MA43400A - Dérivés de phényle en tant qu'agonistes du récepteur cannabinoïde 2 - Google Patents

Dérivés de phényle en tant qu'agonistes du récepteur cannabinoïde 2

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Publication number
MA43400A
MA43400A MA43400A MA43400A MA43400A MA 43400 A MA43400 A MA 43400A MA 43400 A MA43400 A MA 43400A MA 43400 A MA43400 A MA 43400A MA 43400 A MA43400 A MA 43400A
Authority
MA
Morocco
Prior art keywords
cannabinoid
receptor agonists
phenyl derivatives
sup
phenyl
Prior art date
Application number
MA43400A
Other languages
English (en)
Other versions
MA43400B1 (fr
Inventor
Olivier Gavelle
Uwe Grether
Matthias Nettekoven
Stephan Roever
Mark Rogers-Evans
Didier Rombach
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA43400A publication Critical patent/MA43400A/fr
Publication of MA43400B1 publication Critical patent/MA43400B1/fr

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    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • C07D305/08—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

L'invention porte sur un composé de formule (i) dans laquelle r<sup>1</sup> à r<sup>3</sup> sont tels que définis dans la description et dans les revendications. Le composé de formule (i) peut être utilisé comme médicament.
MA43400A 2015-12-09 2016-12-06 Dérivés de phényle en tant qu'agonistes du récepteur cannabinoïde 2 MA43400B1 (fr)

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KR100929376B1 (ko) * 2009-01-21 2009-12-02 (주)둔포기계 스퍼터링 장치
WO2017097732A1 (fr) * 2015-12-09 2017-06-15 F. Hoffmann-La Roche Ag Dérivés de phényle en tant qu'agonistes du récepteur cannabinoïde 2
AR112199A1 (es) 2017-06-20 2019-10-02 Hoffmann La Roche Derivados de piridina como agonistas inversos del receptor cannabinoide 2
EP3814328B1 (fr) 2018-06-27 2026-03-11 F. Hoffmann-La Roche AG Nouveaux composés de pyridine substitués par azétidine en tant qu'inhibiteurs du récepteur cannabinoïde 2
EP3995155A1 (fr) 2018-06-27 2022-05-11 F. Hoffmann-La Roche AG Ligands radiomarqués du récepteur cannabinoïde 2
MX2020012760A (es) 2018-06-27 2021-03-25 Hoffmann La Roche Nuevos compuestos de piridina y pirazina como inhibidores del receptor cannabinoide 2.
EP3814337B1 (fr) 2018-06-27 2025-05-14 F. Hoffmann-La Roche AG Dérivés de pyridine et de pyrazine en tant qu'agonistes de cannabinoïde 2 préférentiels
NO20200333A1 (en) * 2020-03-20 2021-03-29 Axichem As Synthesis of capsaicin derivatives
EP4465102A4 (fr) 2022-01-12 2025-04-16 Sumitomo Electric Industries, Ltd. Câble à fibre optique

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TW200745096A (en) * 2005-08-23 2007-12-16 Organon Nv Indole derivatives
EP2003132B1 (fr) 2006-04-03 2014-03-05 Astellas Pharma Inc. Dérivés d'oxadiazole en tant qu'agonistes du S1P1
RU2425832C2 (ru) * 2006-04-03 2011-08-10 Астеллас Фарма Инк. Гетеросоединение
US9321727B2 (en) * 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
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ES2643058T3 (es) * 2012-12-07 2017-11-21 F. Hoffmann-La Roche Ag Piridina-2-amidas útiles como agonistas de CB2
LT2928881T (lt) * 2012-12-07 2018-06-11 F. Hoffmann-La Roche Ag Nauji piridino dariniai
WO2014086807A1 (fr) 2012-12-07 2014-06-12 F. Hoffmann-La Roche Ag Nouveaux dérivés de pyrazine comme agonistes des récepteurs cb2
PE20151559A1 (es) 2013-03-26 2015-11-05 Hoffmann La Roche Nuevos derivados de piridina
AR099933A1 (es) * 2014-04-04 2016-08-31 Hoffmann La Roche Derivados heterocíclicos de piridina agonistas de cb2
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CN204999979U (zh) * 2015-08-05 2016-01-27 林信涌 电解装置
WO2017097732A1 (fr) * 2015-12-09 2017-06-15 F. Hoffmann-La Roche Ag Dérivés de phényle en tant qu'agonistes du récepteur cannabinoïde 2

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CN116102449A (zh) 2023-05-12
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CA2999216A1 (fr) 2017-06-15
TWI722072B (zh) 2021-03-21
TW202206408A (zh) 2022-02-16
MY195889A (en) 2023-02-27
CR20180298A (es) 2018-07-18
AU2016368475A1 (en) 2018-04-12
HRP20200606T1 (hr) 2020-07-10
PT3386951T (pt) 2020-04-24
EP3386951B1 (fr) 2020-02-26
HK1257166A1 (zh) 2019-10-18
AU2016368475B2 (en) 2021-03-04
KR20180091066A (ko) 2018-08-14
AU2021203482B2 (en) 2023-02-09
AU2021203482A1 (en) 2021-07-01
RU2728823C1 (ru) 2020-07-31
MX376414B (es) 2025-03-07
ES2787855T3 (es) 2020-10-19
NZ740727A (en) 2024-10-25
CL2018001493A1 (es) 2018-09-14
TW201722907A (zh) 2017-07-01
WO2017097732A1 (fr) 2017-06-15
JP6953408B2 (ja) 2021-10-27
HUE048865T2 (hu) 2020-08-28
PH12018501181A1 (en) 2019-01-28
MX2018006802A (es) 2018-09-05
IL258127B (en) 2020-06-30
SI3386951T1 (sl) 2020-07-31
CN108349901B (zh) 2022-08-16
EP3386951A1 (fr) 2018-10-17
US20180290966A1 (en) 2018-10-11
BR112018011562A2 (pt) 2018-11-27
LT3386951T (lt) 2020-05-11
KR102836828B1 (ko) 2025-07-22
IL258127A (en) 2018-05-31
US20210171441A1 (en) 2021-06-10
CN108349901A (zh) 2018-07-31
MA43400B1 (fr) 2020-05-29
JP2022003066A (ja) 2022-01-11
US11339120B2 (en) 2022-05-24
ZA201802449B (en) 2019-01-30
CO2018004573A2 (es) 2018-06-12
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