 2021-08-19 Janssen Sciences Ireland Unlimited Co Derivados de pirimidina para o tratamento de infeções virais
UA111841C2 (uk) 2011-04-21 2016-06-24 Гіліад Сайєнсіз, Інк. Сполуки бензотіазолу та їх фармацевтичне застосування
AU2012258220B2 (en) 2011-05-18 2017-01-19 Janssen Sciences Ireland Uc Quinazoline derivatives for the treatment of viral infections and further diseases
AU2012278976B2 (en) 2011-07-06 2017-05-11 Gilead Sciences, Inc. Compounds for the treatment of HIV
CN102863512B (zh) 2011-07-07 2016-04-20 上海泓博智源医药技术有限公司 抗病毒化合物
US9199997B2 (en) 2011-11-29 2015-12-01 Ono Pharmaceutical Co., Ltd. Purinone derivative hydrochloride
US9399645B2 (en) 2011-12-20 2016-07-26 Boehringer Ingelheim International Gmbh Inhibitors of HIV replication
BR112014015197A8 (pt) 2011-12-21 2017-06-13 Novira Therapeutics Inc agentes antivirais de hepatite b
SG11201404743TA (en) 2012-02-08 2014-09-26 Janssen R & D Ireland Piperidino-pyrimidine derivatives for the treatment of viral infections
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
UY34750A (es) 2012-04-20 2013-11-29 Gilead Sciences Inc ?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?.
PT2861604T (pt) 2012-06-08 2017-05-05 Gilead Sciences Inc Inibidores macrocíclicos de vírus flaviridae
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
BR112014030649A2 (pt) 2012-06-08 2017-06-27 Gilead Sciences Inc inibidores macrocíclicos da flaviviridae vírus
MX369417B (es) 2012-08-10 2019-11-07 Janssen Sciences Ireland Uc Derivados de alquilpirimidina para el tratamiento de infecciones víricas y otras enfermedades.
EA026957B1 (ru) 2012-08-28 2017-06-30 Янссен Сайенсиз Айрлэнд Юси Конденсированные бициклические производные сульфамоила и их применение в качестве лекарственных препаратов для лечения гепатита b
KR102271574B1 (ko) 2012-08-28 2021-07-01 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 설파모일-아릴아미드 및 b형 간염 치료제로서의 그 용도
CA2881322A1 (fr) 2012-09-10 2014-03-13 F. Hoffmann-La Roche Ag Heteroaryldihydropyrimidines d'acide 6-amine pour le traitement et la prophylaxie d'une infection par le virus de l'hepatite b
DK2906563T3 (en) 2012-10-10 2018-06-06 Janssen Sciences Ireland Uc PYRROLO [3,2-D] PYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS AND OTHER DISEASES
EA035431B1 (ru) 2012-11-16 2020-06-15 Янссен Сайенсиз Айрлэнд Юси Гетероциклические замещенные производные 2-амино-хиназолина в качестве модуляторов tlr7 и/или tlr8 для лечения вирусных инфекций
EA030003B1 (ru) 2012-12-21 2018-06-29 Джилид Сайэнс, Инк. Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции
PE20151063A1 (es) 2012-12-27 2015-08-03 Japan Tobacco Inc DERIVADO SUSTITUIDO DE ESPIROPIRIDO[1,2-a]PIRAZINA Y USO MEDICO DEL MISMO COMO INHIBIDOR DE LA INTEGRASA DEL VIH
SG11201506639XA (en) 2013-02-21 2015-09-29 Janssen Sciences Ireland Uc 2-aminopyrimidine derivatives for the treatment of viral infections
WO2014131847A1 (fr) 2013-02-28 2014-09-04 Janssen R&D Ireland Sulfamoyl-arylamides et leur utilisation en tant que médicaments pour le traitement de l'hépatite b
US8993771B2 (en) 2013-03-12 2015-03-31 Novira Therapeutics, Inc. Hepatitis B antiviral agents
BR112015028873A2 (pt) 2013-05-17 2017-07-25 Hoffmann La Roche heteroaril-diidro-pirimidinas interligados na posição 6, para o tratamento e profilaxia de infecção pelo vírus da hepatite b
ES2859102T3 (es) 2013-07-12 2021-10-01 Gilead Sciences Inc Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH
NO2865735T3 (fr) 2013-07-12 2018-07-21
SG11201701520TA (en) * 2014-09-16 2017-04-27 Gilead Sciences Inc Solid forms of a toll-like receptor modulator

Also Published As

Publication number Publication date
EP3341373A1 (fr) 2018-07-04
CA2995004A1 (fr) 2017-03-02
JP2018525412A (ja) 2018-09-06
AU2016312508A1 (en) 2018-02-15
WO2017035230A1 (fr) 2017-03-02
US20210292327A1 (en) 2021-09-23

Similar Documents

Publication Publication Date Title
MA51081A (fr) Composés modulateurs de récepteurs de type toll
MA53943A (fr) Modulateurs de ror-gamma
DK4088612T3 (da) Fastgørelsesanordning
MA45761A (fr) Modulateurs du récepteur farnésoïde x
EP3314912A4 (fr) Dispositif de retenue magnétique
EP3382683A4 (fr) Afficheur
EP3352472A4 (fr) Récepteur
EP3356636A4 (fr) Dispositif de percussion
EP3729708C0 (fr) Indicateur de format d'intervalle de temps multi-niveau
MA42954A (fr) Potentialisateurs cftr deutérés
MA42684A (fr) Modulateurs deutérés du récepteur toll
MA42113A (fr) Dispositif de coffrage
EP3385963A4 (fr) Dispositif de bobine
EP3330117A4 (fr) Dispositif d'affichage de véhicule
EP3270798A4 (fr) Dispositif de compression
EP3319444A4 (fr) Modulateurs du récepteur opioïde de type mu
EP3358424A4 (fr) Dispositif fixateur
EP3297374A4 (fr) Dispositif de terminal
EP3372443A4 (fr) Dispositif antipatinage
EP3337442A4 (fr) Dispositif de compression
EP3398634A4 (fr) Dispositif de distribution
EP3327171A4 (fr) Dispositif creuset
EP3346723A4 (fr) Dispositif de haut-parleur
FR3016346B1 (fr) Dispositif de ficelage ameliore
EP3425717A4 (fr) Dispositif de stratification