MA43019A - Anticorps anti-humain cd19 à affinité élevée - Google Patents

Anticorps anti-humain cd19 à affinité élevée

Info

Publication number
MA43019A
MA43019A MA043019A MA43019A MA43019A MA 43019 A MA43019 A MA 43019A MA 043019 A MA043019 A MA 043019A MA 43019 A MA43019 A MA 43019A MA 43019 A MA43019 A MA 43019A
Authority
MA
Morocco
Prior art keywords
high affinity
human antibodies
antibodies
human
affinity
Prior art date
Application number
MA043019A
Other languages
English (en)
Inventor
Koller Claudia Ferrara
Mi He
Thomas Hofer
Ekkehard Moessner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA43019A publication Critical patent/MA43019A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA043019A 2015-10-02 2016-09-28 Anticorps anti-humain cd19 à affinité élevée MA43019A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15188262 2015-10-02
EP16167893 2016-05-02

Publications (1)

Publication Number Publication Date
MA43019A true MA43019A (fr) 2018-08-08

Family

ID=57042875

Family Applications (1)

Application Number Title Priority Date Filing Date
MA043019A MA43019A (fr) 2015-10-02 2016-09-28 Anticorps anti-humain cd19 à affinité élevée

Country Status (21)

Country Link
US (3) US20180230215A1 (fr)
EP (1) EP3356405A1 (fr)
JP (1) JP6918789B2 (fr)
KR (1) KR102761077B1 (fr)
CN (1) CN108137698B (fr)
AU (1) AU2016330807B2 (fr)
CA (1) CA3000045C (fr)
CL (1) CL2018000829A1 (fr)
CO (1) CO2018004532A2 (fr)
CR (1) CR20180175A (fr)
IL (1) IL258271B (fr)
MA (1) MA43019A (fr)
MX (1) MX391171B (fr)
MY (1) MY193249A (fr)
PE (1) PE20181089A1 (fr)
PH (1) PH12018500707A1 (fr)
RU (1) RU2761077C1 (fr)
TW (1) TWI748964B (fr)
UA (1) UA125685C2 (fr)
WO (1) WO2017055328A1 (fr)
ZA (1) ZA201801993B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX391388B (es) 2014-11-14 2025-03-21 Hoffmann La Roche Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf.
JP6996979B2 (ja) 2015-03-31 2022-02-04 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 三量体ｔｎｆファミリーリガンドを含む抗原結合分子
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
BR112018002570A2 (pt) 2015-10-02 2018-10-16 Hoffmann La Roche molécula de ligação ao antígeno biespecífica, anticorpo biespecífico, polinucleotídeos, anticorpo que se liga especificamente ao ox40, composição farmacêutica e método para inibir o crescimento de células tumorais em um indivíduo
WO2017189964A2 (fr) 2016-04-29 2017-11-02 Voyager Therapeutics, Inc. Compositions pour le traitement de maladies
US11326182B2 (en) 2016-04-29 2022-05-10 Voyager Therapeutics, Inc. Compositions for the treatment of disease
US20180064758A1 (en) * 2016-09-05 2018-03-08 Ucl Business Plc Chimeric antigen receptor
CN117752798A (zh) 2016-12-19 2024-03-26 豪夫迈·罗氏有限公司 用靶向性4-1bb(cd137)激动剂的组合疗法
MX2019006954A (es) 2016-12-20 2019-08-01 Hoffmann La Roche Terapia de combinacion de anticuerpos biespecificos anti-cd20/anti-cd3 y agonistas de 4-1bb (cd137).
KR20190099527A (ko) 2017-01-03 2019-08-27 에프. 호프만-라 로슈 아게 항-4-1bb 클론 20h4.9를 포함하는 이중특이성 항원 결합 분자
JP7196094B2 (ja) 2017-03-29 2022-12-26 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 共刺激ｔｎｆ受容体のための二重特異性抗原結合分子
EP4201953A1 (fr) 2017-04-03 2023-06-28 F. Hoffmann-La Roche AG Immunoconjugués d'un anticorps anti-pd-1 avec une il-2 mutante ou avec l'il-15
TWI704158B (zh) 2017-04-04 2020-09-11 瑞士商赫孚孟拉羅股份公司 能夠特異性結合至cd40及fap之新穎雙特異性抗原結合分子
CN115819588B (zh) * 2017-09-21 2026-05-12 上海药明生物技术有限公司 新型抗cd19抗体
EP3703746A1 (fr) 2017-11-01 2020-09-09 F. Hoffmann-La Roche AG Nouvelles molécules de liaison à l'antigène contenant un trimère de ligands de la famille du tnf
MA51154A (fr) 2017-12-15 2020-10-21 Aleta Biotherapeutics Inc Variants de cd19
CN108047332B (zh) * 2018-01-15 2021-08-24 阿思科力(苏州)生物科技有限公司 以cd19为靶点的特异性抗体、car-nk细胞及其制备和应用
TW202035447A (zh) 2018-07-04 2020-10-01 瑞士商赫孚孟拉羅股份公司 新穎雙特異性促效性4-1bb抗原結合分子
SG11202102477QA (en) 2018-10-01 2021-04-29 Hoffmann La Roche Bispecific antigen binding molecules comprising anti-fap clone 212
MX2021007320A (es) 2018-12-21 2021-07-07 Hoffmann La Roche Moleculas agonistas de union al antigeno cd28 que actuan sobre el tumor.
US12590135B2 (en) 2019-03-01 2026-03-31 Universität Für Bodenkultur Wien Stabilized extracellular domain of CD19
CN118994397A (zh) 2019-05-21 2024-11-22 诺华股份有限公司 针对bcma的三特异性结合分子及其用途
US12544437B2 (en) 2019-10-04 2026-02-10 Ultragenyx Pharmaceutical Inc. Methods for improved therapeutic use of recombinant AAV
JP7734132B2 (ja) * 2019-12-11 2025-09-04 カリナン セラピューティクス インコーポレイテッド 抗血清アルブミン抗体
EP4073122A4 (fr) 2019-12-11 2024-03-27 Cullinan Oncology, Inc. Anticorps anti-cd19 et protéines de liaison multi-spécifiques
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap
TWI852680B (zh) * 2020-06-19 2024-08-11 瑞士商赫孚孟拉羅股份公司 與 cd3 及 cd19 結合之抗體
EP4240491A1 (fr) * 2020-11-06 2023-09-13 Novartis AG Molécules de liaison à cd19 et utilisations associées

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
ES2375931T3 (es) 1997-12-05 2012-03-07 The Scripps Research Institute Humanización de anticuerpo murino.
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
JP5291279B2 (ja) 2000-09-08 2013-09-18 ウニヴェルジテート・チューリッヒ 反復モジュールを含む反復タンパク質の集合体
ES2283368T3 (es) * 2001-11-14 2007-11-01 Affimed Therapeutics Ag Anticuerpos biespecificos anti-cd19 y anti-cd16 y usos de los mismos.
CA2561686C (fr) 2004-03-31 2014-12-02 Genentech, Inc. Anticorps anti-tgf-beta humanises
ES2579805T3 (es) 2004-09-23 2016-08-16 Genentech, Inc. Anticuerpos y conjugados modificados por ingeniería genética con cisteína
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
HUE025945T2 (en) * 2005-02-15 2016-07-28 Univ Duke Anti-CD19 antibodies and their applications in oncology
CN101233156B (zh) * 2005-06-20 2012-06-27 米德列斯公司 Cd19抗体及其用途
EP1899379B1 (fr) 2005-06-20 2018-04-11 E. R. Squibb & Sons, L.L.C. Anticorps cd19 et utilisations
PL2383297T3 (pl) * 2006-08-14 2013-06-28 Xencor Inc Zoptymalizowane przeciwciała ukierunkowane na CD19
JP5401314B2 (ja) * 2006-09-08 2014-01-29 メディミューン，エルエルシー ヒト化抗ｃｄ１９抗体ならびに癌、移植および自己免疫疾患の治療におけるその使用
JP2012518404A (ja) 2009-02-23 2012-08-16 グレンマーク・ファーマシューティカルズ・エスエー Ｃｄ１９に結合するヒト化抗体及びその使用
BR112012009778A2 (pt) 2009-10-27 2017-06-13 Micromet Ag regime de dosagem para administrar um anticorpo biespecífico de cd19xcd3
WO2011147834A1 (fr) * 2010-05-26 2011-12-01 Roche Glycart Ag Anticorps contre cd19 et utilisations associées
EP2409993A1 (fr) * 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anticorps Anti-CD19 doté d'une fonction ADCC et d'un profil de glycosylation amélioré
ES2692268T5 (en) * 2011-03-29 2025-02-26 Roche Glycart Ag Antibody fc variants
WO2015130766A1 (fr) 2014-02-25 2015-09-03 Memorial Sloan-Kettering Cancer Center Protéines se liant a l'antigène spécifiques du peptide de la tumeur de wilms 1 restreint à hla-a2
AP2017009823A0 (en) 2014-09-26 2017-03-31 Macrogenics Inc Bi-specific monovalent diabodies that are capable of binding cd19 and cd3, and uses thereof
MX391388B (es) * 2014-11-14 2025-03-21 Hoffmann La Roche Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf.
JP6996979B2 (ja) * 2015-03-31 2022-02-04 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 三量体ｔｎｆファミリーリガンドを含む抗原結合分子
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización

Also Published As

Publication number Publication date
BR112018006350A2 (en) 2018-10-09
CL2018000829A1 (es) 2019-05-03
JP2018535657A (ja) 2018-12-06
CN108137698B (zh) 2022-04-19
KR20180054863A (ko) 2018-05-24
IL258271B (en) 2022-05-01
CN108137698A (zh) 2018-06-08
CO2018004532A2 (es) 2018-11-22
TW201718654A (zh) 2017-06-01
JP6918789B2 (ja) 2021-08-11
IL258271A (en) 2018-05-31
CA3000045A1 (fr) 2017-04-06
MX2018003827A (es) 2018-06-22
HK1256366A1 (zh) 2019-09-20
AU2016330807A1 (en) 2018-04-12
US20180230215A1 (en) 2018-08-16
WO2017055328A1 (fr) 2017-04-06
RU2761077C1 (ru) 2021-12-03
EP3356405A1 (fr) 2018-08-08
KR102761077B1 (ko) 2025-02-04
MY193249A (en) 2022-09-28
PH12018500707A1 (en) 2018-10-15
TWI748964B (zh) 2021-12-11
US20230312710A1 (en) 2023-10-05
CA3000045C (fr) 2024-01-02
US20200317774A1 (en) 2020-10-08
UA125685C2 (uk) 2022-05-18
PE20181089A1 (es) 2018-07-09
ZA201801993B (en) 2019-01-30
AU2016330807B2 (en) 2023-08-10
MX391171B (es) 2025-03-21
CR20180175A (es) 2018-05-03
US12590151B2 (en) 2026-03-31

Similar Documents

Publication Publication Date Title
IL269405A (en) Anti-sirp alpha antibodies
DK3625259T3 (da) Anti-sirpalpha-antistoffer
EP3661558A4 (fr) Anticorps anti-il1rap
EP3387442A4 (fr) Anticorps anti-cd73 humanisés
PT3606954T (pt) Anticorpos anti-lag3
EP3569709A4 (fr) Anticorps anti-gpc3
EP3498840A4 (fr) Anticorps anti-lag-3
IL258271B (en) Antibodies against human cd19 with high affinity
EP3423089A4 (fr) Anticorps anti-tigit
EP3334757A4 (fr) Anticorps anti-tigit
EP3297671A4 (fr) Anticorps anti-ror1
MA45004A (fr) Anticorps spécifiques anti-wt1-hla
EP3294335A4 (fr) Anticorps anti-fcrn à maturation d'affinité humanisés
DK3344654T3 (da) Anti-lag-3-antistoffer
EP3691447A4 (fr) Anticorps anti-transthyrétine
EP3319984C0 (fr) Anticorps de liaison tau
DK3310809T3 (da) Anti-cgrp-antistofformulering
DK3350218T3 (da) Polyomavirus-neutraliserende antistoffer
IL256097A (en) Antibody epitope
EP3319983C0 (fr) Anticorps de liaison tau
HUE060878T2 (hu) Anti-transztiretin antitestek
DK3250593T3 (da) Anti-transthyretin-antistoffer
DK3606961T3 (da) Garp-tgf-beta-antistoffer
EP3492591A4 (fr) Anticorps anti-b7-h4
EP3526247A4 (fr) Anticorps anti-il1-rap