MA43816A - Protéines de liaison inductibles et méthodes d'utilisation - Google Patents
Protéines de liaison inductibles et méthodes d'utilisationInfo
- Publication number
- MA43816A MA43816A MA043816A MA43816A MA43816A MA 43816 A MA43816 A MA 43816A MA 043816 A MA043816 A MA 043816A MA 43816 A MA43816 A MA 43816A MA 43816 A MA43816 A MA 43816A
- Authority
- MA
- Morocco
- Prior art keywords
- inductible
- methods
- binding proteins
- proteins
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305092P | 2016-03-08 | 2016-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA43816A true MA43816A (fr) | 2018-11-28 |
Family
ID=59789722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA043816A MA43816A (fr) | 2016-03-08 | 2017-03-08 | Protéines de liaison inductibles et méthodes d'utilisation |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20180134789A1 (fr) |
| EP (1) | EP3426689A4 (fr) |
| JP (3) | JP7195927B2 (fr) |
| KR (2) | KR102501921B1 (fr) |
| CN (1) | CN109071667A (fr) |
| AU (1) | AU2017229687A1 (fr) |
| BR (1) | BR112018068189A2 (fr) |
| CA (1) | CA3016165A1 (fr) |
| IL (1) | IL261432B2 (fr) |
| MA (1) | MA43816A (fr) |
| MX (1) | MX2018010824A (fr) |
| SG (1) | SG11201807548SA (fr) |
| TW (2) | TW201808990A (fr) |
| WO (1) | WO2017156178A1 (fr) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3297672B1 (fr) | 2015-05-21 | 2021-09-01 | Harpoon Therapeutics, Inc. | Protéines trispécifiques de liaison et méthodes d'utilisation |
| HUE054131T2 (hu) | 2015-11-19 | 2021-08-30 | Revitope Ltd | Funkcionális ellenanyag-fragmens-komplementáció nemkívánatos sejtek elpusztítására szolgáló kétkomponensû rendszerben |
| US12128102B2 (en) | 2016-03-08 | 2024-10-29 | Takeda Pharmaceutical Company Limited | Constrained conditionally activated binding proteins |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| HRP20251020T1 (hr) | 2016-05-20 | 2025-10-24 | Harpoon Therapeutics, Inc. | Proteini s jednolančanim varijabilnim fragmentom koji vežu cd3 |
| KR102530742B1 (ko) | 2016-05-20 | 2023-05-09 | 하푼 테라퓨틱스, 인크. | 단일 도메인 혈청 알부민 결합 단백질 |
| BR112019007100A2 (pt) | 2016-10-07 | 2019-06-25 | Tcr2 Therapeutics Inc | composições e métodos para reprogramação de receptores de célula t com o uso de proteínas de fusão |
| JP7215997B2 (ja) | 2016-11-23 | 2023-01-31 | ハープーン セラピューティクス，インク． | 前立腺特異的膜抗原（ｐｓｍａ）を標的とする三重特異性タンパク質と使用方法 |
| KR102275008B1 (ko) | 2016-11-23 | 2021-07-13 | 하푼 테라퓨틱스, 인크. | 전립선 특이 막 항원 결합 단백질 |
| WO2018160671A1 (fr) * | 2017-02-28 | 2018-09-07 | Harpoon Therapeutics, Inc. | Inhibiteurs de point de contrôle ciblés et méthodes d'utilisation |
| WO2018160754A2 (fr) | 2017-02-28 | 2018-09-07 | Harpoon Therapeutics, Inc. | Protéine monovalente inductible de fixation d' antigène |
| US20200115461A1 (en) * | 2017-05-03 | 2020-04-16 | Harpoon Therapeutics, Inc. | Compositions and methods for adoptive cell therapies |
| US10730954B2 (en) | 2017-05-12 | 2020-08-04 | Harpoon Therapeutics, Inc. | MSLN targeting trispecific proteins and methods of use |
| SG10202107880XA (en) | 2017-05-12 | 2021-09-29 | Harpoon Therapeutics Inc | Mesothelin binding proteins |
| CN111315773A (zh) | 2017-09-08 | 2020-06-19 | 马弗里克治疗公司 | 含有Fc区的条件性活化的结合部分 |
| CN111356700A (zh) * | 2017-09-08 | 2020-06-30 | 马弗里克治疗公司 | 受约束的条件性活化的结合蛋白 |
| CA3078969A1 (fr) | 2017-10-13 | 2019-04-18 | Harpoon Therapeutics, Inc. | Proteines trispecifiques et methodes d'utilisation |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| KR102578682B1 (ko) * | 2017-11-01 | 2023-09-13 | 난트바이오 인코포레이티드 | Il8의 emt 경로 차단 및 암 줄기 세포 극복(il8 bloking emt pathway and overcoming cancer stem cells) |
| CN110218256B (zh) * | 2018-03-02 | 2020-12-08 | 广西医科大学 | 抗CD3的纳米抗体CD3/Nb29及其制备方法与应用 |
| CN110218253B (zh) * | 2018-03-02 | 2020-12-04 | 广西医科大学 | 抗CD3的纳米抗体CD3/Nb14及其制备方法与应用 |
| WO2019222296A1 (fr) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Polypeptides d'interleukine 12 activables et procédés d'utilisation associés |
| MX2020012251A (es) | 2018-05-14 | 2021-04-28 | Werewolf Therapeutics Inc | Polipeptidos de interleucina-2 activables y metodos de uso de los mismos. |
| MX2020012217A (es) * | 2018-05-14 | 2021-03-02 | Harpoon Therapeutics Inc | Porción de unión para activación condicional de moléculas de inmunoglobulina. |
| US20210130430A1 (en) | 2018-05-14 | 2021-05-06 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| WO2019222282A1 (fr) * | 2018-05-14 | 2019-11-21 | Harpoon Therapeutics, Inc. | Protéine de liaison activée de manière conditionnelle comprenant un domaine de liaison cible à occlusion stérique |
| MX2020014290A (es) * | 2018-06-22 | 2021-08-05 | Cugene Inc | Farmacos bioactivables a base de citoquinas y métodos de usos de los mismos. |
| EP3833444A1 (fr) | 2018-08-09 | 2021-06-16 | Maverick Therapeutics, Inc. | Procédé de coexpression et de purification de protéines de liaison activées de manière conditionnelle |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| CN119306844A (zh) | 2018-09-25 | 2025-01-14 | 哈普恩治疗公司 | Dll3结合蛋白及使用方法 |
| CA3126707A1 (fr) * | 2019-01-29 | 2020-08-06 | Gritstone Bio, Inc. | Proteines de liaison multispecifiques |
| EP4592313A3 (fr) | 2019-03-05 | 2025-11-19 | Takeda Pharmaceutical Company Limited | Protéines de liaison à activation conditionnelle restreinte |
| JP2022524337A (ja) * | 2019-03-05 | 2022-05-02 | 武田薬品工業株式会社 | 腫瘍抗原を標的とするｆｃ領域及び部分を含有する条件的に活性化された結合タンパク質 |
| WO2020232303A1 (fr) | 2019-05-14 | 2020-11-19 | Harpoon Therapeutics, Inc. | Protéines de liaison à epcam et méthodes d'utilisation |
| BR112021022666A2 (pt) | 2019-05-14 | 2022-03-29 | Werewolf Therapeutics Inc | Frações de separação e seus métodos e uso |
| WO2021097060A1 (fr) * | 2019-11-13 | 2021-05-20 | Harpoon Therapeutics, Inc. | Molécule pro-immunomodulatrice comprenant une fraction de groupement |
| BR112022009110A2 (pt) | 2019-11-14 | 2022-07-26 | Werewolf Therapeutics Inc | Polipeptídeos de citocina ativáveis e métodos de uso destes |
| AU2020403148A1 (en) * | 2019-12-13 | 2022-06-30 | Cugene Inc. | Cytokine-based bioactivatable drugs and methods of uses thereof |
| CN114829408B (zh) * | 2019-12-20 | 2024-01-26 | 山东博安生物技术股份有限公司 | 用于免疫治疗的t细胞双特异性抗体生产中的优化抗cd3臂 |
| US12662535B2 (en) | 2020-01-17 | 2026-06-23 | Immunelogic Therapeutics, Inc. | Pro-antibody that reduces off-target toxicity |
| EP4090686A4 (fr) * | 2020-01-17 | 2024-03-27 | Immune Targeting Inc. | Pro-anticorps réduisant la toxicité hors cible |
| BR112022016550A2 (pt) | 2020-02-21 | 2022-11-16 | Harpoon Therapeutics Inc | Proteínas de ligação a flt3 e métodos de uso |
| WO2021207657A1 (fr) | 2020-04-09 | 2021-10-14 | Cytomx Therapeutics, Inc. | Compositions contenant des anticorps activables |
| CN115698072B (zh) | 2020-07-01 | 2023-07-04 | 山东博安生物技术股份有限公司 | 抗gpc3抗体，抗gpc3嵌合抗原受体和gpc3/cd3双特异性抗体 |
| US20240409617A1 (en) | 2020-07-03 | 2024-12-12 | Dana-Farber Cancer Institute, Inc. | Multispecific coronavirus antibodies |
| WO2022040128A2 (fr) | 2020-08-17 | 2022-02-24 | Maverick Therapeutics, Inc. | Protéines de liaison à activation conditionnelle limitée |
| EP4199947A4 (fr) | 2020-08-18 | 2024-10-16 | Onchilles Pharma, Inc. | Protéines d'élastase pancréatique porcine modifiées |
| CN116261592A (zh) * | 2020-08-18 | 2023-06-13 | 昂希莱斯制药公司 | 经修饰的丝氨酸蛋白酶前蛋白 |
| EP4225786A2 (fr) * | 2020-10-07 | 2023-08-16 | Amgen Inc. | Sélection rationnelle de blocs de construction pour l'assemblage d'anticorps multispécifiques |
| WO2022082030A2 (fr) | 2020-10-15 | 2022-04-21 | Gritstone Bio, Inc. | Protéines de liaison à l'antigène et procédés d'utilisation associés |
| JP2023550148A (ja) | 2020-11-20 | 2023-11-30 | シンシア・イノベーション・インコーポレイテッド | がん免疫治療に用いられる武装二重ｃａｒ－ｔ組成物及び方法 |
| EP4259193A4 (fr) | 2020-12-09 | 2025-01-15 | Janux Therapeutics, Inc. | Compositions et méthodes associées à des anticorps activés par des tumeurs ciblant psma et des antigènes de cellules effectrices |
| WO2022155503A1 (fr) | 2021-01-14 | 2022-07-21 | Gritstone Bio, Inc. | Anticorps multi-spécifiques et procédés d'utilisation |
| EP4319806A1 (fr) | 2021-04-06 | 2024-02-14 | Takeda Pharmaceutical Company Limited | Méthodes thérapeutiques utilisant des protéines de liaison activées de manière conditionnelle contraintes |
| US20240262917A1 (en) | 2021-05-06 | 2024-08-08 | Dana-Farber Cancer Institute, Inc. | Antibodies against alk and methods of use thereof |
| WO2023034288A1 (fr) | 2021-08-31 | 2023-03-09 | Dana-Farber Cancer Institute, Inc. | Compositions et méthodes de traitement de troubles auto-immuns et du cancer |
| WO2023097024A1 (fr) | 2021-11-24 | 2023-06-01 | Dana-Farber Cancer Institute, Inc. | Anticorps contre ctla-4 et leurs méthodes d'utilisation |
| WO2023114543A2 (fr) | 2021-12-17 | 2023-06-22 | Dana-Farber Cancer Institute, Inc. | Plateforme pour découverte d'anticorps |
| WO2023114544A1 (fr) | 2021-12-17 | 2023-06-22 | Dana-Farber Cancer Institute, Inc. | Anticorps et leurs utilisations |
| WO2024039672A2 (fr) | 2022-08-15 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | Anticorps anti-mlsn et leurs méthodes d'utilisation |
| CA3263665A1 (fr) | 2022-08-15 | 2024-02-22 | Dana-Farber Cancer Institute, Inc. | Anticorps anti-cldn4 et leurs méthodes d'utilisation |
| WO2024104988A1 (fr) * | 2022-11-15 | 2024-05-23 | F. Hoffmann-La Roche Ag | Protéines de liaison recombinantes ayant un domaine effecteur activable |
| WO2025237931A1 (fr) * | 2024-05-15 | 2025-11-20 | F. Hoffmann-La Roche Ag | Protéines de liaison recombinantes avec lymphocytes t activables de manière conditionnelle et domaines effecteurs recrutant des cellules nk |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004242846A1 (en) * | 2003-05-31 | 2004-12-09 | Micromet Ag | Pharmaceutical compositions comprising bispecific anti-CD3, anti-CD19 antibody constructs for the treatment of B-cell related disorders |
| US8076459B2 (en) * | 2003-10-16 | 2011-12-13 | Micromet Ag | Multispecfic deimmunized CD3-binders |
| US20070269422A1 (en) | 2006-05-17 | 2007-11-22 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| BR112013002167A2 (pt) | 2010-08-24 | 2016-05-31 | Roche Glycart Ag | anticorpo biespecífico, composição farmacêutica, uso, método de tratamento de um paciente que sofre de câncer e de um paciente que sofre de inflamação |
| US20120225081A1 (en) | 2010-09-03 | 2012-09-06 | Boehringer Ingelheim International Gmbh | Vegf-binding molecules |
| WO2012162067A2 (fr) * | 2011-05-21 | 2012-11-29 | Macrogenics, Inc. | Molécules de liaison des cd3 capables de se lier aux cd3 humaines et non humaines |
| AU2012280474A1 (en) | 2011-07-01 | 2014-01-16 | Bayer Intellectual Property Gmbh | Relaxin fusion polypeptides and uses thereof |
| CN108610421B (zh) | 2012-02-27 | 2022-08-19 | 阿布林克斯有限公司 | Cx3cr1结合多肽 |
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| JP6407726B2 (ja) | 2012-03-01 | 2018-10-24 | アムゲン リサーチ （ミュンヘン） ゲーエムベーハーＡＭＧＥＮ Ｒｅｓｅａｒｃｈ（Ｍｕｎｉｃｈ）ＧｍｂＨ | 長寿命ポリペプチド結合分子 |
| WO2014004549A2 (fr) | 2012-06-27 | 2014-01-03 | Amgen Inc. | Protéines de liaison anti-mésothéline |
| CA2912389C (fr) * | 2013-06-10 | 2020-01-28 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Procedes et compositions pour reduire l'immunodepression par des cellules tumorales |
| PL3122781T3 (pl) * | 2014-03-28 | 2020-06-15 | Xencor, Inc. | Dwuswoiste przeciwciała, które wiążą się z CD38 i CD3 |
| HUE054131T2 (hu) * | 2015-11-19 | 2021-08-30 | Revitope Ltd | Funkcionális ellenanyag-fragmens-komplementáció nemkívánatos sejtek elpusztítására szolgáló kétkomponensû rendszerben |
| EP3833444A1 (fr) * | 2018-08-09 | 2021-06-16 | Maverick Therapeutics, Inc. | Procédé de coexpression et de purification de protéines de liaison activées de manière conditionnelle |
-
2017
- 2017-03-08 AU AU2017229687A patent/AU2017229687A1/en not_active Abandoned
- 2017-03-08 CA CA3016165A patent/CA3016165A1/fr active Pending
- 2017-03-08 IL IL261432A patent/IL261432B2/en unknown
- 2017-03-08 WO PCT/US2017/021435 patent/WO2017156178A1/fr not_active Ceased
- 2017-03-08 JP JP2018547940A patent/JP7195927B2/ja active Active
- 2017-03-08 EP EP17764037.2A patent/EP3426689A4/fr active Pending
- 2017-03-08 KR KR1020187029014A patent/KR102501921B1/ko active Active
- 2017-03-08 CN CN201780028480.4A patent/CN109071667A/zh active Pending
- 2017-03-08 SG SG11201807548SA patent/SG11201807548SA/en unknown
- 2017-03-08 MX MX2018010824A patent/MX2018010824A/es unknown
- 2017-03-08 MA MA043816A patent/MA43816A/fr unknown
- 2017-03-08 TW TW106107861A patent/TW201808990A/zh unknown
- 2017-03-08 BR BR112018068189-0A patent/BR112018068189A2/pt not_active IP Right Cessation
- 2017-03-08 TW TW111119065A patent/TW202302631A/zh unknown
- 2017-03-08 KR KR1020237005284A patent/KR20230041739A/ko not_active Ceased
- 2017-10-06 US US15/727,423 patent/US20180134789A1/en not_active Abandoned
-
2022
- 2022-05-18 JP JP2022081366A patent/JP7293456B2/ja active Active
-
2023
- 2023-06-07 JP JP2023093681A patent/JP2023123519A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20180134789A1 (en) | 2018-05-17 |
| SG11201807548SA (en) | 2018-09-27 |
| EP3426689A1 (fr) | 2019-01-16 |
| BR112018068189A2 (pt) | 2019-02-05 |
| IL261432B2 (en) | 2024-03-01 |
| JP2023123519A (ja) | 2023-09-05 |
| JP2022140856A (ja) | 2022-09-28 |
| EP3426689A4 (fr) | 2020-01-15 |
| KR20180120245A (ko) | 2018-11-05 |
| TW202302631A (zh) | 2023-01-16 |
| JP2019513014A (ja) | 2019-05-23 |
| WO2017156178A1 (fr) | 2017-09-14 |
| KR20230041739A (ko) | 2023-03-24 |
| KR102501921B1 (ko) | 2023-02-21 |
| CN109071667A (zh) | 2018-12-21 |
| RU2018134949A (ru) | 2020-04-08 |
| IL261432B1 (en) | 2023-11-01 |
| JP7293456B2 (ja) | 2023-06-19 |
| MX2018010824A (es) | 2019-05-15 |
| CA3016165A1 (fr) | 2017-09-14 |
| RU2018134949A3 (fr) | 2020-08-14 |
| JP7195927B2 (ja) | 2022-12-26 |
| TW201808990A (zh) | 2018-03-16 |
| IL261432A (en) | 2018-10-31 |
| AU2017229687A1 (en) | 2018-09-20 |
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