MA43158B1 - Composés oxa-diazadispiro possédant une activité contre la douleur - Google Patents

Composés oxa-diazadispiro possédant une activité contre la douleur

Info

Publication number
MA43158B1
MA43158B1 MA43158A MA43158A MA43158B1 MA 43158 B1 MA43158 B1 MA 43158B1 MA 43158 A MA43158 A MA 43158A MA 43158 A MA43158 A MA 43158A MA 43158 B1 MA43158 B1 MA 43158B1
Authority
MA
Morocco
Prior art keywords
compounds
oxa
diazadispiro
activity against
against pain
Prior art date
Application number
MA43158A
Other languages
English (en)
Inventor
Carmen Almansa-Rosales
Marina Virgili-Bernado
Carlos Alegret-Molina
Original Assignee
Esteve Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Pharmaceuticals Sa filed Critical Esteve Pharmaceuticals Sa
Publication of MA43158B1 publication Critical patent/MA43158B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne des composés oxa-diazaspiro ayant une activité pharmacologique par rapport au récepteur sigma (s), des procédés de préparation de ces composés, des compositions pharmaceutiques les comprenant, ainsi que leur utilisation thérapeutique, en particulier pour traiter la douleur.
MA43158A 2015-10-23 2016-10-21 Composés oxa-diazadispiro possédant une activité contre la douleur MA43158B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15382523 2015-10-23
PCT/EP2016/001742 WO2017067664A1 (fr) 2015-10-23 2016-10-21 Composés oxa-diazaspiro ayant une activité contre la douleur
EP16784795.3A EP3365346B1 (fr) 2015-10-23 2016-10-21 Composés oxa-diazadispiro possédant une activité contre la douleur

Publications (1)

Publication Number Publication Date
MA43158B1 true MA43158B1 (fr) 2020-03-31

Family

ID=54364221

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43158A MA43158B1 (fr) 2015-10-23 2016-10-21 Composés oxa-diazadispiro possédant une activité contre la douleur

Country Status (31)

Country Link
US (1) US10689398B2 (fr)
EP (1) EP3365346B1 (fr)
JP (1) JP6884973B2 (fr)
KR (1) KR20180073638A (fr)
CN (1) CN108349998B (fr)
AR (1) AR106448A1 (fr)
AU (1) AU2016343551A1 (fr)
BR (1) BR112018007269A2 (fr)
CA (1) CA2999925A1 (fr)
CO (1) CO2018004803A2 (fr)
CY (1) CY1122708T1 (fr)
DK (1) DK3365346T3 (fr)
ES (1) ES2775522T3 (fr)
HR (1) HRP20200309T1 (fr)
HU (1) HUE047997T2 (fr)
IL (1) IL258370A (fr)
LT (1) LT3365346T (fr)
MA (1) MA43158B1 (fr)
ME (1) ME03636B (fr)
MX (1) MX2018004777A (fr)
PH (1) PH12018500682A1 (fr)
PL (1) PL3365346T3 (fr)
PT (1) PT3365346T (fr)
RS (1) RS59956B1 (fr)
RU (1) RU2018118399A (fr)
SG (1) SG11201802988XA (fr)
SI (1) SI3365346T1 (fr)
SM (1) SMT202000128T1 (fr)
TN (1) TN2018000091A1 (fr)
TW (1) TW201731853A (fr)
WO (1) WO2017067664A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
RS59956B1 (sr) 2015-10-23 2020-03-31 Esteve Pharmaceuticals Sa Oksa-diazaspiro jedinjenja koja imaju aktivnost protiv bola

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3481942A (en) 1968-09-06 1969-12-02 Smithkline Corp Oxa-diazaspiro(4.5)decane compounds
US4353900A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
WO1993013101A1 (fr) * 1991-12-27 1993-07-08 Yoshitomi Pharmaceutical Industries, Ltd. Compose de pyridonecarboxylate, son utilisation pharmaceutique et compose spiro
US6114541A (en) 1997-03-10 2000-09-05 Hoffmann-La Roche Inc. Method for the preparation of α-Bromo-Lactam derivatives
NZ533567A (en) 2001-12-28 2007-06-29 Acadia Pharm Inc Spiroazacyclic compounds as monoamine receptor for modulating 5-HT2A receptor-mediated events
JP4823914B2 (ja) * 2003-11-07 2011-11-24 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Ｆｇｆｒ３の阻害および多発性骨髄腫の治療
EP1634873A1 (fr) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Inhibiteurs des récepteurs sigma
DE102005030051A1 (de) 2005-06-27 2006-12-28 Grünenthal GmbH Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
PT1961744E (pt) 2005-11-18 2013-05-15 Ono Pharmaceutical Co Composto que contém um grupo básico e sua utilização
EP1829869A1 (fr) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Dérivés de 4,5,6,7-tétrahydrobenzo[b]thiophène et leur utilisaton comme ligands du récepteur sigma
WO2007124136A1 (fr) 2006-04-19 2007-11-01 Acadia Pharmaceuticals, Inc. Utilisation de 4-amino-piperidines pour le traitement des troubles du sommeil
EP1847542A1 (fr) 2006-04-21 2007-10-24 Laboratorios del Dr. Esteve S.A. Dérivés de spiro[benzopyran] ou de spiro[benzofuran] comme antagonistes du récepteur sigma
CN101622241B (zh) 2007-03-01 2013-05-22 田边三菱制药株式会社 苯并咪唑化合物及其医药用途
EP1982714A1 (fr) 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Pyrano-pyrazole-aminés
EP2020414A1 (fr) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. Derivés spiro[piperidine-4,4'-thieno[3,2-c]pyran] et composés similaires en tant que inhibiteurs du recepteur sigma pour le traitement de pyschose
EP2197876A1 (fr) 2007-08-29 2010-06-23 Glaxosmithkline LLC Inhibiteurs de kinase à base de thiazole et d'oxazole
EP2070933A1 (fr) 2007-12-07 2009-06-17 Laboratorios del Dr. Esteve S.A. Composants triazoliques tricycliques
CN102083839B (zh) 2008-02-06 2014-03-26 阿斯利康(瑞典)有限公司 化合物
EP2460347A4 (fr) 2009-10-25 2014-03-12 Lg Electronics Inc Procédé pour traiter des informations de programme de diffusion et récepteur de diffusion
US8828996B2 (en) * 2011-03-14 2014-09-09 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
US8940085B2 (en) 2011-03-16 2015-01-27 Access Business Group International Llc Humidifier with ultraviolet disinfection
EP2744333B1 (fr) 2011-08-19 2016-10-05 Glaxosmithkline Intellectual Property (No. 2) Limited Inhibiteurs d'acide gras synthase
US9751881B2 (en) 2013-07-31 2017-09-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
JP2017100951A (ja) 2014-04-04 2017-06-08 大正製薬株式会社 オキサゾリジノン及びオキサジナノン誘導体
TW201615643A (zh) * 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
TW201615642A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物
TWI685497B (zh) 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
US10022359B2 (en) 2014-11-21 2018-07-17 Esteve Pharmaceuticals, S.A. 1,9-diazaspiro undecane compounds having multimodal activity against pain
RS59956B1 (sr) 2015-10-23 2020-03-31 Esteve Pharmaceuticals Sa Oksa-diazaspiro jedinjenja koja imaju aktivnost protiv bola

Also Published As

Publication number Publication date
JP2018531263A (ja) 2018-10-25
CO2018004803A2 (es) 2018-07-19
PL3365346T3 (pl) 2020-06-01
SI3365346T1 (sl) 2020-04-30
TN2018000091A1 (en) 2019-07-08
CA2999925A1 (fr) 2017-04-27
KR20180073638A (ko) 2018-07-02
ME03636B (fr) 2020-07-20
ES2775522T3 (es) 2020-07-27
PH12018500682A1 (en) 2018-10-01
DK3365346T3 (da) 2020-03-09
HRP20200309T1 (hr) 2020-06-12
US20190002475A1 (en) 2019-01-03
WO2017067664A1 (fr) 2017-04-27
RS59956B1 (sr) 2020-03-31
SMT202000128T1 (it) 2020-05-08
HUE047997T2 (hu) 2020-05-28
AR106448A1 (es) 2018-01-17
CY1122708T1 (el) 2021-03-12
AU2016343551A1 (en) 2018-04-19
JP6884973B2 (ja) 2021-06-09
LT3365346T (lt) 2020-04-10
TW201731853A (zh) 2017-09-16
MX2018004777A (es) 2018-06-19
IL258370A (en) 2018-05-31
RU2018118399A3 (fr) 2020-01-31
BR112018007269A2 (pt) 2018-10-30
US10689398B2 (en) 2020-06-23
CN108349998A (zh) 2018-07-31
EP3365346B1 (fr) 2019-12-04
RU2018118399A (ru) 2019-11-25
SG11201802988XA (en) 2018-05-30
PT3365346T (pt) 2020-03-05
EP3365346A1 (fr) 2018-08-29
CN108349998B (zh) 2021-10-29
WO2017067664A9 (fr) 2017-06-29

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