MA43568A - Polynucléotides codant pour la méthylmalonyl-coa mutase - Google Patents
Polynucléotides codant pour la méthylmalonyl-coa mutaseInfo
- Publication number
- MA43568A MA43568A MA043568A MA43568A MA43568A MA 43568 A MA43568 A MA 43568A MA 043568 A MA043568 A MA 043568A MA 43568 A MA43568 A MA 43568A MA 43568 A MA43568 A MA 43568A
- Authority
- MA
- Morocco
- Prior art keywords
- methylmalonyl
- coa mutase
- polynucleotides coding
- polynucleotides
- coding
- Prior art date
Links
- 102000019010 Methylmalonyl-CoA Mutase Human genes 0.000 title 1
- 108010051862 Methylmalonyl-CoA mutase Proteins 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/52—Isomerases (5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y504/00—Intramolecular transferases (5.4)
- C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
- C12Y504/99002—Methylmalonyl-CoA mutase (5.4.99.2)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dispersion Chemistry (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562269089P | 2015-12-17 | 2015-12-17 | |
| US201562269092P | 2015-12-17 | 2015-12-17 | |
| US201562273112P | 2015-12-30 | 2015-12-30 | |
| US201562273108P | 2015-12-30 | 2015-12-30 | |
| US201662274727P | 2016-01-04 | 2016-01-04 | |
| US201662274722P | 2016-01-04 | 2016-01-04 | |
| US201662274733P | 2016-01-04 | 2016-01-04 | |
| US201662274726P | 2016-01-04 | 2016-01-04 | |
| US201662338456P | 2016-05-18 | 2016-05-18 | |
| US201662338478P | 2016-05-18 | 2016-05-18 | |
| US201662409343P | 2016-10-17 | 2016-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA43568A true MA43568A (fr) | 2018-11-14 |
Family
ID=57738001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA043568A MA43568A (fr) | 2015-12-17 | 2016-12-16 | Polynucléotides codant pour la méthylmalonyl-coa mutase |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US10406112B2 (fr) |
| EP (1) | EP3390630B1 (fr) |
| JP (1) | JP7065036B2 (fr) |
| AU (1) | AU2016369612B2 (fr) |
| CA (1) | CA3007108A1 (fr) |
| IL (2) | IL259667B (fr) |
| MA (1) | MA43568A (fr) |
| WO (1) | WO2017106799A1 (fr) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| WO2015105955A1 (fr) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Dispositif d'acoustophorèse avec double chambre acoustophorétique |
| PL4023249T3 (pl) | 2014-04-23 | 2025-03-10 | Modernatx, Inc. | Szczepionki z kwasem nukleinowym |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
| MA42543A (fr) | 2015-07-30 | 2018-06-06 | Modernatx Inc | Arn épitope peptidiques concatémériques |
| US11564893B2 (en) | 2015-08-17 | 2023-01-31 | Modernatx, Inc. | Methods for preparing particles and related compositions |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| WO2017070624A1 (fr) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Vaccins contre des maladies tropicales |
| WO2017070601A1 (fr) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Vaccins à base d'acide nucléique contre le virus varicelle-zona (vzv) |
| AU2016341309A1 (en) | 2015-10-22 | 2018-06-07 | Modernatx, Inc. | Cancer vaccines |
| EP4011451A1 (fr) | 2015-10-22 | 2022-06-15 | ModernaTX, Inc. | Vaccins contre le virus respiratoire |
| AU2016342045A1 (en) | 2015-10-22 | 2018-06-07 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| PL3386484T3 (pl) | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| MA43568A (fr) | 2015-12-17 | 2018-11-14 | Modernatx Inc | Polynucléotides codant pour la méthylmalonyl-coa mutase |
| LT3394030T (lt) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| EP3458108A4 (fr) | 2016-05-18 | 2020-04-22 | ModernaTX, Inc. | Polynucléotides codant pour un régulateur de conductance transmembranaire de fibrose kystique pour le traitement de la fibrose kystique |
| US11001861B2 (en) | 2016-05-18 | 2021-05-11 | Modernatx, Inc. | Polynucleotides encoding galactose-1-phosphate uridylyltransferase for the treatment of galactosemia type 1 |
| MA45036A (fr) | 2016-05-18 | 2019-03-27 | Modernatx Inc | Polynucléotides codant pour la citrine pour le traitement de la citrullinémie de type 2 |
| US12123030B2 (en) | 2016-05-18 | 2024-10-22 | Modernatx, Inc. | Polynucleotides encoding lipoprotein lipase for the treatment of hyperlipidemia |
| WO2017201342A1 (fr) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucléotides codant pour jagged1 pour le traitement du syndrome d'alagille |
| JP2019519601A (ja) | 2016-05-18 | 2019-07-11 | モダーナティエックス・インコーポレイテッドＭｏｄｅｒｎａＴＸ， Ｉｎｃ． | 急性間欠性ポルフィリン症の治療のためのポルホビリノゲン脱アミノ酵素をコードするポリヌクレオチド |
| US20190298657A1 (en) * | 2016-05-18 | 2019-10-03 | Modernatx, Inc. | Polynucleotides Encoding Acyl-CoA Dehydrogenase, Very Long-Chain for the Treatment of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency |
| CA3036831A1 (fr) | 2016-09-14 | 2018-03-22 | Modernatx, Inc. | Compositions d'arn de haute purete et procedes pour leur preparation |
| EP3528821A4 (fr) | 2016-10-21 | 2020-07-01 | ModernaTX, Inc. | Vaccin contre le cytomégalovirus humain |
| US12491261B2 (en) | 2016-10-26 | 2025-12-09 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| MA46766A (fr) | 2016-11-11 | 2019-09-18 | Modernatx Inc | Vaccin antigrippal |
| WO2018107088A2 (fr) | 2016-12-08 | 2018-06-14 | Modernatx, Inc. | Vaccins à acide nucléique contre des virus respiratoires |
| US11384352B2 (en) | 2016-12-13 | 2022-07-12 | Modernatx, Inc. | RNA affinity purification |
| WO2018170270A1 (fr) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Vaccin contre le virus varicelle-zona |
| CA3055653A1 (fr) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Formulation de nanoparticules lipidiques |
| WO2018170322A1 (fr) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Formes cristallines d'aminolipides |
| EP3595713A4 (fr) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | Vaccin contre le virus respiratoire syncytial |
| WO2018170256A1 (fr) * | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Vaccin contre le virus de l'herpès simplex |
| WO2018170245A1 (fr) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Vaccin à large spectre contre le virus de la grippe |
| EP4186888B1 (fr) | 2017-03-15 | 2025-11-26 | ModernaTX, Inc. | Composé et compositions pour l'administration intracellulaire d'agents thérapeutiques |
| EP3595676A4 (fr) | 2017-03-17 | 2021-05-05 | Modernatx, Inc. | Vaccins à base d'arn contre des maladies zoonotiques |
| US11905525B2 (en) | 2017-04-05 | 2024-02-20 | Modernatx, Inc. | Reduction of elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins |
| WO2018232120A1 (fr) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Composés et compositions pour l'administration intracellulaire d'agents |
| US20200131498A1 (en) * | 2017-06-14 | 2020-04-30 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| MA49914A (fr) | 2017-08-18 | 2021-04-21 | Modernatx Inc | Procédés analytiques par hplc |
| EP3668979A4 (fr) | 2017-08-18 | 2021-06-02 | Modernatx, Inc. | Procédés pour analyse par clhp |
| WO2019036682A1 (fr) | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | Variants d'arn polymérase |
| EP3675817A1 (fr) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Procédés de fabrication de nanoparticules lipidiques |
| EP3679379A2 (fr) * | 2017-09-08 | 2020-07-15 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Biomarqueurs d'acidémies organiques |
| WO2019055807A1 (fr) | 2017-09-14 | 2019-03-21 | Modernatx, Inc. | Vaccins à arn contre le virus zika |
| KR102439221B1 (ko) | 2017-12-14 | 2022-09-01 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| CN111712468A (zh) | 2017-12-22 | 2020-09-25 | 北卡罗莱纳州立大学 | 聚合物荧光团、包含其的组合物及制备和使用其的方法 |
| EP3746090A4 (fr) | 2018-01-29 | 2021-11-17 | ModernaTX, Inc. | Vaccins à base d'arn contre le vrs |
| US20190314291A1 (en) * | 2018-01-30 | 2019-10-17 | Modernatx, Inc. | Compositions and methods for delivery of agents to immune cells |
| CN108704162A (zh) * | 2018-08-08 | 2018-10-26 | 中国科学院长春应用化学研究所 | 一种吸水敷料及其制备方法 |
| EP3849617A1 (fr) * | 2018-09-14 | 2021-07-21 | Translate Bio, Inc. | Compositions et méthodes de traitement de l'acidémie méthylmalonique |
| WO2020061295A1 (fr) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Lipides peg de haute pureté et leurs utilisations |
| CA3113025A1 (fr) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Lipides peg et leurs utilisations |
| WO2020061367A1 (fr) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Composés et compositions pour l'administration intracellulaire d'agents thérapeutiques |
| WO2020061457A1 (fr) | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Préparation de nanoparticules lipidiques et leurs méthodes d'administration |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CA3116576A1 (fr) | 2018-10-18 | 2020-04-23 | Acuitas Therapeutics, Inc. | Lipides pour l'administration de nanoparticules lipidiques d'agents actifs |
| WO2020106946A1 (fr) | 2018-11-21 | 2020-05-28 | Translate Bio, Inc. | Traitement de la fibrose kystique par administration d'arnm nébulisé codant pour la cftr |
| AU2020224103A1 (en) | 2019-02-20 | 2021-09-16 | Modernatx, Inc. | Rna polymerase variants for co-transcriptional capping |
| US11851694B1 (en) | 2019-02-20 | 2023-12-26 | Modernatx, Inc. | High fidelity in vitro transcription |
| EP3931312A4 (fr) * | 2019-02-27 | 2022-08-24 | The Regents of The University of Michigan | Carbamoyl phosphate synthétase-1 pour le traitement et la prévention d'une lésion hépatique |
| CN113874502A (zh) | 2019-03-11 | 2021-12-31 | 摩登纳特斯有限公司 | 补料分批体外转录方法 |
| US12070495B2 (en) | 2019-03-15 | 2024-08-27 | Modernatx, Inc. | HIV RNA vaccines |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| EP4031662A1 (fr) | 2019-09-20 | 2022-07-27 | Translate Bio, Inc. | Arnm codant pour cftr modifiée |
| WO2021204175A1 (fr) | 2020-04-09 | 2021-10-14 | Suzhou Abogen Biosciences Co., Ltd. | Compositions de nanoparticules lipidiques |
| EP4132576A1 (fr) | 2020-04-09 | 2023-02-15 | Suzhou Abogen Biosciences Co., Ltd. | Vaccins à base d'acide nucléique pour coronavirus |
| IL297419B2 (en) | 2020-04-22 | 2025-02-01 | BioNTech SE | Coronavirus vaccine |
| ES3054438T3 (en) | 2020-07-16 | 2026-02-03 | Acuitas Therapeutics Inc | Cationic lipids for use in lipid nanoparticles |
| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| EP4274607A1 (fr) | 2021-01-11 | 2023-11-15 | ModernaTX, Inc. | Vaccins contre le virus de la grippe à arn saisonnière |
| US20240226025A1 (en) * | 2021-03-24 | 2024-07-11 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia |
| US20220363937A1 (en) | 2021-05-14 | 2022-11-17 | Armstrong World Industries, Inc. | Stabilization of antimicrobial coatings |
| US20240269248A1 (en) * | 2021-05-19 | 2024-08-15 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia |
| US20250195666A1 (en) * | 2021-05-20 | 2025-06-19 | City Of Hope | Mir-142 compounds and uses thereof |
| US20240398940A1 (en) | 2021-09-03 | 2024-12-05 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| EP4422698A1 (fr) | 2021-10-29 | 2024-09-04 | CureVac SE | Arn circulaire amélioré pour exprimer des protéines thérapeutiques |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| US12529047B1 (en) | 2021-12-21 | 2026-01-20 | Modernatx, Inc. | mRNA quantification methods |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| US20250345407A1 (en) | 2022-05-25 | 2025-11-13 | CureVac SE | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
| WO2024002985A1 (fr) | 2022-06-26 | 2024-01-04 | BioNTech SE | Vaccin contre le coronavirus |
| EP4608442A1 (fr) | 2022-10-28 | 2025-09-03 | GlaxoSmithKline Biologicals S.A. | Vaccin à base d'acide nucléique |
| WO2024184500A1 (fr) | 2023-03-08 | 2024-09-12 | CureVac SE | Nouvelles formulations de nanoparticules lipidiques pour l'administration d'acides nucléiques |
| WO2024230934A1 (fr) | 2023-05-11 | 2024-11-14 | CureVac SE | Acide nucléique thérapeutique pour le traitement de maladies ophtalmiques |
| AU2024347117A1 (en) * | 2023-09-21 | 2026-04-09 | The Board Of Regents Of The University Of Texas System | Endogenous mitochondria targeting signal peptides and uses thereof |
| WO2025126242A1 (fr) * | 2023-12-11 | 2025-06-19 | Dr. Reddy's Institute Of Life Sciences | Séquence(s) d'acide nucléique et construction(s) pour le traitement de l'acidémie méthylmalonique et leur(s) procédé(s) |
| CN118360253A (zh) * | 2024-05-11 | 2024-07-19 | 中山大学附属第六医院 | 一种干扰甲基丙二酰辅酶a变位酶表达的细胞系及其构建方法与应用 |
| WO2026014954A1 (fr) * | 2024-07-10 | 2026-01-15 | 주식회사 엣진 | Éditeur de bases d'adn mitochondrial à efficacité d'édition améliorée |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5489677A (en) | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
| CA2188675A1 (fr) | 1994-04-11 | 1995-10-19 | Savio L. C. Woo | Compositions et procedes de therapie genique pour traiter des maladies |
| US6652886B2 (en) | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
| US20070122885A1 (en) | 2005-08-22 | 2007-05-31 | Fermalogic, Inc. | Methods of increasing production of secondary metabolites by manipulating metabolic pathways that include methylmalonyl-coa |
| PL2578685T3 (pl) | 2005-08-23 | 2020-01-31 | The Trustees Of The University Of Pennsylvania | Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania |
| WO2009030254A1 (fr) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes d'arn et de peptides cationiques pour transfection et immunostimulation |
| CN107028886A (zh) * | 2009-11-04 | 2017-08-11 | 不列颠哥伦比亚大学 | 含有核酸的脂质粒子及相关的方法 |
| EP3318248B1 (fr) | 2009-12-01 | 2019-04-10 | Translate Bio, Inc. | Administration d'arnm pour l'augmentation des protéines et des enzymes dans des maladies génétiques humaines |
| SE535869C2 (sv) * | 2010-04-01 | 2013-01-22 | Elways Ab | Ett för ett eller flera, elektriskt framdrivbara, fordon anpassat system (Laddningssystem). |
| WO2013086373A1 (fr) * | 2011-12-07 | 2013-06-13 | Alnylam Pharmaceuticals, Inc. | Lipides pour l'administration d'agents actifs |
| JP6188728B2 (ja) | 2012-02-07 | 2017-08-30 | グローバル・バイオ・セラピューティクス・インコーポレイテッドＧｌｏｂａｌ Ｂｉｏ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 核酸送達の区画化方法ならびにその組成物および使用 |
| WO2013151665A2 (fr) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Polynucléotides modifiés destinés à la production de protéines associées à une maladie humaine |
| CN104411338A (zh) * | 2012-04-02 | 2015-03-11 | 现代治疗公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
| US9255250B2 (en) | 2012-12-05 | 2016-02-09 | Sangamo Bioscience, Inc. | Isolated mouse or human cell having an exogenous transgene in an endogenous albumin gene |
| AU2013374345A1 (en) | 2013-01-17 | 2015-08-06 | Moderna Therapeutics, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
| WO2014151927A1 (fr) * | 2013-03-14 | 2014-09-25 | Ipg Photonics Corporation | Connecteur de fibre optique universel |
| EP3750903A1 (fr) | 2013-03-14 | 2020-12-16 | Translate Bio, Inc. | Acides ribonucléiques avec nucléotides modifiés 4'-thio et procédés associés |
| ES2644468T3 (es) | 2013-03-15 | 2017-11-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Transgén sintético de la metilmalonil-CoA mutasa para el tratamiento de la acidemia metilmalónica (MMA) de clase MUT |
| US9944918B2 (en) | 2013-03-15 | 2018-04-17 | The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services | Synthetic methylmalonyl-CoA mutase transgene for the treatment of MUT class methylmalonic acidemia (MMA) |
| AU2014296278C1 (en) * | 2013-07-30 | 2023-02-02 | Genevant Sciences Gmbh | Block copolymers and their conjugates or complexes with oligonucleotides |
| HUE060907T2 (hu) | 2014-06-25 | 2023-04-28 | Acuitas Therapeutics Inc | Új lipidek és lipid nanorészecske formulációk nukleinsavak bevitelére |
| WO2016077125A1 (fr) | 2014-11-10 | 2016-05-19 | Moderna Therapeutics, Inc. | Molécules d'acide nucléique de remplacement contenant une quantité réduite d'uracile et utilisations associées |
| JP2018509387A (ja) | 2015-01-21 | 2018-04-05 | フェーズアールエックス インコーポレイテッド | 細胞に治療および診断剤を送達するための方法、組成物、ならびにシステム |
| WO2016172574A2 (fr) * | 2015-04-24 | 2016-10-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Forme marquée de l'enzyme mut, constructions génétiques comprenant celle-ci, et son utilisation en thérapie génique |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| HRP20230209T1 (hr) | 2015-10-28 | 2023-04-14 | Acuitas Therapeutics Inc. | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| WO2017100551A1 (fr) | 2015-12-09 | 2017-06-15 | Alexion Pharmaceuticals, Inc. | Séquences utr hétérologues pour l'amplification de l'expression d'arnm |
| MA43568A (fr) | 2015-12-17 | 2018-11-14 | Modernatx Inc | Polynucléotides codant pour la méthylmalonyl-coa mutase |
| WO2017147720A1 (fr) | 2016-03-04 | 2017-09-08 | Exerkine Corporation | Méthode de traitement d'un trouble du système nerveux central |
| EP3426775A1 (fr) | 2016-03-10 | 2019-01-16 | Novartis AG | Arn messager chimiquement modifié |
| US20180126003A1 (en) | 2016-05-04 | 2018-05-10 | Curevac Ag | New targets for rna therapeutics |
| WO2017191274A2 (fr) | 2016-05-04 | 2017-11-09 | Curevac Ag | Arn codant pour une protéine thérapeutique |
| US11001861B2 (en) | 2016-05-18 | 2021-05-11 | Modernatx, Inc. | Polynucleotides encoding galactose-1-phosphate uridylyltransferase for the treatment of galactosemia type 1 |
| JP2019519601A (ja) | 2016-05-18 | 2019-07-11 | モダーナティエックス・インコーポレイテッドＭｏｄｅｒｎａＴＸ， Ｉｎｃ． | 急性間欠性ポルフィリン症の治療のためのポルホビリノゲン脱アミノ酵素をコードするポリヌクレオチド |
| US12123030B2 (en) | 2016-05-18 | 2024-10-22 | Modernatx, Inc. | Polynucleotides encoding lipoprotein lipase for the treatment of hyperlipidemia |
| US20190298657A1 (en) | 2016-05-18 | 2019-10-03 | Modernatx, Inc. | Polynucleotides Encoding Acyl-CoA Dehydrogenase, Very Long-Chain for the Treatment of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency |
| EP3458108A4 (fr) | 2016-05-18 | 2020-04-22 | ModernaTX, Inc. | Polynucléotides codant pour un régulateur de conductance transmembranaire de fibrose kystique pour le traitement de la fibrose kystique |
| MA45036A (fr) | 2016-05-18 | 2019-03-27 | Modernatx Inc | Polynucléotides codant pour la citrine pour le traitement de la citrullinémie de type 2 |
| WO2018157009A1 (fr) | 2017-02-24 | 2018-08-30 | Modernatx, Inc. | Thérapie de dystrophies musculaires à base d'acide nucléique |
| US20200131498A1 (en) | 2017-06-14 | 2020-04-30 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| EP3849617A1 (fr) | 2018-09-14 | 2021-07-21 | Translate Bio, Inc. | Compositions et méthodes de traitement de l'acidémie méthylmalonique |
-
2016
- 2016-12-16 MA MA043568A patent/MA43568A/fr unknown
- 2016-12-16 WO PCT/US2016/067393 patent/WO2017106799A1/fr not_active Ceased
- 2016-12-16 CA CA3007108A patent/CA3007108A1/fr active Pending
- 2016-12-16 EP EP16822592.8A patent/EP3390630B1/fr active Active
- 2016-12-16 AU AU2016369612A patent/AU2016369612B2/en not_active Ceased
- 2016-12-16 JP JP2018551890A patent/JP7065036B2/ja active Active
-
2018
- 2018-05-29 IL IL259667A patent/IL259667B/en unknown
- 2018-06-07 US US16/002,376 patent/US10406112B2/en active Active
- 2018-06-07 US US16/002,472 patent/US10426738B2/en active Active
- 2018-08-27 US US16/113,814 patent/US20190022019A1/en not_active Abandoned
-
2019
- 2019-07-18 US US16/515,256 patent/US11504337B2/en active Active
-
2021
- 2021-12-19 IL IL289098A patent/IL289098A/en unknown
-
2022
- 2022-11-18 US US17/989,941 patent/US20230270685A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20200078314A1 (en) | 2020-03-12 |
| AU2016369612A1 (en) | 2018-06-14 |
| JP7065036B2 (ja) | 2022-05-11 |
| EP3390630B1 (fr) | 2025-01-22 |
| IL289098A (en) | 2022-02-01 |
| EP3390630A1 (fr) | 2018-10-24 |
| CA3007108A1 (fr) | 2017-06-22 |
| US11504337B2 (en) | 2022-11-22 |
| US20180289838A1 (en) | 2018-10-11 |
| US20190022019A1 (en) | 2019-01-24 |
| AU2016369612B2 (en) | 2023-06-01 |
| IL259667B (en) | 2022-01-01 |
| WO2017106799A1 (fr) | 2017-06-22 |
| US10426738B2 (en) | 2019-10-01 |
| US10406112B2 (en) | 2019-09-10 |
| IL259667A (en) | 2018-07-31 |
| US20180271795A1 (en) | 2018-09-27 |
| JP2019500430A (ja) | 2019-01-10 |
| US20230270685A1 (en) | 2023-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL289098A (en) | Polynucleotides encoding methylmalonyl–coa mutase | |
| MA45051A (fr) | Polynucléotides codant la relaxine | |
| EP3360001A4 (fr) | Visiocasque | |
| DK3356636T3 (da) | Slagindretning | |
| EP3408858A4 (fr) | Structures de graphène pour supercondensateurs | |
| PT3298027T (pt) | Compostos depsipéptidos antelmínticos | |
| BR112016021624A2 (pt) | indexação de locais baseada em polígono | |
| PT4197530T (pt) | Comprimido de ribociclib | |
| EP3337164A4 (fr) | Visiocasque | |
| EP3358200A4 (fr) | Machine de construction | |
| EP3305993A4 (fr) | Machine de construction | |
| CL2016002165A1 (es) | Compuestos de aminocarbonilcarbamato | |
| HUE054351T2 (hu) | Vegyületek | |
| DK3597189T3 (da) | Krystallinske forbindelser | |
| EP3359485C0 (fr) | Production de graphène | |
| ES2789757T8 (es) | Herramienta de conformado | |
| DK3289490T3 (da) | Flertrins cache-udfyldning | |
| LT3253749T (lt) | Junginiai, pasižymintys priešnavikiniu aktyvumu | |
| FR3032494B1 (fr) | Aube de soufflante | |
| DK3325728T3 (da) | Spildevandsbrønd | |
| UY4467S (es) | Frasco | |
| LT3331885T (lt) | Junginiai | |
| ES2811901T8 (es) | Cerradura de cilindro | |
| EP3388149A4 (fr) | Structure de pilier pour biopuce | |
| FR3039220B1 (fr) | Dipositif de postcombustion pour turboreacteur |