MA42692A - Compositions biopharmaceutiques - Google Patents

Compositions biopharmaceutiques

Info

Publication number: MA42692A
Authority: MA; Morocco
Prior art keywords: biopharmaceutical compositions; biopharmaceutical; compositions
Prior art date: 2015-08-24

Application number

MA042692A

Other languages

English (en)

Inventor

Narendra B Bam

Jennifer Dally

Myrna A Monck

Michelle Spatara

Original Assignee

Glaxosmithkline Ip No 2 Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-08-24

Filing date

2016-08-22

Publication date

2018-07-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56877084&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA42692(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2016-08-22 Application filed by Glaxosmithkline Ip No 2 Ltd filed Critical Glaxosmithkline Ip No 2 Ltd

2018-07-04 Publication of MA42692A publication Critical patent/MA42692A/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Microbiology (AREA)
Mycology (AREA)
Inorganic Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

MA042692A 2015-08-24 2016-08-22 Compositions biopharmaceutiques MA42692A (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US201562209000P	2015-08-24	2015-08-24
US201562240131P	2015-10-12	2015-10-12
US201562247906P	2015-10-29	2015-10-29
US201562249497P	2015-11-02	2015-11-02

Publications (1)

Publication Number	Publication Date
MA42692A true MA42692A (fr)	2018-07-04

Family

ID=56877084

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA042692A MA42692A (fr)	2015-08-24	2016-08-22	Compositions biopharmaceutiques

Country Status (23)

Country	Link
US (11)	US10870695B2 (fr)
EP (3)	EP4717700A2 (fr)
JP (5)	JP6821659B2 (fr)
KR (3)	KR20180037275A (fr)
CN (5)	CN108137683A (fr)
AU (1)	AU2016311385C1 (fr)
BR (1)	BR112018003741A2 (fr)
CA (1)	CA2996088A1 (fr)
CL (1)	CL2018000499A1 (fr)
CO (1)	CO2018001840A2 (fr)
CR (1)	CR20180115A (fr)
DO (1)	DOP2018000057A (fr)
EA (1)	EA037487B1 (fr)
ES (1)	ES3053874T3 (fr)
IL (2)	IL326469A (fr)
MA (1)	MA42692A (fr)
MX (2)	MX2018002319A (fr)
PE (1)	PE20181176A1 (fr)
PH (1)	PH12018500379B1 (fr)
TW (2)	TWI780988B (fr)
UY (1)	UY36868A (fr)
WO (1)	WO2017033121A1 (fr)
ZA (1)	ZA201801158B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20180037275A (ko)	2015-08-24	2018-04-11	글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드	생물제약 조성물
EP3368092B9 (fr)	2015-10-29	2020-07-29	Novartis AG	Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
EP4549463A3 (fr) *	2016-06-17	2025-07-30	F. Hoffmann-La Roche AG	Purification d'anticorps multispécifiques
WO2018119016A1 (fr)	2016-12-23	2018-06-28	Cephalon, Inc.	Anticorps anti-il-5
CN117018188A (zh)	2017-05-26	2023-11-10	葛兰素史密斯克莱知识产权发展有限公司	生物制药组合物和相关方法
BR112019025736A2 (pt) *	2017-06-06	2020-06-30	Glaxosmithkline Llc	uso de um anticorpo e composições para tratar uma doença e para diminuir uma contagem absoluta de eosinófilo no sangue
US11365247B2 (en)	2017-09-29	2022-06-21	Jiangsu Hengrui Medicine Co., Ltd.	IL-5 antibody, antigen binding fragment thereof, and medical application therefor
US11613571B2 (en)	2018-05-23	2023-03-28	Glaxosmithkline Intellectual Property Development Limited	Biopharmaceutical compositions comprising antibody variants
AU2020251627A1 (en) *	2019-03-29	2021-11-11	Jiangsu Hengrui Medicine Co., Ltd.	Pharmaceutical composition containing antibody against IL-5 and use thereof
US20210008199A1 (en) *	2019-07-10	2021-01-14	Regeneron Pharmaceuticals, Inc.	Methods and compositions comprising reduced level of host cell proteins
WO2021126657A1 (fr) *	2019-12-18	2021-06-24	Tesaro, Inc.	Compositions biopharmaceutiques et procédés associés
EP4272756A4 (fr) *	2021-02-05	2024-12-11	Bio-Thera Solutions, Ltd.	Formulation d'anticorps anti-il-5, son procédé de préparation et son utilisation
EP4367136A1 (fr) *	2021-07-09	2024-05-15	Janssen Biotech, Inc.	Procédés de fabrication pour produire des compositions d'anticorps anti-tnf
CN118251407A (zh) *	2021-09-22	2024-06-25	索诺玛生物治疗公司	Il5ra细胞表面标记物

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUT67943A (en)	1992-02-06	1995-05-29	Schering Corp	Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5
WO1995014040A1 (fr) *	1993-11-19	1995-05-26	Baylor College Of Medicine	Anticorps monoclonaux specifiques de l'interleukine humaine 5
GB9412230D0 (en)	1994-06-17	1994-08-10	Celltech Ltd	Interleukin-5 specific recombiant antibodies
US6056957A (en)	1994-08-04	2000-05-02	Schering Corporation	Humanized monoclonal antibodies against human interleukin-5
US7399837B2 (en)	1995-12-22	2008-07-15	Smithkline Beecham Corporation	Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
US5693323A (en)	1994-12-23	1997-12-02	Smithkline Beecham Corporation	Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
US5783184A (en)	1994-12-23	1998-07-21	Smithkline Beecham Corporation	Method for treatment and diagnosis of IL-5 mediated disorders
CA2208503C (fr)	1994-12-23	2009-12-01	Smithkline Beecham P.L.C.	Antagonistes de recombinaison de l'il-5 utiles dans le traitement des troubles induits par l'il-5
GB9712410D0 (en)	1997-06-14	1997-08-13	Glaxo Group Ltd	Peptides and compounds that bind to the il-5 receptor
EP1723178A4 (fr) *	2004-03-12	2007-12-12	Human Genome Sciences Inc	Recepteur humain (ccr5) hdgnr10 de chimiokine de la proteine g
EP1739078A1 (fr)	2005-05-30	2007-01-03	Jerini AG	Antagonistes du recepteur C5a
EP3222142A1 (fr)	2006-02-28	2017-09-27	Kodiak Sciences Inc.	Conjugués de polymères contenant de l'acryloyloxyéthylphosphorylcholine et leur préparation
DK2152290T3 (da)	2007-04-30	2014-08-18	Glaxosmithkline Llc	Fremgangsmåder til indgivelse af anti-il-5-antistoffer
WO2009070642A1 (fr)	2007-11-28	2009-06-04	Medimmune, Llc	Formulation de protéine
US20090148905A1 (en)	2007-11-30	2009-06-11	Claire Ashman	Antigen-binding constructs
TWI472339B (zh) *	2008-01-30	2015-02-11	Genentech Inc	包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
JP5917143B2 (ja)	2008-03-28	2016-05-11	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅＬＬＣ	処置方法
FR2944448B1 (fr)	2008-12-23	2012-01-13	Adocia	Composition pharmaceutique stable comprenant au moins un anticorps monodonal et au moins un polysacharide amphiphile comprenant des substituants derives d'alcools hydrofobes ou d'amines hydrophobes.
JP5657224B2 (ja)	2009-08-31	2015-01-21	富士フイルム株式会社	放射線画像検出器の撮像面の設置誤差の程度を判定する方法および装置
FR2958646B1 (fr)	2010-04-07	2012-05-18	Adocia	Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive d'acide hydrophobe.
ES2468827T3 (es)	2010-01-14	2014-06-17	Sanwa Kagaku Kenkyusho Co., Ltd	Producto farmacéutico para prevenir o tratar trastornos acompañados de angiog�nesis ocular y/o permeabilidad vascular ocular elevada
JP6125436B2 (ja)	2011-02-09	2017-05-10	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅＬＬＣ	凍結乾燥製剤
EA201391489A1 (ru)	2011-04-07	2014-02-28	ГЛЭКСОСМИТКЛАЙН ЭлЭлСи	Композиции со сниженной вязкостью
SG193963A1 (en)	2011-04-07	2013-11-29	Glaxosmithkline Llc	Formulations with reduced viscosity
EP2738172A1 (fr)	2012-11-28	2014-06-04	Almirall, S.A.	Nouveaux composés bicycliques utilisés comme modulateurs du canal crac
BR112015017307A2 (pt) *	2013-03-14	2017-11-21	Abbvie Inc	composições de espécies com baixa acidez e métodos para produção e uso das mesmas
WO2014141149A1 (fr)	2013-03-15	2014-09-18	Glaxosmithkline Intellectual Property (No.2) Limited	Formulations présentant une viscosité réduite
EP2848615A1 (fr)	2013-07-03	2015-03-18	Almirall, S.A.	Nouveaux dérivés de pyrazole utilisés comme modulateurs du canal CRAC
WO2015049519A2 (fr)	2013-10-02	2015-04-09	Vectura Limited	Procédé et appareil
PE20170256A1 (es)	2014-01-24	2017-04-22	Ngm Biopharmaceuticals Inc	Proteinas de union y sus metodos de uso
WO2015117711A1 (fr)	2014-02-06	2015-08-13	Arsanis Biosciences Gmbh	Séquences d'anticorps spécifiques dirigés contre e. coli
TW201705961A (zh)	2015-06-11	2017-02-16	阿爾米雷爾有限公司	作為ｊａｋ抑制劑的２－（吡唑并吡啶－３－基）嘧啶衍生物
KR20180037275A (ko)	2015-08-24	2018-04-11	글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드	생물제약 조성물

2016
- 2016-08-22 KR KR1020187007847A patent/KR20180037275A/ko not_active Ceased
- 2016-08-22 CN CN201680059580.9A patent/CN108137683A/zh active Pending
- 2016-08-22 MX MX2018002319A patent/MX2018002319A/es unknown
- 2016-08-22 TW TW110143679A patent/TWI780988B/zh active
- 2016-08-22 CA CA2996088A patent/CA2996088A1/fr active Pending
- 2016-08-22 EP EP26152573.7A patent/EP4717700A2/fr active Pending
- 2016-08-22 CR CR20180115A patent/CR20180115A/es unknown
- 2016-08-22 KR KR1020257018360A patent/KR20250086801A/ko not_active Ceased
- 2016-08-22 ES ES22152628T patent/ES3053874T3/es active Active
- 2016-08-22 US US15/754,768 patent/US10870695B2/en active Active
- 2016-08-22 MA MA042692A patent/MA42692A/fr unknown
- 2016-08-22 EA EA201890572A patent/EA037487B1/ru not_active IP Right Cessation
- 2016-08-22 CN CN202310268490.2A patent/CN116327923A/zh active Pending
- 2016-08-22 KR KR1020247020339A patent/KR20240099511A/ko active Pending
- 2016-08-22 PE PE2018000264A patent/PE20181176A1/es unknown
- 2016-08-22 TW TW105126697A patent/TWI750133B/zh active
- 2016-08-22 EP EP22152628.8A patent/EP4056590B1/fr active Active
- 2016-08-22 BR BR112018003741-9A patent/BR112018003741A2/en not_active Application Discontinuation
- 2016-08-22 EP EP16760801.7A patent/EP3341409B1/fr active Active
- 2016-08-22 CN CN202310261338.1A patent/CN116327921A/zh active Pending
- 2016-08-22 CN CN202310261355.5A patent/CN116327922A/zh active Pending
- 2016-08-22 IL IL326469A patent/IL326469A/en unknown
- 2016-08-22 WO PCT/IB2016/055012 patent/WO2017033121A1/fr not_active Ceased
- 2016-08-22 PH PH1/2018/500379A patent/PH12018500379B1/en unknown
- 2016-08-22 CN CN202310263809.2A patent/CN116474091A/zh active Pending
- 2016-08-22 JP JP2018510388A patent/JP6821659B2/ja active Active
- 2016-08-22 UY UY0001036868A patent/UY36868A/es unknown
- 2016-08-22 AU AU2016311385A patent/AU2016311385C1/en active Active
2018
- 2018-02-14 IL IL257539A patent/IL257539B1/en unknown
- 2018-02-20 ZA ZA2018/01158A patent/ZA201801158B/en unknown
- 2018-02-21 DO DO2018000057A patent/DOP2018000057A/es unknown
- 2018-02-22 CO CONC2018/0001840A patent/CO2018001840A2/es unknown
- 2018-02-23 MX MX2024001617A patent/MX2024001617A/es unknown
- 2018-02-23 CL CL2018000499A patent/CL2018000499A1/es unknown
2019
- 2019-10-02 JP JP2019182057A patent/JP7463070B2/ja active Active
2020
- 2020-03-02 US US16/806,071 patent/US20200199219A1/en not_active Abandoned
2021
- 2021-07-12 US US17/373,412 patent/US11286298B2/en active Active
- 2021-07-12 US US17/373,223 patent/US11274148B2/en active Active
- 2021-07-12 US US17/373,537 patent/US11299541B2/en active Active
- 2021-09-21 JP JP2021153060A patent/JP2022023049A/ja active Pending
2022
- 2022-03-02 US US17/684,907 patent/US11459384B2/en active Active
- 2022-08-05 US US17/881,988 patent/US12454571B2/en active Active
2024
- 2024-04-30 US US18/650,552 patent/US12187790B2/en active Active
- 2024-04-30 US US18/650,526 patent/US12187789B2/en active Active
- 2024-04-30 US US18/650,566 patent/US12187791B2/en active Active
- 2024-06-05 JP JP2024091451A patent/JP2024123040A/ja active Pending
2025
- 2025-08-05 US US19/290,422 patent/US20260049130A1/en active Pending
- 2025-12-22 JP JP2025272435A patent/JP2026053516A/ja active Pending

Also Published As

Publication number	Publication date
US12187789B2 (en)	2025-01-07
US10870695B2 (en)	2020-12-22
US11459384B2 (en)	2022-10-04
CR20180115A (es)	2018-04-12
US11299541B2 (en)	2022-04-12
AU2016311385B2 (en)	2019-05-09
PH12018500379A1 (en)	2018-09-03
CN116474091A (zh)	2023-07-25
IL326469A (en)	2026-04-01
JP2026053516A (ja)	2026-03-25
IL257539B1 (en)	2026-03-01
US20210340246A1 (en)	2021-11-04
US20210340247A1 (en)	2021-11-04
JP2020033351A (ja)	2020-03-05
DOP2018000057A (es)	2018-03-15
AU2016311385A1 (en)	2018-03-15
TW201722473A (zh)	2017-07-01
US11274148B2 (en)	2022-03-15
EP4056590A1 (fr)	2022-09-14
JP2024123040A (ja)	2024-09-10
US12187790B2 (en)	2025-01-07
US20240294628A1 (en)	2024-09-05
US20200199219A1 (en)	2020-06-25
EP3341409A1 (fr)	2018-07-04
US11286298B2 (en)	2022-03-29
CN116327921A (zh)	2023-06-27
CN108137683A (zh)	2018-06-08
CO2018001840A2 (es)	2018-05-31
JP7463070B2 (ja)	2024-04-08
CL2018000499A1 (es)	2018-07-06
US20240294629A1 (en)	2024-09-05
TWI750133B (zh)	2021-12-21
US20240294630A1 (en)	2024-09-05
JP2022023049A (ja)	2022-02-07
PE20181176A1 (es)	2018-07-20
US20210332125A1 (en)	2021-10-28
PH12018500379B1 (en)	2022-11-23
JP2018526369A (ja)	2018-09-13
JP6821659B2 (ja)	2021-01-27
IL257539A (en)	2018-04-30
US20220185878A1 (en)	2022-06-16
ZA201801158B (en)	2019-08-28
MX2018002319A (es)	2018-04-11
US20220380452A1 (en)	2022-12-01
AU2016311385C1 (en)	2019-08-22
EA037487B1 (ru)	2021-04-02
ES3053874T3 (en)	2026-01-27
EP4056590B1 (fr)	2025-10-15
KR20250086801A (ko)	2025-06-13
EA201890572A1 (ru)	2018-10-31
NZ739899A (en)	2025-05-02
US12454571B2 (en)	2025-10-28
EP4717700A2 (fr)	2026-04-01
CA2996088A1 (fr)	2017-03-02
UY36868A (es)	2017-03-31
WO2017033121A1 (fr)	2017-03-02
TWI780988B (zh)	2022-10-11
KR20240099511A (ko)	2024-06-28
KR20180037275A (ko)	2018-04-11
EP3341409B1 (fr)	2026-02-25
CN116327922A (zh)	2023-06-27
US12187791B2 (en)	2025-01-07
CN116327923A (zh)	2023-06-27
BR112018003741A2 (en)	2018-09-25
MX2024001617A (es)	2024-03-06
TW202233238A (zh)	2022-09-01
US20180251539A1 (en)	2018-09-06
US20260049130A1 (en)	2026-02-19

Publication	Publication Date	Title
NO2023005I1 (no)	2023-02-02	tirzepatide
EP3534968A4 (fr)	2020-07-01	Compositions de lymphocytes t car anti-bcma
DK3361870T3 (da)	2020-05-11	Fungicidsammensætninger
DK3283625T3 (da)	2020-03-02	Nukleasemedieret genomeditering
DK3331528T3 (da)	2021-10-25	Muskarinagonister
DK3277719T3 (da)	2022-05-02	Polypeptider
EP3339331A4 (fr)	2019-05-01	Composition
PT3298027T (pt)	2022-01-26	Compostos depsipéptidos antelmínticos
EP3398996A4 (fr)	2019-07-31	Composition
MA42692A (fr)	2018-07-04	Compositions biopharmaceutiques
DK3331529T3 (da)	2021-10-18	Muskarinagonister
DK3250182T3 (da)	2023-06-26	Dispergible sammensætninger
DK3310450T3 (da)	2019-08-05	Olie-vand-separator
DK3334726T3 (da)	2022-05-16	Plinabulinsammensætninger
DK3270930T3 (da)	2021-10-04	Præeklampsi
HUE054351T2 (hu)	2021-09-28	Vegyületek
EP3395887C0 (fr)	2024-08-28	Composition de caoutchouc fluoré
DK3322295T3 (da)	2022-12-19	Sammensætning
DK3597189T3 (da)	2022-06-27	Krystallinske forbindelser
DK3274482T3 (da)	2020-01-06	Stenborsknop
DE112015006486A5 (de)	2018-01-04	Inkubationsrinne
DK3316857T3 (da)	2021-10-18	Multifasiske sammensætninger
DK3528791T3 (da)	2024-01-29	Dispergible sammensætninger
DK3393254T3 (da)	2021-07-26	Sammensætning
LT3173071T (lt)	2021-07-12	Maropitanto kompozicija