MA43017A - Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf - Google Patents
Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnfInfo
- Publication number
- MA43017A MA43017A MA043017A MA43017A MA43017A MA 43017 A MA43017 A MA 43017A MA 043017 A MA043017 A MA 043017A MA 43017 A MA43017 A MA 43017A MA 43017 A MA43017 A MA 43017A
- Authority
- MA
- Morocco
- Prior art keywords
- tnf
- bispecific antibodies
- antibodies specific
- stimulation receptor
- stimulation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
- C12Y304/14005—Dipeptidyl-peptidase IV (3.4.14.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15188095 | 2015-10-02 | ||
| EP16170363 | 2016-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA43017A true MA43017A (fr) | 2018-08-08 |
Family
ID=57018141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA043017A MA43017A (fr) | 2015-10-02 | 2016-09-29 | Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10526413B2 (fr) |
| EP (1) | EP3356403A2 (fr) |
| JP (2) | JP7034066B2 (fr) |
| KR (1) | KR20180053674A (fr) |
| CN (3) | CN108602887B (fr) |
| AU (1) | AU2016329120B2 (fr) |
| BR (1) | BR112018002570A2 (fr) |
| CA (1) | CA2992863A1 (fr) |
| CL (1) | CL2018000390A1 (fr) |
| CO (1) | CO2018000710A2 (fr) |
| CR (1) | CR20180163A (fr) |
| IL (1) | IL257112A (fr) |
| MA (1) | MA43017A (fr) |
| MX (2) | MX2018003820A (fr) |
| MY (2) | MY198560A (fr) |
| PE (2) | PE20240096A1 (fr) |
| PH (1) | PH12018500636A1 (fr) |
| RU (1) | RU2761115C1 (fr) |
| TW (2) | TWI757252B (fr) |
| UA (1) | UA125962C2 (fr) |
| WO (1) | WO2017055398A2 (fr) |
| ZA (1) | ZA201800535B (fr) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| CA2824824A1 (fr) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Proteines monovalentes de liaison a l'antigene |
| JP5764677B2 (ja) | 2011-02-28 | 2015-08-19 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 抗原結合タンパク質 |
| BR112016006929A2 (pt) * | 2013-10-11 | 2017-09-19 | Hoffmann La Roche | Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo |
| DK3489256T3 (da) | 2014-11-14 | 2021-05-25 | Hoffmann La Roche | Antigenbindende molekyler omfattende en TNF-familieligandtrimer |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| EP3973980A1 (fr) | 2015-03-31 | 2022-03-30 | F. Hoffmann-La Roche AG | Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| MA43017A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| WO2017194593A1 (fr) | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Procédé de nettoyage et/ou de désinfection d'une matrice de séparation |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| CN109311949B (zh) | 2016-05-11 | 2022-09-16 | 思拓凡生物工艺研发有限公司 | 储存分离基质的方法 |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US10513537B2 (en) | 2016-05-11 | 2019-12-24 | Ge Healthcare Bioprocess R&D Ab | Separation matrix |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| TW201831513A (zh) | 2016-06-20 | 2018-09-01 | Ｆ星貝塔有限公司 | 結合物件(一) |
| CA3030636A1 (fr) | 2016-07-14 | 2018-01-18 | Genmab A/S | Anticorps multispecifiques diriges contre cd40 et cd137 |
| EP3494139B1 (fr) | 2016-08-05 | 2022-01-12 | F. Hoffmann-La Roche AG | Anticorps multivalents et multiépitopiques ayant une activité agoniste et procédés d'utilisation |
| CN109983033B (zh) * | 2016-09-23 | 2023-10-31 | 美勒斯公司 | 调节细胞表达的生物活性的结合分子 |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| IL267284B2 (en) | 2016-12-19 | 2023-03-01 | Hoffmann La Roche | Combination therapy with a targeted 4-bb1 agonist (cd137) |
| KR102692708B1 (ko) | 2016-12-20 | 2024-08-07 | 에프. 호프만-라 로슈 아게 | 항-cd20/항-cd3 이중특이성 항체 및 4-1bb(cd137) 작용물질의 병용 요법 |
| EP3565843A1 (fr) | 2017-01-03 | 2019-11-13 | H. Hoffnabb-La Roche Ag | Molécules bispécifiques de liaison à l'antigène comprenant un clone 20h4.9 anti-4-1bb |
| EP4491234A3 (fr) | 2017-02-08 | 2025-04-09 | Dragonfly Therapeutics, Inc. | Protéines de fixation multi-spécifiques destinées à l'activation de cellules tueuses naturelles et leurs utilisations thérapeutiques pour traiter le cancer |
| BR112019017197A2 (pt) | 2017-02-20 | 2020-04-14 | Dragonfly Therapeutics, Inc. | proteínas que se ligam a her2, nkg2d e cd16 |
| WO2018178055A1 (fr) * | 2017-03-29 | 2018-10-04 | F. Hoffmann-La Roche Ag | Molécule bispécifique de liaison à l'antigène pour un récepteur de co-stimulation du tnf |
| WO2018178076A1 (fr) | 2017-03-29 | 2018-10-04 | F. Hoffmann-La Roche Ag | Molécule bispécifique de liaison à l'antigène pour un récepteur de co-stimulation du tnf |
| MA49039A (fr) | 2017-04-04 | 2020-02-12 | Hoffmann La Roche | Nouvelles molécules bispécifiques de liaison à l'antigène capables de se lier spécifiquement à cd40 et à fap |
| SG11201909160WA (en) | 2017-04-11 | 2019-10-30 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same |
| KR102629972B1 (ko) | 2017-04-13 | 2024-01-29 | 아게누스 인코포레이티드 | 항-cd137 항체 및 이의 사용 방법 |
| EP3635002A1 (fr) | 2017-06-08 | 2020-04-15 | Black Belt Therapeutics Limited | Anticorps permettant de moduler cd38 |
| EP3635001A1 (fr) | 2017-06-08 | 2020-04-15 | Black Belt Therapeutics Limited | Anticorps permettant de moduler cd38 |
| WO2018237341A1 (fr) * | 2017-06-22 | 2018-12-27 | Development Center For Biotechnology | Format d'anticorps hybride fc-scfv hétérodimère asymétrique d'activation et impliquant des lymphocytes t dépendant de cellules cibles pour la cancérothérapie |
| WO2019025545A1 (fr) | 2017-08-04 | 2019-02-07 | Genmab A/S | Agents de liaison se liant à pd-l1 et cd137 et leur utilisation |
| KR102770110B1 (ko) | 2017-08-16 | 2025-02-20 | 블랙 벨트 테라퓨틱스 리미티드 | Cd38 항체 |
| US11542338B2 (en) * | 2017-08-16 | 2023-01-03 | Black Belt Therapeutics Limited | CD38 modulating antibody |
| KR102770107B1 (ko) | 2017-08-16 | 2025-02-20 | 블랙 벨트 테라퓨틱스 리미티드 | Cd38 조정 항체 |
| WO2019084067A1 (fr) * | 2017-10-24 | 2019-05-02 | Magenta Therapeutics, Inc. | Anticorps anti-cd117 et leurs méthodes d'utilisation |
| KR20200069364A (ko) | 2017-10-24 | 2020-06-16 | 마젠타 테라퓨틱스 인코포레이티드 | Cd117+ 세포의 고갈을 위한 조성물 및 방법 |
| AU2018354189A1 (en) | 2017-10-24 | 2020-04-23 | Crispr Therapeutics Ag | Compositions and methods for the depletion of CD117+ cells |
| MY205342A (en) | 2017-11-01 | 2024-10-16 | Hoffmann La Roche | Bispecific 2+1 contorsbodies |
| CN111315781A (zh) * | 2017-11-01 | 2020-06-19 | 豪夫迈·罗氏有限公司 | 用靶向性ox40激动剂的组合疗法 |
| EP3728317A2 (fr) | 2017-12-21 | 2020-10-28 | F. Hoffmann-La Roche AG | Anticorps se liant à hla-a2/wt1 |
| EP3502140A1 (fr) * | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Thérapie de combinaison d'agonistes d'icos ciblés contre la tumeur avec des molécules bispécifiques à cellules t |
| JP2021511793A (ja) * | 2018-01-31 | 2021-05-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｌａｇ３に結合する抗原結合部位を含む二重特異性抗体 |
| AU2019218125B2 (en) | 2018-02-08 | 2025-03-13 | Dragonfly Therapeutics, Inc. | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| PE20220278A1 (es) | 2018-02-08 | 2022-02-25 | Dragonfly Therapeutics Inc | Dominios variables de anticuerpos que se dirigen al receptor nkg2d |
| TW201942134A (zh) | 2018-02-20 | 2019-11-01 | 美商蜻蜓醫療公司 | 結合cd33、nkg2d及cd16之多特異性結合蛋白及使用方法 |
| TWI841551B (zh) | 2018-03-13 | 2024-05-11 | 瑞士商赫孚孟拉羅股份公司 | 使用靶向4-1bb (cd137)之促效劑的組合療法 |
| WO2019200022A1 (fr) | 2018-04-11 | 2019-10-17 | Inhibrx, Inc. | Produits de recombinaison de polypeptides plurispécifiques comprenant une fixation à cd3 contrainte et méthodes d'utilisation associées |
| WO2019197600A1 (fr) | 2018-04-13 | 2019-10-17 | F. Hoffmann-La Roche Ag | Molécules de liaison à l'antigène ciblant her2 comprenant 4-1bbl |
| MA52366A (fr) | 2018-04-25 | 2021-03-03 | Prometheus Biosciences Inc | Anticorps anti-tl1a optimisés |
| CN112424228B (zh) * | 2018-07-04 | 2024-08-09 | 豪夫迈·罗氏有限公司 | 新型双特异性激动性4-1bb抗原结合分子 |
| GB201811450D0 (en) | 2018-07-12 | 2018-08-29 | F Star Delta Ltd | Mesothelin and CD137 binding molecules |
| US12344672B2 (en) | 2018-07-12 | 2025-07-01 | Invox Pharma Limited | Antibody molecules that bind PD-L1 and CD137 |
| GB201811415D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-Mesothelin Anti bodies |
| GB201811403D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Antibody molecules |
| MX2021000399A (es) | 2018-07-12 | 2021-05-27 | F Star Therapeutics Ltd | Moleculas de anticuerpo que se unen a cd137 y ox40. |
| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
| GB201811404D0 (en) * | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-CD137 Antibodies |
| TW202035451A (zh) | 2018-07-24 | 2020-10-01 | 美商英伊布里克斯公司 | 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法 |
| KR20210041586A (ko) * | 2018-08-01 | 2021-04-15 | 세파론, 인코포레이티드 | 항-cxcr2 항체 및 이의 용도 |
| KR20250112921A (ko) | 2018-08-08 | 2025-07-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| EA202190468A1 (ru) | 2018-08-08 | 2021-07-06 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают bcma, nkg2d и cd16, и способы их применения |
| CN112654641A (zh) * | 2018-10-01 | 2021-04-13 | 豪夫迈·罗氏有限公司 | 具有与cd40的三价结合的双特异性抗原结合分子 |
| PE20211863A1 (es) | 2018-10-01 | 2021-09-21 | Hoffmann La Roche | Moleculas de union a antigeno biespecificas que comprenden el clon 212 anti-fap |
| WO2020076977A2 (fr) | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Anticorps à domaine unique dll3 et compositions thérapeutiques |
| WO2020127618A1 (fr) | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Molécules de liaison à l'antigène cd28 agonistes de ciblage de tumeurs |
| AU2020289080A1 (en) * | 2019-06-04 | 2021-12-23 | Molecular Partners Ag | Multispecific proteins |
| CN110452294B (zh) * | 2019-08-06 | 2020-08-07 | 复旦大学 | 五种铰链区及其嵌合抗原受体和免疫细胞 |
| AU2020329217A1 (en) * | 2019-08-12 | 2022-07-28 | Aptevo Research And Development Llc | 4-1BB and OX40 binding proteins and related compositions and methods, antibodies against 4-1BB, antibodies against OX40 |
| PH12022550978A1 (en) | 2019-10-24 | 2023-10-09 | Cedars Sinai Medical Center | Humanized antibodies to tnf-like ligand 1a (tl1a) and uses thereof |
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| JP2022513495A (ja) | 2018-12-21 | 2022-02-08 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 腫瘍標的化スーパーアゴニストｃｄ２８抗原結合分子 |
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| EP3952996A1 (fr) | 2019-04-12 | 2022-02-16 | F. Hoffmann-La Roche AG | Molécules bispécifiques de liaison à un antigène comprenant des mutéines de lipocalines |
| WO2020260329A1 (fr) | 2019-06-26 | 2020-12-30 | F. Hoffmann-La Roche Ag | Fusion d'un anticorps se liant à cea et 4-1bbl |
| EP4087866A1 (fr) | 2020-01-09 | 2022-11-16 | F. Hoffmann-La Roche AG | Nouvelles molécules de liaison à l'antigène contenant un trimère de 4-1bbl |
| AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
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- 2016-09-29 CA CA2992863A patent/CA2992863A1/fr active Pending
- 2016-09-29 MY MYPI2018701272A patent/MY198560A/en unknown
- 2016-09-29 CN CN201680057465.8A patent/CN108602887B/zh active Active
- 2016-09-29 CN CN202210623357.XA patent/CN115594765A/zh active Pending
- 2016-09-29 CN CN202210629610.2A patent/CN115746143A/zh active Pending
- 2016-09-29 EP EP16774491.1A patent/EP3356403A2/fr active Pending
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